Motif ID: FOXO1,3,4.p2

Z-value: 1.029


Transcription factors associated with FOXO1,3,4.p2:

Gene SymbolEntrez IDGene Name
Foxo1 56458 forkhead box O1
Foxo3 56484 forkhead box O3
Foxo4 54601 forkhead box O4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo4chrX_+_984498660.321.4e-05Click!
Foxo1chr3_+_520723020.199.3e-03Click!
Foxo3chr10_-_41996462-0.181.5e-02Click!


Activity profile for motif FOXO1,3,4.p2.

activity profile for motif FOXO1,3,4.p2


Sorted Z-values histogram for motif FOXO1,3,4.p2

Sorted Z-values for motif FOXO1,3,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXO1,3,4.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_45390415 21.306 Col3a1
collagen, type III, alpha 1
chr1_+_45368443 12.175 Col3a1
collagen, type III, alpha 1
chr1_+_90031368 10.673 NM_145079
 Ugt1a6a
UDP glucuronosyltransferase 1 family, polypeptide A6A
chr4_+_104829867 10.643 Ppap2b
phosphatidic acid phosphatase type 2B
chr15_+_3220766 9.512 NM_001042613
NM_001042614
NM_009155
 Sepp1


selenoprotein P, plasma, 1


chr15_+_3230053 9.475


chr15_+_3220994 9.414 Sepp1
selenoprotein P, plasma, 1
chr15_+_3220999 9.333 Sepp1
selenoprotein P, plasma, 1
chr3_-_10208480 9.088 Fabp4
Fabp9
fatty acid binding protein 4, adipocyte
fatty acid binding protein 9, testis
chr4_+_104829963 8.898 Ppap2b
phosphatidic acid phosphatase type 2B
chr4_+_104830022 8.748 Ppap2b
phosphatidic acid phosphatase type 2B
chr4_+_104829951 8.746 NM_080555
 Ppap2b
phosphatidic acid phosphatase type 2B
chr6_+_15750966 8.592 Mdfic
MyoD family inhibitor domain containing
chr13_+_49703402 8.446 NM_008760
 Ogn
osteoglycin
chr16_+_48872720 8.144 NM_181596
 Retnlg
resistin like gamma
chr4_+_94405963 8.139 NM_013690
 Tek
endothelial-specific receptor tyrosine kinase
chr5_-_98459943 8.041 NM_133738
 Antxr2
anthrax toxin receptor 2
chr15_+_102289600 7.998 NM_001170911
NM_025385
 Prr13

proline rich 13

chr2_-_84614960 7.817 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr1_+_133867185 7.634 NM_145977
 Slc45a3
solute carrier family 45, member 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 61 entries
Enrichment   P-value GO Accession GO Term
2.46 2.36e-03 GO:0006732 coenzyme metabolic process
2.40 2.49e-04 GO:0051186 cofactor metabolic process
2.34 2.12e-02 GO:0060537 muscle tissue development
2.17 1.00e-05 GO:0009725 response to hormone stimulus
2.05 1.15e-03 GO:0001944 vasculature development
2.03 5.96e-03 GO:0001568 blood vessel development
2.00 1.99e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
2.00 4.55e-02 GO:0061061 muscle structure development
1.99 1.91e-04 GO:0009719 response to endogenous stimulus
1.94 9.31e-04 GO:0032583 regulation of gene-specific transcription
1.90 3.83e-02 GO:0051270 regulation of cellular component movement
1.88 5.61e-03 GO:0045597 positive regulation of cell differentiation
1.84 7.96e-06 GO:0010629 negative regulation of gene expression
1.84 4.30e-04 GO:0051094 positive regulation of developmental process
1.84 6.45e-04 GO:0072358 cardiovascular system development
1.84 6.45e-04 GO:0072359 circulatory system development
1.83 9.28e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.79 1.32e-04 GO:0070887 cellular response to chemical stimulus
1.77 8.44e-05 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.77 5.54e-04 GO:0045892 negative regulation of transcription, DNA-dependent

Gene overrepresentation in compartment category:

Showing 1 to 20 of 29 entries
Enrichment   P-value GO Accession GO Term
2.86 2.50e-02 GO:0044437 vacuolar part
2.85 3.11e-10 GO:0000323 lytic vacuole
2.85 3.11e-10 GO:0005764 lysosome
2.80 1.05e-11 GO:0005773 vacuole
1.85 1.54e-02 GO:0005792 microsome
1.83 4.79e-02 GO:0042175 nuclear membrane-endoplasmic reticulum network
1.80 2.92e-02 GO:0042598 vesicular fraction
1.69 9.43e-05 GO:0005615 extracellular space
1.67 2.08e-06 GO:0044421 extracellular region part
1.49 1.93e-03 GO:0005783 endoplasmic reticulum
1.47 8.28e-04 GO:0031090 organelle membrane
1.46 7.99e-05 GO:0005739 mitochondrion
1.44 4.97e-02 GO:0005624 membrane fraction
1.43 4.93e-03 GO:0000267 cell fraction
1.43 4.72e-02 GO:0005626 insoluble fraction
1.42 7.32e-22 GO:0044444 cytoplasmic part
1.40 1.74e-04 GO:0005576 extracellular region
1.39 4.85e-03 GO:0005829 cytosol
1.34 7.93e-27 GO:0005737 cytoplasm
1.24 5.03e-22 GO:0044424 intracellular part

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
Enrichment   P-value GO Accession GO Term
1.98 1.42e-02 GO:0048037 cofactor binding
1.73 2.58e-02 GO:0008289 lipid binding
1.66 5.42e-04 GO:0016491 oxidoreductase activity
1.54 2.13e-03 GO:XXXXXXX unannotated
1.53 3.56e-02 GO:0046983 protein dimerization activity
1.27 1.25e-08 GO:0005515 protein binding
1.22 1.52e-04 GO:0003824 catalytic activity
1.14 9.80e-07 GO:0005488 binding