Motif ID: HBP1_HMGB_SSRP1_UBTF.p2

Z-value: 2.587


Transcription factors associated with HBP1_HMGB_SSRP1_UBTF.p2:

Gene SymbolEntrez IDGene Name
Hbp1 73389 high mobility group box transcription factor 1
Hmgb2 97165 high mobility group box 2
Hmgb3 15354 high mobility group box 3
Ssrp1 20833 structure specific recognition protein 1
Ubtf 21429 upstream binding transcription factor, RNA polymerase I

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmgb2chr8_+_59990639-0.485.6e-12Click!
Ssrp1chr2_+_84877325-0.358.9e-07Click!
Hmgb3chrX_+_688091280.241.2e-03Click!
Ubtfchr11_-_102180258,
chr11_-_102178941,
chr11_-_102178559,
chr11_-_102180282
-0.163.2e-02Click!
Hbp1chr12_-_32635399-0.138.3e-02Click!


Activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2.

activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2


Sorted Z-values histogram for motif HBP1_HMGB_SSRP1_UBTF.p2

Sorted Z-values for motif HBP1_HMGB_SSRP1_UBTF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HBP1_HMGB_SSRP1_UBTF.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_34548512 68.496 Cald1
caldesmon 1
chr8_-_87297283 57.839 Nfix
nuclear factor I/X
chr2_-_84614960 57.230 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr3_+_137004089 56.151 Emcn
endomucin
chr3_+_137004041 54.654 NM_001163522
NM_016885
Emcn

endomucin

chr16_+_43619057 54.469 Zbtb20
zinc finger and BTB domain containing 20
chr4_-_75779379 52.199 NM_001014288
Ptprd
protein tyrosine phosphatase, receptor type, D
chr1_+_45390415 51.725 Col3a1
collagen, type III, alpha 1
chr16_+_35002066 50.435 Mylk
myosin, light polypeptide kinase
chr3_-_57651621 50.184 NM_019410
Pfn2
profilin 2
chr8_-_11312686 50.161 Col4a1
collagen, type IV, alpha 1
chr4_-_76240202 48.405 NM_011211
Ptprd
protein tyrosine phosphatase, receptor type, D
chr9_-_117539030 47.932 NM_001172121
Rbms3
RNA binding motif, single stranded interacting protein
chr2_-_84615535 47.051 NM_009776
Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr6_-_87285690 46.194 NM_054041
Antxr1
anthrax toxin receptor 1
chr4_-_82150687 45.898 Nfib
nuclear factor I/B
chr4_-_82151590 44.976 Nfib
nuclear factor I/B
chr14_-_122097583 44.374 NM_001081039
Dock9
dedicator of cytokinesis 9
chrX_+_54032914 43.281 Fhl1
four and a half LIM domains 1
chr4_-_82151004 42.906 Nfib
nuclear factor I/B

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 222 entries
Enrichment   P-value GO Accession GO Term
6.70 2.32e-04 GO:0031113 regulation of microtubule polymerization
5.78 5.12e-04 GO:0031111 negative regulation of microtubule polymerization or depolymerization
5.48 3.31e-02 GO:0060420 regulation of heart growth
5.00 6.11e-05 GO:0031110 regulation of microtubule polymerization or depolymerization
4.57 7.30e-04 GO:0010464 regulation of mesenchymal cell proliferation
4.30 1.05e-02 GO:0002053 positive regulation of mesenchymal cell proliferation
3.95 1.40e-02 GO:0043242 negative regulation of protein complex disassembly
3.80 6.43e-05 GO:0051494 negative regulation of cytoskeleton organization
3.69 1.18e-04 GO:0016202 regulation of striated muscle tissue development
3.62 7.28e-07 GO:0048706 embryonic skeletal system development
3.62 2.25e-02 GO:0031333 negative regulation of protein complex assembly
3.58 2.10e-04 GO:0048634 regulation of muscle organ development
3.58 6.65e-03 GO:0070507 regulation of microtubule cytoskeleton organization
3.47 3.92e-02 GO:0043244 regulation of protein complex disassembly
3.43 1.42e-04 GO:0048638 regulation of developmental growth
3.20 1.94e-02 GO:0032886 regulation of microtubule-based process
3.17 7.23e-03 GO:0048738 cardiac muscle tissue development
3.06 3.86e-02 GO:0045667 regulation of osteoblast differentiation
3.04 1.43e-02 GO:0008016 regulation of heart contraction
3.02 1.34e-04 GO:0051146 striated muscle cell differentiation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 76 entries
Enrichment   P-value GO Accession GO Term
4.89 1.97e-03 GO:0005581 collagen
3.96 4.41e-03 GO:0030175 filopodium
3.58 2.09e-06 GO:0030427 site of polarized growth
3.57 4.39e-06 GO:0030426 growth cone
3.46 1.39e-08 GO:0044420 extracellular matrix part
3.45 1.22e-02 GO:0031256 leading edge membrane
3.43 3.57e-03 GO:0030018 Z disc
3.27 4.30e-02 GO:0005913 cell-cell adherens junction
3.11 4.19e-02 GO:0030863 cortical cytoskeleton
3.03 1.16e-02 GO:0031674 I band
2.93 2.41e-03 GO:0014069 postsynaptic density
2.86 3.60e-03 GO:0030027 lamellipodium
2.86 5.93e-03 GO:0005604 basement membrane
2.74 4.76e-04 GO:0030016 myofibril
2.71 2.55e-04 GO:0043292 contractile fiber
2.65 8.04e-03 GO:0016327 apicolateral plasma membrane
2.64 3.57e-03 GO:0044449 contractile fiber part
2.64 1.32e-02 GO:0030017 sarcomere
2.63 3.16e-04 GO:0033267 axon part
2.58 1.85e-02 GO:0043296 apical junction complex

Gene overrepresentation in function category:

Showing 1 to 20 of 32 entries
Enrichment   P-value GO Accession GO Term
11.57 3.91e-02 GO:0008157 protein phosphatase 1 binding
4.54 1.93e-06 GO:0008013 beta-catenin binding
4.39 1.09e-02 GO:0005201 extracellular matrix structural constituent
3.49 6.02e-04 GO:0005178 integrin binding
3.33 4.50e-03 GO:0004714 transmembrane receptor protein tyrosine kinase activity
3.20 4.50e-03 GO:0019902 phosphatase binding
3.08 2.43e-02 GO:0051015 actin filament binding
3.01 6.76e-03 GO:0019199 transmembrane receptor protein kinase activity
2.50 3.44e-02 GO:0008201 heparin binding
2.47 6.25e-09 GO:0003779 actin binding
2.47 2.97e-03 GO:0005539 glycosaminoglycan binding
2.40 1.11e-14 GO:0008092 cytoskeletal protein binding
2.36 3.74e-03 GO:0001871 pattern binding
2.36 3.74e-03 GO:0030247 polysaccharide binding
2.35 2.24e-02 GO:0004713 protein tyrosine kinase activity
2.35 3.12e-02 GO:0005516 calmodulin binding
2.17 2.33e-04 GO:0019901 protein kinase binding
2.08 1.23e-04 GO:0019900 kinase binding
2.03 4.77e-08 GO:0019904 protein domain specific binding
1.99 1.01e-04 GO:0032403 protein complex binding