Motif ID: FEV.p2

Z-value: 2.872


Transcription factors associated with FEV.p2:

Gene SymbolEntrez IDGene Name
Fev 260298 FEV (ETS oncogene family)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fevchr1_-_74931895-0.027.5e-01Click!


Activity profile for motif FEV.p2.

activity profile for motif FEV.p2


Sorted Z-values histogram for motif FEV.p2

Sorted Z-values for motif FEV.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FEV.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_140071818 52.296 NM_001111316
NM_011210
Ptprc

protein tyrosine phosphatase, receptor type, C

chr12_-_32893074 48.741 NM_001146201
NM_020272
NM_001146200
Pik3cg


phosphoinositide-3-kinase, catalytic, gamma polypeptide


chr16_+_36935029 48.285 NM_008225
Hcls1
hematopoietic cell specific Lyn substrate 1
chr17_+_34726750 45.211 NM_134116
Gpsm3
G-protein signalling modulator 3 (AGS3-like, C. elegans)
chr6_-_136889984 44.145 Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr14_+_75576599 43.386 Lcp1
lymphocyte cytosolic protein 1
chr17_+_34727032 42.010 Gpsm3
G-protein signalling modulator 3 (AGS3-like, C. elegans)
chr16_-_19983049 40.609 NM_183390
Klhl6
kelch-like 6 (Drosophila)
chr15_+_78075220 39.981 NM_008677
Ncf4
neutrophil cytosolic factor 4
chrX_-_98463514 39.767 NM_013563
Il2rg
interleukin 2 receptor, gamma chain
chr11_-_83462722 35.304 NM_011337
Ccl3
chemokine (C-C motif) ligand 3
chr7_-_52494453 34.614 Cd37
CD37 antigen
chr9_-_123883223 33.858 Ccr1
chemokine (C-C motif) receptor 1
chrX_+_45499599 32.852 NM_028773
Sash3
SAM and SH3 domain containing 3
chr9_+_107885355 32.330 NM_177090
Cdh29
Uba7
cadherin-like 29
ubiquitin-like modifier activating enzyme 7
chr11_-_69479553 32.025 NM_009853
Cd68
CD68 antigen
chr4_-_63064369 32.021 NM_001045514
Akna
AT-hook transcription factor
chr1_-_133173495 31.909 Ikbke
inhibitor of kappaB kinase epsilon
chr5_+_34886013 31.568 NM_001145858
Sh3bp2
SH3-domain binding protein 2
chr2_+_90936845 31.304 NM_011355
Sfpi1
SFFV proviral integration 1
chr19_-_5661634 30.563 Sipa1
signal-induced proliferation associated gene 1
chr1_+_154654953 30.271 NM_010877
Ncf2
neutrophil cytosolic factor 2
chr10_+_126760748 29.945 NM_146011
Arhgap9
Rho GTPase activating protein 9
chr19_-_41068625 29.466 Blnk
B-cell linker
chr6_-_136890189 29.397 NM_007486
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr16_-_75909440 29.116 NM_023380
Samsn1
SAM domain, SH3 domain and nuclear localization signals, 1
chr11_-_83406475 29.073 NM_009139
Ccl6
chemokine (C-C motif) ligand 6
chr7_-_109398578 28.804 NM_019566
Rhog
ras homolog gene family, member G
chr1_-_175810248 28.537 NM_001170853
Mndal
myeloid nuclear differentiation antigen like
chr1_-_130256055 27.587 NM_008567
Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr6_-_16848314 27.386 Tcfec
transcription factor EC
chr1_-_140071630 27.360 Ptprc
protein tyrosine phosphatase, receptor type, C
chr14_+_51748742 26.459 NM_030098
Rnase6
ribonuclease, RNase A family, 6
chr3_-_10208575 26.416 NM_024406
Fabp4
fatty acid binding protein 4, adipocyte
chr11_-_79343891 26.201 Evi2a
ecotropic viral integration site 2a
chr1_+_175560938 25.535 NM_175026
Pyhin1
pyrin and HIN domain family, member 1
chr14_-_33998251 25.441 NM_001146022
Wdfy4
WD repeat and FYVE domain containing 4
chr15_-_66392539 25.392 NM_172514
Tmem71
transmembrane protein 71
chr11_-_79337178 25.078 Evi2b
ecotropic viral integration site 2b
chr3_-_106592919 24.941 NM_007651
Cd53
CD53 antigen
chr6_-_16848352 24.684 NM_031198
Tcfec
transcription factor EC
chr19_-_18706239 24.329 NM_017375
Ostf1
osteoclast stimulating factor 1
chr7_+_108526635 23.731 NM_001040112
Arap1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr19_-_41069024 23.706 NM_008528
Blnk
B-cell linker
chr19_-_18706181 23.463 Ostf1
osteoclast stimulating factor 1
chr19_+_11592938 23.076 NM_027209
Ms4a6b
membrane-spanning 4-domains, subfamily A, member 6B
chr7_+_134439804 23.035 NM_008400
Itgal
integrin alpha L
chr9_+_5308846 22.896 NM_007609
Casp4
caspase 4, apoptosis-related cysteine peptidase
chr19_-_11679293 22.888 NM_026835
Ms4a6d
membrane-spanning 4-domains, subfamily A, member 6D
chr15_+_78427476 22.844 NM_028195
Cyth4
cytohesin 4
chr15_+_6529846 22.330 NM_011815
Fyb
FYN binding protein
chr2_+_103810274 22.289 NM_001142335
NM_008505
Lmo2

LIM domain only 2

chr2_-_25052245 22.287 NM_146115
A830007P12Rik
RIKEN cDNA A830007P12 gene
chr6_-_123239765 22.282 Clec4e
C-type lectin domain family 4, member e
chr19_-_11679242 22.153 Ms4a6d
membrane-spanning 4-domains, subfamily A, member 6D
chr3_-_137644466 21.826 NM_011932
Dapp1
dual adaptor for phosphotyrosine and 3-phosphoinositides 1
chr5_+_145875080 21.615 NM_023142
Arpc1b
actin related protein 2/3 complex, subunit 1B
chr16_+_44765848 21.268 NM_021325
Cd200r1
CD200 receptor 1
chr19_+_11543816 21.242 NM_001166376
NM_028595
Ms4a6c

membrane-spanning 4-domains, subfamily A, member 6C

chr4_+_66488753 21.164 NM_021297
Tlr4
toll-like receptor 4
chrX_+_104344953 21.013 NM_175442
A630033H20Rik
RIKEN cDNA A630033H20 gene
chr1_+_58859345 20.796 NM_001080126
Casp8
caspase 8
chr7_+_149646740 20.713 NM_001136071
Lsp1
lymphocyte specific 1
chr9_-_123883398 20.654 NM_009912
Ccr1
chemokine (C-C motif) receptor 1
chr3_+_79690856 20.464 Fam198b
family with sequence similarity 198, member B
chrX_-_9046362 20.212 NM_007807
Cybb
cytochrome b-245, beta polypeptide
chr9_-_88626434 19.986 Bcl2a1d
B-cell leukemia/lymphoma 2 related protein A1d
chr1_+_89516886 19.814 NM_001110192
NM_001110193
NM_010566
Inpp5d


inositol polyphosphate-5-phosphatase D


chr1_+_58852217 19.720 NM_009812
Casp8
caspase 8
chr10_-_17742931 19.642 NM_028440
3110003A17Rik
RIKEN cDNA 3110003A17 gene
chr6_-_124688630 19.449 NM_001077705
Ptpn6
protein tyrosine phosphatase, non-receptor type 6
chr11_-_79344055 19.380 NM_001033711
NM_010161
NM_146023
Evi2a

Evi2b
ecotropic viral integration site 2a

ecotropic viral integration site 2b
chr2_-_126317267 19.287 NM_001080944
Atp8b4
ATPase, class I, type 8B, member 4
chr2_+_14151018 19.037 NM_008625
Mrc1
mannose receptor, C type 1
chr3_+_95330700 18.954 NM_021281
Ctss
cathepsin S
chr8_+_74676404 18.870 Tpm4
tropomyosin 4
chr3_+_116564564 18.843 NM_009146
Frrs1
ferric-chelate reductase 1
chr15_+_84155149 18.314 NM_022321
Parvg
parvin, gamma
chr1_+_58852303 18.294 Casp8
caspase 8
chr10_+_96079634 18.226 NM_007569
Btg1
B-cell translocation gene 1, anti-proliferative
chr7_+_149646716 18.171 Lsp1
lymphocyte specific 1
chr19_+_4231881 18.089 NM_027196
Pold4
polymerase (DNA-directed), delta 4
chrX_+_104344792 18.041 NM_001122595
A630033H20Rik
RIKEN cDNA A630033H20 gene
chr10_-_88875526 17.647 Gas2l3
growth arrest-specific 2 like 3
chr4_+_125181288 17.630 NM_008049
Gm15590
Ftl1
Ftl2
ferritin light chain 1 pseudogene
ferritin light chain 1
ferritin light chain 2
chr11_-_70468019 17.622 Pfn1
profilin 1
chr1_+_173319048 17.590 NM_001005508
Arhgap30
Rho GTPase activating protein 30
chr19_+_4231936 17.383 Pold4
polymerase (DNA-directed), delta 4
chr9_+_124016886 17.200 NM_009915
Ccr2
chemokine (C-C motif) receptor 2
chr8_-_124956759 16.964 NM_007806
Cyba
cytochrome b-245, alpha polypeptide
chr14_-_55725370 16.880 NM_007455
Ap1g2
adaptor protein complex AP-1, gamma 2 subunit
chr1_+_58852471 16.558 Casp8
caspase 8
chr12_-_56087322 16.431 NM_013815
Baz1a
bromodomain adjacent to zinc finger domain 1A
chr6_-_123239886 16.320 NM_019948
Clec4e
C-type lectin domain family 4, member e
chr2_-_73323746 16.226 Wipf1
WAS/WASL interacting protein family, member 1
chr1_-_173537404 16.217 NM_008534
Ly9
lymphocyte antigen 9
chr13_+_103483611 16.164 NM_008533
Cd180
CD180 antigen
chr11_+_11586215 16.155 NM_001025597
NM_009578
Ikzf1

IKAROS family zinc finger 1

chr10_-_61970481 16.140 NM_011157
Srgn
serglycin
chr13_-_55629845 16.131 NM_013739
Dok3
docking protein 3
chr11_-_79337251 16.096 NM_001077496
Evi2b
ecotropic viral integration site 2b
chr7_-_147174332 15.991 Adam8
a disintegrin and metallopeptidase domain 8
chr7_+_31198774 15.967 NM_011662
Tyrobp
TYRO protein tyrosine kinase binding protein
chr6_+_145070255 15.882 NM_008511
Lrmp
lymphoid-restricted membrane protein
chr19_-_8848911 15.812 NM_026325
Tmem179b
transmembrane protein 179B
chr7_-_53176582 15.674 NM_010129
Emp3
epithelial membrane protein 3
chr7_-_53176218 15.655 NM_001146346
Emp3
epithelial membrane protein 3
chr9_-_7872821 15.622 Birc3
baculoviral IAP repeat-containing 3
chr7_+_108534039 15.593 NM_027180
Arap1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr2_-_25052129 15.581 A830007P12Rik
RIKEN cDNA A830007P12 gene
chrX_+_104451216 15.560 NM_001177781
NM_001033251
Gpr174

G protein-coupled receptor 174

chr7_-_148196526 15.531 Ifitm3
interferon induced transmembrane protein 3
chrX_-_54591905 15.353 NM_152801
Arhgef6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr7_-_31204764 15.273 NM_011827
Hcst
hematopoietic cell signal transducer
chr1_+_34529567 15.188 Ptpn18
protein tyrosine phosphatase, non-receptor type 18
chr2_+_13500271 15.151 Vim
vimentin
chr7_+_134234872 14.869 NM_178901
AI467606
expressed sequence AI467606
chr6_-_51962458 14.849 NM_018773
Skap2
src family associated phosphoprotein 2
chr3_-_107949028 14.833 NM_010306
Gnai3
guanine nucleotide binding protein (G protein), alpha inhibiting 3
chr10_+_59809598 14.771 NM_001159572
NM_028732
4632428N05Rik

RIKEN cDNA 4632428N05 gene

chr9_+_21330620 14.712 NM_001198794
NM_206536
AB124611

cDNA sequence AB124611

chr2_+_172847371 14.693 NM_019547
Rbm38
RNA binding motif protein 38
chr6_+_129347314 14.689 NM_019985
Clec1b
C-type lectin domain family 1, member b
chr9_+_88851757 14.588 NM_009742
Bcl2a1a
B-cell leukemia/lymphoma 2 related protein A1a
chr7_-_16844541 14.437 C5ar1
complement component 5a receptor 1
chr11_+_95703598 14.286 NM_023121
Gngt2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr2_+_127161893 14.245 NM_010090
Dusp2
dual specificity phosphatase 2
chr8_-_91159932 14.227 NM_027840
Snx20
sorting nexin 20
chr7_-_20408100 14.210 NM_033601
Bcl3
B-cell leukemia/lymphoma 3
chr16_+_52031704 14.069 Cblb
Casitas B-lineage lymphoma b
chr1_+_132762248 14.050 Faim3
Fas apoptotic inhibitory molecule 3
chr2_-_119980210 14.014 Ehd4
EH-domain containing 4
chr1_+_16678536 14.007 NM_001159711
NM_016923
Ly96

lymphocyte antigen 96

chr7_-_16844888 13.995 NM_007577
C5ar1
complement component 5a receptor 1
chr4_+_3605207 13.919 NM_001111096
NM_010747
Lyn

Yamaguchi sarcoma viral (v-yes-1) oncogene homolog

chr1_+_173770709 13.912 NM_013489
Cd84
CD84 antigen
chrX_+_156278399 13.906 NM_001135728
Sh3kbp1
SH3-domain kinase binding protein 1
chr11_+_33946927 13.899 Lcp2
lymphocyte cytosolic protein 2
chr11_+_100721765 13.839 NM_001164062
Stat5a
signal transducer and activator of transcription 5A
chr1_+_174437040 13.780 Tagln2
transgelin 2
chr9_+_55937776 13.774 NM_011193
Pstpip1
proline-serine-threonine phosphatase-interacting protein 1
chr18_+_67365012 13.752 NM_024190
Chmp1b
chromatin modifying protein 1B
chr5_-_75440460 13.559 Chic2
cysteine-rich hydrophobic domain 2
chr9_+_51021793 13.520 NM_011136
Pou2af1
POU domain, class 2, associating factor 1
chr1_-_133096633 13.509 Rassf5
Ras association (RalGDS/AF-6) domain family member 5
chr11_+_33947115 13.454 NM_010696
Lcp2
lymphocyte cytosolic protein 2
chr19_+_25073995 13.426 NM_028785
Dock8
dedicator of cytokinesis 8
chr8_+_90812964 13.391 NM_001037723
Adcy7
adenylate cyclase 7
chr19_+_29441927 13.345 NM_021893
Cd274
CD274 antigen
chr11_-_114863193 13.279 NM_134158
AF251705
cDNA sequence AF251705
chr9_-_32348863 13.130 NM_008026
Fli1
Friend leukemia integration 1
chr9_+_55937980 13.087 Pstpip1
proline-serine-threonine phosphatase-interacting protein 1
chr11_+_106612525 12.974 NM_001033435
Gm885
predicted gene 885
chr8_-_86217895 12.963 Pkn1
protein kinase N1
chr19_+_12873063 12.955 NM_134152
Lpxn
leupaxin
chr7_+_29225955 12.949 NM_001039192
Gmfg
glia maturation factor, gamma
chr1_-_146622545 12.940 NM_022881
Rgs18
regulator of G-protein signaling 18
chr3_+_95303177 12.933 NM_007802
Ctsk
cathepsin K
chr3_-_107948968 12.916 Gnai3
guanine nucleotide binding protein (G protein), alpha inhibiting 3
chr8_+_74743620 12.902 NM_026455
Fam32a
family with sequence similarity 32, member A
chr9_-_75407338 12.896 NM_016963
Tmod3
tropomodulin 3
chr9_-_88626613 12.810 NM_007536
Bcl2a1d
B-cell leukemia/lymphoma 2 related protein A1d
chr3_+_95392855 12.769 NM_001177669
NM_001177670
NM_146133
Golph3l


golgi phosphoprotein 3-like


chr3_-_135354151 12.756 Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
chr3_-_135354500 12.749 NM_008689
Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
chr19_-_7093919 12.736 NM_153795
Fermt3
fermitin family homolog 3 (Drosophila)
chr13_+_4190423 12.654 NM_013778
Akr1c13
aldo-keto reductase family 1, member C13
chr11_-_83391984 12.600 Ccl9
chemokine (C-C motif) ligand 9
chr8_+_123263681 12.535 Irf8
interferon regulatory factor 8
chr5_-_65324796 12.513 Tlr1
toll-like receptor 1
chr5_-_124315478 12.511 NM_030701
Niacr1
niacin receptor 1
chr11_-_6420931 12.501 NM_178440
Myo1g
myosin IG
chr10_+_76993060 12.409 NM_008404
Itgb2
integrin beta 2
chr6_-_129422702 12.345 NM_020008
Clec7a
C-type lectin domain family 7, member a
chr7_-_16844686 12.336 NM_001173550
C5ar1
complement component 5a receptor 1
chr1_+_153418580 12.313 Fam129a
family with sequence similarity 129, member A
chr3_+_84470113 12.305 NM_177260
Tmem154
transmembrane protein 154
chr4_+_130469187 12.265 NM_010686
Laptm5
lysosomal-associated protein transmembrane 5
chr14_+_32308287 12.257 Eaf1
ELL associated factor 1
chr6_-_87483228 12.201 NM_001037727
Arhgap25
Rho GTPase activating protein 25
chr7_-_80686630 12.163 NM_001081345
Chd2
chromodomain helicase DNA binding protein 2
chr2_-_73291933 12.134 Wipf1
WAS/WASL interacting protein family, member 1
chr11_+_69980275 12.080 NM_010796
Clec10a
C-type lectin domain family 10, member A
chr10_+_57834201 12.050 NM_201242
Lims1
LIM and senescent cell antigen-like domains 1
chr11_-_106243873 12.043 NM_010494
Icam2
intercellular adhesion molecule 2
chr14_+_70499874 11.923 NM_021328
Bin3
bridging integrator 3
chr3_-_58329780 11.913 NM_030685
Serp1
stress-associated endoplasmic reticulum protein 1
chr11_-_83343962 11.879 NM_013653
Ccl5
chemokine (C-C motif) ligand 5
chr10_-_117252126 11.843


chr6_+_48689045 11.825 NM_008376
NM_175860
Gimap1

GTPase, IMAP family member 1

chr3_+_84470230 11.803 Tmem154
transmembrane protein 154
chr14_-_31981804 11.792 NM_138672
Stab1
stabilin 1
chr17_+_35378690 11.778 NM_019693
H2-Q6
Ddx39b
histocompatibility 2, Q region locus 6
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr4_+_125701902 11.720 NM_007782
Csf3r
colony stimulating factor 3 receptor (granulocyte)
chr9_+_108239210 11.711 Rhoa
ras homolog gene family, member A
chrX_-_7667574 11.664 NM_009515
Was
Wiskott-Aldrich syndrome homolog (human)
chr3_+_106288967 11.641 NM_028110
Dennd2d
DENN/MADD domain containing 2D
chr1_-_158404299 11.555 NM_009230
Soat1
sterol O-acyltransferase 1
chr19_+_9016335 11.520 NM_011842
Mta2
metastasis-associated gene family, member 2
chr5_+_86500770 11.479 NM_019992
Stap1
signal transducing adaptor family member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.41 1.86e-40 GO:0044260 cellular macromolecule metabolic process
1.37 7.95e-39 GO:0043170 macromolecule metabolic process
1.28 4.27e-30 GO:0044238 primary metabolic process
1.28 2.30e-29 GO:0044237 cellular metabolic process
1.24 9.99e-26 GO:0008152 metabolic process
1.85 5.54e-25 GO:0002376 immune system process
1.47 2.77e-24 GO:0010467 gene expression
1.33 7.37e-22 GO:0019222 regulation of metabolic process
1.38 2.73e-21 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.42 5.84e-21 GO:0090304 nucleic acid metabolic process
1.35 1.68e-20 GO:0031323 regulation of cellular metabolic process
1.44 2.84e-19 GO:0016070 RNA metabolic process
1.34 2.93e-19 GO:0080090 regulation of primary metabolic process
1.34 3.08e-18 GO:0060255 regulation of macromolecule metabolic process
1.52 2.57e-17 GO:0048583 regulation of response to stimulus
1.43 3.74e-17 GO:0044267 cellular protein metabolic process
1.41 5.06e-17 GO:0009059 macromolecule biosynthetic process
1.31 1.29e-16 GO:0006807 nitrogen compound metabolic process
1.40 1.40e-16 GO:0034645 cellular macromolecule biosynthetic process
1.37 2.18e-16 GO:0048518 positive regulation of biological process
1.32 3.25e-16 GO:0034641 cellular nitrogen compound metabolic process
1.35 1.40e-15 GO:0071840 cellular component organization or biogenesis
1.36 2.74e-15 GO:0051171 regulation of nitrogen compound metabolic process
1.36 3.11e-15 GO:0019538 protein metabolic process
1.36 5.35e-15 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.37 1.08e-14 GO:0010556 regulation of macromolecule biosynthetic process
1.37 1.35e-14 GO:0048522 positive regulation of cellular process
2.17 2.47e-14 GO:0001775 cell activation
1.35 2.97e-14 GO:0010468 regulation of gene expression
2.26 3.15e-14 GO:0045321 leukocyte activation
1.35 3.57e-14 GO:0009889 regulation of biosynthetic process
1.34 9.72e-14 GO:0031326 regulation of cellular biosynthetic process
1.35 3.51e-13 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.11 3.52e-13 GO:0009987 cellular process
1.30 6.95e-13 GO:0009058 biosynthetic process
1.31 8.65e-13 GO:0044249 cellular biosynthetic process
1.77 1.02e-12 GO:0002682 regulation of immune system process
1.94 5.55e-12 GO:0002684 positive regulation of immune system process
1.95 8.23e-12 GO:0006955 immune response
1.35 1.21e-11 GO:0051252 regulation of RNA metabolic process
1.31 1.99e-11 GO:0016043 cellular component organization
1.46 2.30e-11 GO:0009893 positive regulation of metabolic process
1.43 2.65e-11 GO:0006950 response to stress
1.35 2.87e-11 GO:0006355 regulation of transcription, DNA-dependent
1.48 5.23e-11 GO:0010604 positive regulation of macromolecule metabolic process
1.33 1.43e-10 GO:0048519 negative regulation of biological process
1.45 4.35e-10 GO:0031325 positive regulation of cellular metabolic process
2.18 8.26e-10 GO:0046649 lymphocyte activation
1.92 1.69e-09 GO:0050776 regulation of immune response
1.34 1.74e-09 GO:0048523 negative regulation of cellular process
1.59 1.77e-09 GO:0048584 positive regulation of response to stimulus
1.50 1.83e-09 GO:0035556 intracellular signal transduction
1.38 1.91e-09 GO:0032774 RNA biosynthetic process
1.33 2.16e-09 GO:0071841 cellular component organization or biogenesis at cellular level
1.38 2.27e-09 GO:0006351 transcription, DNA-dependent
1.39 2.45e-09 GO:0006464 protein modification process
1.71 4.58e-09 GO:0006396 RNA processing
1.46 5.17e-09 GO:0009966 regulation of signal transduction
1.37 6.85e-09 GO:0043412 macromolecule modification
2.40 8.33e-09 GO:0002764 immune response-regulating signaling pathway
1.41 8.62e-09 GO:0006996 organelle organization
1.49 1.15e-08 GO:0010941 regulation of cell death
1.50 1.23e-08 GO:0042981 regulation of apoptosis
1.49 2.69e-08 GO:0043067 regulation of programmed cell death
2.27 3.42e-08 GO:0002521 leukocyte differentiation
1.51 3.67e-08 GO:0042127 regulation of cell proliferation
1.99 8.72e-08 GO:0050778 positive regulation of immune response
1.47 2.43e-07 GO:0006357 regulation of transcription from RNA polymerase II promoter
2.31 2.80e-07 GO:0002757 immune response-activating signal transduction
1.66 3.00e-07 GO:0010942 positive regulation of cell death
1.52 3.24e-07 GO:0007049 cell cycle
2.12 3.42e-07 GO:0022613 ribonucleoprotein complex biogenesis
1.67 4.06e-07 GO:0043068 positive regulation of programmed cell death
1.67 4.25e-07 GO:0043065 positive regulation of apoptosis
1.55 4.44e-07 GO:0016265 death
1.55 5.76e-07 GO:0008219 cell death
1.78 7.97e-07 GO:0016071 mRNA metabolic process
3.02 8.32e-07 GO:0002768 immune response-regulating cell surface receptor signaling pathway
1.84 1.81e-06 GO:0030097 hemopoiesis
1.47 1.87e-06 GO:0010557 positive regulation of macromolecule biosynthetic process
2.04 1.90e-06 GO:0071843 cellular component biogenesis at cellular level
1.79 1.93e-06 GO:0048534 hemopoietic or lymphoid organ development
2.24 3.52e-06 GO:0042110 T cell activation
1.44 3.96e-06 GO:0009891 positive regulation of biosynthetic process
1.44 4.24e-06 GO:0031328 positive regulation of cellular biosynthetic process
1.87 4.40e-06 GO:0001817 regulation of cytokine production
1.55 4.54e-06 GO:0006915 apoptosis
2.09 4.75e-06 GO:0002253 activation of immune response
1.42 5.40e-06 GO:0008104 protein localization
2.27 6.13e-06 GO:0042254 ribosome biogenesis
1.48 9.32e-06 GO:0015031 protein transport
1.73 9.78e-06 GO:0002520 immune system development
1.27 1.06e-05 GO:0071842 cellular component organization at cellular level
1.53 1.08e-05 GO:0012501 programmed cell death
1.56 1.10e-05 GO:0022402 cell cycle process
1.63 1.20e-05 GO:0080134 regulation of response to stress
1.40 1.33e-05 GO:0009892 negative regulation of metabolic process
1.47 1.35e-05 GO:0045184 establishment of protein localization
1.68 1.43e-05 GO:0009611 response to wounding
1.41 1.75e-05 GO:0044085 cellular component biogenesis
1.41 1.82e-05 GO:0010605 negative regulation of macromolecule metabolic process
1.45 1.96e-05 GO:0010628 positive regulation of gene expression
2.89 2.28e-05 GO:0002429 immune response-activating cell surface receptor signaling pathway
1.58 2.71e-05 GO:0006952 defense response
3.09 3.72e-05 GO:0030888 regulation of B cell proliferation
1.51 4.06e-05 GO:0070887 cellular response to chemical stimulus
1.80 4.29e-05 GO:0031347 regulation of defense response
1.67 4.41e-05 GO:0010627 regulation of intracellular protein kinase cascade
1.77 4.89e-05 GO:0006397 mRNA processing
1.56 5.11e-05 GO:0008284 positive regulation of cell proliferation
1.85 5.88e-05 GO:0002694 regulation of leukocyte activation
1.36 6.37e-05 GO:0033036 macromolecule localization
2.57 6.38e-05 GO:0050864 regulation of B cell activation
2.19 7.24e-05 GO:0030098 lymphocyte differentiation
1.78 7.87e-05 GO:0008380 RNA splicing
1.32 8.87e-05 GO:0023051 regulation of signaling
1.59 9.33e-05 GO:0051726 regulation of cell cycle
2.96 1.19e-04 GO:0050851 antigen receptor-mediated signaling pathway
2.18 1.19e-04 GO:0050670 regulation of lymphocyte proliferation
2.10 1.28e-04 GO:0001819 positive regulation of cytokine production
1.87 1.41e-04 GO:0006954 inflammatory response
2.16 1.61e-04 GO:0032944 regulation of mononuclear cell proliferation
1.64 1.73e-04 GO:0000278 mitotic cell cycle
2.14 1.77e-04 GO:0048872 homeostasis of number of cells
1.38 1.98e-04 GO:0031324 negative regulation of cellular metabolic process
1.80 1.98e-04 GO:0050865 regulation of cell activation
2.33 2.02e-04 GO:0016072 rRNA metabolic process
2.97 2.06e-04 GO:0007249 I-kappaB kinase/NF-kappaB cascade
1.84 2.14e-04 GO:0030036 actin cytoskeleton organization
2.34 2.40e-04 GO:0006364 rRNA processing
1.44 2.44e-04 GO:0045893 positive regulation of transcription, DNA-dependent
1.40 2.53e-04 GO:0051173 positive regulation of nitrogen compound metabolic process
1.86 2.69e-04 GO:0051249 regulation of lymphocyte activation
2.13 2.89e-04 GO:0070663 regulation of leukocyte proliferation
1.96 3.04e-04 GO:0002697 regulation of immune effector process
1.80 3.11e-04 GO:0030029 actin filament-based process
1.37 3.12e-04 GO:0006793 phosphorus metabolic process
2.79 3.33e-04 GO:0050871 positive regulation of B cell activation
1.66 3.46e-04 GO:0031401 positive regulation of protein modification process
1.27 3.50e-04 GO:0065008 regulation of biological quality
1.74 3.62e-04 GO:0007264 small GTPase mediated signal transduction
1.27 3.73e-04 GO:0048513 organ development
1.37 4.02e-04 GO:0006796 phosphate metabolic process
1.99 4.37e-04 GO:0002252 immune effector process
1.42 4.73e-04 GO:0051254 positive regulation of RNA metabolic process
1.59 4.90e-04 GO:0032583 regulation of gene-specific transcription
2.32 6.82e-04 GO:0006414 translational elongation
1.81 7.49e-04 GO:0010564 regulation of cell cycle process
1.76 7.97e-04 GO:0051056 regulation of small GTPase mediated signal transduction
1.39 8.13e-04 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.81 9.30e-04 GO:0046578 regulation of Ras protein signal transduction
1.94 9.32e-04 GO:0031349 positive regulation of defense response
1.57 9.99e-04 GO:0032270 positive regulation of cellular protein metabolic process
2.21 1.05e-03 GO:0032103 positive regulation of response to external stimulus
1.20 1.21e-03 GO:0048856 anatomical structure development
1.44 1.43e-03 GO:0033554 cellular response to stress
1.29 1.44e-03 GO:0065009 regulation of molecular function
1.95 1.78e-03 GO:0002696 positive regulation of leukocyte activation
1.57 1.81e-03 GO:0006974 response to DNA damage stimulus
1.55 1.89e-03 GO:0051247 positive regulation of protein metabolic process
2.30 1.93e-03 GO:0030217 T cell differentiation
1.47 2.03e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.09 2.15e-03 GO:0065007 biological regulation
1.35 2.66e-03 GO:0032268 regulation of cellular protein metabolic process
1.91 2.88e-03 GO:0050867 positive regulation of cell activation
1.21 3.47e-03 GO:0048731 system development
1.34 3.74e-03 GO:0032879 regulation of localization
1.70 4.16e-03 GO:0010608 posttranscriptional regulation of gene expression
1.49 4.19e-03 GO:0051276 chromosome organization
1.95 4.22e-03 GO:0051251 positive regulation of lymphocyte activation
1.09 4.51e-03 GO:0050789 regulation of biological process
2.17 4.73e-03 GO:0002699 positive regulation of immune effector process
1.77 4.81e-03 GO:0034097 response to cytokine stimulus
1.17 4.90e-03 GO:0051179 localization
1.40 4.99e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.17 5.35e-03 GO:0032502 developmental process
1.38 5.43e-03 GO:0044093 positive regulation of molecular function
2.03 5.59e-03 GO:0050727 regulation of inflammatory response
1.38 6.11e-03 GO:0009890 negative regulation of biosynthetic process
1.58 6.24e-03 GO:0007243 intracellular protein kinase cascade
1.58 6.24e-03 GO:0023014 signal transduction via phosphorylation event
1.58 8.07e-03 GO:0051301 cell division
1.71 8.81e-03 GO:0043193 positive regulation of gene-specific transcription
1.51 8.86e-03 GO:0016044 cellular membrane organization
2.26 9.08e-03 GO:0042035 regulation of cytokine biosynthetic process
1.24 9.50e-03 GO:0042221 response to chemical stimulus
2.54 9.67e-03 GO:0002274 myeloid leukocyte activation
2.95 9.87e-03 GO:0001776 leukocyte homeostasis
1.51 1.06e-02 GO:0022403 cell cycle phase
1.51 1.14e-02 GO:0061024 membrane organization
2.11 1.14e-02 GO:0002703 regulation of leukocyte mediated immunity
1.69 1.15e-02 GO:0032880 regulation of protein localization
2.67 1.37e-02 GO:0002687 positive regulation of leukocyte migration
1.09 1.38e-02 GO:0050794 regulation of cellular process
1.63 1.58e-02 GO:0031329 regulation of cellular catabolic process
1.35 1.61e-02 GO:0016310 phosphorylation
2.53 1.67e-02 GO:0042108 positive regulation of cytokine biosynthetic process
2.95 1.72e-02 GO:0002260 lymphocyte homeostasis
2.95 1.72e-02 GO:0030890 positive regulation of B cell proliferation
1.39 1.74e-02 GO:0010629 negative regulation of gene expression
1.48 1.77e-02 GO:0043066 negative regulation of apoptosis
1.37 1.77e-02 GO:0031327 negative regulation of cellular biosynthetic process
2.17 1.92e-02 GO:0050671 positive regulation of lymphocyte proliferation
1.47 2.08e-02 GO:0043069 negative regulation of programmed cell death
1.60 2.12e-02 GO:0006917 induction of apoptosis
2.45 2.14e-02 GO:0002263 cell activation involved in immune response
2.45 2.14e-02 GO:0002366 leukocyte activation involved in immune response
1.55 2.26e-02 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
2.18 2.34e-02 GO:0042113 B cell activation
1.46 2.39e-02 GO:0009967 positive regulation of signal transduction
1.60 2.45e-02 GO:0012502 induction of programmed cell death
2.48 2.49e-02 GO:0032675 regulation of interleukin-6 production
1.74 2.54e-02 GO:0030155 regulation of cell adhesion
2.14 2.58e-02 GO:0032946 positive regulation of mononuclear cell proliferation
2.72 2.61e-02 GO:0043409 negative regulation of MAPKKK cascade
2.56 3.29e-02 GO:0050729 positive regulation of inflammatory response
1.45 3.71e-02 GO:0060548 negative regulation of cell death
1.55 3.77e-02 GO:0001944 vasculature development
2.34 3.79e-02 GO:0060326 cell chemotaxis
1.30 3.90e-02 GO:0051641 cellular localization
1.28 3.91e-02 GO:0050790 regulation of catalytic activity
1.37 4.00e-02 GO:0006468 protein phosphorylation
1.29 4.07e-02 GO:0051246 regulation of protein metabolic process
1.68 4.42e-02 GO:0043408 regulation of MAPKKK cascade
1.98 4.52e-02 GO:0043122 regulation of I-kappaB kinase/NF-kappaB cascade
2.09 4.57e-02 GO:0070665 positive regulation of leukocyte proliferation
1.20 4.84e-02 GO:0048869 cellular developmental process
1.58 4.89e-02 GO:0018193 peptidyl-amino acid modification
1.54 4.92e-02 GO:0016568 chromatin modification

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.27 3.19e-75 GO:0005622 intracellular
1.27 5.49e-72 GO:0044424 intracellular part
1.28 1.50e-56 GO:0043226 organelle
1.28 2.09e-55 GO:0043229 intracellular organelle
1.29 2.24e-48 GO:0043227 membrane-bounded organelle
1.28 2.07e-47 GO:0043231 intracellular membrane-bounded organelle
1.41 1.47e-44 GO:0005634 nucleus
1.11 1.56e-33 GO:0005623 cell
1.11 1.56e-33 GO:0044464 cell part
1.38 5.96e-31 GO:0044422 organelle part
1.64 1.26e-30 GO:0044428 nuclear part
1.23 4.51e-30 GO:0005737 cytoplasm
1.38 1.11e-29 GO:0044446 intracellular organelle part
1.62 2.10e-23 GO:0031981 nuclear lumen
1.38 4.52e-23 GO:0032991 macromolecular complex
1.56 1.81e-22 GO:0043233 organelle lumen
1.56 2.24e-22 GO:0070013 intracellular organelle lumen
1.54 1.45e-21 GO:0031974 membrane-enclosed lumen
1.58 9.25e-21 GO:0005829 cytosol
1.23 1.00e-16 GO:0044444 cytoplasmic part
1.64 2.74e-16 GO:0005654 nucleoplasm
1.37 3.89e-15 GO:0043228 non-membrane-bounded organelle
1.37 3.89e-15 GO:0043232 intracellular non-membrane-bounded organelle
1.34 1.31e-14 GO:0043234 protein complex
1.66 2.11e-11 GO:0044451 nucleoplasm part
1.80 2.22e-11 GO:0030529 ribonucleoprotein complex
1.72 5.02e-07 GO:0005730 nucleolus
2.21 1.77e-06 GO:0005681 spliceosomal complex
2.02 3.88e-06 GO:0031252 cell leading edge
2.17 5.27e-05 GO:0044445 cytosolic part
1.29 1.80e-04 GO:0005856 cytoskeleton
1.77 3.38e-04 GO:0009897 external side of plasma membrane
1.52 4.87e-04 GO:0005768 endosome
2.30 5.19e-04 GO:0071013 catalytic step 2 spliceosome
1.38 5.24e-04 GO:0012505 endomembrane system
1.50 5.75e-04 GO:0009986 cell surface
1.61 9.22e-04 GO:0005667 transcription factor complex
2.17 2.56e-03 GO:0030027 lamellipodium
1.32 3.35e-03 GO:0005794 Golgi apparatus
1.57 8.66e-03 GO:0015629 actin cytoskeleton
1.71 8.93e-03 GO:0005635 nuclear envelope
2.49 1.14e-02 GO:0022626 cytosolic ribosome
5.58 1.88e-02 GO:0070761 pre-snoRNP complex
1.27 2.18e-02 GO:0005783 endoplasmic reticulum

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.21 1.11e-44 GO:0005488 binding
1.32 4.29e-33 GO:0005515 protein binding
1.39 8.53e-18 GO:0003676 nucleic acid binding
1.60 1.31e-09 GO:0003723 RNA binding
1.31 1.26e-08 GO:0000166 nucleotide binding
1.33 8.87e-08 GO:0003677 DNA binding
1.50 5.56e-07 GO:0001071 nucleic acid binding transcription factor activity
1.50 5.56e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.33 6.55e-07 GO:0046914 transition metal ion binding
1.36 8.34e-07 GO:0008270 zinc ion binding
1.65 1.02e-05 GO:0030695 GTPase regulator activity
1.90 2.15e-05 GO:0005096 GTPase activator activity
1.72 2.41e-05 GO:0008047 enzyme activator activity
1.28 2.98e-05 GO:0017076 purine nucleotide binding
1.61 3.33e-05 GO:0060589 nucleoside-triphosphatase regulator activity
1.28 3.93e-05 GO:0032553 ribonucleotide binding
1.14 5.07e-05 GO:0003824 catalytic activity
1.27 5.17e-05 GO:0032555 purine ribonucleotide binding
1.28 5.51e-05 GO:0035639 purine ribonucleoside triphosphate binding
1.40 7.55e-05 GO:0019899 enzyme binding
1.18 1.10e-04 GO:0043169 cation binding
1.18 1.19e-04 GO:0043167 ion binding
1.18 2.20e-04 GO:0046872 metal ion binding
1.50 2.51e-04 GO:0019904 protein domain specific binding
1.73 3.09e-04 GO:0005083 small GTPase regulator activity
1.44 3.94e-04 GO:0043565 sequence-specific DNA binding
1.37 9.59e-04 GO:0030234 enzyme regulator activity
2.26 1.07e-03 GO:0005099 Ras GTPase activator activity
1.33 3.39e-03 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.23 5.53e-03 GO:0016740 transferase activity
1.25 6.81e-03 GO:0030554 adenyl nucleotide binding
1.54 8.51e-03 GO:0016563 transcription activator activity
1.32 9.43e-03 GO:0030528 transcription regulator activity
1.55 9.53e-03 GO:0016564 transcription repressor activity
1.24 1.12e-02 GO:0032559 adenyl ribonucleotide binding
1.70 1.19e-02 GO:0019787 small conjugating protein ligase activity
1.24 1.54e-02 GO:0005524 ATP binding
1.68 1.67e-02 GO:0043566 structure-specific DNA binding
1.60 1.73e-02 GO:0019901 protein kinase binding
1.71 1.97e-02 GO:0004842 ubiquitin-protein ligase activity
1.53 3.27e-02 GO:0019900 kinase binding
1.31 4.09e-02 GO:0016301 kinase activity
2.58 4.64e-02 GO:0042379 chemokine receptor binding
1.64 4.89e-02 GO:0010843 promoter binding
1.62 4.90e-02 GO:0000975 regulatory region DNA binding
1.62 4.90e-02 GO:0001067 regulatory region nucleic acid binding
1.62 4.90e-02 GO:0044212 transcription regulatory region DNA binding