Motif ID: HAND1,2.p2

Z-value: 1.649


Transcription factors associated with HAND1,2.p2:

Gene SymbolEntrez IDGene Name
Hand1 15110 heart and neural crest derivatives expressed transcript 1
Hand2 15111 heart and neural crest derivatives expressed transcript 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hand1chr11_-_576454980.073.5e-01Click!
Hand2chr8_+_597997790.046.3e-01Click!


Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_37437194 26.928 NM_010745
Ly86
lymphocyte antigen 86
chr8_-_124948837 21.576


chr3_+_94497485 19.200 NM_019414
Selenbp2
selenium binding protein 2
chr14_+_75536138 17.394 NM_008879
Lcp1
lymphocyte cytosolic protein 1
chr19_+_11543816 16.850 NM_001166376
NM_028595
Ms4a6c

membrane-spanning 4-domains, subfamily A, member 6C

chr18_+_60963495 16.541 NM_001042605
NM_010545
Cd74

CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)

chr9_+_50302624 15.908 NM_029639
1600029D21Rik
RIKEN cDNA 1600029D21 gene
chr19_+_11592938 15.763 NM_027209
Ms4a6b
membrane-spanning 4-domains, subfamily A, member 6B
chr7_-_135073617 15.368 NM_133351
Prss8
protease, serine, 8 (prostasin)
chr3_+_108163704 15.312 Sort1
sortilin 1
chr7_-_135073600 15.140 Prss8
protease, serine, 8 (prostasin)
chr7_-_135073577 14.594 Prss8
protease, serine, 8 (prostasin)
chr7_-_135073508 14.262 Prss8
protease, serine, 8 (prostasin)
chr7_+_113988126 14.107 NM_146596
Olfr703
olfactory receptor 703
chr19_+_58803376 13.476 NM_018874
Pnliprp1
pancreatic lipase related protein 1
chr1_+_74421706 13.337 NM_013612
Slc11a1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
chr4_+_130469187 12.226 NM_010686
Laptm5
lysosomal-associated protein transmembrane 5
chr4_-_136441982 12.192 NM_009777
C1qb
complement component 1, q subcomponent, beta polypeptide
chr6_-_97262013 11.599 Frmd4b
FERM domain containing 4B
chrX_-_20508584 11.594 NM_008823
Cfp
complement factor properdin
chr12_-_77896363 11.392 Gpx2
glutathione peroxidase 2
chr8_+_56040080 10.283 NM_153581
Gpm6a
glycoprotein m6a
chr12_-_77896410 9.774 Gpx2
glutathione peroxidase 2
chr6_+_70676428 9.762


chr12_-_77896534 9.347 NM_030677
Gpx2
glutathione peroxidase 2
chr5_-_17341512 9.278 Cd36
CD36 antigen
chrX_+_98572571 9.186 NM_008124
Gjb1
gap junction protein, beta 1
chr6_-_54921654 9.101 NM_001171007
Nod1
nucleotide-binding oligomerization domain containing 1
chr10_-_22539906 9.078 NM_011545
Tcf21
transcription factor 21
chr14_-_21475715 9.067 Myoz1
myozenin 1
chr14_-_21475760 8.992 NM_021508
Myoz1
myozenin 1
chr6_-_41586378 8.952 NM_022413
Trpv6
transient receptor potential cation channel, subfamily V, member 6
chr9_-_37062963 8.863 Slc37a2
solute carrier family 37 (glycerol-3-phosphate transporter), member 2
chr12_-_77896481 8.758 Gpx2
glutathione peroxidase 2
chr17_+_34400152 8.653 NM_207105
H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr5_-_17341713 8.651 NM_001159555
NM_007643
Cd36

CD36 antigen

chr6_+_70676803 8.398


chr4_-_60594959 8.204 NM_001122647
Mup10
LOC100048884
Mup1
major urinary protein 10
novel member of the major urinary protein (Mup) gene family
major urinary protein 1
chrX_-_20508314 8.140 Cfp
complement factor properdin
chr4_-_59973470 8.116 NM_008648
Mup4
major urinary protein 4
chr5_-_17341534 7.918 Cd36
CD36 antigen
chr14_-_21475679 7.684 Myoz1
myozenin 1
chr1_-_174520562 7.599 NM_029084
Slamf8
SLAM family member 8
chr19_-_44470218 7.448 Scd1
stearoyl-Coenzyme A desaturase 1
chr10_+_127705664 7.334 Apof
apolipoprotein F
chr16_+_44820840 7.154 NM_207244
Cd200r4
CD200 receptor 4
chr2_+_84976516 6.946 NM_011784
Aplnr
apelin receptor
chr5_+_150076605 6.787 NM_009663
Alox5ap
arachidonate 5-lipoxygenase activating protein
chr1_+_45368443 6.768 Col3a1
collagen, type III, alpha 1
chr6_-_41586296 6.637 Trpv6
transient receptor potential cation channel, subfamily V, member 6
chr5_+_44260035 6.619 NM_007646
Cd38
CD38 antigen
chr6_-_41264706 6.613 NM_001003405
Try5
trypsin 5
chr7_-_3867085 6.552 NM_011087
NM_011090
Pira1
Lilra6
paired-Ig-like receptor A1
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
chr10_-_22539936 6.459 Tcf21
transcription factor 21
chr1_-_39535525 6.417 NM_018775
Tbc1d8
TBC1 domain family, member 8
chr14_+_32031041 6.397 NM_001025379
Sema3g
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr11_+_105846442 6.369 Ace
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr10_+_97028134 6.255 NM_008524
Lum
lumican
chr4_+_137280366 6.206 Rap1gap
Rap1 GTPase-activating protein
chr15_+_3220766 6.030 NM_001042613
NM_001042614
NM_009155
Sepp1


selenoprotein P, plasma, 1


chr14_+_79601537 5.996


chr17_+_33692639 5.995 NM_053214
Myo1f
myosin IF
chr19_+_6384413 5.970 NM_011224
Pygm
muscle glycogen phosphorylase
chr19_+_25484006 5.939 Kank1
KN motif and ankyrin repeat domains 1
chr14_-_51766415 5.887 NM_011271
Rnase1
ribonuclease, RNase A family, 1 (pancreatic)
chr12_-_77923303 5.881 NM_134050
Rab15
RAB15, member RAS oncogene family
chr5_+_136520613 5.874 Upk3b
uroplakin 3B
chr7_+_108570222 5.847 Pde2a
phosphodiesterase 2A, cGMP-stimulated
chr15_-_78136032 5.818 NM_007781
Csf2rb2
colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)
chr7_-_26324847 5.734 NM_001113368
NM_001113369
NM_007543
Ceacam2


carcinoembryonic antigen-related cell adhesion molecule 2


chr11_+_48900507 5.728 NM_008330
Ifi47
Olfr56
interferon gamma inducible protein 47
olfactory receptor 56
chr11_+_67051128 5.718 Myh4
myosin, heavy polypeptide 4, skeletal muscle
chr7_-_26262552 5.688 NM_001039185
NM_001039186
NM_001039187
NM_011926
Ceacam1



carcinoembryonic antigen-related cell adhesion molecule 1



chr11_+_28767772 5.667 Efemp1
epidermal growth factor-containing fibulin-like extracellular matrix protein 1
chr3_+_94736974 5.567 Selenbp1
selenium binding protein 1
chr10_-_111434265 5.497 NM_028608
Glipr1
GLI pathogenesis-related 1 (glioma)
chr19_+_11482121 5.374 NM_029499
Ms4a4c
membrane-spanning 4-domains, subfamily A, member 4C
chr5_-_66543123 5.368 NM_001127382
Rbm47
RNA binding motif protein 47
chr7_+_31206749 5.326 Nfkbid
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
chr16_+_34785006 5.317 NM_139300
Mylk
myosin, light polypeptide kinase
chr4_+_109088251 5.244 NM_001145948
Ttc39a
tetratricopeptide repeat domain 39A
chr1_+_165992203 5.157 NM_001164059
NM_011346
Sell

selectin, lymphocyte

chr7_-_118089700 5.079 NM_010826
Mrvi1
MRV integration site 1
chr9_+_45127182 5.039 NM_001013373
Tmprss13
transmembrane protease, serine 13
chr7_+_108570211 4.986 NM_001008548
NM_001143848
Pde2a

phosphodiesterase 2A, cGMP-stimulated

chr5_-_75073816 4.953 NM_001159578
NM_001159579
NM_001159580
NM_010727
Lnx1



ligand of numb-protein X 1



chr2_-_103143352 4.950 NM_007914
Ehf
ets homologous factor
chr1_+_90003410 4.885 Ugt1a6b
UDP glucuronosyltransferase 1 family, polypeptide A6B
chr10_-_111434231 4.878 Glipr1
GLI pathogenesis-related 1 (glioma)
chr4_-_61443185 4.803 NM_001135127
Mup10
LOC100048884
Mup19
Mup1
major urinary protein 10
novel member of the major urinary protein (Mup) gene family
major urinary protein 19
major urinary protein 1
chr19_-_11124897 4.801 NM_001177351
AW112010
expressed sequence AW112010
chr4_-_61496155 4.792 NM_008649
Mup5
major urinary protein 5
chr11_+_62389367 4.791 Trpv2
transient receptor potential cation channel, subfamily V, member 2
chr11_-_99354449 4.780 Krt23
keratin 23
chr17_+_8428907 4.671 NM_001190333
Ccr6
chemokine (C-C motif) receptor 6
chr6_-_67485779 4.653 Tacstd2
tumor-associated calcium signal transducer 2
chr11_-_99354417 4.636 NM_033373
Krt23
keratin 23
chrX_+_160876032 4.620 NM_026853
Asb11
ankyrin repeat and SOCS box-containing 11
chr2_-_18314344 4.619 Dnajc1
DnaJ (Hsp40) homolog, subfamily C, member 1
chr17_+_24079343 4.581 Sbp
spermine binding protein
chr13_-_49243351 4.563 NM_029361
Wnk2
WNK lysine deficient protein kinase 2
chr12_-_81213930 4.550 NM_007564
Zfp36l1
zinc finger protein 36, C3H type-like 1
chr16_+_35001358 4.496 Mylk
myosin, light polypeptide kinase
chr10_+_96942181 4.473 Dcn
decorin
chr14_-_56377260 4.469 NM_009894
Cideb
cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
chr11_+_32196488 4.386 NM_001083955
NM_008218
Hba-a2
Hba-a1
hemoglobin alpha, adult chain 2
hemoglobin alpha, adult chain 1
chr6_+_41252267 4.363 NM_011646
Try4
trypsin 4
chr8_+_112515370 4.327 Tat
tyrosine aminotransferase
chr7_-_25457058 4.242 NM_019981
Tex101
testis expressed gene 101
chr8_+_125710222 4.208 Dpep1
dipeptidase 1 (renal)
chr7_-_109005707 4.203 NM_008035
Folr2
folate receptor 2 (fetal)
chr3_-_95695852 4.203 NM_153513
BC028528
cDNA sequence BC028528
chr6_-_69367406 4.182 Igkv4-68
immunoglobulin kappa variable 4-68
chr11_+_32183671 4.161 NM_001083955
NM_008218
Hba-a2
Hba-a1
hemoglobin alpha, adult chain 2
hemoglobin alpha, adult chain 1
chr17_+_24546733 4.129 Abca3
ATP-binding cassette, sub-family A (ABC1), member 3
chr6_-_87446228 4.087 NM_175476
Arhgap25
Rho GTPase activating protein 25
chr3_-_88351996 4.036 NM_016899
Rab25
RAB25, member RAS oncogene family
chr14_+_28051224 3.985 NM_027871
Arhgef3
Rho guanine nucleotide exchange factor (GEF) 3
chr11_-_3404756 3.984 NM_172439
Inpp5j
inositol polyphosphate 5-phosphatase J
chr6_+_78320878 3.983 NM_011036
Reg3b
regenerating islet-derived 3 beta
chr8_+_96996662 3.970 NM_001033207
Nlrc5
NLR family, CARD domain containing 5
chr2_+_158328394 3.957 Adig
adipogenin
chr4_-_46579311 3.904 NM_178893
Coro2a
coronin, actin binding protein 2A
chr7_-_3671918 3.865 NM_011095
Lilrb3
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
chr11_-_55125758 3.855 NM_001029988
Fat2
FAT tumor suppressor homolog 2 (Drosophila)
chr8_+_56040211 3.824 Gpm6a
glycoprotein m6a
chr17_-_35309483 3.766 Aif1
allograft inflammatory factor 1
chr7_+_108570359 3.735 Pde2a
phosphodiesterase 2A, cGMP-stimulated
chr7_-_3796619 3.728 Pira1
Pira2
Lilrb3
paired-Ig-like receptor A1
paired-Ig-like receptor A2
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
chr10_+_75036192 3.722 NM_008116
Ggt1
gamma-glutamyltransferase 1
chr11_+_68316520 3.722 NM_001004435
NM_001081566
Pik3r6

phosphoinositide-3-kinase, regulatory subunit 6

chr10_-_80753957 3.705 NM_013769
Tjp3
tight junction protein 3
chr12_+_32123083 3.695 NM_021353
Slc26a3
solute carrier family 26, member 3
chr13_-_37141055 3.678 NM_028784
F13a1
coagulation factor XIII, A1 subunit
chr19_+_9090816 3.669 Ahnak
AHNAK nucleoprotein (desmoyokin)
chrX_+_3748193 3.667 NM_001099643
Gm3750
predicted gene 3750
chr4_+_130469048 3.666 Laptm5
lysosomal-associated protein transmembrane 5
chr6_+_68375560 3.665 Igkv16-104
immunoglobulin kappa variable 16-104
chr17_-_35309654 3.642 Aif1
allograft inflammatory factor 1
chr1_+_45402907 3.637 Col3a1
collagen, type III, alpha 1
chr3_+_93136665 3.606 Hrnr
hornerin
chr7_+_4225744 3.583 NM_011093
NM_008848
Pira6

paired-Ig-like receptor A6

chr17_+_24078962 3.576 NM_011321
Sbp
spermine binding protein
chr4_-_53156928 3.574 Abca1
ATP-binding cassette, sub-family A (ABC1), member 1
chr15_-_78136047 3.571 Csf2rb2
colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)
chr18_+_60535680 3.508 NM_001146275
NM_021792
Iigp1

interferon inducible GTPase 1

chr2_+_145648290 3.400 Rin2
Ras and Rab interactor 2
chr4_-_60083321 3.400 NM_001134675
Mup7
major urinary protein 7
chr4_+_19935389 3.378 Ttpa
tocopherol (alpha) transfer protein
chr2_+_158328317 3.363 NM_145635
Adig
adipogenin
chr14_-_44579933 3.361 NM_001011876
Ang6
angiogenin, ribonuclease A family, member 6
chr2_+_118598504 3.334 NM_001145644
Phgr1
proline/histidine/glycine-rich 1
chrX_+_10173557 3.324


chr3_-_88262982 3.312 NM_001163490
Sema4a
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr12_-_32893074 3.259 NM_001146201
NM_020272
NM_001146200
Pik3cg


phosphoinositide-3-kinase, catalytic, gamma polypeptide


chr19_-_8206403 3.218 NM_001013820
Gm5631
predicted gene 5631
chr14_-_56377206 3.188 Cideb
cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
chr4_-_149575220 3.171 NM_009802
Car6
carbonic anhydrase 6
chr7_+_109378512 3.157 Pgap2
post-GPI attachment to proteins 2
chr6_-_68967061 3.140


chr12_+_80231774 3.107 NM_009705
Arg2
arginase type II
chr6_-_70067577 3.069 Gm10883
predicted gene 10883
chr5_+_115373398 3.060 Oasl1
2'-5' oligoadenylate synthetase-like 1
chr11_+_67013553 3.051 NM_030679
Myh1
myosin, heavy polypeptide 1, skeletal muscle, adult
chr8_+_56040445 3.049 Gpm6a
glycoprotein m6a
chr14_-_104242892 3.048 NM_007904
Ednrb
endothelin receptor type B
chr8_+_125710134 3.046 NM_007876
Dpep1
dipeptidase 1 (renal)
chr12_+_105644917 3.027 NM_009252
Serpina3n
serine (or cysteine) peptidase inhibitor, clade A, member 3N
chr11_+_101443690 3.022 Tmem106a
transmembrane protein 106A
chrX_-_31877468 3.019 NM_001145038
Gm2933
predicted gene 2933
chr11_+_58028487 3.007 Irgm2
immunity-related GTPase family M member 2
chr1_+_89999782 2.996 NM_201410
Ugt1a6b
UDP glucuronosyltransferase 1 family, polypeptide A6B
chr10_+_68675404 2.987 NM_001081347
Rhobtb1
Rho-related BTB domain containing 1
chr14_-_56377231 2.969 Cideb
cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
chr15_+_74785366 2.908 NM_001164037
NM_001164038
NM_001164039
NM_001164036
NM_008529
NM_001164040
Ly6e





lymphocyte antigen 6 complex, locus E





chr3_+_90346956 2.892 S100a16
S100 calcium binding protein A16
chr4_+_133871031 2.878 NM_001039048
Trim63
tripartite motif-containing 63
chr7_-_134195490 2.847 NM_026918
Zg16
zymogen granule protein 16
chr7_-_3796651 2.823 NM_011089
Pira2
paired-Ig-like receptor A2
chr10_+_126952029 2.810 Ndufa4l2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr16_-_14291427 2.801 NM_001161775
NM_013607
Myh11

myosin, heavy polypeptide 11, smooth muscle

chr3_+_89251875 2.794 Pbxip1
pre-B-cell leukemia transcription factor interacting protein 1
chr5_-_105539282 2.777 NM_172777
Gbp9
guanylate-binding protein 9
chr1_+_90031368 2.774 NM_145079
Ugt1a6a
UDP glucuronosyltransferase 1 family, polypeptide A6A
chr10_-_127837521 2.769 NM_028051
NM_028092
Slc39a5

solute carrier family 39 (metal ion transporter), member 5

chr1_+_173612173 2.763 NM_007649
Cd48
CD48 antigen
chr11_-_3817574 2.761 Tcn2
transcobalamin 2
chr7_-_3820753 2.751 Gm10693
predicted pseudogene 10693
chr7_+_27620354 2.734 NM_007812
Cyp2a5
cytochrome P450, family 2, subfamily a, polypeptide 5
chr10_+_79353650 2.730 Cfd
complement factor D (adipsin)
chr11_+_67611772 2.725 NM_001013013
Dhrs7c
dehydrogenase/reductase (SDR family) member 7C
chr5_+_138422718 2.717 NM_013478
Azgp1
alpha-2-glycoprotein 1, zinc
chr3_-_116671573 2.710 Palmd
palmdelphin
chr14_-_104243541 2.698 Ednrb
endothelin receptor type B
chr4_-_124742875 2.683 NM_175223
Dnali1
dynein, axonemal, light intermediate polypeptide 1
chr8_+_56040553 2.671 Gpm6a
glycoprotein m6a
chr3_+_89866717 2.662 NM_028567
1700094D03Rik
RIKEN cDNA 1700094D03 gene
chr2_-_126444323 2.654 Hdc
histidine decarboxylase
chr7_+_19469999 2.651 NM_009402
Pglyrp1
peptidoglycan recognition protein 1
chr6_+_88775664 2.643 Mgll
monoglyceride lipase

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.04 7.25e-09 GO:0006952 defense response
3.05 2.81e-06 GO:0006955 immune response
2.10 7.10e-05 GO:0002376 immune system process
3.49 9.45e-05 GO:0009617 response to bacterium
3.89 3.43e-04 GO:0045087 innate immune response
2.81 6.08e-04 GO:0050776 regulation of immune response
4.88 1.41e-03 GO:0002443 leukocyte mediated immunity
5.26 3.75e-03 GO:0002449 lymphocyte mediated immunity
3.59 4.41e-03 GO:0002252 immune effector process
6.74 8.29e-03 GO:0002673 regulation of acute inflammatory response
2.58 1.11e-02 GO:0051707 response to other organism
2.76 1.18e-02 GO:0031347 regulation of defense response
2.08 2.24e-02 GO:0002682 regulation of immune system process
2.34 2.38e-02 GO:0009607 response to biotic stimulus
2.87 2.45e-02 GO:0006631 fatty acid metabolic process
20.46 2.45e-02 GO:0002579 positive regulation of antigen processing and presentation
2.52 3.54e-02 GO:0032787 monocarboxylic acid metabolic process
5.03 3.89e-02 GO:0045807 positive regulation of endocytosis
2.02 4.30e-02 GO:0019752 carboxylic acid metabolic process
2.02 4.30e-02 GO:0043436 oxoacid metabolic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.06 1.35e-11 GO:0005576 extracellular region
1.86 1.74e-03 GO:0044421 extracellular region part
2.61 2.47e-03 GO:0005792 microsome
1.98 3.12e-03 GO:0005615 extracellular space
2.54 3.90e-03 GO:0042598 vesicular fraction
1.82 5.19e-03 GO:0005626 insoluble fraction
1.84 6.16e-03 GO:0005624 membrane fraction
2.19 6.37e-03 GO:0009986 cell surface
1.67 1.42e-02 GO:0000267 cell fraction
2.73 2.18e-02 GO:0009897 external side of plasma membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.20 1.88e-03 GO:0008236 serine-type peptidase activity
24.55 2.08e-03 GO:0050544 arachidonic acid binding
3.15 2.38e-03 GO:0017171 serine hydrolase activity
3.53 2.60e-03 GO:0004252 serine-type endopeptidase activity
2.44 5.63e-03 GO:0004175 endopeptidase activity
20.46 6.08e-03 GO:0050542 icosanoid binding
20.46 6.08e-03 GO:0050543 icosatetraenoic acid binding
2.00 2.66e-02 GO:0070011 peptidase activity, acting on L-amino acid peptides