Motif ID: GLI1..3.p2

Z-value: 1.522


Transcription factors associated with GLI1..3.p2:

Gene SymbolEntrez IDGene Name
Gli1 14632 GLI-Kruppel family member GLI1
Gli2 14633 GLI-Kruppel family member GLI2
Gli3 14634 GLI-Kruppel family member GLI3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli2chr1_-_1209501110.231.5e-03Click!
Gli3chr13_+_155554830.222.7e-03Click!
Gli1chr10_-_126778634-0.083.1e-01Click!


Activity profile for motif GLI1..3.p2.

activity profile for motif GLI1..3.p2


Sorted Z-values histogram for motif GLI1..3.p2

Sorted Z-values for motif GLI1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GLI1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_37182910 30.573 NM_019439
 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr8_+_56040193 26.057 Gpm6a
glycoprotein m6a
chr8_+_56040211 25.232 Gpm6a
glycoprotein m6a
chr8_+_56040553 23.678 Gpm6a
glycoprotein m6a
chr8_+_56040445 23.037 Gpm6a
glycoprotein m6a
chr8_+_56040080 22.776 NM_153581
 Gpm6a
glycoprotein m6a
chr9_+_43875175 20.454 Usp2
ubiquitin specific peptidase 2
chr13_-_100286521 19.966 NM_008634
 Mtap1b
microtubule-associated protein 1B
chr8_-_67171481 19.427 Cpe
carboxypeptidase E
chr7_-_82453216 19.062 NM_001109753
 Sv2b
synaptic vesicle glycoprotein 2 b
chr8_-_67171692 18.864 Cpe
carboxypeptidase E
chr13_-_100286446 18.714 Mtap1b
microtubule-associated protein 1B
chr8_-_67171805 18.708 NM_013494
 Cpe
carboxypeptidase E
chr9_+_43875103 18.139 NM_198092
 Usp2
ubiquitin specific peptidase 2
chr1_-_137063881 17.999 Gpr37l1
G protein-coupled receptor 37-like 1
chr7_+_138122822 17.466 Htra1
HtrA serine peptidase 1
chr2_+_157385835 17.178 NM_010923
NM_180960
 Nnat

neuronatin

chr13_-_78337844 17.102 Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr12_+_45429966 17.035 Nrcam
neuron-glia-CAM-related cell adhesion molecule
chr12_+_45429913 16.790 Nrcam
neuron-glia-CAM-related cell adhesion molecule

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 37 entries
Enrichment   P-value GO Accession GO Term
2.63 2.66e-02 GO:0006887 exocytosis
2.43 2.49e-02 GO:0006813 potassium ion transport
2.40 2.76e-05 GO:0007268 synaptic transmission
2.40 4.24e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
2.40 4.24e-02 GO:0022604 regulation of cell morphogenesis
2.30 4.85e-06 GO:0019226 transmission of nerve impulse
2.30 4.85e-06 GO:0035637 multicellular organismal signaling
2.28 4.43e-02 GO:0042391 regulation of membrane potential
2.02 4.94e-02 GO:0048812 neuron projection morphogenesis
2.00 1.16e-03 GO:0051960 regulation of nervous system development
1.97 6.06e-04 GO:0007267 cell-cell signaling
1.97 1.24e-02 GO:0040012 regulation of locomotion
1.94 1.77e-02 GO:0031175 neuron projection development
1.92 2.06e-02 GO:0007420 brain development
1.87 3.47e-03 GO:0055082 cellular chemical homeostasis
1.85 6.40e-03 GO:0006873 cellular ion homeostasis
1.83 2.60e-02 GO:0060284 regulation of cell development
1.78 1.40e-02 GO:0050801 ion homeostasis
1.75 1.24e-04 GO:0051049 regulation of transport
1.73 9.25e-07 GO:0032879 regulation of localization

Gene overrepresentation in compartment category:

Showing 1 to 20 of 42 entries
Enrichment   P-value GO Accession GO Term
8.21 1.68e-03 GO:0030673 axolemma
4.58 4.70e-03 GO:0044304 main axon
3.51 3.15e-09 GO:0019717 synaptosome
3.42 2.53e-08 GO:0033267 axon part
3.26 3.80e-05 GO:0008021 synaptic vesicle
2.98 8.93e-03 GO:0043679 axon terminus
2.92 7.23e-03 GO:0030427 site of polarized growth
2.87 1.54e-02 GO:0030426 growth cone
2.83 1.95e-10 GO:0030424 axon
2.83 4.86e-02 GO:0043197 dendritic spine
2.81 2.67e-11 GO:0030425 dendrite
2.77 2.56e-02 GO:0044306 neuron projection terminus
2.65 8.39e-05 GO:0045211 postsynaptic membrane
2.65 3.64e-03 GO:0044420 extracellular matrix part
2.60 1.33e-10 GO:0044456 synapse part
2.57 2.75e-15 GO:0045202 synapse
2.49 2.56e-16 GO:0043005 neuron projection
2.48 2.66e-03 GO:0030136 clathrin-coated vesicle
2.41 6.17e-08 GO:0043025 neuronal cell body
2.37 5.96e-08 GO:0044297 cell body

Gene overrepresentation in function category:

Showing 1 to 20 of 23 entries
Enrichment   P-value GO Accession GO Term
2.76 4.66e-04 GO:0022843 voltage-gated cation channel activity
2.73 3.32e-02 GO:0005249 voltage-gated potassium channel activity
2.50 1.67e-02 GO:0005267 potassium channel activity
2.29 5.30e-03 GO:0005244 voltage-gated ion channel activity
2.29 5.30e-03 GO:0022832 voltage-gated channel activity
2.20 1.75e-02 GO:0005543 phospholipid binding
2.14 5.17e-04 GO:0022836 gated channel activity
2.11 2.82e-03 GO:0005261 cation channel activity
2.05 7.43e-03 GO:0005083 small GTPase regulator activity
1.87 4.57e-03 GO:0005216 ion channel activity
1.83 8.55e-03 GO:0022838 substrate-specific channel activity
1.79 1.39e-02 GO:0030695 GTPase regulator activity
1.78 2.08e-02 GO:0015267 channel activity
1.77 1.65e-02 GO:0060589 nucleoside-triphosphatase regulator activity
1.77 2.23e-02 GO:0022803 passive transmembrane transporter activity
1.75 4.77e-03 GO:0008324 cation transmembrane transporter activity
1.73 4.10e-03 GO:0008092 cytoskeletal protein binding
1.65 2.86e-03 GO:0015075 ion transmembrane transporter activity
1.55 1.24e-02 GO:0022891 substrate-specific transmembrane transporter activity
1.52 2.83e-02 GO:0016301 kinase activity