Motif ID: HES1.p2

Z-value: 1.556


Transcription factors associated with HES1.p2:

Gene SymbolEntrez IDGene Name
Hes1 15205 hairy and enhancer of split 1 (Drosophila)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hes1chr16_+_300654190.121.2e-01Click!


Activity profile for motif HES1.p2.

activity profile for motif HES1.p2


Sorted Z-values histogram for motif HES1.p2

Sorted Z-values for motif HES1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HES1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_169956719 19.509 NM_001033299
 Zfp217
zinc finger protein 217
chr6_-_91066773 15.400 Nup210
nucleoporin 210
chr4_+_147965596 10.636 NM_009272
 Srm
spermidine synthase
chr1_-_169215216 9.339 NM_030724
 Uck2
uridine-cytidine kinase 2
chr11_-_120685366 9.327 Fasn
fatty acid synthase
chr1_-_169215189 9.114 Uck2
uridine-cytidine kinase 2
chr9_+_72510153 9.104 NM_010890
 Nedd4
neural precursor cell expressed, developmentally down-regulated 4
chr11_-_120685392 8.897 Fasn
fatty acid synthase
chr6_-_91066809 8.742 NM_018815
 Nup210
nucleoporin 210
chr8_+_125091925 8.708 Cdt1
chromatin licensing and DNA replication factor 1
chr11_+_74462965 8.588 NM_001081158
 1300001I01Rik
RIKEN cDNA 1300001I01 gene
chr12_+_119082333 8.557 NM_146040
 Cdca7l
cell division cycle associated 7 like
chr11_-_120685418 8.125 Fasn
fatty acid synthase
chr2_-_37558794 7.712 Strbp
spermatid perinuclear RNA binding protein
chr15_+_54943878 7.453 Deptor
DEP domain containing MTOR-interacting protein
chr15_+_54943978 7.347 NM_145470
 Deptor
DEP domain containing MTOR-interacting protein
chr2_+_119063090 7.241 NM_016907
 Spint1
serine protease inhibitor, Kunitz type 1
chr19_-_40346017 7.149 Pdlim1
PDZ and LIM domain 1 (elfin)
chr11_-_120685860 7.114 NM_007988
 Fasn
fatty acid synthase
chr9_+_110034489 7.086 NM_009211
 Smarcc1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 236 entries
Enrichment   P-value GO Accession GO Term
5.85 8.19e-04 GO:0018022 peptidyl-lysine methylation
3.80 1.84e-05 GO:0060606 tube closure
3.72 2.37e-02 GO:0045669 positive regulation of osteoblast differentiation
3.70 7.10e-05 GO:0001843 neural tube closure
3.59 2.24e-03 GO:0060349 bone morphogenesis
3.57 1.24e-03 GO:0001889 liver development
3.51 2.11e-04 GO:0014020 primary neural tube formation
3.50 1.77e-03 GO:0061008 hepaticobiliary system development
3.32 1.87e-07 GO:0018205 peptidyl-lysine modification
3.10 1.44e-03 GO:0001841 neural tube formation
3.06 1.91e-03 GO:0018394 peptidyl-lysine acetylation
3.05 1.29e-04 GO:0035148 tube formation
3.00 5.55e-04 GO:0001838 embryonic epithelial tube formation
3.00 5.55e-04 GO:0072175 epithelial tube formation
2.98 1.51e-05 GO:0016331 morphogenesis of embryonic epithelium
2.97 5.96e-03 GO:0006475 internal protein amino acid acetylation
2.97 5.96e-03 GO:0018393 internal peptidyl-lysine acetylation
2.93 7.75e-03 GO:0006479 protein methylation
2.93 7.75e-03 GO:0008213 protein alkylation
2.93 3.56e-02 GO:0016458 gene silencing

Gene overrepresentation in compartment category:

Showing 1 to 20 of 50 entries
Enrichment   P-value GO Accession GO Term
7.98 3.17e-02 GO:0005677 chromatin silencing complex
6.63 3.28e-04 GO:0016581 NuRD complex
5.04 2.68e-03 GO:0031519 PcG protein complex
4.54 4.07e-06 GO:0000118 histone deacetylase complex
3.75 1.50e-04 GO:0017053 transcriptional repressor complex
3.65 3.15e-06 GO:0000792 heterochromatin
3.53 7.00e-03 GO:0005720 nuclear heterochromatin
3.43 4.80e-07 GO:0016585 chromatin remodeling complex
3.26 1.62e-07 GO:0000790 nuclear chromatin
2.96 1.30e-08 GO:0016604 nuclear body
2.69 3.06e-02 GO:0000123 histone acetyltransferase complex
2.61 2.73e-04 GO:0000151 ubiquitin ligase complex
2.55 1.13e-08 GO:0000785 chromatin
2.49 1.14e-06 GO:0044454 nuclear chromosome part
2.39 2.45e-37 GO:0005654 nucleoplasm
2.37 1.18e-23 GO:0044451 nucleoplasm part
2.36 1.73e-06 GO:0000228 nuclear chromosome
2.23 2.95e-44 GO:0031981 nuclear lumen
2.18 2.69e-51 GO:0044428 nuclear part
2.17 1.87e-07 GO:0005667 transcription factor complex

Gene overrepresentation in function category:

Showing 1 to 20 of 66 entries
Enrichment   P-value GO Accession GO Term
4.35 2.32e-02 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters
4.10 7.76e-03 GO:0016278 lysine N-methyltransferase activity
4.10 7.76e-03 GO:0016279 protein-lysine N-methyltransferase activity
4.05 2.12e-02 GO:0018024 histone-lysine N-methyltransferase activity
3.94 2.51e-03 GO:0002039 p53 binding
3.83 3.78e-03 GO:0042054 histone methyltransferase activity
3.59 3.87e-02 GO:0030145 manganese ion binding
3.07 1.24e-02 GO:0008276 protein methyltransferase activity
3.06 4.13e-02 GO:0008170 N-methyltransferase activity
3.02 1.17e-13 GO:0003682 chromatin binding
2.88 1.14e-04 GO:0008135 translation factor activity, nucleic acid binding
2.81 3.87e-03 GO:0042393 histone binding
2.70 3.07e-03 GO:0004519 endonuclease activity
2.65 1.74e-02 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
2.40 2.31e-07 GO:0016881 acid-amino acid ligase activity
2.37 1.66e-02 GO:0019838 growth factor binding
2.37 3.45e-02 GO:0016566 specific transcriptional repressor activity
2.35 2.49e-05 GO:0004842 ubiquitin-protein ligase activity
2.34 1.33e-07 GO:0016879 ligase activity, forming carbon-nitrogen bonds
2.28 3.39e-05 GO:0019787 small conjugating protein ligase activity