• All motifs sorted by activity significance
• All samples sorted alphabetically

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)

Motif ID: HES1.p2

Z-value: 1.556

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr2_-_169956719	19.509	NM_001033299	Zfp217	zinc finger protein 217
chr6_-_91066773	15.400		Nup210	nucleoporin 210
chr4_+_147965596	10.636	NM_009272	Srm	spermidine synthase
chr1_-_169215216	9.339	NM_030724	Uck2	uridine-cytidine kinase 2
chr11_-_120685366	9.327		Fasn	fatty acid synthase
chr1_-_169215189	9.114		Uck2	uridine-cytidine kinase 2
chr9_+_72510153	9.104	NM_010890	Nedd4	neural precursor cell expressed, developmentally down-regulated 4
chr11_-_120685392	8.897		Fasn	fatty acid synthase
chr6_-_91066809	8.742	NM_018815	Nup210	nucleoporin 210
chr8_+_125091925	8.708		Cdt1	chromatin licensing and DNA replication factor 1
chr11_+_74462965	8.588	NM_001081158	1300001I01Rik	RIKEN cDNA 1300001I01 gene
chr12_+_119082333	8.557	NM_146040	Cdca7l	cell division cycle associated 7 like
chr11_-_120685418	8.125		Fasn	fatty acid synthase
chr2_-_37558794	7.712		Strbp	spermatid perinuclear RNA binding protein
chr15_+_54943878	7.453		Deptor	DEP domain containing MTOR-interacting protein
chr15_+_54943978	7.347	NM_145470	Deptor	DEP domain containing MTOR-interacting protein
chr2_+_119063090	7.241	NM_016907	Spint1	serine protease inhibitor, Kunitz type 1
chr19_-_40346017	7.149		Pdlim1	PDZ and LIM domain 1 (elfin)
chr11_-_120685860	7.114	NM_007988	Fasn	fatty acid synthase
chr9_+_110034489	7.086	NM_009211	Smarcc1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr19_-_40345985	7.058		Pdlim1	PDZ and LIM domain 1 (elfin)
chr17_+_64950988	7.033	NM_008549	Man2a1	mannosidase 2, alpha 1
chr17_-_24833089	7.018	NM_023040	Gfer	growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
chr11_-_97049143	6.873		Kpnb1	karyopherin (importin) beta 1
chr2_+_119063134	6.854		Spint1	serine protease inhibitor, Kunitz type 1
chr19_-_40346058	6.784	NM_016861	Pdlim1	PDZ and LIM domain 1 (elfin)
chr2_+_119063194	6.709
chr12_+_114336416	6.557	NM_054081	Mta1	metastasis associated 1
chr8_+_13338741	6.456		Tfdp1	transcription factor Dp 1
chr11_+_115676023	6.265	NM_029557	Tsen54	tRNA splicing endonuclease 54 homolog (S. cerevisiae)
chr8_+_13339673	6.262	NM_009361	Tfdp1	transcription factor Dp 1
chr11_-_97049185	6.214	NM_008379	Kpnb1	karyopherin (importin) beta 1
chr7_+_26444141	6.192	NM_138586	Exosc5	exosome component 5
chr7_-_134169938	6.151	NM_010772	Maz	MYC-associated zinc finger protein (purine-binding transcription factor)
chr4_+_140258090	6.093		Rcc2	regulator of chromosome condensation 2
chr1_+_59741800	5.992	NM_018868	Nop58	NOP58 ribonucleoprotein homolog (yeast)
chr17_-_46766302	5.992	NM_175168	Ptk7	PTK7 protein tyrosine kinase 7
chr8_+_125091889	5.975	NM_026014	Cdt1	chromatin licensing and DNA replication factor 1
chr1_-_55144687	5.742	NM_010477	Hspd1	heat shock protein 1 (chaperonin)
chr6_-_114987860	5.637	NM_026894	1500001M20Rik	RIKEN cDNA 1500001M20 gene
chr16_-_78376912	5.429	NM_009770	Btg3	B-cell translocation gene 3
chr14_-_99498905	5.299	NM_028315	Dis3	DIS3 mitotic control homolog (S. cerevisiae)
chr11_-_69485842	5.298	NM_001159375 NM_144958	Eif4a1	eukaryotic translation initiation factor 4A1
chr8_+_109417539	5.240	NM_011574	Cirh1a	cirrhosis, autosomal recessive 1A (human)
chr2_+_153475189	5.234	NM_001003960 NM_001003961 NM_001003963 NM_001122997 NM_010068	Dnmt3b	DNA methyltransferase 3B
chr17_-_24832880	5.233		Gfer	growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
chr12_-_70299271	5.223	NM_027269	1110034A24Rik	RIKEN cDNA 1110034A24 gene
chr1_-_38186482	5.208	NM_019570	Rev1	REV1 homolog (S. cerevisiae)
chr11_-_60624733	5.176	NM_009171	Shmt1	serine hydroxymethyltransferase 1 (soluble)
chr5_-_21290925	5.161		Dnajc2	DnaJ (Hsp40) homolog, subfamily C, member 2
chr9_+_21351307	5.125	NM_021531 NM_153141	Carm1	coactivator-associated arginine methyltransferase 1
chr13_+_51740804	5.064		Cks2	CDC28 protein kinase regulatory subunit 2
chr3_-_89222140	5.058	NM_016904	Cks1b	CDC28 protein kinase 1b
chr13_+_51740600	5.046	NM_025415	Cks2	CDC28 protein kinase regulatory subunit 2
chr17_-_35137799	5.015		D17H6S56E-5	DNA segment, Chr 17, human D6S56E 5
chr1_-_55144637	5.011		Hspd1	heat shock protein 1 (chaperonin)
chr2_-_163575826	4.972	NM_007398	Ada	adenosine deaminase
chr18_+_67959756	4.958	NM_027556	Cep192	centrosomal protein 192
chr17_+_71965554	4.945	NM_175639	Wdr43	WD repeat domain 43
chr10_-_62064925	4.896		Ddx21	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
chr1_-_20810238	4.795	NM_008563	Mcm3	minichromosome maintenance deficient 3 (S. cerevisiae)
chr3_-_99966292	4.794	NM_175552	Wdr3	WD repeat domain 3
chr15_-_85864206	4.726	NM_009886	Celsr1	cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
chr3_-_130412360	4.725	NM_025509	Ostc	oligosaccharyltransferase complex subunit
chr13_+_69750891	4.723	NM_145354	Nsun2	NOL1/NOP2/Sun domain family member 2
chr15_-_75739695	4.695	NM_023240 NM_029663	Eef1d	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
chr5_+_38611707	4.687	NM_025281	Lyar	Ly1 antibody reactive clone
chr9_+_106379599	4.606	NM_145620	Rrp9	RRP9, small subunit (SSU) processome component, homolog (yeast)
chr9_+_72380046	4.595	NM_001033536	Rfx7	regulatory factor X, 7
chr10_-_128002934	4.594		Pa2g4	proliferation-associated 2G4
chr11_-_51420064	4.589		Hnrnpab	heterogeneous nuclear ribonucleoprotein A/B
chr10_-_83996516	4.584		Ckap4	cytoskeleton-associated protein 4
chr11_-_102268771	4.483	NM_026542	Slc25a39	solute carrier family 25, member 39
chr2_+_156665812	4.465	NM_173396	Tgif2	TGFB-induced factor homeobox 2
chr13_+_72766425	4.435	NM_010574	Irx2	Iroquois related homeobox 2 (Drosophila)
chr11_-_69485800	4.404		Eif4a1	eukaryotic translation initiation factor 4A1
chr5_-_123350242	4.384	NM_013910	Kdm2b	lysine (K)-specific demethylase 2B
chr5_+_135485575	4.375		Abhd11	abhydrolase domain containing 11
chr9_+_50665024	4.345	NM_001034085 NM_028614	Ppp2r1b	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform
chr13_-_23663006	4.345	NM_178187	Hist1h2ae	histone cluster 1, H2ae
chr12_+_17551678	4.344	NM_013614	Odc1	ornithine decarboxylase, structural 1
chr5_+_74489078	4.308		2700023E23Rik	RIKEN cDNA 2700023E23 gene
chr7_-_142908061	4.305	NM_001081117	Mki67	antigen identified by monoclonal antibody Ki 67
chr11_-_53113682	4.285		Hspa4	heat shock protein 4
chr10_-_128003058	4.284		Pa2g4	proliferation-associated 2G4
chrX_-_106208659	4.247	NM_016710	Hmgn5	high-mobility group nucleosome binding domain 5
chr11_-_78364173	4.216	NM_133706	Tmem97	transmembrane protein 97
chr5_+_135485552	4.210		Abhd11	abhydrolase domain containing 11
chr11_+_72254841	4.201	NM_016776	Mybbp1a	MYB binding protein (P160) 1a
chr2_-_27331122	4.189	NM_001113573 NM_001113574	Brd3	bromodomain containing 3
chr2_-_105239368	4.175	NM_009037	Rcn1	reticulocalbin 1
chr17_-_35137690	4.167		D17H6S56E-5	DNA segment, Chr 17, human D6S56E 5
chr11_-_83943060	4.118	NM_172562	Tada2a	transcriptional adaptor 2A
chr1_-_191746072	4.109	NM_026796	Smyd2	SET and MYND domain containing 2
chr5_+_123526279	4.097	NM_001039723	Tmem120b	transmembrane protein 120B
chr1_+_137715515	4.034		Lad1	ladinin
chr10_-_62064997	4.032	NM_019553	Ddx21	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
chr10_+_13273025	4.008		Adat2	adenosine deaminase, tRNA-specific 2, TAD2 homolog (S. cerevisiae)
chrX_+_72341436	3.977		Dkc1	dyskeratosis congenita 1, dyskerin homolog (human)
chr10_-_116387419	3.976	NM_001003950	Rab3ip	RAB3A interacting protein
chr8_-_125075222	3.967	NM_001037298	Fam38a	family with sequence similarity 38, member A
chr4_-_131901576	3.964	NM_001197082 NM_133878	Rcc1	regulator of chromosome condensation 1
chr9_+_20692618	3.867	NM_145610	Ppan	peter pan homolog (Drosophila)
chr6_+_117857771	3.839	NM_001166428 NM_001166429	Hnrnpf	heterogeneous nuclear ribonucleoprotein F
chr6_+_108778633	3.817	NM_138677	Edem1	ER degradation enhancer, mannosidase alpha-like 1
chr10_-_83996632	3.813	NM_175451	Ckap4	cytoskeleton-associated protein 4
chr4_-_120242805	3.807	NM_016748	Ctps	cytidine 5'-triphosphate synthase
chr9_-_114473486	3.805	NM_001042503	Trim71	tripartite motif-containing 71
chr17_+_46339730	3.794	NM_028198	Xpo5	exportin 5
chr14_+_45970767	3.767	NM_019637	Styx	serine/threonine/tyrosine interaction protein
chr9_+_109778461	3.763		Cdc25a	cell division cycle 25 homolog A (S. pombe)
chr10_+_13272699	3.711	NM_025748	Adat2	adenosine deaminase, tRNA-specific 2, TAD2 homolog (S. cerevisiae)
chr8_-_97437166	3.700		Ccdc102a	coiled-coil domain containing 102A
chr19_+_4000579	3.699	NM_025529	Nudt8	nudix (nucleoside diphosphate linked moiety X)-type motif 8
chr12_+_8778260	3.694		Sdc1	syndecan 1
chr6_-_95668770	3.657	NM_011507	Suclg2	succinate-Coenzyme A ligase, GDP-forming, beta subunit
chr17_+_46633703	3.628	NM_207161	BC048355	cDNA sequence BC048355
chr7_+_73205454	3.620		Snrpa1	small nuclear ribonucleoprotein polypeptide A'
chr1_+_159342482	3.601		2810025M15Rik	RIKEN cDNA 2810025M15 gene
chr19_+_38470458	3.591	NM_175507	Tmem20	transmembrane protein 20
chr8_-_124431581	3.587	NM_011404	Slc7a5	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
chr14_-_19164241	3.555	NM_009455	Ube2e1	ubiquitin-conjugating enzyme E2E 1, UBC4/5 homolog (yeast)
chr2_-_13977502	3.554		Ptpla	protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a
chr7_+_73205419	3.554		Snrpa1	small nuclear ribonucleoprotein polypeptide A'
chr5_-_21290971	3.545	NM_009584	Dnajc2	DnaJ (Hsp40) homolog, subfamily C, member 2
chr3_+_19088109	3.511	NM_026182	Mtfr1	mitochondrial fission regulator 1
chr14_-_32643594	3.508	NM_001024604	Ankrd28	ankyrin repeat domain 28
chr1_+_173433762	3.473		Refbp2	RNA and export factor binding protein 2
chr4_+_44313764	3.463	NM_010790	Melk	maternal embryonic leucine zipper kinase
chr1_+_173433608	3.453	NM_019484	Refbp2	RNA and export factor binding protein 2
chr1_-_194681914	3.450	NM_198247	Sertad4	SERTA domain containing 4
chr17_+_35031503	3.429	NM_198886	Zbtb12	zinc finger and BTB domain containing 12
chr10_-_128002991	3.421		Pa2g4	proliferation-associated 2G4
chr5_-_66089061	3.406	NM_001081321	Pds5a	PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr1_+_137715339	3.391		Lad1	ladinin
chr8_-_81032730	3.389		Rbmxrt	RNA binding motif protein, X chromosome retrogene
chr16_+_92058498	3.378	NM_080456 NM_017391	Mrps6 Slc5a3	mitochondrial ribosomal protein S6 solute carrier family 5 (inositol transporters), member 3
chr12_+_16901671	3.374	NM_009072	Rock2	Rho-associated coiled-coil containing protein kinase 2
chr8_-_124431559	3.366		Slc7a5	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
chr8_-_81032819	3.359	NM_009033	Rbmxrt	RNA binding motif protein, X chromosome retrogene
chr11_-_53113856	3.355		Hspa4	heat shock protein 4
chr4_+_44313865	3.331		Melk	maternal embryonic leucine zipper kinase
chr4_+_116692006	3.324	NM_001111277 NM_175135	Eif2b3	eukaryotic translation initiation factor 2B, subunit 3
chr10_-_128002987	3.321	NM_011119	Pa2g4	proliferation-associated 2G4
chr16_-_17928207	3.321		Slc25a1	solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1
chr6_-_72389491	3.309	NM_145569	Mat2a	methionine adenosyltransferase II, alpha
chr16_-_96212502	3.307	NM_019537	Psmg1	proteasome (prosome, macropain) assembly chaperone 1
chr4_-_118109775	3.266	NM_023223	Cdc20	cell division cycle 20 homolog (S. cerevisiae)
chr8_-_109417431	3.256	NM_145412	Chtf8	CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr5_-_114221640	3.250	NM_016926	Sart3	squamous cell carcinoma antigen recognized by T-cells 3
chr8_-_81032795	3.248		Rbmxrt	RNA binding motif protein, X chromosome retrogene
chr11_-_76031013	3.219	NM_177367	Gemin4	gem (nuclear organelle) associated protein 4
chr10_-_94879435	3.215	NM_007706	Socs2	suppressor of cytokine signaling 2
chr11_+_57822347	3.213	NM_028451	Larp1	La ribonucleoprotein domain family, member 1
chr16_+_20717874	3.207	NM_145632	Polr2h	polymerase (RNA) II (DNA directed) polypeptide H
chr18_+_70727897	3.191	NM_010773	Mbd2	methyl-CpG binding domain protein 2
chrX_+_72341385	3.183		Dkc1	dyskeratosis congenita 1, dyskerin homolog (human)
chr1_-_179726514	3.182	NM_007422	Adss	adenylosuccinate synthetase, non muscle
chr6_+_88415396	3.182	NM_019685	Ruvbl1	RuvB-like protein 1
chr10_+_126500607	3.179	NM_009870	Cdk4	cyclin-dependent kinase 4
chr16_+_20717922	3.167		Polr2h	polymerase (RNA) II (DNA directed) polypeptide H
chr15_-_102076706	3.157	NM_001042727	Rarg	retinoic acid receptor, gamma
chr5_-_124804583	3.149	NM_013812	Cdk2ap1	CDK2 (cyclin-dependent kinase 2)-associated protein 1
chr17_+_35137851	3.147	NM_011690	Vars	valyl-tRNA synthetase
chr4_+_122960059	3.144	NM_130881	Pabpc4	poly(A) binding protein, cytoplasmic 4
chr2_+_132672645	3.113		Crls1	cardiolipin synthase 1
chr10_-_94879369	3.102		Socs2	suppressor of cytokine signaling 2
chr1_-_130313846	3.100	NM_145507 NM_177445	Dars	aspartyl-tRNA synthetase
chr5_-_124804365	3.097		Cdk2ap1	CDK2 (cyclin-dependent kinase 2)-associated protein 1
chr7_+_13609719	3.095		Trim28	tripartite motif-containing 28
chr2_+_74543545	3.091	NM_008276	Hoxd8	homeobox D8
chr17_+_35137995	3.089		Vars	valyl-tRNA synthetase
chr17_+_35561811	3.085	NM_207648	H2-Q6	histocompatibility 2, Q region locus 6
chr19_-_47125334	3.081	NM_027654	Pcgf6	polycomb group ring finger 6
chrX_-_138825032	3.076	NM_001033600 NM_019477 NM_207625	Acsl4	acyl-CoA synthetase long-chain family member 4
chr11_-_115971521	3.071		Trim47	tripartite motif-containing 47
chr9_-_30939272	3.071		St14	suppression of tumorigenicity 14 (colon carcinoma)
chr17_-_31795654	3.066	NM_001163769 NM_024187	U2af1	U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1
chr11_+_23565975	3.052	NM_028304	Pus10	pseudouridylate synthase 10
chr1_-_187153269	3.050	NM_198653	Iars2	isoleucine-tRNA synthetase 2, mitochondrial
chr11_-_51420336	3.048	NM_001048061 NM_010448	Hnrnpab	heterogeneous nuclear ribonucleoprotein A/B
chr14_-_56341060	3.040		Rabggta	Rab geranylgeranyl transferase, a subunit
chr9_-_30939380	3.021	NM_011176	St14	suppression of tumorigenicity 14 (colon carcinoma)
chr9_-_21936207	3.011	NM_001102404	Acp5	acid phosphatase 5, tartrate resistant
chr7_-_38892432	2.994	NM_007633	Ccne1	cyclin E1
chr14_+_99445595	2.994	NM_175265	6720463M24Rik	RIKEN cDNA 6720463M24 gene
chr15_+_98860321	2.990	NM_009448	Tuba1c	tubulin, alpha 1C
chr17_+_45700882	2.982		Slc35b2	solute carrier family 35, member B2
chr12_+_9036802	2.979	NM_029321	Ttc32	tetratricopeptide repeat domain 32
chr18_+_24363784	2.977	NM_013814	Galnt1	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1
chr2_-_104857155	2.967	NM_145380	Eif3m	eukaryotic translation initiation factor 3, subunit M
chr1_-_187153212	2.941		Iars2	isoleucine-tRNA synthetase 2, mitochondrial
chr9_-_20703010	2.931	NM_016876	Eif3g	eukaryotic translation initiation factor 3, subunit G
chr13_+_44826121	2.927	NM_021878	Jarid2	jumonji, AT rich interactive domain 2
chr11_+_117127762	2.914		Sept9	septin 9
chr19_+_8797973	2.872		Snhg1	small nucleolar RNA host gene (non-protein coding) 1
chr11_-_94515067	2.870	NM_177752	Eme1	essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr10_-_75395207	2.868	NM_008606	Mmp11	matrix metallopeptidase 11
chr15_-_3533122	2.844	NM_001048178 NM_010284	Ghr	growth hormone receptor
chr2_-_65076584	2.843	NM_027225 NM_177025	Cobll1	Cobl-like 1

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
1.83	4.27e-85	GO:0044260	cellular macromolecule metabolic process
1.71	5.46e-73	GO:0043170	macromolecule metabolic process
1.61	2.77e-72	GO:0044237	cellular metabolic process
1.57	1.12e-65	GO:0044238	primary metabolic process
1.49	6.76e-62	GO:0008152	metabolic process
1.96	6.88e-56	GO:0090304	nucleic acid metabolic process
1.98	5.73e-54	GO:0010467	gene expression
1.83	7.59e-52	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.99	1.53e-49	GO:0016070	RNA metabolic process
1.76	3.56e-49	GO:0034641	cellular nitrogen compound metabolic process
1.73	1.65e-47	GO:0006807	nitrogen compound metabolic process
1.92	1.19e-44	GO:0034645	cellular macromolecule biosynthetic process
1.92	2.18e-44	GO:0009059	macromolecule biosynthetic process
1.78	3.63e-44	GO:0044249	cellular biosynthetic process
1.71	7.07e-42	GO:0060255	regulation of macromolecule metabolic process
1.69	1.31e-41	GO:0031323	regulation of cellular metabolic process
1.75	1.77e-41	GO:0009058	biosynthetic process
1.86	3.09e-41	GO:2000112	regulation of cellular macromolecule biosynthetic process
1.83	4.96e-40	GO:0010556	regulation of macromolecule biosynthetic process
1.62	1.70e-39	GO:0019222	regulation of metabolic process
1.80	3.06e-39	GO:0031326	regulation of cellular biosynthetic process
1.81	5.02e-39	GO:0010468	regulation of gene expression
1.67	5.56e-39	GO:0080090	regulation of primary metabolic process
1.78	1.00e-38	GO:0009889	regulation of biosynthetic process
1.84	9.65e-37	GO:0051252	regulation of RNA metabolic process
1.76	1.72e-35	GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.75	2.79e-35	GO:0051171	regulation of nitrogen compound metabolic process
1.82	3.07e-34	GO:0006355	regulation of transcription, DNA-dependent
1.83	1.24e-32	GO:0044267	cellular protein metabolic process
1.91	1.36e-29	GO:0006351	transcription, DNA-dependent
1.90	1.96e-29	GO:0032774	RNA biosynthetic process
1.64	4.10e-25	GO:0019538	protein metabolic process
1.19	1.40e-22	GO:0009987	cellular process
1.76	2.21e-20	GO:0043412	macromolecule modification
1.76	1.23e-19	GO:0006464	protein modification process
1.62	2.11e-18	GO:0071841	cellular component organization or biogenesis at cellular level
2.18	2.86e-17	GO:2000113	negative regulation of cellular macromolecule biosynthetic process
1.50	2.95e-17	GO:0071840	cellular component organization or biogenesis
2.19	3.20e-17	GO:0010629	negative regulation of gene expression
1.82	4.92e-17	GO:0010604	positive regulation of macromolecule metabolic process
2.12	6.00e-17	GO:0031327	negative regulation of cellular biosynthetic process
2.25	7.53e-17	GO:0045892	negative regulation of transcription, DNA-dependent
1.95	7.99e-17	GO:0010605	negative regulation of macromolecule metabolic process
1.96	9.80e-17	GO:0006357	regulation of transcription from RNA polymerase II promoter
2.23	1.17e-16	GO:0051253	negative regulation of RNA metabolic process
1.60	1.30e-16	GO:0048523	negative regulation of cellular process
1.47	2.34e-16	GO:0032502	developmental process
2.12	2.37e-16	GO:0010558	negative regulation of macromolecule biosynthetic process
1.80	2.63e-16	GO:0031325	positive regulation of cellular metabolic process
2.08	2.69e-16	GO:0009890	negative regulation of biosynthetic process
1.76	6.38e-16	GO:0009893	positive regulation of metabolic process
1.59	6.67e-16	GO:0071842	cellular component organization at cellular level
2.13	6.96e-16	GO:0051172	negative regulation of nitrogen compound metabolic process
2.03	7.40e-16	GO:0009790	embryo development
2.13	1.07e-15	GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.53	1.40e-15	GO:0048522	positive regulation of cellular process
1.87	2.39e-15	GO:0009892	negative regulation of metabolic process
1.49	2.51e-15	GO:0016043	cellular component organization
1.91	3.16e-15	GO:0031324	negative regulation of cellular metabolic process
1.49	4.18e-15	GO:0048518	positive regulation of biological process
2.67	4.69e-15	GO:0016568	chromatin modification
1.73	5.46e-15	GO:0006996	organelle organization
1.47	8.31e-15	GO:0007275	multicellular organismal development
2.29	1.63e-14	GO:0009792	embryo development ending in birth or egg hatching
2.28	3.99e-14	GO:0043009	chordate embryonic development
1.93	4.99e-14	GO:0010557	positive regulation of macromolecule biosynthetic process
1.53	5.20e-14	GO:0048519	negative regulation of biological process
2.49	6.36e-14	GO:0006325	chromatin organization
2.22	1.07e-13	GO:0006396	RNA processing
1.87	2.69e-13	GO:0031328	positive regulation of cellular biosynthetic process
2.23	4.24e-13	GO:0051276	chromosome organization
1.47	5.50e-13	GO:0048856	anatomical structure development
1.94	6.96e-13	GO:0007049	cell cycle
1.84	9.05e-13	GO:0009891	positive regulation of biosynthetic process
1.91	1.66e-12	GO:0010628	positive regulation of gene expression
1.87	3.46e-12	GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.86	3.49e-12	GO:0051173	positive regulation of nitrogen compound metabolic process
1.94	5.77e-12	GO:0045893	positive regulation of transcription, DNA-dependent
2.29	6.88e-12	GO:0000122	negative regulation of transcription from RNA polymerase II promoter
1.92	9.49e-12	GO:0051254	positive regulation of RNA metabolic process
1.47	1.57e-11	GO:0048731	system development
1.56	3.95e-11	GO:0048513	organ development
1.65	4.32e-11	GO:0009653	anatomical structure morphogenesis
2.46	1.19e-09	GO:0006412	translation
1.78	1.42e-09	GO:0009888	tissue development
2.48	1.67e-09	GO:0008380	RNA splicing
1.93	2.20e-09	GO:0009887	organ morphogenesis
2.13	3.31e-09	GO:0048598	embryonic morphogenesis
2.00	1.37e-08	GO:0072358	cardiovascular system development
2.00	1.37e-08	GO:0072359	circulatory system development
2.27	1.64e-08	GO:0035295	tube development
2.22	2.02e-08	GO:0016071	mRNA metabolic process
2.90	2.47e-08	GO:0048705	skeletal system morphogenesis
2.01	2.50e-08	GO:0006259	DNA metabolic process
1.66	4.22e-08	GO:0050793	regulation of developmental process
2.33	5.40e-08	GO:0048568	embryonic organ development
2.33	6.42e-08	GO:0006397	mRNA processing
1.95	7.62e-08	GO:0048646	anatomical structure formation involved in morphogenesis
2.33	1.11e-07	GO:0001501	skeletal system development
3.32	1.87e-07	GO:0018205	peptidyl-lysine modification
2.05	3.18e-07	GO:0032583	regulation of gene-specific transcription
2.05	3.63e-07	GO:0060429	epithelium development
2.27	4.27e-07	GO:0018193	peptidyl-amino acid modification
2.22	4.48e-07	GO:0001701	in utero embryonic development
2.57	4.74e-07	GO:0016569	covalent chromatin modification
2.26	6.10e-07	GO:0002009	morphogenesis of an epithelium
1.42	6.98e-07	GO:0048869	cellular developmental process
1.57	7.27e-07	GO:0007399	nervous system development
1.43	7.39e-07	GO:0030154	cell differentiation
2.56	8.31e-07	GO:0016570	histone modification
1.71	1.10e-06	GO:0045595	regulation of cell differentiation
2.11	1.39e-06	GO:0010551	regulation of gene-specific transcription from RNA polymerase II promoter
2.06	2.44e-06	GO:0007167	enzyme linked receptor protein signaling pathway
1.82	2.92e-06	GO:0045944	positive regulation of transcription from RNA polymerase II promoter
2.75	3.49e-06	GO:0060541	respiratory system development
1.59	4.58e-06	GO:0006796	phosphate metabolic process
1.59	5.34e-06	GO:0006793	phosphorus metabolic process
2.32	5.79e-06	GO:0034660	ncRNA metabolic process
2.18	7.39e-06	GO:0007507	heart development
2.01	7.44e-06	GO:0048729	tissue morphogenesis
2.98	1.51e-05	GO:0016331	morphogenesis of embryonic epithelium
1.81	1.62e-05	GO:0051094	positive regulation of developmental process
3.80	1.84e-05	GO:0060606	tube closure
2.11	1.85e-05	GO:0001568	blood vessel development
1.57	2.31e-05	GO:0044085	cellular component biogenesis
1.57	2.55e-05	GO:0042981	regulation of apoptosis
1.69	2.61e-05	GO:0006468	protein phosphorylation
1.61	2.74e-05	GO:2000026	regulation of multicellular organismal development
2.26	3.23e-05	GO:0043193	positive regulation of gene-specific transcription
2.38	3.59e-05	GO:0048562	embryonic organ morphogenesis
1.55	3.74e-05	GO:0010941	regulation of cell death
2.20	4.11e-05	GO:0048514	blood vessel morphogenesis
2.02	4.42e-05	GO:0001944	vasculature development
1.50	4.68e-05	GO:0009966	regulation of signal transduction
1.55	5.67e-05	GO:0043067	regulation of programmed cell death
3.70	7.10e-05	GO:0001843	neural tube closure
1.61	8.85e-05	GO:0016310	phosphorylation
1.80	8.91e-05	GO:0060548	negative regulation of cell death
1.73	1.09e-04	GO:0022402	cell cycle process
1.55	1.12e-04	GO:0032268	regulation of cellular protein metabolic process
1.57	1.13e-04	GO:0042127	regulation of cell proliferation
1.89	1.20e-04	GO:0045597	positive regulation of cell differentiation
2.49	1.21e-04	GO:0006260	DNA replication
3.05	1.29e-04	GO:0035148	tube formation
1.90	2.01e-04	GO:0007389	pattern specification process
2.20	2.08e-04	GO:0048732	gland development
3.51	2.11e-04	GO:0014020	primary neural tube formation
2.62	2.12e-04	GO:0030323	respiratory tube development
2.17	2.31e-04	GO:0035239	tube morphogenesis
1.80	2.58e-04	GO:0043066	negative regulation of apoptosis
1.93	2.64e-04	GO:0022603	regulation of anatomical structure morphogenesis
1.82	2.92e-04	GO:0022403	cell cycle phase
1.82	3.62e-04	GO:0044265	cellular macromolecule catabolic process
2.58	4.62e-04	GO:0030324	lung development
1.77	4.72e-04	GO:0043069	negative regulation of programmed cell death
1.39	4.92e-04	GO:0048583	regulation of response to stimulus
2.29	5.10e-04	GO:0010552	positive regulation of gene-specific transcription from RNA polymerase II promoter
1.85	5.52e-04	GO:0000278	mitotic cell cycle
3.00	5.55e-04	GO:0001838	embryonic epithelial tube formation
3.00	5.55e-04	GO:0072175	epithelial tube formation
2.85	6.19e-04	GO:2000027	regulation of organ morphogenesis
2.67	7.03e-04	GO:0021915	neural tube development
5.85	8.19e-04	GO:0018022	peptidyl-lysine methylation
1.90	9.00e-04	GO:0051301	cell division
3.57	1.24e-03	GO:0001889	liver development
3.10	1.44e-03	GO:0001841	neural tube formation
2.26	1.45e-03	GO:0060562	epithelial tube morphogenesis
1.92	1.50e-03	GO:0045596	negative regulation of cell differentiation
2.86	1.56e-03	GO:0040029	regulation of gene expression, epigenetic
2.22	1.65e-03	GO:0034470	ncRNA processing
3.50	1.77e-03	GO:0061008	hepaticobiliary system development
1.90	1.89e-03	GO:0070647	protein modification by small protein conjugation or removal
3.06	1.91e-03	GO:0018394	peptidyl-lysine acetylation
3.59	2.24e-03	GO:0060349	bone morphogenesis
1.46	2.72e-03	GO:0051246	regulation of protein metabolic process
1.13	3.29e-03	GO:0050794	regulation of cellular process
1.12	3.33e-03	GO:0065007	biological regulation
1.97	3.55e-03	GO:0003002	regionalization
2.57	4.18e-03	GO:0006399	tRNA metabolic process
1.73	4.97e-03	GO:0051247	positive regulation of protein metabolic process
1.83	5.20e-03	GO:0007420	brain development
1.12	5.73e-03	GO:0050789	regulation of biological process
2.97	5.96e-03	GO:0006475	internal protein amino acid acetylation
2.97	5.96e-03	GO:0018393	internal peptidyl-lysine acetylation
1.57	6.67e-03	GO:0033554	cellular response to stress
1.74	7.01e-03	GO:0032270	positive regulation of cellular protein metabolic process
2.17	7.63e-03	GO:0006730	one-carbon metabolic process
2.93	7.75e-03	GO:0006479	protein methylation
2.93	7.75e-03	GO:0008213	protein alkylation
2.65	7.99e-03	GO:0022612	gland morphogenesis
1.94	8.89e-03	GO:0061061	muscle structure development
2.82	9.11e-03	GO:0006473	protein acetylation
2.43	9.52e-03	GO:0032259	methylation
1.95	9.76e-03	GO:0010608	posttranscriptional regulation of gene expression
1.99	9.93e-03	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
2.56	1.05e-02	GO:0043414	macromolecule methylation
2.12	1.12e-02	GO:0007346	regulation of mitotic cell cycle
2.59	1.23e-02	GO:0048706	embryonic skeletal system development
2.85	1.28e-02	GO:0048704	embryonic skeletal system morphogenesis
1.65	1.32e-02	GO:0009057	macromolecule catabolic process
1.81	1.35e-02	GO:0008283	cell proliferation
2.91	1.40e-02	GO:0016573	histone acetylation
1.36	1.41e-02	GO:0023051	regulation of signaling
1.48	1.42e-02	GO:0022607	cellular component assembly
2.16	1.55e-02	GO:0010553	negative regulation of gene-specific transcription from RNA polymerase II promoter
1.72	1.99e-02	GO:0051093	negative regulation of developmental process
2.19	2.00e-02	GO:0001655	urogenital system development
2.06	2.27e-02	GO:0009952	anterior/posterior pattern formation
1.67	2.34e-02	GO:0007417	central nervous system development
3.72	2.37e-02	GO:0045669	positive regulation of osteoblast differentiation
2.74	2.63e-02	GO:0050657	nucleic acid transport
2.74	2.63e-02	GO:0050658	RNA transport
2.74	2.63e-02	GO:0051236	establishment of RNA localization
2.02	2.75e-02	GO:0071843	cellular component biogenesis at cellular level
1.65	2.81e-02	GO:0051726	regulation of cell cycle
1.56	2.82e-02	GO:0046907	intracellular transport
2.35	2.84e-02	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
1.92	2.99e-02	GO:0016567	protein ubiquitination
1.87	3.13e-02	GO:0032446	protein modification by small protein conjugation
1.82	3.18e-02	GO:0006281	DNA repair
1.81	3.53e-02	GO:0044257	cellular protein catabolic process
2.93	3.56e-02	GO:0016458	gene silencing
2.93	3.56e-02	GO:0060348	bone development
1.46	3.69e-02	GO:0048468	cell development
1.78	3.82e-02	GO:0030163	protein catabolic process
2.16	3.88e-02	GO:0042692	muscle cell differentiation
1.84	3.93e-02	GO:0006511	ubiquitin-dependent protein catabolic process
2.49	3.97e-02	GO:0030879	mammary gland development
2.82	4.18e-02	GO:0045667	regulation of osteoblast differentiation
2.03	4.20e-02	GO:0022613	ribonucleoprotein complex biogenesis
1.48	4.24e-02	GO:0048584	positive regulation of response to stimulus
1.81	4.37e-02	GO:0051603	proteolysis involved in cellular protein catabolic process
2.59	4.45e-02	GO:0060485	mesenchyme development
2.09	4.58e-02	GO:0043434	response to peptide hormone stimulus
1.98	4.61e-02	GO:0032582	negative regulation of gene-specific transcription
2.53	4.67e-02	GO:0015931	nucleobase, nucleoside, nucleotide and nucleic acid transport

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
1.42	4.11e-101	GO:0005622	intracellular
1.43	1.25e-99	GO:0044424	intracellular part
1.83	1.20e-94	GO:0005634	nucleus
1.54	9.95e-93	GO:0043227	membrane-bounded organelle
1.54	8.58e-92	GO:0043231	intracellular membrane-bounded organelle
1.48	6.87e-89	GO:0043226	organelle
1.48	1.64e-87	GO:0043229	intracellular organelle
2.18	2.69e-51	GO:0044428	nuclear part
2.16	1.02e-46	GO:0070013	intracellular organelle lumen
2.16	1.63e-46	GO:0043233	organelle lumen
2.14	1.63e-46	GO:0031974	membrane-enclosed lumen
2.23	2.95e-44	GO:0031981	nuclear lumen
1.59	2.42e-37	GO:0044446	intracellular organelle part
2.39	2.45e-37	GO:0005654	nucleoplasm
1.35	8.22e-37	GO:0005737	cytoplasm
1.57	2.66e-36	GO:0044422	organelle part
1.15	5.64e-30	GO:0005623	cell
1.15	5.64e-30	GO:0044464	cell part
1.56	2.28e-25	GO:0032991	macromolecular complex
2.37	1.18e-23	GO:0044451	nucleoplasm part
1.49	5.12e-16	GO:0043234	protein complex
1.31	7.99e-16	GO:0044444	cytoplasmic part
2.16	9.37e-12	GO:0030529	ribonucleoprotein complex
1.60	2.00e-11	GO:0005829	cytosol
2.14	7.48e-11	GO:0005694	chromosome
1.57	2.60e-10	GO:0005739	mitochondrion
2.10	2.41e-09	GO:0044427	chromosomal part
1.40	5.53e-09	GO:0043228	non-membrane-bounded organelle
1.40	5.53e-09	GO:0043232	intracellular non-membrane-bounded organelle
2.55	1.13e-08	GO:0000785	chromatin
2.96	1.30e-08	GO:0016604	nuclear body
3.26	1.62e-07	GO:0000790	nuclear chromatin
2.17	1.87e-07	GO:0005667	transcription factor complex
3.43	4.80e-07	GO:0016585	chromatin remodeling complex
2.49	1.14e-06	GO:0044454	nuclear chromosome part
2.36	1.73e-06	GO:0000228	nuclear chromosome
3.65	3.15e-06	GO:0000792	heterochromatin
1.96	3.59e-06	GO:0005730	nucleolus
4.54	4.07e-06	GO:0000118	histone deacetylase complex
3.75	1.50e-04	GO:0017053	transcriptional repressor complex
2.61	2.73e-04	GO:0000151	ubiquitin ligase complex
1.61	3.15e-04	GO:0031967	organelle envelope
6.63	3.28e-04	GO:0016581	NuRD complex
1.59	6.33e-04	GO:0031975	envelope
5.04	2.68e-03	GO:0031519	PcG protein complex
3.53	7.00e-03	GO:0005720	nuclear heterochromatin
2.01	7.75e-03	GO:0005635	nuclear envelope
2.69	3.06e-02	GO:0000123	histone acetyltransferase complex
7.98	3.17e-02	GO:0005677	chromatin silencing complex
2.07	4.98e-02	GO:0005681	spliceosomal complex

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
1.32	2.75e-53	GO:0005488	binding
1.87	8.90e-45	GO:0003676	nucleic acid binding
1.41	1.07e-28	GO:0005515	protein binding
1.81	5.49e-25	GO:0003677	DNA binding
2.23	2.58e-20	GO:0003723	RNA binding
1.62	1.17e-18	GO:0000166	nucleotide binding
1.33	3.01e-16	GO:0003824	catalytic activity
3.02	1.17e-13	GO:0003682	chromatin binding
1.87	1.94e-13	GO:0030528	transcription regulator activity
1.63	4.23e-12	GO:0005524	ATP binding
1.63	5.11e-12	GO:0032559	adenyl ribonucleotide binding
1.62	9.05e-12	GO:0030554	adenyl nucleotide binding
1.54	4.27e-11	GO:0035639	purine ribonucleoside triphosphate binding
2.22	7.23e-11	GO:0016874	ligase activity
1.53	9.01e-11	GO:0032555	purine ribonucleotide binding
1.53	9.67e-11	GO:0032553	ribonucleotide binding
1.52	1.47e-10	GO:0017076	purine nucleotide binding
1.49	9.78e-09	GO:0016740	transferase activity
2.26	1.13e-08	GO:0008134	transcription factor binding
1.75	3.76e-08	GO:0001071	nucleic acid binding transcription factor activity
1.75	3.76e-08	GO:0003700	sequence-specific DNA binding transcription factor activity
2.20	5.80e-08	GO:0016564	transcription repressor activity
1.48	6.41e-08	GO:0046914	transition metal ion binding
1.54	6.80e-08	GO:0008270	zinc ion binding
2.34	1.33e-07	GO:0016879	ligase activity, forming carbon-nitrogen bonds
1.64	1.82e-07	GO:0016772	transferase activity, transferring phosphorus-containing groups
2.40	2.31e-07	GO:0016881	acid-amino acid ligase activity
1.29	4.66e-07	GO:0043167	ion binding
1.29	7.22e-07	GO:0046872	metal ion binding
1.76	7.28e-07	GO:0043565	sequence-specific DNA binding
1.29	8.36e-07	GO:0043169	cation binding
2.35	2.49e-05	GO:0004842	ubiquitin-protein ligase activity
2.28	3.39e-05	GO:0019787	small conjugating protein ligase activity
1.57	4.44e-05	GO:0019899	enzyme binding
1.69	1.08e-04	GO:0004672	protein kinase activity
2.88	1.14e-04	GO:0008135	translation factor activity, nucleic acid binding
1.92	1.21e-04	GO:0016563	transcription activator activity
1.56	2.04e-04	GO:0016301	kinase activity
2.19	2.49e-04	GO:0010843	promoter binding
2.14	2.60e-04	GO:0000975	regulatory region DNA binding
2.14	2.60e-04	GO:0001067	regulatory region nucleic acid binding
2.14	2.60e-04	GO:0044212	transcription regulatory region DNA binding
1.60	2.74e-04	GO:0016773	phosphotransferase activity, alcohol group as acceptor
1.99	1.53e-03	GO:0003712	transcription cofactor activity
1.98	1.74e-03	GO:0000989	transcription factor binding transcription factor activity
2.21	1.98e-03	GO:0016741	transferase activity, transferring one-carbon groups
3.94	2.51e-03	GO:0002039	p53 binding
1.96	2.52e-03	GO:0000988	protein binding transcription factor activity
2.21	2.83e-03	GO:0008168	methyltransferase activity
2.70	3.07e-03	GO:0004519	endonuclease activity
3.83	3.78e-03	GO:0042054	histone methyltransferase activity
2.81	3.87e-03	GO:0042393	histone binding
1.60	5.27e-03	GO:0019904	protein domain specific binding
4.10	7.76e-03	GO:0016278	lysine N-methyltransferase activity
4.10	7.76e-03	GO:0016279	protein-lysine N-methyltransferase activity
3.07	1.24e-02	GO:0008276	protein methyltransferase activity
2.37	1.66e-02	GO:0019838	growth factor binding
2.65	1.74e-02	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
1.64	1.95e-02	GO:0004674	protein serine/threonine kinase activity
4.05	2.12e-02	GO:0018024	histone-lysine N-methyltransferase activity
4.35	2.32e-02	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters
2.03	2.65e-02	GO:0008022	protein C-terminus binding
1.92	2.82e-02	GO:0043566	structure-specific DNA binding
2.37	3.45e-02	GO:0016566	specific transcriptional repressor activity
3.59	3.87e-02	GO:0030145	manganese ion binding
3.06	4.13e-02	GO:0008170	N-methyltransferase activity