Motif ID: HAND1,2.p2

Z-value: 1.649


Transcription factors associated with HAND1,2.p2:

Gene SymbolEntrez IDGene Name
Hand1 15110 heart and neural crest derivatives expressed transcript 1
Hand2 15111 heart and neural crest derivatives expressed transcript 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hand1chr11_-_576454980.073.5e-01Click!
Hand2chr8_+_597997790.046.3e-01Click!


Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_37437194 26.928 NM_010745
 Ly86
lymphocyte antigen 86
chr8_-_124948837 21.576


chr3_+_94497485 19.200 NM_019414
 Selenbp2
selenium binding protein 2
chr14_+_75536138 17.394 NM_008879
 Lcp1
lymphocyte cytosolic protein 1
chr19_+_11543816 16.850 NM_001166376
NM_028595
 Ms4a6c

membrane-spanning 4-domains, subfamily A, member 6C

chr18_+_60963495 16.541 NM_001042605
NM_010545
 Cd74

CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)

chr9_+_50302624 15.908 NM_029639
 1600029D21Rik
RIKEN cDNA 1600029D21 gene
chr19_+_11592938 15.763 NM_027209
 Ms4a6b
membrane-spanning 4-domains, subfamily A, member 6B
chr7_-_135073617 15.368 NM_133351
 Prss8
protease, serine, 8 (prostasin)
chr3_+_108163704 15.312 Sort1
sortilin 1
chr7_-_135073600 15.140 Prss8
protease, serine, 8 (prostasin)
chr7_-_135073577 14.594 Prss8
protease, serine, 8 (prostasin)
chr7_-_135073508 14.262 Prss8
protease, serine, 8 (prostasin)
chr7_+_113988126 14.107 NM_146596
 Olfr703
olfactory receptor 703
chr19_+_58803376 13.476 NM_018874
 Pnliprp1
pancreatic lipase related protein 1
chr1_+_74421706 13.337 NM_013612
 Slc11a1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
chr4_+_130469187 12.226 NM_010686
 Laptm5
lysosomal-associated protein transmembrane 5
chr4_-_136441982 12.192 NM_009777
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr6_-_97262013 11.599 Frmd4b
FERM domain containing 4B
chrX_-_20508584 11.594 NM_008823
 Cfp
complement factor properdin

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 20 entries
Enrichment   P-value GO Accession GO Term
20.46 2.45e-02 GO:0002579 positive regulation of antigen processing and presentation
6.74 8.29e-03 GO:0002673 regulation of acute inflammatory response
5.26 3.75e-03 GO:0002449 lymphocyte mediated immunity
5.03 3.89e-02 GO:0045807 positive regulation of endocytosis
4.88 1.41e-03 GO:0002443 leukocyte mediated immunity
3.89 3.43e-04 GO:0045087 innate immune response
3.59 4.41e-03 GO:0002252 immune effector process
3.49 9.45e-05 GO:0009617 response to bacterium
3.05 2.81e-06 GO:0006955 immune response
3.04 7.25e-09 GO:0006952 defense response
2.87 2.45e-02 GO:0006631 fatty acid metabolic process
2.81 6.08e-04 GO:0050776 regulation of immune response
2.76 1.18e-02 GO:0031347 regulation of defense response
2.58 1.11e-02 GO:0051707 response to other organism
2.52 3.54e-02 GO:0032787 monocarboxylic acid metabolic process
2.34 2.38e-02 GO:0009607 response to biotic stimulus
2.10 7.10e-05 GO:0002376 immune system process
2.08 2.24e-02 GO:0002682 regulation of immune system process
2.02 4.30e-02 GO:0019752 carboxylic acid metabolic process
2.02 4.30e-02 GO:0043436 oxoacid metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 10 of 10 entries
Enrichment   P-value GO Accession GO Term
2.73 2.18e-02 GO:0009897 external side of plasma membrane
2.61 2.47e-03 GO:0005792 microsome
2.54 3.90e-03 GO:0042598 vesicular fraction
2.19 6.37e-03 GO:0009986 cell surface
2.06 1.35e-11 GO:0005576 extracellular region
1.98 3.12e-03 GO:0005615 extracellular space
1.86 1.74e-03 GO:0044421 extracellular region part
1.84 6.16e-03 GO:0005624 membrane fraction
1.82 5.19e-03 GO:0005626 insoluble fraction
1.67 1.42e-02 GO:0000267 cell fraction

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
Enrichment   P-value GO Accession GO Term
24.55 2.08e-03 GO:0050544 arachidonic acid binding
20.46 6.08e-03 GO:0050542 icosanoid binding
20.46 6.08e-03 GO:0050543 icosatetraenoic acid binding
3.53 2.60e-03 GO:0004252 serine-type endopeptidase activity
3.20 1.88e-03 GO:0008236 serine-type peptidase activity
3.15 2.38e-03 GO:0017171 serine hydrolase activity
2.44 5.63e-03 GO:0004175 endopeptidase activity
2.00 2.66e-02 GO:0070011 peptidase activity, acting on L-amino acid peptides