Motif ID: HIF1A.p2

Z-value: 1.740


Transcription factors associated with HIF1A.p2:

Gene SymbolEntrez IDGene Name
Hif1a 15251 hypoxia inducible factor 1, alpha subunit

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hif1achr12_+_75002361,
chr12_+_75028976		0.281.7e-04Click!


Activity profile for motif HIF1A.p2.

activity profile for motif HIF1A.p2


Sorted Z-values histogram for motif HIF1A.p2

Sorted Z-values for motif HIF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIF1A.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_125075222 23.840 NM_001037298
 Fam38a
family with sequence similarity 38, member A
chr10_+_43198945 21.892 NM_199028
 Bend3
BEN domain containing 3
chr11_-_115971327 19.821 NM_172570
 Trim47
tripartite motif-containing 47
chr8_+_49195311 14.709 NM_178788
NM_001161515
 Dctd

dCMP deaminase

chr2_-_13977688 14.572 Ptpla
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a
chr9_-_58160063 14.566 Loxl1
lysyl oxidase-like 1
chr19_+_7049425 13.520 NM_008889
 Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr7_+_54101157 13.468 NM_010699
 Ldha
lactate dehydrogenase A
chr12_+_33505307 13.392 Nampt
nicotinamide phosphoribosyltransferase
chr19_+_7049639 12.923 Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr12_+_33505364 12.777 Nampt
nicotinamide phosphoribosyltransferase
chr9_+_107490100 12.304 Ifrd2
interferon-related developmental regulator 2
chr4_-_118966945 12.234 NM_011732
 Ybx1
Y box protein 1
chr14_-_45938164 11.916 Ero1l
ERO1-like (S. cerevisiae)
chr17_+_35137995 11.835 Vars
valyl-tRNA synthetase
chr10_-_68815606 11.724 NM_007659
 Cdk1
cyclin-dependent kinase 1
chr7_+_54101226 11.163 Ldha
lactate dehydrogenase A
chr1_-_55144637 11.081 Hspd1
heat shock protein 1 (chaperonin)
chr2_-_169956719 10.922 NM_001033299
 Zfp217
zinc finger protein 217
chr11_+_3190334 10.635 NM_019574
 Patz1
POZ (BTB) and AT hook containing zinc finger 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 145 entries
Enrichment   P-value GO Accession GO Term
3.94 1.86e-04 GO:0016573 histone acetylation
3.82 3.15e-04 GO:0006475 internal protein amino acid acetylation
3.82 3.15e-04 GO:0018393 internal peptidyl-lysine acetylation
3.77 4.06e-04 GO:0018394 peptidyl-lysine acetylation
3.70 2.82e-04 GO:0050657 nucleic acid transport
3.70 2.82e-04 GO:0050658 RNA transport
3.70 2.82e-04 GO:0051236 establishment of RNA localization
3.63 7.12e-06 GO:0018205 peptidyl-lysine modification
3.56 5.76e-04 GO:0006403 RNA localization
3.54 4.63e-03 GO:0051028 mRNA transport
3.48 1.68e-03 GO:0006473 protein acetylation
3.39 9.01e-03 GO:0006479 protein methylation
3.39 9.01e-03 GO:0008213 protein alkylation
3.28 1.41e-03 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
3.10 6.94e-03 GO:0043543 protein acylation
2.98 5.31e-07 GO:0016570 histone modification
2.97 4.09e-04 GO:0042254 ribosome biogenesis
2.93 8.90e-07 GO:0016569 covalent chromatin modification
2.85 9.16e-12 GO:0016568 chromatin modification
2.73 2.01e-05 GO:0071843 cellular component biogenesis at cellular level

Gene overrepresentation in compartment category:

Showing 1 to 20 of 48 entries
Enrichment   P-value GO Accession GO Term
7.19 3.55e-04 GO:0032592 integral to mitochondrial membrane
7.15 9.17e-05 GO:0031519 PcG protein complex
5.17 2.92e-02 GO:0001739 sex chromatin
4.94 4.30e-02 GO:0000803 sex chromosome
3.70 2.26e-02 GO:0005643 nuclear pore
3.39 4.61e-03 GO:0000123 histone acetyltransferase complex
3.23 1.60e-02 GO:0000792 heterochromatin
2.85 2.83e-02 GO:0016585 chromatin remodeling complex
2.66 2.95e-02 GO:0000790 nuclear chromatin
2.52 2.82e-02 GO:0005819 spindle
2.48 2.83e-04 GO:0005635 nuclear envelope
2.43 3.49e-02 GO:0031301 integral to organelle membrane
2.41 2.32e-03 GO:0005840 ribosome
2.37 2.91e-08 GO:0005730 nucleolus
2.13 1.15e-02 GO:0000785 chromatin
2.11 2.17e-10 GO:0044451 nucleoplasm part
2.10 2.62e-30 GO:0044428 nuclear part
2.10 2.09e-02 GO:0000228 nuclear chromosome
2.09 1.17e-23 GO:0031981 nuclear lumen
2.02 2.16e-24 GO:0070013 intracellular organelle lumen

Gene overrepresentation in function category:

Showing 1 to 20 of 34 entries
Enrichment   P-value GO Accession GO Term
4.27 1.70e-02 GO:0019205 nucleobase, nucleoside, nucleotide kinase activity
3.59 1.30e-02 GO:0008276 protein methyltransferase activity
2.80 1.40e-02 GO:0016566 specific transcriptional repressor activity
2.43 2.94e-07 GO:0016564 transcription repressor activity
2.27 3.42e-03 GO:0003682 chromatin binding
2.26 4.57e-02 GO:0008168 methyltransferase activity
2.15 8.53e-12 GO:0003723 RNA binding
2.02 2.43e-03 GO:0008134 transcription factor binding
1.90 7.02e-32 GO:0003676 nucleic acid binding
1.89 3.25e-06 GO:0043565 sequence-specific DNA binding
1.84 3.01e-08 GO:0030528 transcription regulator activity
1.84 1.54e-06 GO:0001071 nucleic acid binding transcription factor activity
1.84 1.54e-06 GO:0003700 sequence-specific DNA binding transcription factor activity
1.82 4.86e-17 GO:0003677 DNA binding
1.82 1.09e-02 GO:0016874 ligase activity
1.65 1.23e-07 GO:0008270 zinc ion binding
1.58 1.21e-03 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.55 1.10e-06 GO:0046914 transition metal ion binding
1.54 6.87e-07 GO:0016740 transferase activity
1.54 1.95e-02 GO:0016301 kinase activity