Motif ID: HIC1.p2

Z-value: 1.783


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
Hic1 15248 hypermethylated in cancer 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hic1chr11_-_74982551,
chr11_-_74981653,
chr11_-_74983756		-0.092.1e-01Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_78337844 46.185 Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr13_-_78338131 34.734 NM_010151
 Nr2f1
nuclear receptor subfamily 2, group F, member 1
chrX_+_53984926 25.322 NM_010211
 Fhl1
four and a half LIM domains 1
chrX_+_53985133 21.727 NM_001077361
 Fhl1
four and a half LIM domains 1
chr2_+_28061156 21.642 NM_001038612
NM_019498
 Olfm1

olfactomedin 1

chr11_+_6963421 19.731 NM_009622
 Adcy1
adenylate cyclase 1
chr9_+_60560734 18.030 Larp6
La ribonucleoprotein domain family, member 6
chr3_-_125641429 17.188 NM_011674
 Ugt8a
UDP galactosyltransferase 8A
chr4_+_138011061 16.976 NM_025451
 Camk2n1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr9_+_60560923 16.228 NM_026235
 Larp6
La ribonucleoprotein domain family, member 6
chr11_-_5965743 15.820 NM_001174053
NM_001174054
NM_007595
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr8_+_86424565 15.614 Lphn1
latrophilin 1
chr2_+_164312023 15.050 Dbndd2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr6_+_115085096 15.008 Syn2
synapsin II
chr2_+_164312087 14.740 Dbndd2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr4_-_151235861 14.404 NM_001081557
NM_001195565
 Camta1

calmodulin binding transcription activator 1

chr10_-_75807976 14.325 NM_001081419
 Dip2a
DIP2 disco-interacting protein 2 homolog A (Drosophila)
chr12_+_113960424 14.146 AW555464
expressed sequence AW555464
chr12_+_50484907 13.999 Foxg1
forkhead box G1
chr8_-_87323896 13.257 Nfix
nuclear factor I/X

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 179 entries
Enrichment   P-value GO Accession GO Term
4.01 4.21e-02 GO:0031114 regulation of microtubule depolymerization
3.58 6.55e-06 GO:0050773 regulation of dendrite development
3.58 7.17e-04 GO:0048814 regulation of dendrite morphogenesis
3.18 2.62e-02 GO:0010469 regulation of receptor activity
3.13 1.38e-03 GO:0007269 neurotransmitter secretion
2.94 2.75e-03 GO:0022037 metencephalon development
2.89 4.37e-04 GO:0031345 negative regulation of cell projection organization
2.84 1.35e-04 GO:0017157 regulation of exocytosis
2.76 6.06e-05 GO:0001505 regulation of neurotransmitter levels
2.72 1.37e-02 GO:0007272 ensheathment of neurons
2.72 1.37e-02 GO:0008366 axon ensheathment
2.70 2.65e-02 GO:0042552 myelination
2.69 1.03e-02 GO:0050808 synapse organization
2.59 5.53e-11 GO:0010975 regulation of neuron projection development
2.54 2.18e-02 GO:0070588 calcium ion transmembrane transport
2.51 1.19e-02 GO:0045667 regulation of osteoblast differentiation
2.48 1.18e-12 GO:0007409 axonogenesis
2.47 1.63e-02 GO:0021543 pallium development
2.45 2.97e-14 GO:0048812 neuron projection morphogenesis
2.45 7.39e-04 GO:0006836 neurotransmitter transport

Gene overrepresentation in compartment category:

Showing 1 to 20 of 86 entries
Enrichment   P-value GO Accession GO Term
3.53 2.92e-03 GO:0032589 neuron projection membrane
3.45 4.69e-05 GO:0043198 dendritic shaft
3.17 7.44e-03 GO:0044304 main axon
3.08 7.88e-09 GO:0030426 growth cone
3.07 1.58e-04 GO:0031256 leading edge membrane
3.05 6.39e-09 GO:0030427 site of polarized growth
2.95 3.79e-03 GO:0042734 presynaptic membrane
2.70 1.29e-10 GO:0019717 synaptosome
2.69 7.18e-06 GO:0014069 postsynaptic density
2.57 3.76e-02 GO:0005913 cell-cell adherens junction
2.54 3.52e-04 GO:0005875 microtubule associated complex
2.54 3.52e-04 GO:0044309 neuron spine
2.52 6.61e-04 GO:0043197 dendritic spine
2.44 3.08e-09 GO:0045211 postsynaptic membrane
2.44 3.14e-03 GO:0030662 coated vesicle membrane
2.43 3.81e-02 GO:0030665 clathrin coated vesicle membrane
2.42 1.02e-16 GO:0030425 dendrite
2.35 1.43e-02 GO:0008076 voltage-gated potassium channel complex
2.35 1.43e-02 GO:0034705 potassium channel complex
2.32 1.07e-16 GO:0043025 neuronal cell body

Gene overrepresentation in function category:

Showing 1 to 20 of 54 entries
Enrichment   P-value GO Accession GO Term
4.01 1.09e-02 GO:0042813 Wnt receptor activity
2.42 2.59e-04 GO:0030165 PDZ domain binding
2.32 4.76e-02 GO:0019902 phosphatase binding
2.24 1.45e-04 GO:0005516 calmodulin binding
2.06 7.74e-08 GO:0005083 small GTPase regulator activity
2.02 1.60e-02 GO:0003774 motor activity
1.98 1.71e-11 GO:0060589 nucleoside-triphosphatase regulator activity
1.97 5.97e-11 GO:0030695 GTPase regulator activity
1.95 1.71e-02 GO:0022843 voltage-gated cation channel activity
1.88 6.02e-04 GO:0005096 GTPase activator activity
1.85 3.67e-06 GO:0008047 enzyme activator activity
1.81 3.50e-10 GO:0008092 cytoskeletal protein binding
1.81 1.98e-05 GO:0003779 actin binding
1.79 2.32e-02 GO:0005244 voltage-gated ion channel activity
1.79 2.32e-02 GO:0022832 voltage-gated channel activity
1.72 4.41e-08 GO:0019904 protein domain specific binding
1.72 3.66e-03 GO:0005261 cation channel activity
1.70 2.47e-03 GO:0022836 gated channel activity
1.60 2.74e-03 GO:0005216 ion channel activity
1.58 3.82e-03 GO:0022838 substrate-specific channel activity