Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 2.520


Transcription factors associated with FOS_FOS{B,L1}_JUN{B,D}.p2:

Gene SymbolEntrez IDGene Name
Fos 14281 FBJ osteosarcoma oncogene
Fosb 14282 FBJ osteosarcoma oncogene B
Fosl1 14283 fos-like antigen 1
Junb 16477 Jun-B oncogene
Jund 16478 Jun proto-oncogene related gene d

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Junbchr8_-_875025920.473.5e-11Click!
Fosl1chr19_+_54475460.321.5e-05Click!
Jundchr8_+_732242880.303.5e-05Click!
Fosbchr7_-_19895354-0.155.1e-02Click!
Foschr12_+_868148220.121.1e-01Click!


Activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2.

activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2


Sorted Z-values histogram for motif FOS_FOS{B,L1}_JUN{B,D}.p2

Sorted Z-values for motif FOS_FOS{B,L1}_JUN{B,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOS_FOS{B,L1}_JUN{B,D}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_135313010 81.639 Emp1
epithelial membrane protein 1
chr6_+_135312948 81.011 NM_010128
 Emp1
epithelial membrane protein 1
chr3_-_88307198 72.199 Lmna
lamin A
chr3_-_88307024 67.177 Lmna
lamin A
chr3_-_88307253 67.024 NM_001002011
NM_001111102
 Lmna

lamin A

chr11_-_69479553 58.762 NM_009853
 Cd68
CD68 antigen
chr2_+_32780021 57.869


chr6_+_72494378 57.549 NM_007599
 Capg
capping protein (actin filament), gelsolin-like
chr6_+_48986501 42.633 NM_053110
 Gpnmb
glycoprotein (transmembrane) nmb
chr2_+_145686480 40.980 Rin2
Ras and Rab interactor 2
chr2_+_155576833 40.639 Procr
protein C receptor, endothelial
chr7_-_53176218 39.499 NM_001146346
 Emp3
epithelial membrane protein 3
chr1_-_155033576 39.422 NM_008485
 Lamc2
laminin, gamma 2
chr1_+_109486582 38.097 NM_001159748
NM_011459
 Serpinb8

serine (or cysteine) peptidase inhibitor, clade B, member 8

chr6_+_72494474 37.102 Capg
capping protein (actin filament), gelsolin-like
chr6_-_122806042 36.117 C3ar1
complement component 3a receptor 1
chr2_+_145686377 34.623 Rin2
Ras and Rab interactor 2
chr6_-_122806122 34.490 NM_009779
 C3ar1
complement component 3a receptor 1
chr6_-_122806020 33.796 C3ar1
complement component 3a receptor 1
chr3_+_79689897 32.963 Fam198b
family with sequence similarity 198, member B

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 181 entries
Enrichment   P-value GO Accession GO Term
12.19 7.25e-04 GO:0032332 positive regulation of chondrocyte differentiation
8.52 8.21e-06 GO:0032330 regulation of chondrocyte differentiation
7.37 9.05e-04 GO:0031424 keratinization
6.90 6.78e-03 GO:0045104 intermediate filament cytoskeleton organization
6.63 9.89e-03 GO:0045103 intermediate filament-based process
6.21 5.38e-04 GO:0061035 regulation of cartilage development
5.95 2.75e-02 GO:0032963 collagen metabolic process
4.79 2.10e-05 GO:0048660 regulation of smooth muscle cell proliferation
4.79 1.19e-02 GO:0048661 positive regulation of smooth muscle cell proliferation
4.79 2.96e-02 GO:0071222 cellular response to lipopolysaccharide
4.58 4.68e-02 GO:0018108 peptidyl-tyrosine phosphorylation
4.58 4.68e-02 GO:0018212 peptidyl-tyrosine modification
4.42 2.90e-02 GO:0030216 keratinocyte differentiation
3.69 1.31e-02 GO:0071216 cellular response to biotic stimulus
3.68 1.88e-03 GO:0007265 Ras protein signal transduction
3.48 2.87e-02 GO:0051291 protein heterooligomerization
3.42 2.63e-05 GO:0008544 epidermis development
3.40 6.42e-03 GO:0043122 regulation of I-kappaB kinase/NF-kappaB cascade
3.38 1.28e-02 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
3.31 5.35e-05 GO:0030855 epithelial cell differentiation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 55 entries
Enrichment   P-value GO Accession GO Term
5.90 1.29e-02 GO:0016328 lateral plasma membrane
5.23 6.12e-04 GO:0032432 actin filament bundle
5.14 1.97e-03 GO:0001725 stress fiber
5.00 1.02e-03 GO:0042641 actomyosin
4.60 2.64e-03 GO:0005884 actin filament
4.46 5.49e-05 GO:0001726 ruffle
4.17 3.75e-02 GO:0005913 cell-cell adherens junction
3.41 6.20e-07 GO:0031252 cell leading edge
3.18 8.00e-08 GO:0005911 cell-cell junction
2.92 3.79e-02 GO:0019898 extrinsic to membrane
2.85 4.84e-03 GO:0070161 anchoring junction
2.82 1.44e-02 GO:0005912 adherens junction
2.73 2.77e-06 GO:0015629 actin cytoskeleton
2.51 4.27e-05 GO:0048471 perinuclear region of cytoplasm
2.43 2.83e-04 GO:0005578 proteinaceous extracellular matrix
2.34 1.27e-02 GO:0016323 basolateral plasma membrane
2.34 4.60e-02 GO:0016324 apical plasma membrane
2.31 3.47e-04 GO:0031012 extracellular matrix
2.22 1.74e-02 GO:0045177 apical part of cell
2.07 6.24e-03 GO:0005625 soluble fraction

Gene overrepresentation in function category:

Showing 1 to 20 of 23 entries
Enrichment   P-value GO Accession GO Term
3.47 1.05e-03 GO:0019838 growth factor binding
2.97 2.04e-04 GO:0005126 cytokine receptor binding
2.56 2.76e-05 GO:0003779 actin binding
2.49 3.59e-09 GO:0008092 cytoskeletal protein binding
2.48 1.60e-06 GO:0005198 structural molecule activity
2.00 2.68e-02 GO:0032403 protein complex binding
1.89 3.31e-03 GO:0004672 protein kinase activity
1.88 2.14e-04 GO:0046983 protein dimerization activity
1.73 2.99e-03 GO:0016301 kinase activity
1.72 1.93e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.71 2.74e-04 GO:0005102 receptor binding
1.70 3.56e-03 GO:0019899 enzyme binding
1.68 4.89e-36 GO:0005515 protein binding
1.63 4.04e-02 GO:0042802 identical protein binding
1.59 2.62e-02 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.46 3.75e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.45 4.83e-03 GO:0017076 purine nucleotide binding
1.45 6.26e-03 GO:0032555 purine ribonucleotide binding
1.45 6.44e-03 GO:0032553 ribonucleotide binding
1.45 4.53e-02 GO:0005524 ATP binding