Motif ID: FOX{C1,C2}.p2

Z-value: 1.272


Transcription factors associated with FOX{C1,C2}.p2:

Gene SymbolEntrez IDGene Name
Foxc1 17300 forkhead box C1
Foxc2 14234 forkhead box C2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxc1chr13_+_318985010.064.5e-01Click!
Foxc2chr8_+_1236400690.018.9e-01Click!


Activity profile for motif FOX{C1,C2}.p2.

activity profile for motif FOX{C1,C2}.p2


Sorted Z-values histogram for motif FOX{C1,C2}.p2

Sorted Z-values for motif FOX{C1,C2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{C1,C2}.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_45368443 39.911 Col3a1
collagen, type III, alpha 1
chr1_+_196765124 22.620 Cd34
CD34 antigen
chr3_+_137949734 21.122 Adh1
alcohol dehydrogenase 1 (class I)
chr11_+_28821585 20.983 Efemp1
epidermal growth factor-containing fibulin-like extracellular matrix protein 1
chr1_-_174228105 18.852 NM_178405
Atp1a2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr1_+_45368382 18.803 NM_009930
Col3a1
collagen, type III, alpha 1
chr6_-_83486194 18.404 NM_009610
Actg2
actin, gamma 2, smooth muscle, enteric
chr1_-_170362298 17.423 Pbx1
pre B-cell leukemia transcription factor 1
chr1_+_196765014 17.397 NM_001111059
NM_133654
Cd34

CD34 antigen

chr6_-_55124983 16.858 NM_009349
Inmt
indolethylamine N-methyltransferase
chr1_+_137737433 16.331 NM_001130176
Tnnt2
troponin T2, cardiac
chr19_+_23241546 16.125 Klf9
Kruppel-like factor 9
chr9_-_71440061 15.686 NM_001033208
Gcom1
GRINL1A complex locus
chr4_-_61179982 15.095 Mup1
major urinary protein 1
chr11_-_55223449 14.691 Sparc
secreted acidic cysteine rich glycoprotein
chr4_-_60594496 14.269 Mup1
major urinary protein 1
chr12_-_105066203 14.242 Serpina1b
serine (or cysteine) preptidase inhibitor, clade A, member 1B
chr4_-_60594469 14.103 Mup1
major urinary protein 1
chr1_-_45460310 14.084 Col5a2
collagen, type V, alpha 2
chr11_+_108256590 13.775 NM_013475
Apoh
apolipoprotein H
chr4_-_49562400 13.483 Aldob
aldolase B, fructose-bisphosphate
chr6_+_4483741 13.430 Col1a2
collagen, type I, alpha 2
chr1_+_92100572 13.049 NM_007722
Cxcr7
chemokine (C-X-C motif) receptor 7
chr1_+_196765079 11.746 Cd34
CD34 antigen
chr1_-_79855209 11.743 Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr1_-_79855177 11.739 Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr18_-_60769648 11.479 NM_001109975
Synpo
synaptopodin
chr16_+_7069971 11.401 Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chrX_+_98644445 10.832 NM_013712
Itgb1bp2
integrin beta 1 binding protein 2
chrX_+_98644459 10.498 Itgb1bp2
integrin beta 1 binding protein 2
chr7_+_149628285 10.074 NM_009405
Tnni2
troponin I, skeletal, fast 2
chr12_-_104976382 9.967 NM_009244
Serpina1b
serine (or cysteine) preptidase inhibitor, clade A, member 1B
chr19_+_40164158 9.882 NM_001167875
NM_001167877
NM_134144
Cyp2c50


cytochrome P450, family 2, subfamily c, polypeptide 50


chr4_-_49562319 9.798 NM_144903
Aldob
aldolase B, fructose-bisphosphate
chr1_+_21230683 9.615 Gsta3
glutathione S-transferase, alpha 3
chr12_-_105101768 9.216 Serpina1a
serine (or cysteine) peptidase inhibitor, clade A, member 1A
chr9_-_50554613 8.767 NM_025865
2310030G06Rik
RIKEN cDNA 2310030G06 gene
chr5_-_77543903 8.709 Hopx
HOP homeobox
chr12_-_105143108 8.432 NM_009245
Serpina1c
serine (or cysteine) peptidase inhibitor, clade A, member 1C
chr15_-_78236262 8.388 NM_009437
Tst
thiosulfate sulfurtransferase, mitochondrial
chr1_+_166726827 8.274 NM_019759
Dpt
dermatopontin
chr3_-_122737855 8.205 NM_021503
Myoz2
myozenin 2
chr1_-_71686889 8.102 Fn1
fibronectin 1
chr6_-_92851434 7.806 NM_175314
Adamts9
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9
chr15_-_76853069 7.761 NM_001164048
NM_001164047
Mb

myoglobin

chr9_-_101101334 7.695 NM_172144
Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr2_-_10052196 7.681 NM_010582
Itih2
inter-alpha trypsin inhibitor, heavy chain 2
chr7_-_116760660 7.582 NM_001001326
NM_029811
St5

suppression of tumorigenicity 5

chr11_+_32183671 7.573 NM_001083955
NM_008218
Hba-a2
Hba-a1
hemoglobin alpha, adult chain 2
hemoglobin alpha, adult chain 1
chr11_+_67611772 7.496 NM_001013013
Dhrs7c
dehydrogenase/reductase (SDR family) member 7C
chr13_+_42776161 7.416 Phactr1
phosphatase and actin regulator 1
chr2_-_79748552 7.253 NM_001009978
NM_001009979
Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr15_+_54964990 7.167 NM_001037937
Deptor
DEP domain containing MTOR-interacting protein
chr18_+_37821598 7.152 NM_033584
Pcdhga1
protocadherin gamma subfamily A, 1
chr3_+_94928435 6.831 NM_016712
Tmod4
tropomodulin 4
chr12_-_105101825 6.807 NM_009243
Serpina1a
serine (or cysteine) peptidase inhibitor, clade A, member 1A
chr1_-_79855229 6.641 NM_009255
Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr19_-_34952328 6.580 Pank1
pantothenate kinase 1
chr13_+_42775991 6.522 NM_198419
Phactr1
phosphatase and actin regulator 1
chr19_-_44471675 6.514 Scd1
stearoyl-Coenzyme A desaturase 1
chr12_+_71008808 6.513 Atl1
atlastin GTPase 1
chr11_+_32196488 6.486 NM_001083955
NM_008218
Hba-a2
Hba-a1
hemoglobin alpha, adult chain 2
hemoglobin alpha, adult chain 1
chr8_-_13494457 6.399 NM_019521
Gas6
growth arrest specific 6
chr7_-_135073577 6.343 Prss8
protease, serine, 8 (prostasin)
chrX_+_54032858 6.288 NM_001077362
Fhl1
four and a half LIM domains 1
chr1_+_21230664 6.278 NM_001077353
NM_010356
Gsta3

glutathione S-transferase, alpha 3

chr6_+_71149869 6.273 NM_017399
Fabp1
fatty acid binding protein 1, liver
chr5_-_146821173 6.228 NM_019792
Cyp3a25
cytochrome P450, family 3, subfamily a, polypeptide 25
chr12_-_105101743 6.189 Serpina1a
Serpina1b
Serpina1c
serine (or cysteine) peptidase inhibitor, clade A, member 1A
serine (or cysteine) preptidase inhibitor, clade A, member 1B
serine (or cysteine) peptidase inhibitor, clade A, member 1C
chr13_-_41923709 5.912 9530008L14Rik
RIKEN cDNA 9530008L14 gene
chr12_-_105195097 5.904 NM_009247
Serpina1e
serine (or cysteine) peptidase inhibitor, clade A, member 1E
chr18_-_70301202 5.837 NM_001082553
Rab27b
RAB27b, member RAS oncogene family
chr19_-_34952377 5.799 NM_023792
Pank1
pantothenate kinase 1
chr19_-_5845001 5.795 Neat1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr11_-_11798101 5.638 Ddc
dopa decarboxylase
chr7_-_135073508 5.568 Prss8
protease, serine, 8 (prostasin)
chr8_-_48437701 5.563 NM_175162
Stox2
storkhead box 2
chr16_+_34921598 5.443 Mylk
myosin, light polypeptide kinase
chr19_-_44472087 5.408 Scd1
stearoyl-Coenzyme A desaturase 1
chr10_-_76172218 5.298 Col6a1
collagen, type VI, alpha 1
chr16_+_7069927 5.265 NM_183188
Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr7_-_108025317 5.264 Arhgef17
Rho guanine nucleotide exchange factor (GEF) 17
chr3_-_130951398 5.232 Hadh
hydroxyacyl-Coenzyme A dehydrogenase
chr9_+_21397379 5.120 1810026J23Rik
RIKEN cDNA 1810026J23 gene
chr11_-_11798138 4.971 NM_001190448
Ddc
dopa decarboxylase
chr10_+_18189773 4.907 NM_001163592
Nhsl1
NHS-like 1
chr3_+_67868723 4.815 NM_001113420
NM_001113421
Schip1

schwannomin interacting protein 1

chr12_-_105143089 4.736 Serpina1c
serine (or cysteine) peptidase inhibitor, clade A, member 1C
chr15_+_97923019 4.730 NM_001163488
Pfkm
phosphofructokinase, muscle
chr19_+_39361574 4.604 NM_007815
Cyp2c29
cytochrome P450, family 2, subfamily c, polypeptide 29
chr2_+_135883963 4.601 6330527O06Rik
RIKEN cDNA 6330527O06 gene
chr2_+_135567565 4.462 NM_013829
Plcb4
phospholipase C, beta 4
chr1_-_174149963 4.442 Casq1
calsequestrin 1
chr16_+_56477956 4.416 NM_001014399
NM_001014422
NM_001014423
NM_001014424
NM_178790
Abi3bp




ABI gene family, member 3 (NESH) binding protein




chr1_-_170362388 4.391 NM_008783
NM_183355
Pbx1

pre B-cell leukemia transcription factor 1

chr2_-_66622823 4.344 NM_009135
Scn7a
sodium channel, voltage-gated, type VII, alpha
chr6_+_47194393 4.304 NM_025771
Cntnap2
contactin associated protein-like 2
chr5_+_136514548 4.089 Upk3b
uroplakin 3B
chr19_+_40066913 3.970 NM_010001
Cyp2c37
cytochrome P450, family 2. subfamily c, polypeptide 37
chrX_+_133242520 3.912 NM_146236
Tceal1
transcription elongation factor A (SII)-like 1
chr1_-_89291303 3.793 NM_001110227
Kcnj13
potassium inwardly-rectifying channel, subfamily J, member 13
chr3_-_57098670 3.791 Tm4sf1
transmembrane 4 superfamily member 1
chr7_-_112748585 3.778 Hpx
hemopexin
chr13_+_25035416 3.718 Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr3_-_87067445 3.680 NM_030707
Fcrls
Fc receptor-like S, scavenger receptor
chr3_-_90318178 3.667 NM_011309
S100a1
S100 calcium binding protein A1
chr2_+_10075169 3.651 NM_172471
Itih5
inter-alpha (globulin) inhibitor H5
chr5_-_130354822 3.613 NM_011079
Phkg1
phosphorylase kinase gamma 1
chr14_-_65035722 3.597 Msra
methionine sulfoxide reductase A
chr7_-_112748624 3.542 NM_017371
Hpx
hemopexin
chr12_-_105011767 3.482 Serpina1d
serine (or cysteine) peptidase inhibitor, clade A, member 1D
chr11_-_11798035 3.482 Ddc
dopa decarboxylase
chr12_-_105011807 3.415 NM_009246
Serpina1d
serine (or cysteine) peptidase inhibitor, clade A, member 1D
chr11_+_52202137 3.410 Vdac1
voltage-dependent anion channel 1
chr16_-_44016471 3.398 NM_153528
Gramd1c
GRAM domain containing 1C
chr7_+_88202481 3.393 NM_054085
Alpk3
alpha-kinase 3
chr4_-_44096969 3.382 NM_015828
Gne
glucosamine
chr17_+_75578120 3.377 NM_206958
Ltbp1
latent transforming growth factor beta binding protein 1
chr12_-_105011795 3.367 Serpina1d
serine (or cysteine) peptidase inhibitor, clade A, member 1D
chr19_-_24299389 3.330 Tjp2
tight junction protein 2
chr12_-_104976324 3.291 Serpina1b
serine (or cysteine) preptidase inhibitor, clade A, member 1B
chr2_+_49921978 3.264 NM_177139
Lypd6
LY6/PLAUR domain containing 6
chr6_+_4484651 3.264 Col1a2
collagen, type I, alpha 2
chr14_+_30822097 3.251 NM_001136240
Chdh
choline dehydrogenase
chr7_-_135073600 3.206 Prss8
protease, serine, 8 (prostasin)
chr11_+_115626733 3.192 NM_028014
2310067B10Rik
RIKEN cDNA 2310067B10 gene
chr1_+_173155184 3.136 NM_013474
Apoa2
apolipoprotein A-II
chr5_+_53440591 3.021 NM_011402
Slc34a2
solute carrier family 34 (sodium phosphate), member 2
chr2_+_35122282 2.949 Gsn
gelsolin
chr11_-_68770359 2.881 NM_177566
Arhgef15
Rho guanine nucleotide exchange factor (GEF) 15
chr3_-_121518046 2.849 NM_008991
Abcd3
ATP-binding cassette, sub-family D (ALD), member 3
chr11_+_115626816 2.842 2310067B10Rik
RIKEN cDNA 2310067B10 gene
chr17_-_37712365 2.776 NM_146289
Olfr113
olfactory receptor 113
chr14_-_32454060 2.672 Hacl1
2-hydroxyacyl-CoA lyase 1
chr15_-_6824238 2.661 NM_011019
Osmr
oncostatin M receptor
chr7_-_135073617 2.628 NM_133351
Prss8
protease, serine, 8 (prostasin)
chr16_+_38362258 2.617 NM_001081984
NM_022318
Popdc2

popeye domain containing 2

chr3_+_124023954 2.595 NM_146140
Tram1l1
translocation associated membrane protein 1-like 1
chr15_+_10107168 2.569 Prlr
prolactin receptor
chr15_-_73640331 2.554 Ndufb4
NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4
chr8_-_47060486 2.542 NM_001033148
1700029J07Rik
RIKEN cDNA 1700029J07 gene
chr19_+_6241665 2.539 NM_194348
Atg2a
ATG2 autophagy related 2 homolog A (S. cerevisiae)
chr16_+_30065419 2.524 NM_008235
Hes1
hairy and enhancer of split 1 (Drosophila)
chr1_+_135142673 2.509 NM_001160268
NM_182930
Plekha6

pleckstrin homology domain containing, family A member 6

chr2_+_30663433 2.464 NM_170592
Mettl11a
methyltransferase like 11A
chr14_-_32454146 2.461 NM_019975
Hacl1
2-hydroxyacyl-CoA lyase 1
chr2_-_60511707 2.453 NM_021359
Itgb6
integrin beta 6
chr9_-_50560397 2.441 NM_001164708
NM_024441
Hspb2

heat shock protein 2

chr9_-_119932620 2.428 NM_011724
Xirp1
xin actin-binding repeat containing 1
chr11_+_72974015 2.415 NM_033321
P2rx5
purinergic receptor P2X, ligand-gated ion channel, 5
chr11_-_11790403 2.409 NM_016672
Ddc
dopa decarboxylase
chr18_+_37844927 2.358 NM_033587
Pcdhga4
protocadherin gamma subfamily A, 4
chr11_+_72974053 2.352 P2rx5
purinergic receptor P2X, ligand-gated ion channel, 5
chr5_-_34530284 2.334 NM_010753
Mxd4
Max dimerization protein 4
chr1_+_12708582 2.329 NM_172294
Sulf1
sulfatase 1
chr11_+_68939734 2.310 NM_011786
Aloxe3
arachidonate lipoxygenase 3
chr14_+_119187092 2.286 NM_001160096
NM_001160097
NM_001160098
NM_023878
Cldn10



claudin 10



chr1_+_93076578 2.285 Ramp1
receptor (calcitonin) activity modifying protein 1
chr9_-_107571304 2.249 Slc38a3
solute carrier family 38, member 3
chr19_-_24299471 2.236 NM_011597
Tjp2
tight junction protein 2
chr18_+_37979199 2.233 NM_033583
Pcdhgb4
Pcdhgc5
protocadherin gamma subfamily B, 4
protocadherin gamma subfamily C, 5
chr5_-_75098910 2.229 NM_001159577
Lnx1
ligand of numb-protein X 1
chr16_-_94591826 2.192 NM_001159619
NM_001159620
Pigp

phosphatidylinositol glycan anchor biosynthesis, class P

chr17_+_12571455 2.170 NM_008877
Plg
plasminogen
chr18_+_37911236 2.160 NM_033579
Pcdhgb7
protocadherin gamma subfamily B, 7
chr8_+_23348971 2.157 NM_019576
Thsd1
thrombospondin, type I, domain 1
chr12_+_31597051 2.131 Sh3yl1
Sh3 domain YSC-like 1
chr19_-_54018933 2.131 Bbip1
BBSome interacting protein 1
chr4_-_76240202 2.057 NM_011211
Ptprd
protein tyrosine phosphatase, receptor type, D
chr8_-_25707414 2.056 NM_008324
Ido1
indoleamine 2,3-dioxygenase 1
chr10_+_62524324 2.051 NM_026701
Pbld1
phenazine biosynthesis-like protein domain containing 1
chr4_-_107596088 2.043 Cpt2
carnitine palmitoyltransferase 2
chr4_+_44769430 2.021 NM_138590
Zcchc7
zinc finger, CCHC domain containing 7
chr9_+_21397165 2.019 NM_178619
1810026J23Rik
RIKEN cDNA 1810026J23 gene
chr6_+_141472906 2.011 NM_001177772
NM_021471
Slco1c1

solute carrier organic anion transporter family, member 1c1

chr8_+_120225803 1.999 NM_008290
Hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
chr11_+_34934956 1.980 NM_011412
Slit3
slit homolog 3 (Drosophila)
chr16_-_84955488 1.960 App
amyloid beta (A4) precursor protein
chr9_-_121825422 1.953 NM_010012
Cyp8b1
cytochrome P450, family 8, subfamily b, polypeptide 1
chr3_-_95085997 1.952 NM_173347
Prune
prune homolog (Drosophila)
chr1_+_90031368 1.935 NM_145079
Ugt1a6a
UDP glucuronosyltransferase 1 family, polypeptide A6A
chr15_+_100965071 1.889 Acvrl1
activin A receptor, type II-like 1
chr19_+_8738840 1.841 Chrm1
cholinergic receptor, muscarinic 1, CNS
chr11_-_119903061 1.827 NM_001198787
Aatk
apoptosis-associated tyrosine kinase
chr17_-_90436488 1.824 Nrxn1
neurexin I
chr2_+_67955769 1.810 NM_020283
B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chrX_-_92673432 1.800 NM_080858
Asb12
ankyrin repeat and SOCS box-containing 12
chr10_+_40657980 1.733 Wasf1
WASP family 1
chr2_+_10075242 1.728 Itih5
inter-alpha (globulin) inhibitor H5
chr9_-_121825407 1.708 Cyp8b1
cytochrome P450, family 8, subfamily b, polypeptide 1
chr10_+_127774845 1.688 Cs
citrate synthase
chr17_+_41071633 1.682 NM_008650
Mut
methylmalonyl-Coenzyme A mutase
chr17_-_31266539 1.668 NM_011575
Tff3
trefoil factor 3, intestinal
chr16_-_38800293 1.628 NM_178924
Upk1b
uroplakin 1B
chr12_+_29360082 1.621 Adi1
acireductone dioxygenase 1
chrX_+_97969784 1.607 NM_001177779
Dlg3
discs, large homolog 3 (Drosophila)
chr2_+_58607580 1.595 NM_029692
Upp2
uridine phosphorylase 2
chr15_-_102993714 1.594 NM_027885
Smug1
single-strand selective monofunctional uracil DNA glycosylase
chr4_-_15076093 1.551 NM_178617
Necab1
N-terminal EF-hand calcium binding protein 1
chr2_-_91469372 1.544 F2
coagulation factor II

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
4.94 3.09e-03 GO:0051346 negative regulation of hydrolase activity
2.38 1.95e-02 GO:0055114 oxidation-reduction process
1.88 1.97e-02 GO:0044281 small molecule metabolic process
2.55 2.41e-02 GO:0007155 cell adhesion
2.54 2.55e-02 GO:0046483 heterocycle metabolic process
2.53 2.77e-02 GO:0022610 biological adhesion
2.83 3.86e-02 GO:0006461 protein complex assembly
2.82 4.13e-02 GO:0070271 protein complex biogenesis
2.72 4.35e-02 GO:0006753 nucleoside phosphate metabolic process
2.72 4.35e-02 GO:0009117 nucleotide metabolic process
4.14 4.46e-02 GO:0043062 extracellular structure organization

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.53 5.05e-07 GO:0000267 cell fraction
2.54 5.46e-05 GO:0005624 membrane fraction
2.42 1.62e-04 GO:0005626 insoluble fraction
3.53 7.43e-04 GO:0005792 microsome
3.44 1.06e-03 GO:0042598 vesicular fraction
1.86 1.48e-03 GO:0005576 extracellular region
2.32 8.32e-03 GO:0005615 extracellular space
2.08 1.41e-02 GO:0044421 extracellular region part
3.17 1.61e-02 GO:0005578 proteinaceous extracellular matrix
2.98 2.00e-02 GO:0031012 extracellular matrix

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
6.40 3.53e-05 GO:0046906 tetrapyrrole binding
6.86 4.99e-05 GO:0004867 serine-type endopeptidase inhibitor activity
3.88 5.97e-04 GO:0004857 enzyme inhibitor activity
9.06 6.91e-04 GO:0046332 SMAD binding
4.91 7.47e-04 GO:0004866 endopeptidase inhibitor activity
5.74 9.68e-04 GO:0020037 heme binding
4.73 1.13e-03 GO:0061135 endopeptidase regulator activity
4.65 1.37e-03 GO:0030414 peptidase inhibitor activity
4.29 1.52e-03 GO:0061134 peptidase regulator activity
3.98 7.21e-03 GO:0005506 iron ion binding
2.63 1.07e-02 GO:0005509 calcium ion binding
1.36 1.74e-02 GO:0005515 protein binding
1.38 2.24e-02 GO:0003824 catalytic activity
10.72 2.47e-02 GO:0070330 aromatase activity
10.00 3.48e-02 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen