Motif ID: FOXP3.p2

Z-value: 1.001


Transcription factors associated with FOXP3.p2:

Gene SymbolEntrez IDGene Name
Foxp3 20371 forkhead box P3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxp3chrX_+_71568010.121.1e-01Click!


Activity profile for motif FOXP3.p2.

activity profile for motif FOXP3.p2


Sorted Z-values histogram for motif FOXP3.p2

Sorted Z-values for motif FOXP3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXP3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_20760625 28.245 NM_001177776
Ahi1
Abelson helper integration site 1
chr3_-_126646303 25.267 NM_001034168
Ank2
ankyrin 2, brain
chrX_+_155897056 20.995 Mtap7d2
MAP7 domain containing 2
chr19_+_4711220 19.218 NM_021287
Spnb3
spectrin beta 3
chr2_+_135883662 17.767 NM_029530
6330527O06Rik
RIKEN cDNA 6330527O06 gene
chr19_-_8913619 17.225 NM_010316
Gng3
guanine nucleotide binding protein (G protein), gamma 3
chr19_+_4711207 16.602 Spnb3
spectrin beta 3
chr9_+_111277323 16.581 Trank1
tetratricopeptide repeat and ankyrin repeat containing 1
chr8_-_73316331 16.100 NM_199308
Mast3
microtubule associated serine/threonine kinase 3
chr2_+_135883963 14.727 6330527O06Rik
RIKEN cDNA 6330527O06 gene
chr8_+_12984287 13.761 Mcf2l
mcf.2 transforming sequence-like
chr13_+_43218207 11.451 NM_001005748
Phactr1
phosphatase and actin regulator 1
chr6_-_128493413 11.242 BC048546
cDNA sequence BC048546
chr18_+_23573939 9.843 Dtna
dystrobrevin alpha
chr15_-_98568883 9.422


chr18_+_23573977 8.349 Dtna
dystrobrevin alpha
chr4_-_46416895 7.518 Hemgn
hemogen
chr9_+_34296412 7.371 Kirrel3
kin of IRRE like 3 (Drosophila)
chr2_+_84820615 7.330 NM_008920
Prg2
proteoglycan 2, bone marrow
chr6_-_93863547 7.038 NM_001083321
NM_001083320
Magi1

membrane associated guanylate kinase, WW and PDZ domain containing 1

chr12_+_90191833 6.876 NM_172544
Nrxn3
neurexin III
chrX_+_133357268 6.624 NM_011123
Plp1
proteolipid protein (myelin) 1
chr7_+_107423813 6.253 Pgm2l1
phosphoglucomutase 2-like 1
chr6_-_148937854 6.139 Dennd5b
DENN/MADD domain containing 5B
chr9_-_103595136 5.951 Tmem108
transmembrane protein 108
chr15_-_88808967 5.897 NM_133241
Mlc1
megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)
chr18_+_37633193 5.820 NM_053140
Pcdhb15
protocadherin beta 15
chr4_-_120781830 5.800 NM_001081312
Tmco2
transmembrane and coiled-coil domains 2
chr11_-_91438844 5.789 NM_028547
Kif2b
kinesin family member 2B
chr5_-_114541313 5.709 NM_026805
Svop
SV2 related protein
chr9_-_109986879 5.704 Dhx30
DEAH (Asp-Glu-Ala-His) box polypeptide 30
chr4_-_41454658 5.473 NM_028624
1110017D15Rik
RIKEN cDNA 1110017D15 gene
chr16_+_49913305 5.057 Cd47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chr1_-_197002841 5.040 NM_007758
Cr2
complement receptor 2
chr7_+_97529155 4.850 NM_001040086
Sytl2
synaptotagmin-like 2
chr9_+_34296315 4.739 NM_001190911
NM_001190912
NM_001190913
NM_001190914
NM_026324
Kirrel3




kin of IRRE like 3 (Drosophila)




chr18_+_23573908 4.547 NM_010087
NM_207650
Dtna

dystrobrevin alpha

chr14_-_9142289 4.305 NM_183187
Fam107a
family with sequence similarity 107, member A
chr18_-_12978106 4.277 Osbpl1a
oxysterol binding protein-like 1A
chr3_-_126701367 4.089 NM_178655
Ank2
ankyrin 2, brain
chr7_-_25457058 4.075 NM_019981
Tex101
testis expressed gene 101
chr1_+_132762353 3.947 NM_026976
Faim3
Fas apoptotic inhibitory molecule 3
chr8_-_54724277 3.771 NM_146208
Neil3
nei like 3 (E. coli)
chr18_+_59222034 3.318 NM_001167925
NM_173759
A730017C20Rik

RIKEN cDNA A730017C20 gene

chr15_-_43002356 3.199 NM_172815
Rspo2
R-spondin 2 homolog (Xenopus laevis)
chr7_-_30736911 3.186 NM_178384
Zfp74
zinc finger protein 74
chr1_-_178737254 3.072 NM_001099637
Cep170
centrosomal protein 170
chr17_-_40379205 3.022 NM_009639
Crisp3
cysteine-rich secretory protein 3
chr10_+_62849310 3.008 NM_013888
Dnajc12
DnaJ (Hsp40) homolog, subfamily C, member 12
chr2_+_120802698 2.974 NM_175285
Tmem62
transmembrane protein 62
chr16_+_17331463 2.918 NM_008223
Serpind1
serine (or cysteine) peptidase inhibitor, clade D, member 1
chr5_+_89012547 2.889 Rufy3
RUN and FYVE domain containing 3
chr2_+_148645816 2.856 NM_027024
Cst13
cystatin 13
chr14_-_122364309 2.818 NM_183031
Gpr183
G protein-coupled receptor 183
chrX_+_6645338 2.708 NM_001042542
Akap4
A kinase (PRKA) anchor protein 4
chr6_-_119146426 2.698 NM_009781
Cacna1c
calcium channel, voltage-dependent, L type, alpha 1C subunit
chr2_+_120967876 2.490 NM_029475
Adal
adenosine deaminase-like
chr1_+_132762248 2.356 Faim3
Fas apoptotic inhibitory molecule 3
chr14_-_54902599 2.310 NM_010991
Olfr49
olfactory receptor 49
chr1_-_38878059 2.287 NM_001029878
Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr14_+_53070067 2.151 NM_020514
Olfr1509
olfactory receptor 1509
chr4_-_153531656 2.115


chr19_+_30307417 2.060 Mbl2
mannose-binding lectin (protein C) 2
chr16_+_17331507 1.978 Serpind1
serine (or cysteine) peptidase inhibitor, clade D, member 1
chr3_-_98663713 1.940 NM_008293
Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
chr16_-_17144515 1.938 NM_029779
Ccdc116
coiled-coil domain containing 116
chr1_+_173180542 1.798 NM_172845
Adamts4
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4
chr18_+_37560490 1.762 NM_053134
Pcdhb9
protocadherin beta 9
chr19_-_7877136 1.758 NM_146232
BC014805
cDNA sequence BC014805
chrX_-_16488889 1.754 NM_010883
Ndp
Norrie disease (pseudoglioma) (human)
chr5_+_88408469 1.746 NM_027631
4931407G18Rik
RIKEN cDNA 4931407G18 gene
chrX_-_121249518 1.725 NM_001100616
Vmn2r121
vomeronasal 2, receptor 121
chr13_+_55827167 1.651 Txndc15
thioredoxin domain containing 15
chr18_-_15562126 1.600 NM_009700
Aqp4
aquaporin 4
chr14_-_55479326 1.554 NM_183174
Homez
homeodomain leucine zipper-encoding gene
chr4_-_91813911 1.541 NM_027034
Izumo3
IZUMO family member 3
chr4_-_14723198 1.517 NM_028499
Lrrc69
leucine rich repeat containing 69
chr18_+_37896589 1.494 NM_033592
Pcdhga9
protocadherin gamma subfamily A, 9
chr9_-_106463955 1.454 NM_026645
Iqcf3
IQ motif containing F3
chr1_+_162917586 1.446 Serpinc1
serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
chrX_-_136533089 1.443 NM_001172147
NM_001172148
NM_153586
Rbm41


RNA binding motif protein 41


chr16_-_31314534 1.419 NM_007470
Apod
apolipoprotein D
chrX_-_75336699 1.411 NM_008754
Obp1a
odorant binding protein Ia
chr1_-_52714729 1.392 Mfsd6
major facilitator superfamily domain containing 6
chr15_-_71864639 1.379 NM_027174
Col22a1
collagen, type XXII, alpha 1
chr9_+_3335472 1.368 Alkbh8
alkB, alkylation repair homolog 8 (E. coli)
chr2_-_28321788 1.367 NM_027040
1700007K13Rik
RIKEN cDNA 1700007K13 gene
chr4_-_49562319 1.356 NM_144903
Aldob
aldolase B, fructose-bisphosphate
chr6_-_38077491 1.345 D630045J12Rik
RIKEN cDNA D630045J12 gene
chr3_-_15748418 1.343 NM_001173459
LOC100038947
Sirpb1a
signal-regulatory protein beta 1-like
signal-regulatory protein beta 1A
chr1_-_175872522 1.301 NM_008328
NM_001045481
Ifi203

interferon activated gene 203

chr8_+_97835414 1.301 NM_199455
NM_028532
Tepp

testis, prostate and placenta expressed

chr19_+_8667671 1.299 NM_001164635
Slc22a8
solute carrier family 22 (organic anion transporter), member 8
chr3_+_84668066 1.291 NM_001177774
Fbxw7
F-box and WD-40 domain protein 7
chr13_+_43497279 1.278 Nol7
nucleolar protein 7
chr7_+_69493148 1.249 NM_010882
Ndn
necdin
chr7_-_13007839 1.232 NM_001033820
Zfp551
zinc fingr protein 551
chrX_+_109207104 1.228 NM_031382
Tex16
testis expressed gene 16
chr17_-_53602610 1.211 NM_172497
Efhb
EF hand domain family, member B
chr17_+_48386894 1.199 NM_021407
Trem3
triggering receptor expressed on myeloid cells 3
chrX_+_75370805 1.195 NM_001085534
Gm5938
predicted gene 5938
chr19_+_39585311 1.180 NM_010003
Cyp2c39
cytochrome P450, family 2, subfamily c, polypeptide 39
chr1_+_87804349 1.174 Itm2c
integral membrane protein 2C
chr4_+_155384263 1.169 Sdf4
stromal cell derived factor 4
chr4_-_36665923 1.151 NM_001166000
Lingo2
leucine rich repeat and Ig domain containing 2
chr16_-_52268571 1.139 Alcam
activated leukocyte cell adhesion molecule
chr4_+_115273542 1.123 NM_001100181
Cyp4a32
cytochrome P450, family 4, subfamily a, polypeptide 32
chr10_+_117641997 1.121 NM_016971
Il22
interleukin 22
chr8_-_108503199 1.111 NM_027960
Dpep3
dipeptidase 3
chr19_-_11340591 1.110 NM_007641
Ms4a1
membrane-spanning 4-domains, subfamily A, member 1
chr12_+_34079718 1.101 NM_029152
Efcab10
EF-hand calcium binding domain 10
chrX_-_136533042 1.098 Rbm41
RNA binding motif protein 41
chrX_-_98459313 1.097 NM_001033362
Gm614
predicted gene 614
chr1_+_75396650 1.084 NM_001173477
Speg
SPEG complex locus
chrX_+_8860889 1.075 NM_029588
1700012L04Rik
RIKEN cDNA 1700012L04 gene
chr1_-_163089444 1.064 NM_001195189
4930469G21Rik
RIKEN cDNA 4930469G21 gene
chr9_-_44817429 1.063 NM_007648
Cd3e
CD3 antigen, epsilon polypeptide
chr5_+_34974750 1.048


chr19_+_30307446 1.034 NM_010776
Mbl2
mannose-binding lectin (protein C) 2
chr4_+_125701902 1.029 NM_007782
Csf3r
colony stimulating factor 3 receptor (granulocyte)
chr17_+_19190456 0.990 NM_001104550
Vmn2r98
vomeronasal 2, receptor 98
chr14_-_66696533 0.980 NM_009618
Adam2
a disintegrin and metallopeptidase domain 2
chr8_-_55606109 0.966 Spcs3
signal peptidase complex subunit 3 homolog (S. cerevisiae)
chr1_+_179375951 0.962 NM_013915
Zfp238
zinc finger protein 238
chr16_+_23058492 0.956 Kng1
kininogen 1
chr4_-_49562400 0.952 Aldob
aldolase B, fructose-bisphosphate
chr19_+_8913817 0.951 NM_008144
Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr7_-_148068161 0.944 NM_022433
Sirt3
sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)
chr19_+_8913965 0.929 Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr2_-_155479292 0.927 Trpc4ap
transient receptor potential cation channel, subfamily C, member 4 associated protein
chr12_+_72149332 0.922 Arid4a
AT rich interactive domain 4A (RBP1-like)
chrX_+_10885885 0.920 NM_001111037
Gm14483
predicted gene 14483
chr16_+_45224449 0.914 NM_001037719
NM_177584
Btla

B and T lymphocyte associated

chr10_+_98478207 0.911 Atp2b1
ATPase, Ca++ transporting, plasma membrane 1
chr1_-_179178874 0.904 NM_011785
Akt3
thymoma viral proto-oncogene 3
chr1_+_162917640 0.878 Serpinc1
serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
chrX_+_98877684 0.874 Ogt
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chrX_-_9149516 0.868 NM_001085517
Gm5132
predicted gene 5132
chr6_-_40535762 0.859 NM_001038604
NM_021364
Clec5a

C-type lectin domain family 5, member a

chr17_-_42829185 0.854 NM_030067
Gpr115
G protein-coupled receptor 115
chr5_-_87683812 0.844 NM_053215
Ugt2b37
UDP glucuronosyltransferase 2 family, polypeptide B37
chr4_+_126800830 0.829 Zmym6
zinc finger, MYM-type 6
chrX_+_10889059 0.828 NM_001025260
Gm14484
predicted gene 14484
chrX_-_105011493 0.813 NM_025921
2610002M06Rik
RIKEN cDNA 2610002M06 gene
chr7_-_28317608 0.799 Pld3
phospholipase D family, member 3
chr19_-_7877065 0.786 BC014805
cDNA sequence BC014805
chr13_-_77230519 0.773 Ankrd32
ankyrin repeat domain 32
chr9_+_106724228 0.772 NM_001015507
Vprbp
Vpr (HIV-1) binding protein
chr2_+_78710638 0.764 Ube2e3
ubiquitin-conjugating enzyme E2E 3, UBC4/5 homolog (yeast)
chr6_+_48626133 0.757 NM_174960
Gimap9
GTPase, IMAP family member 9
chr9_+_45238375 0.750 NM_001081270
Dscaml1
Down syndrome cell adhesion molecule-like 1
chrX_-_34650263 0.746 NM_026573
Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr14_+_119187092 0.728 NM_001160096
NM_001160097
NM_001160098
NM_023878
Cldn10



claudin 10



chr16_+_23058457 0.728 Kng1
kininogen 1
chr9_+_3335139 0.725 NM_026303
Alkbh8
alkB, alkylation repair homolog 8 (E. coli)
chr1_-_136443526 0.716 NM_001145300
4931440L10Rik
RIKEN cDNA 4931440L10 gene
chr17_+_85427686 0.711 NM_009205
Slc3a1
solute carrier family 3, member 1
chr6_+_18816317 0.710 NM_001167757
NM_029202
Ankrd7

ankyrin repeat domain 7

chr6_-_129457171 0.710 NM_138648
Olr1
oxidized low density lipoprotein (lectin-like) receptor 1
chr5_+_20930720 0.709 NM_177869
Fam185a
family with sequence similarity 185, member A
chr12_+_105350933 0.697 NM_001167705
Serpina3a
serine (or cysteine) peptidase inhibitor, clade A, member 3A
chr1_+_175603760 0.689 NM_001162938
Pydc3
pyrin domain containing 3
chr17_+_19051285 0.684 NM_001104549
Vmn2r97
vomeronasal 2, receptor 97
chr6_-_34126949 0.670 NM_021435
Slc35b4
solute carrier family 35, member B4
chr17_-_18414529 0.661 NM_001104543
Vmn2r94
vomeronasal 2, receptor 94
chr14_+_33647147 0.652 NM_001164485
Fam170b
family with sequence similarity 170, member B
chrX_+_104479684 0.637 NM_001177782
Gpr174
G protein-coupled receptor 174
chr1_-_99024782 0.630 NM_028942
Slco6c1
solute carrier organic anion transporter family, member 6c1
chr18_+_37678006 0.620 NM_053147
Pcdhb22
protocadherin beta 22
chr5_-_31950177 0.615 Rbks
ribokinase
chr16_-_89488129 0.582 NM_010675
Krtap8-1
keratin associated protein 8-1
chr3_-_141645214 0.582 NM_007560
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr8_+_123209286 0.569


chr16_-_23029154 0.559 NM_001102409
NM_001102410
NM_201375
Kng2


kininogen 2


chr1_+_173847645 0.551 NM_030710
Slamf6
SLAM family member 6
chr2_-_58177217 0.551 NM_001033369
Acvr1c
activin A receptor, type IC
chr6_-_57340560 0.509 NM_134181
Vmn1r18
vomeronasal 1 receptor 18
chr4_-_154041819 0.498 NM_028513
Actrt2
actin-related protein T2
chr19_+_8914035 0.495 Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr1_+_31279683 0.487 NM_029062
4930521A18Rik
RIKEN cDNA 4930521A18 gene
chrX_-_146875621 0.476 NM_001164684
Tmem29
transmembrane protein 29
chr13_-_64190493 0.471 NM_008291
Hsd17b3
hydroxysteroid (17-beta) dehydrogenase 3
chr2_+_92061718 0.457 NM_001109690
Phf21a
PHD finger protein 21A
chr2_+_136357921 0.452 NM_175667
Ankrd5
ankyrin repeat domain 5
chrX_-_135619753 0.451 NM_177920
Serpina7
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr11_-_62190182 0.437 Ncor1
nuclear receptor co-repressor 1
chr13_+_120251565 0.434 NM_001113550
NM_026127
4833420G17Rik

RIKEN cDNA 4833420G17 gene

chrX_+_148613496 0.433 NM_001005475
Iqsec2
IQ motif and Sec7 domain 2
chrX_+_13788273 0.430 NM_001034100
Gm5382
predicted gene 5382
chr4_-_94595442 0.424 NM_027089
4930579C15Rik
RIKEN cDNA 4930579C15 gene
chrX_-_151384047 0.410 NM_020017
Magea3
melanoma antigen, family A, 3
chr16_-_23029138 0.410 Kng2
kininogen 2
chr9_-_109306800 0.402 NM_001014395
Fbxw22
F-box and WD-40 domain protein 22
chr17_-_37706393 0.383 NM_001013575
Olfr112
olfactory receptor 112
chr10_-_114622068 0.376 NM_173391
Tph2
tryptophan hydroxylase 2
chr4_-_116300533 0.368 NM_016777
Nasp
nuclear autoantigenic sperm protein (histone-binding)
chr17_+_48594225 0.366 NM_152823
Unc5cl
unc-5 homolog C (C. elegans)-like
chr13_-_56649852 0.365 Lect2
leukocyte cell-derived chemotaxin 2
chr4_-_151665770 0.358 NM_008237
Hes3
hairy and enhancer of split 3 (Drosophila)
chr12_+_105452740 0.352 NM_009251
NM_001168294
NM_001168295
NM_001033335
Serpina3g
Serpina3f


Serpina3h
serine (or cysteine) peptidase inhibitor, clade A, member 3G
serine (or cysteine) peptidase inhibitor, clade A, member 3F


serine (or cysteine) peptidase inhibitor, clade A, member 3H

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
5.83 5.40e-03 GO:0030162 regulation of proteolysis
8.26 1.32e-02 GO:0010951 negative regulation of endopeptidase activity

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
7.04 2.49e-05 GO:0004866 endopeptidase inhibitor activity
6.78 3.73e-05 GO:0061135 endopeptidase regulator activity
6.66 4.54e-05 GO:0030414 peptidase inhibitor activity
5.71 2.35e-04 GO:0061134 peptidase regulator activity
7.99 3.22e-04 GO:0004867 serine-type endopeptidase inhibitor activity
4.61 9.19e-04 GO:0004857 enzyme inhibitor activity