Motif ID: GTF2I.p2

Z-value: 2.007


Transcription factors associated with GTF2I.p2:

Gene SymbolEntrez IDGene Name
Gtf2i 14886 general transcription factor II I

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gtf2ichr5_-_1347902770.381.1e-07Click!


Activity profile for motif GTF2I.p2.

activity profile for motif GTF2I.p2


Sorted Z-values histogram for motif GTF2I.p2

Sorted Z-values for motif GTF2I.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2I.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_37182910 34.757 NM_019439
 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr16_-_42340613 34.722 NM_008083
 Gap43
growth associated protein 43
chr1_-_82287990 31.340 NM_010570
 Irs1
insulin receptor substrate 1
chr5_+_37637027 29.234 NM_007765
 Crmp1
collapsin response mediator protein 1
chrX_+_70728994 28.213 Bgn
biglycan
chr4_+_126290825 27.888


chr6_-_77929543 27.478 Ctnna2
catenin (cadherin associated protein), alpha 2
chr7_-_25772525 26.870 Atp1a3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chr6_-_77929685 25.176 Ctnna2
catenin (cadherin associated protein), alpha 2
chrX_+_70728939 24.294 NM_007542
 Bgn
biglycan
chr14_-_55735114 23.098 NM_177049
 Jph4
junctophilin 4
chr11_+_69831951 22.612 NM_001109752
NM_007864
 Dlg4

discs, large homolog 4 (Drosophila)

chr4_+_138011061 22.538 NM_025451
 Camk2n1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr9_+_43851466 22.400 NM_009382
 Thy1
thymus cell antigen 1, theta
chr6_-_77929660 22.342 NM_001109764
NM_009819
NM_145732
 Ctnna2


catenin (cadherin associated protein), alpha 2


chr2_-_181048957 22.332 Stmn3
stathmin-like 3
chr2_+_136539202 21.744 Snap25
synaptosomal-associated protein 25
chr13_+_42804911 21.629 NM_001005740
 Phactr1
phosphatase and actin regulator 1
chr2_+_136539143 21.337 NM_011428
 Snap25
synaptosomal-associated protein 25
chrX_+_162782484 20.974 NM_001177955
NM_001177956
NM_001177957
NM_001177958
NM_001177959
NM_001177960
 Gpm6b





glycoprotein m6b






Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 291 entries
Enrichment   P-value GO Accession GO Term
3.99 3.03e-02 GO:0021697 cerebellar cortex formation
3.27 4.75e-02 GO:0021696 cerebellar cortex morphogenesis
2.94 3.47e-02 GO:0030199 collagen fibril organization
2.81 6.90e-03 GO:0046928 regulation of neurotransmitter secretion
2.77 3.03e-03 GO:0051588 regulation of neurotransmitter transport
2.62 6.48e-03 GO:0048489 synaptic vesicle transport
2.61 4.22e-03 GO:0007269 neurotransmitter secretion
2.57 1.72e-02 GO:0043242 negative regulation of protein complex disassembly
2.49 7.89e-03 GO:0060349 bone morphogenesis
2.44 8.36e-03 GO:0001649 osteoblast differentiation
2.39 2.07e-02 GO:0043244 regulation of protein complex disassembly
2.31 2.12e-02 GO:0050808 synapse organization
2.29 8.09e-18 GO:0048812 neuron projection morphogenesis
2.27 7.51e-15 GO:0007409 axonogenesis
2.24 1.31e-21 GO:0031175 neuron projection development
2.24 1.33e-02 GO:0050680 negative regulation of epithelial cell proliferation
2.24 2.05e-02 GO:0070588 calcium ion transmembrane transport
2.21 2.27e-03 GO:0001764 neuron migration
2.20 3.48e-03 GO:0001505 regulation of neurotransmitter levels
2.19 2.12e-14 GO:0048667 cell morphogenesis involved in neuron differentiation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 95 entries
Enrichment   P-value GO Accession GO Term
3.14 1.66e-04 GO:0030672 synaptic vesicle membrane
3.11 1.29e-06 GO:0042734 presynaptic membrane
3.02 4.97e-02 GO:0008328 ionotropic glutamate receptor complex
2.91 2.24e-02 GO:0043209 myelin sheath
2.90 7.79e-05 GO:0043198 dendritic shaft
2.78 4.30e-03 GO:0044304 main axon
2.63 1.43e-03 GO:0031594 neuromuscular junction
2.57 7.15e-05 GO:0030665 clathrin coated vesicle membrane
2.39 7.12e-03 GO:0005913 cell-cell adherens junction
2.39 7.12e-03 GO:0042641 actomyosin
2.39 1.10e-02 GO:0032432 actin filament bundle
2.36 2.62e-05 GO:0044309 neuron spine
2.33 4.16e-02 GO:0001725 stress fiber
2.32 9.34e-10 GO:0033267 axon part
2.32 5.64e-07 GO:0008021 synaptic vesicle
2.29 1.43e-09 GO:0019717 synaptosome
2.29 1.48e-04 GO:0043197 dendritic spine
2.28 1.85e-21 GO:0030425 dendrite
2.28 2.64e-05 GO:0030427 site of polarized growth
2.25 9.37e-05 GO:0030426 growth cone

Gene overrepresentation in function category:

Showing 1 to 20 of 67 entries
Enrichment   P-value GO Accession GO Term
3.99 7.98e-03 GO:0048407 platelet-derived growth factor binding
3.11 2.89e-02 GO:0035255 ionotropic glutamate receptor binding
3.05 1.98e-02 GO:0005520 insulin-like growth factor binding
2.84 2.73e-03 GO:0035254 glutamate receptor binding
2.59 1.08e-02 GO:0005518 collagen binding
2.55 2.73e-10 GO:0019838 growth factor binding
2.50 2.58e-05 GO:0019902 phosphatase binding
2.39 8.42e-03 GO:0051219 phosphoprotein binding
2.39 4.85e-02 GO:0019208 phosphatase regulator activity
2.34 2.41e-06 GO:0030165 PDZ domain binding
2.26 1.31e-02 GO:0019903 protein phosphatase binding
2.03 2.92e-02 GO:0019199 transmembrane receptor protein kinase activity
2.02 1.09e-03 GO:0008201 heparin binding
1.97 1.23e-02 GO:0005249 voltage-gated potassium channel activity
1.91 1.49e-03 GO:0005516 calmodulin binding
1.90 8.15e-04 GO:0022843 voltage-gated cation channel activity
1.87 1.14e-02 GO:0031267 small GTPase binding
1.86 1.26e-03 GO:0005539 glycosaminoglycan binding
1.78 3.89e-04 GO:0005244 voltage-gated ion channel activity
1.78 3.89e-04 GO:0022832 voltage-gated channel activity