Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 2.520


Transcription factors associated with FOS_FOS{B,L1}_JUN{B,D}.p2:

Gene SymbolEntrez IDGene Name
Fos 14281 FBJ osteosarcoma oncogene
Fosb 14282 FBJ osteosarcoma oncogene B
Fosl1 14283 fos-like antigen 1
Junb 16477 Jun-B oncogene
Jund 16478 Jun proto-oncogene related gene d

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Junbchr8_-_875025920.473.5e-11Click!
Fosl1chr19_+_54475460.321.5e-05Click!
Jundchr8_+_732242880.303.5e-05Click!
Fosbchr7_-_19895354-0.155.1e-02Click!
Foschr12_+_868148220.121.1e-01Click!


Activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2.

activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2


Sorted Z-values histogram for motif FOS_FOS{B,L1}_JUN{B,D}.p2

Sorted Z-values for motif FOS_FOS{B,L1}_JUN{B,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOS_FOS{B,L1}_JUN{B,D}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_135313010 81.639 Emp1
epithelial membrane protein 1
chr6_+_135312948 81.011 NM_010128
Emp1
epithelial membrane protein 1
chr3_-_88307198 72.199 Lmna
lamin A
chr3_-_88307024 67.177 Lmna
lamin A
chr3_-_88307253 67.024 NM_001002011
NM_001111102
Lmna

lamin A

chr11_-_69479553 58.762 NM_009853
Cd68
CD68 antigen
chr2_+_32780021 57.869


chr6_+_72494378 57.549 NM_007599
Capg
capping protein (actin filament), gelsolin-like
chr6_+_48986501 42.633 NM_053110
Gpnmb
glycoprotein (transmembrane) nmb
chr2_+_145686480 40.980 Rin2
Ras and Rab interactor 2
chr2_+_155576833 40.639 Procr
protein C receptor, endothelial
chr7_-_53176218 39.499 NM_001146346
Emp3
epithelial membrane protein 3
chr1_-_155033576 39.422 NM_008485
Lamc2
laminin, gamma 2
chr1_+_109486582 38.097 NM_001159748
NM_011459
Serpinb8

serine (or cysteine) peptidase inhibitor, clade B, member 8

chr6_+_72494474 37.102 Capg
capping protein (actin filament), gelsolin-like
chr6_-_122806042 36.117 C3ar1
complement component 3a receptor 1
chr2_+_145686377 34.623 Rin2
Ras and Rab interactor 2
chr6_-_122806122 34.490 NM_009779
C3ar1
complement component 3a receptor 1
chr6_-_122806020 33.796 C3ar1
complement component 3a receptor 1
chr3_+_79689897 32.963 Fam198b
family with sequence similarity 198, member B
chr3_+_121426422 32.133 NM_010171
F3
coagulation factor III
chr9_+_7272513 32.048 NM_008607
Mmp13
matrix metallopeptidase 13
chr3_+_79690082 31.717 Fam198b
family with sequence similarity 198, member B
chr6_+_72499398 30.428 NM_001042534
Capg
capping protein (actin filament), gelsolin-like
chr1_+_109407998 30.198 NM_001174170
NM_011111
Serpinb2

serine (or cysteine) peptidase inhibitor, clade B, member 2

chr6_+_17413930 29.250 NM_008591
Met
met proto-oncogene
chr3_-_95543477 27.867 Ecm1
extracellular matrix protein 1
chr3_-_95543488 27.855 Ecm1
extracellular matrix protein 1
chr3_-_95543490 27.672 NM_007899
Ecm1
extracellular matrix protein 1
chr11_+_81859212 27.409 NM_013654
Ccl7
chemokine (C-C motif) ligand 7
chr9_+_78463352 27.401 NM_153098
Cd109
CD109 antigen
chr14_+_103912557 27.242 NM_022886
Scel
sciellin
chr7_-_108112785 26.980 NM_183168
P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr3_-_10208575 26.944 NM_024406
Fabp4
fatty acid binding protein 4, adipocyte
chr9_+_78463569 26.563 Cd109
CD109 antigen
chr9_+_7347373 24.981 NM_008605
Mmp12
matrix metallopeptidase 12
chr9_+_69301471 24.706 NM_007585
Anxa2
annexin A2
chr6_+_48986625 24.572 Gpnmb
glycoprotein (transmembrane) nmb
chr2_+_155576943 23.688 NM_011171
Procr
protein C receptor, endothelial
chr3_-_88297220 23.667 NM_019390
Lmna
lamin A
chr6_-_137468412 23.651 Eps8
epidermal growth factor receptor pathway substrate 8
chr2_+_151931424 23.290 Srxn1
sulfiredoxin 1 homolog (S. cerevisiae)
chr7_+_28271928 23.223 NM_018820
Sertad1
SERTA domain containing 1
chr2_+_151931465 22.987 NM_029688
Srxn1
sulfiredoxin 1 homolog (S. cerevisiae)
chr1_-_184447549 22.897 NM_009794
Capn2
calpain 2
chr2_+_24192373 22.759 NM_031167
Il1rn
interleukin 1 receptor antagonist
chr3_+_93324411 22.379 NM_016740
S100a11
S100 calcium binding protein A11 (calgizzarin)
chr9_-_116084154 22.266 Tgfbr2
transforming growth factor, beta receptor II
chr16_-_85173930 22.107 App
amyloid beta (A4) precursor protein
chr19_+_6298046 21.976 Ehd1
EH-domain containing 1
chr16_+_65815758 21.831 NM_028572
Vgll3
vestigial like 3 (Drosophila)
chr16_-_85173764 21.825 App
amyloid beta (A4) precursor protein
chr16_-_84955488 21.811 App
amyloid beta (A4) precursor protein
chr16_-_85173944 21.642 NM_001198823
NM_001198824
NM_001198825
NM_001198826
NM_007471
App




amyloid beta (A4) precursor protein




chr16_-_85173918 21.532 App
amyloid beta (A4) precursor protein
chr5_-_135422795 21.524 NM_009903
Cldn4
claudin 4
chr7_-_125629996 21.511 Itpripl2
inositol 1,4,5-triphosphate receptor interacting protein-like 2
chr3_+_79689851 21.435 NM_133187
Fam198b
family with sequence similarity 198, member B
chr18_-_52689504 21.128 Lox
lysyl oxidase
chr16_-_85173978 20.687 App
amyloid beta (A4) precursor protein
chr15_-_57702643 20.620 Derl1
Der1-like domain family, member 1
chr4_-_19849637 20.296 Atp6v0d2
ATPase, H+ transporting, lysosomal V0 subunit D2
chr7_+_133728451 20.073 Apobr
apolipoprotein B receptor
chr16_-_85173851 20.006 App
amyloid beta (A4) precursor protein
chr3_+_93324437 19.966 S100a11
S100 calcium binding protein A11 (calgizzarin)
chr11_-_100068823 19.928 NM_016958
Krt14
keratin 14
chrX_-_7248403 19.754 NM_019755
Plp2
proteolipid protein 2
chr11_+_78002309 19.740 Rab34
RAB34, member of RAS oncogene family
chr4_-_141161882 19.604 NM_133754
Fblim1
filamin binding LIM protein 1
chr4_-_19849712 19.597 NM_175406
Atp6v0d2
ATPase, H+ transporting, lysosomal V0 subunit D2
chr12_+_76409299 19.210 NM_023275
Rhoj
ras homolog gene family, member J
chr11_-_99997241 18.949 NM_008469
Krt15
keratin 15
chr7_+_133728483 18.830 NM_138310
Apobr
apolipoprotein B receptor
chr7_-_140179678 18.706 Ctbp2
C-terminal binding protein 2
chr11_+_78001871 18.543 NM_001159482
Rab34
RAB34, member of RAS oncogene family
chr5_-_92777875 18.375 NM_021274
Cxcl10
chemokine (C-X-C motif) ligand 10
chr9_-_116084395 18.045 NM_009371
NM_029575
Tgfbr2

transforming growth factor, beta receptor II

chr16_-_84955086 17.515 App
amyloid beta (A4) precursor protein
chr2_+_143741050 17.491 NM_019771
Dstn
destrin
chr10_+_96945057 17.484 Dcn
decorin
chr17_+_35187185 17.229 NM_033444
Clic1
chloride intracellular channel 1
chr10_+_96944961 16.958 NM_007833
Dcn
decorin
chr11_+_94797565 16.706 NM_007742
Col1a1
collagen, type I, alpha 1
chr3_+_14641726 16.437 NM_024495
Car13
carbonic anhydrase 13
chr7_-_87884693 16.433 Iqgap1
IQ motif containing GTPase activating protein 1
chr17_+_35187325 16.407 Clic1
chloride intracellular channel 1
chr7_+_135206153 16.318 NM_001082960
NM_008401
Itgam

integrin alpha M

chr11_+_78002249 16.289 NM_033475
Rab34
RAB34, member of RAS oncogene family
chr9_-_116084547 16.136 Tgfbr2
transforming growth factor, beta receptor II
chr3_+_137880777 16.053 Adh7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr7_-_112630662 15.980 NM_028444
Prkcdbp
protein kinase C, delta binding protein
chr18_-_52689185 15.955 Lox
lysyl oxidase
chr5_+_30339682 15.805 NM_031168
Il6
interleukin 6
chr2_-_129135707 15.791 NM_010554
Il1a
interleukin 1 alpha
chr10_-_76188683 15.641 NM_009933
Col6a1
collagen, type VI, alpha 1
chr11_+_9018007 15.523 NM_001159401
Upp1
uridine phosphorylase 1
chr7_-_29692382 15.378 Actn4
actinin alpha 4
chr16_+_24448176 15.117 NM_001145952
Lpp
LIM domain containing preferred translocation partner in lipoma
chr7_+_31548774 15.030 NM_001166173
NM_001166174
NM_172899
Dmkn


dermokine


chr13_+_75977323 14.988 NM_053108
Glrx
glutaredoxin
chr10_+_80392814 14.956 NM_008655
Gadd45b
growth arrest and DNA-damage-inducible 45 beta
chr7_+_135667095 14.939 NM_013863
Bag3
BCL2-associated athanogene 3
chr5_-_135090819 14.908 NM_020044
NM_022964
Lat2

linker for activation of T cells family, member 2

chr1_-_151808361 14.889 NM_008869
Pla2g4a
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr10_-_127935725 14.704 NM_172259
Myl6b
myosin, light polypeptide 6B
chr5_-_135422780 14.683 Cldn4
claudin 4
chr7_+_63097598 14.651 Cyfip1
cytoplasmic FMR1 interacting protein 1
chr3_-_92289795 14.561 NM_009264
Sprr1a
small proline-rich protein 1A
chr3_+_137880725 14.541 NM_009626
Adh7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr15_+_79177959 14.476 Maff
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
chr19_+_46380418 14.430 NM_001177370
Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100
chr7_+_135667279 14.405 Bag3
BCL2-associated athanogene 3
chr7_+_25247448 14.271 NM_011113
Plaur
plasminogen activator, urokinase receptor
chr5_-_17341713 13.953 NM_001159555
NM_007643
Cd36

CD36 antigen

chr7_+_25421586 13.930 NM_133743
Lypd3
Ly6/Plaur domain containing 3
chr6_+_29222487 13.833 NM_001190461
NM_023516
2310016C08Rik

RIKEN cDNA 2310016C08 gene

chr3_-_92819586 13.743 NM_028798
Crct1
cysteine-rich C-terminal 1
chr9_+_44850616 13.727 Mpzl2
myelin protein zero-like 2
chr7_-_30033397 13.713 2200002D01Rik
RIKEN cDNA 2200002D01 gene
chr15_-_103196944 13.702 Itga5
integrin alpha 5 (fibronectin receptor alpha)
chr9_+_44850426 13.582 NM_007962
Mpzl2
myelin protein zero-like 2
chr7_+_138087002 13.523 Htra1
HtrA serine peptidase 1
chr19_+_10917005 13.352 NM_023044
Slc15a3
solute carrier family 15, member 3
chr7_+_148654681 13.337 NM_001111050
Cd151
CD151 antigen
chr6_+_29222664 13.266 2310016C08Rik
RIKEN cDNA 2310016C08 gene
chr17_+_64245366 13.186 NM_001037997
Fert2
fer (fms/fps related) protein kinase, testis specific 2
chrX_+_71669985 13.181 Ikbkg
inhibitor of kappaB kinase gamma
chr18_+_24812370 13.172 Mocos
molybdenum cofactor sulfurase
chr2_+_145611851 13.159 NM_028724
Rin2
Ras and Rab interactor 2
chr7_+_25421551 13.139 Lypd3
Ly6/Plaur domain containing 3
chr1_+_108757767 13.133 Serpinb5
serine (or cysteine) peptidase inhibitor, clade B, member 5
chr10_-_43724651 13.119 NM_172393
Aim1
absent in melanoma 1
chr3_+_54165028 13.046 NM_001198765
NM_001198766
NM_015784
Postn


periostin, osteoblast specific factor


chr15_+_79178063 13.022 NM_010755
Maff
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
chrX_+_21292025 12.951 NM_020049
Slc6a14
solute carrier family 6 (neurotransmitter transporter), member 14
chr7_-_108993807 12.860 Folr2
folate receptor 2 (fetal)
chr4_-_140221801 12.834 NM_001112722
Arhgef10l
Rho guanine nucleotide exchange factor (GEF) 10-like
chr15_+_79178408 12.719 Maff
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
chr10_+_18564876 12.707 NM_022032
Perp
PERP, TP53 apoptosis effector
chr14_+_120724380 12.685 Mbnl2
muscleblind-like 2
chr5_-_135422730 12.509 Cldn4
claudin 4
chr7_-_53176582 12.452 NM_010129
Emp3
epithelial membrane protein 3
chrX_+_20447291 12.365 NM_001044384
NM_011593
Timp1

tissue inhibitor of metalloproteinase 1

chr6_+_29222698 12.276 2310016C08Rik
RIKEN cDNA 2310016C08 gene
chr7_+_31572920 12.267 NM_001033131
Krtdap
keratinocyte differentiation associated protein
chr1_+_108831025 12.140 NM_027971
Serpinb12
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 12
chr7_+_31536489 12.079 NM_001083903
NM_172205
Sbsn

suprabasin

chr9_+_118961874 11.990 NM_001164567
NM_011700
Vill

villin-like

chr11_+_9018105 11.856 NM_009477
Upp1
uridine phosphorylase 1
chr1_+_183081066 11.843 Cnih4
cornichon homolog 4 (Drosophila)
chr15_+_78757148 11.814 NM_008495
Lgals1
lectin, galactose binding, soluble 1
chr17_-_25891264 11.709 NM_018857
Msln
mesothelin
chr3_+_109376824 11.607 NM_146139
Vav3
vav 3 oncogene
chr7_+_31561419 11.602 NM_028618
Dmkn
dermokine
chr2_+_131735663 11.544 NM_011170
Prnp
prion protein
chr7_+_117916117 11.507 NM_009667
Ampd3
adenosine monophosphate deaminase 3
chr2_+_119063090 11.480 NM_016907
Spint1
serine protease inhibitor, Kunitz type 1
chr5_-_5265981 11.453 Cdk14
cyclin-dependent kinase 14
chr10_-_44178474 11.447 NM_007548
Prdm1
PR domain containing 1, with ZNF domain
chr7_+_148662315 11.399 Tspan4
tetraspanin 4
chr4_-_43053029 11.347 B230312A22Rik
RIKEN cDNA B230312A22 gene
chr1_-_157881946 11.330 NM_001160019
Tor1aip1
torsin A interacting protein 1
chr4_-_133157683 11.329 Sfn
stratifin
chr10_+_18564932 11.248 Perp
PERP, TP53 apoptosis effector
chr18_-_52689279 11.128 NM_010728
Lox
lysyl oxidase
chrX_+_71669971 11.121 Ikbkg
inhibitor of kappaB kinase gamma
chr9_-_108962219 11.119 NM_011637
Trex1
three prime repair exonuclease 1
chr3_-_58999025 11.066 Gpr87
G protein-coupled receptor 87
chr7_-_31826775 10.946 NM_001111073
Fxyd5
FXYD domain-containing ion transport regulator 5
chr2_+_119063134 10.919 Spint1
serine protease inhibitor, Kunitz type 1
chr2_-_164268672 10.914 NM_011521
Sdc4
syndecan 4
chr3_-_91887051 10.842 NM_008508
Lor
loricrin
chr14_+_63754443 10.832 Ctsb
cathepsin B
chr8_+_90812964 10.825 NM_001037723
Adcy7
adenylate cyclase 7
chr1_-_193006986 10.714 Atf3
activating transcription factor 3
chr7_-_152469796 10.692 NM_146206
Tpcn2
two pore segment channel 2
chr17_+_75578120 10.691 NM_206958
Ltbp1
latent transforming growth factor beta binding protein 1
chr15_+_78757171 10.646 Lgals1
lectin, galactose binding, soluble 1
chr5_-_17394776 10.636 NM_001159558
Cd36
CD36 antigen
chr15_-_101524677 10.606 NM_008476
Krt6a
Krt6b
keratin 6A
keratin 6B
chr4_-_133158082 10.593 NM_018754
Sfn
stratifin
chr11_+_120328948 10.540 NM_001159328
NM_008244
Hgs

HGF-regulated tyrosine kinase substrate

chr5_-_140212063 10.523 NM_174850
Micall2
MICAL-like 2
chr8_-_64069935 10.455 Palld
palladin, cytoskeletal associated protein
chr9_-_44728790 10.352 NM_013795
Atp5l
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g
chr15_-_103197178 10.311 NM_010577
Itga5
integrin alpha 5 (fibronectin receptor alpha)
chr11_-_32122259 10.302 NM_010117
Rhbdf1
rhomboid family 1 (Drosophila)
chr19_+_46380107 10.243 NM_019408
Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100
chr2_+_119063194 10.217


chr8_-_84927109 10.209 Il15
interleukin 15
chr2_+_119063436 10.190 Spint1
serine protease inhibitor, Kunitz type 1
chr11_+_75469516 10.112 NM_001080775
Myo1c
myosin IC
chr7_+_148662278 10.064 Tspan4
tetraspanin 4
chr10_+_21713735 10.058 Sgk1
serum/glucocorticoid regulated kinase 1
chr12_+_31950097 10.044 NM_008482
Lamb1
laminin B1
chr1_+_108757751 10.023 NM_009257
Serpinb5
serine (or cysteine) peptidase inhibitor, clade B, member 5
chr18_+_24812191 10.015 NM_026779
Mocos
molybdenum cofactor sulfurase
chr16_-_52453104 10.012 NM_009655
Alcam
activated leukocyte cell adhesion molecule
chr18_+_42213320 9.987 NM_001146299
NM_172966
Sh3rf2

SH3 domain containing ring finger 2

chr8_+_34763918 9.986 Gsr
glutathione reductase

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.66 4.17e-19 GO:0009888 tissue development
1.78 4.63e-17 GO:0048518 positive regulation of biological process
1.77 4.75e-16 GO:0048856 anatomical structure development
1.81 2.56e-15 GO:0048731 system development
1.66 9.95e-15 GO:0032502 developmental process
1.77 1.10e-14 GO:0048522 positive regulation of cellular process
2.09 6.65e-14 GO:0009653 anatomical structure morphogenesis
1.66 3.00e-13 GO:0007275 multicellular organismal development
1.87 6.30e-12 GO:0042221 response to chemical stimulus
1.87 6.55e-12 GO:0048513 organ development
2.97 4.49e-11 GO:0060429 epithelium development
1.75 1.61e-10 GO:0048869 cellular developmental process
1.76 3.76e-10 GO:0030154 cell differentiation
2.57 1.91e-09 GO:0051094 positive regulation of developmental process
2.18 1.95e-09 GO:2000026 regulation of multicellular organismal development
1.82 2.82e-09 GO:0048583 regulation of response to stimulus
1.57 4.15e-09 GO:0016043 cellular component organization
1.18 8.40e-09 GO:0009987 cellular process
1.54 1.88e-08 GO:0071840 cellular component organization or biogenesis
2.96 2.06e-08 GO:0001944 vasculature development
2.01 2.69e-08 GO:0050793 regulation of developmental process
1.61 3.50e-08 GO:0048519 negative regulation of biological process
2.01 8.86e-08 GO:0042981 regulation of apoptosis
1.90 1.01e-07 GO:0009966 regulation of signal transduction
1.97 1.50e-07 GO:0010941 regulation of cell death
1.98 1.71e-07 GO:0043067 regulation of programmed cell death
2.28 2.52e-07 GO:0007155 cell adhesion
2.26 3.68e-07 GO:0022610 biological adhesion
1.48 4.12e-07 GO:0051179 localization
1.82 4.43e-07 GO:0010604 positive regulation of macromolecule metabolic process
2.90 5.01e-07 GO:0001568 blood vessel development
2.97 5.92e-07 GO:0001501 skeletal system development
2.03 8.28e-07 GO:0048468 cell development
1.60 8.40e-07 GO:0048523 negative regulation of cellular process
2.58 8.60e-07 GO:0045597 positive regulation of cell differentiation
2.64 8.64e-07 GO:0048729 tissue morphogenesis
1.90 8.74e-07 GO:0010033 response to organic substance
1.77 1.03e-06 GO:0009893 positive regulation of metabolic process
2.08 1.03e-06 GO:0045595 regulation of cell differentiation
1.73 1.66e-06 GO:0051239 regulation of multicellular organismal process
1.89 2.18e-06 GO:0051246 regulation of protein metabolic process
2.86 3.20e-06 GO:0002009 morphogenesis of an epithelium
2.10 3.60e-06 GO:0016265 death
2.41 5.21e-06 GO:0007010 cytoskeleton organization
2.10 5.38e-06 GO:0008219 cell death
1.67 7.38e-06 GO:0006950 response to stress
8.52 8.21e-06 GO:0032330 regulation of chondrocyte differentiation
2.02 8.68e-06 GO:0048584 positive regulation of response to stimulus
2.13 1.14e-05 GO:0012501 programmed cell death
1.62 1.25e-05 GO:0065008 regulation of biological quality
2.13 1.31e-05 GO:0006915 apoptosis
1.70 1.35e-05 GO:0023051 regulation of signaling
1.48 1.66e-05 GO:0051234 establishment of localization
1.73 2.03e-05 GO:0031325 positive regulation of cellular metabolic process
1.48 2.03e-05 GO:0006810 transport
4.79 2.10e-05 GO:0048660 regulation of smooth muscle cell proliferation
2.13 2.39e-05 GO:0002682 regulation of immune system process
3.42 2.63e-05 GO:0008544 epidermis development
3.25 2.70e-05 GO:0001525 angiogenesis
2.43 2.88e-05 GO:0009611 response to wounding
2.12 2.93e-05 GO:0016192 vesicle-mediated transport
2.25 3.26e-05 GO:0043009 chordate embryonic development
1.86 3.42e-05 GO:0032268 regulation of cellular protein metabolic process
2.89 3.79e-05 GO:0030029 actin filament-based process
1.36 4.02e-05 GO:0019222 regulation of metabolic process
2.27 4.11e-05 GO:0032989 cellular component morphogenesis
2.34 5.02e-05 GO:0016044 cellular membrane organization
3.31 5.35e-05 GO:0030855 epithelial cell differentiation
2.21 5.44e-05 GO:0009792 embryo development ending in birth or egg hatching
1.86 5.81e-05 GO:0002376 immune system process
1.87 5.83e-05 GO:0042127 regulation of cell proliferation
2.33 5.88e-05 GO:0061024 membrane organization
2.04 7.05e-05 GO:0070887 cellular response to chemical stimulus
1.96 7.35e-05 GO:0031399 regulation of protein modification process
1.39 8.40e-05 GO:0060255 regulation of macromolecule metabolic process
2.90 8.95e-05 GO:0030036 actin cytoskeleton organization
2.03 9.61e-05 GO:0019220 regulation of phosphate metabolic process
2.03 9.61e-05 GO:0051174 regulation of phosphorus metabolic process
1.20 1.28e-04 GO:0065007 biological regulation
1.78 1.79e-04 GO:0032879 regulation of localization
2.26 2.09e-04 GO:0051247 positive regulation of protein metabolic process
2.24 2.81e-04 GO:0000902 cell morphogenesis
3.21 3.16e-04 GO:0048705 skeletal system morphogenesis
1.36 4.92e-04 GO:0031323 regulation of cellular metabolic process
6.21 5.38e-04 GO:0061035 regulation of cartilage development
2.98 5.39e-04 GO:0051272 positive regulation of cellular component movement
2.13 5.56e-04 GO:0060548 negative regulation of cell death
2.17 5.87e-04 GO:0043066 negative regulation of apoptosis
2.10 5.92e-04 GO:0072358 cardiovascular system development
2.10 5.92e-04 GO:0072359 circulatory system development
12.19 7.25e-04 GO:0032332 positive regulation of chondrocyte differentiation
3.01 7.33e-04 GO:0030335 positive regulation of cell migration
3.01 7.33e-04 GO:2000147 positive regulation of cell motility
2.65 8.20e-04 GO:0048514 blood vessel morphogenesis
2.14 8.86e-04 GO:0043069 negative regulation of programmed cell death
2.22 8.96e-04 GO:0032270 positive regulation of cellular protein metabolic process
7.37 9.05e-04 GO:0031424 keratinization
2.07 9.29e-04 GO:0048646 anatomical structure formation involved in morphogenesis
1.35 9.44e-04 GO:0080090 regulation of primary metabolic process
1.95 1.33e-03 GO:0042325 regulation of phosphorylation
1.81 1.67e-03 GO:0009790 embryo development
1.20 1.69e-03 GO:0008152 metabolic process
2.34 1.81e-03 GO:0032535 regulation of cellular component size
1.81 1.84e-03 GO:0016310 phosphorylation
2.87 1.86e-03 GO:0040017 positive regulation of locomotion
1.72 1.86e-03 GO:0006796 phosphate metabolic process
3.68 1.88e-03 GO:0007265 Ras protein signal transduction
1.71 2.03e-03 GO:0006793 phosphorus metabolic process
2.22 2.29e-03 GO:0010627 regulation of intracellular protein kinase cascade
2.34 2.54e-03 GO:0051270 regulation of cellular component movement
2.51 2.78e-03 GO:0061061 muscle structure development
1.82 2.99e-03 GO:0048699 generation of neurons
1.96 3.33e-03 GO:0001932 regulation of protein phosphorylation
2.13 3.59e-03 GO:0048666 neuron development
2.11 3.84e-03 GO:0048598 embryonic morphogenesis
2.27 3.93e-03 GO:0031401 positive regulation of protein modification process
2.60 4.00e-03 GO:0006897 endocytosis
2.60 4.00e-03 GO:0010324 membrane invagination
1.78 4.01e-03 GO:0022008 neurogenesis
1.90 4.12e-03 GO:0009887 organ morphogenesis
2.19 4.27e-03 GO:0090066 regulation of anatomical structure size
1.76 5.05e-03 GO:0051128 regulation of cellular component organization
1.79 5.09e-03 GO:0044093 positive regulation of molecular function
2.37 5.09e-03 GO:0030334 regulation of cell migration
1.84 5.68e-03 GO:0006468 protein phosphorylation
1.21 6.13e-03 GO:0044238 primary metabolic process
2.20 6.30e-03 GO:0007167 enzyme linked receptor protein signaling pathway
1.65 6.30e-03 GO:0010646 regulation of cell communication
3.40 6.42e-03 GO:0043122 regulation of I-kappaB kinase/NF-kappaB cascade
1.23 6.60e-03 GO:0050896 response to stimulus
6.90 6.78e-03 GO:0045104 intermediate filament cytoskeleton organization
2.34 7.02e-03 GO:2000145 regulation of cell motility
1.54 7.04e-03 GO:0065009 regulation of molecular function
2.01 7.36e-03 GO:0030030 cell projection organization
1.17 7.61e-03 GO:0050789 regulation of biological process
2.21 7.64e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.61 7.72e-03 GO:0050790 regulation of catalytic activity
1.89 8.99e-03 GO:0040011 locomotion
1.61 9.04e-03 GO:0007399 nervous system development
1.18 9.23e-03 GO:0050794 regulation of cellular process
1.60 9.65e-03 GO:0033036 macromolecule localization
2.34 9.86e-03 GO:0048568 embryonic organ development
6.63 9.89e-03 GO:0045103 intermediate filament-based process
1.43 1.12e-02 GO:0071842 cellular component organization at cellular level
4.79 1.19e-02 GO:0048661 positive regulation of smooth muscle cell proliferation
1.99 1.22e-02 GO:0009967 positive regulation of signal transduction
2.02 1.28e-02 GO:0080134 regulation of response to stress
3.38 1.28e-02 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
3.69 1.31e-02 GO:0071216 cellular response to biotic stimulus
2.21 1.39e-02 GO:0035295 tube development
2.09 1.44e-02 GO:0002684 positive regulation of immune system process
2.53 1.51e-02 GO:0006954 inflammatory response
1.36 1.64e-02 GO:0019538 protein metabolic process
1.74 1.92e-02 GO:0015031 protein transport
2.25 2.13e-02 GO:0009150 purine ribonucleotide metabolic process
1.72 2.14e-02 GO:0045184 establishment of protein localization
2.94 2.19e-02 GO:0010720 positive regulation of cell development
2.19 2.25e-02 GO:0040012 regulation of locomotion
1.70 2.30e-02 GO:0010628 positive regulation of gene expression
2.75 2.49e-02 GO:0006979 response to oxidative stress
3.22 2.57e-02 GO:0051216 cartilage development
3.22 2.57e-02 GO:0090047 positive regulation of transcription regulator activity
1.90 2.64e-02 GO:0008284 positive regulation of cell proliferation
5.95 2.75e-02 GO:0032963 collagen metabolic process
2.74 2.77e-02 GO:0031349 positive regulation of defense response
3.48 2.87e-02 GO:0051291 protein heterooligomerization
4.42 2.90e-02 GO:0030216 keratinocyte differentiation
1.99 2.93e-02 GO:0006928 cellular component movement
4.79 2.96e-02 GO:0071222 cellular response to lipopolysaccharide
2.16 2.98e-02 GO:0031175 neuron projection development
2.79 3.11e-02 GO:0042692 muscle cell differentiation
1.39 3.31e-02 GO:0071841 cellular component organization or biogenesis at cellular level
2.48 3.31e-02 GO:0052547 regulation of peptidase activity
2.27 3.35e-02 GO:0007264 small GTPase mediated signal transduction
2.34 3.55e-02 GO:0008361 regulation of cell size
2.19 4.11e-02 GO:0009259 ribonucleotide metabolic process
2.08 4.18e-02 GO:0006163 purine nucleotide metabolic process
2.39 4.67e-02 GO:0035239 tube morphogenesis
4.58 4.68e-02 GO:0018108 peptidyl-tyrosine phosphorylation
4.58 4.68e-02 GO:0018212 peptidyl-tyrosine modification
3.08 4.91e-02 GO:0050769 positive regulation of neurogenesis

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.38 1.76e-20 GO:0005737 cytoplasm
1.26 7.92e-17 GO:0044424 intracellular part
1.25 1.24e-15 GO:0005622 intracellular
1.42 3.86e-13 GO:0044444 cytoplasmic part
1.50 4.48e-11 GO:0071944 cell periphery
1.50 1.90e-10 GO:0005886 plasma membrane
1.23 3.08e-09 GO:0043226 organelle
1.23 4.13e-09 GO:0043229 intracellular organelle
2.01 1.17e-08 GO:0044421 extracellular region part
1.70 1.26e-08 GO:0044459 plasma membrane part
1.12 1.55e-08 GO:0005623 cell
1.12 1.55e-08 GO:0044464 cell part
1.78 1.71e-08 GO:0005829 cytosol
1.76 6.04e-08 GO:0005856 cytoskeleton
3.18 8.00e-08 GO:0005911 cell-cell junction
1.65 1.80e-07 GO:0005576 extracellular region
3.41 6.20e-07 GO:0031252 cell leading edge
2.03 1.78e-06 GO:0005615 extracellular space
2.73 2.77e-06 GO:0015629 actin cytoskeleton
1.75 5.15e-06 GO:0000267 cell fraction
1.42 4.16e-05 GO:0043234 protein complex
2.51 4.27e-05 GO:0048471 perinuclear region of cytoplasm
4.46 5.49e-05 GO:0001726 ruffle
1.45 7.37e-05 GO:0043228 non-membrane-bounded organelle
1.45 7.37e-05 GO:0043232 intracellular non-membrane-bounded organelle
2.43 2.83e-04 GO:0005578 proteinaceous extracellular matrix
1.92 3.07e-04 GO:0030054 cell junction
1.18 3.41e-04 GO:0043227 membrane-bounded organelle
2.31 3.47e-04 GO:0031012 extracellular matrix
1.18 3.56e-04 GO:0043231 intracellular membrane-bounded organelle
1.72 5.31e-04 GO:0005626 insoluble fraction
5.23 6.12e-04 GO:0032432 actin filament bundle
1.70 9.56e-04 GO:0044430 cytoskeletal part
5.00 1.02e-03 GO:0042641 actomyosin
1.64 1.47e-03 GO:0005783 endoplasmic reticulum
5.14 1.97e-03 GO:0001725 stress fiber
2.01 2.48e-03 GO:0005768 endosome
4.60 2.64e-03 GO:0005884 actin filament
1.95 3.52e-03 GO:0009986 cell surface
2.85 4.84e-03 GO:0070161 anchoring junction
2.07 6.24e-03 GO:0005625 soluble fraction
1.26 6.98e-03 GO:0044422 organelle part
1.29 1.01e-02 GO:0032991 macromolecular complex
2.34 1.27e-02 GO:0016323 basolateral plasma membrane
5.90 1.29e-02 GO:0016328 lateral plasma membrane
2.82 1.44e-02 GO:0005912 adherens junction
2.22 1.74e-02 GO:0045177 apical part of cell
1.15 1.93e-02 GO:0016020 membrane
1.53 2.29e-02 GO:0042995 cell projection
1.60 2.32e-02 GO:0005624 membrane fraction
4.17 3.75e-02 GO:0005913 cell-cell adherens junction
2.92 3.79e-02 GO:0019898 extrinsic to membrane
1.23 4.16e-02 GO:0044446 intracellular organelle part
1.61 4.57e-02 GO:0012505 endomembrane system
2.34 4.60e-02 GO:0016324 apical plasma membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.68 4.89e-36 GO:0005515 protein binding
1.31 2.76e-24 GO:0005488 binding
2.49 3.59e-09 GO:0008092 cytoskeletal protein binding
2.48 1.60e-06 GO:0005198 structural molecule activity
2.56 2.76e-05 GO:0003779 actin binding
2.97 2.04e-04 GO:0005126 cytokine receptor binding
1.88 2.14e-04 GO:0046983 protein dimerization activity
1.71 2.74e-04 GO:0005102 receptor binding
3.47 1.05e-03 GO:0019838 growth factor binding
1.73 2.99e-03 GO:0016301 kinase activity
1.89 3.31e-03 GO:0004672 protein kinase activity
1.70 3.56e-03 GO:0019899 enzyme binding
1.46 3.75e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.45 4.83e-03 GO:0017076 purine nucleotide binding
1.45 6.26e-03 GO:0032555 purine ribonucleotide binding
1.45 6.44e-03 GO:0032553 ribonucleotide binding
1.38 1.31e-02 GO:0000166 nucleotide binding
1.72 1.93e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.59 2.62e-02 GO:0016772 transferase activity, transferring phosphorus-containing groups
2.00 2.68e-02 GO:0032403 protein complex binding
1.63 4.04e-02 GO:0042802 identical protein binding
1.44 4.50e-02 GO:0030554 adenyl nucleotide binding
1.45 4.53e-02 GO:0005524 ATP binding