Motif ID: EWSR1-FLI1.p2

Z-value: 1.359


Transcription factors associated with EWSR1-FLI1.p2:

fusion protein between EWSR1 and FLI1 in an oncogenic event

Gene SymbolEntrez IDGene Name
Ewsr1 14030 Ewing sarcoma breakpoint region 1
Fli1 14247 Friend leukemia integration 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ewsr1chr11_-_4999069-0.272.6e-04Click!
Fli1chr9_-_323488630.046.2e-01Click!


Activity profile for motif EWSR1-FLI1.p2.

activity profile for motif EWSR1-FLI1.p2


Sorted Z-values histogram for motif EWSR1-FLI1.p2

Sorted Z-values for motif EWSR1-FLI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EWSR1-FLI1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_79451245 41.390 NM_027455
 Qpct
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
chr17_+_79451501 39.996 Qpct
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
chr11_+_31900378 32.212 NM_008741
 Nsg2
neuron specific gene family member 2
chrX_-_133403050 25.457 NM_176971
 Rab9b
RAB9B, member RAS oncogene family
chr4_+_43419445 23.104 NM_199057
 Rusc2
RUN and SH3 domain containing 2
chr14_-_55585407 22.639 Myh6
myosin, heavy polypeptide 6, cardiac muscle, alpha
chr6_-_77929543 21.910 Ctnna2
catenin (cadherin associated protein), alpha 2
chr14_-_55585412 19.030 NM_001164171
NM_010856
 Myh6

myosin, heavy polypeptide 6, cardiac muscle, alpha

chr7_-_147268395 18.261 NM_001190385
NM_026769
 Caly

calcyon neuron-specific vesicular protein

chr16_-_42340613 15.575 NM_008083
 Gap43
growth associated protein 43
chr2_-_122420914 14.841 Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr6_-_77929685 14.549 Ctnna2
catenin (cadherin associated protein), alpha 2
chr12_+_89055024 14.258 NM_001177573
 Gm4027
BB287469
predicted gene 4027
expressed sequence BB287469
chr6_-_77929575 14.152 Ctnna2
catenin (cadherin associated protein), alpha 2
chr6_-_77929660 11.832 NM_001109764
NM_009819
NM_145732
 Ctnna2


catenin (cadherin associated protein), alpha 2


chr16_-_28753276 11.704 NM_010199
 Fgf12
fibroblast growth factor 12
chr11_+_56825192 10.571 NM_001113325
NM_008165
 Gria1

glutamate receptor, ionotropic, AMPA1 (alpha 1)

chr2_-_91469372 9.869 F2
coagulation factor II
chr16_-_28753298 9.718 Fgf12
fibroblast growth factor 12
chr5_-_121161653 9.621 Dtx1
deltex 1 homolog (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 4 of 4 entries
Enrichment   P-value GO Accession GO Term
4.15 1.08e-04 GO:0007268 synaptic transmission
3.29 4.32e-03 GO:0019226 transmission of nerve impulse
3.29 4.32e-03 GO:0035637 multicellular organismal signaling
3.22 6.52e-04 GO:0007267 cell-cell signaling

Gene overrepresentation in compartment category:

Showing 1 to 3 of 3 entries
Enrichment   P-value GO Accession GO Term
22.95 4.55e-02 GO:0034366 spherical high-density lipoprotein particle
2.81 8.08e-04 GO:0045202 synapse
2.32 2.74e-02 GO:0043005 neuron projection

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
Enrichment   P-value GO Accession GO Term
2.21 3.65e-03 GO:0019899 enzyme binding
1.33 2.29e-02 GO:0005515 protein binding