Motif ID: HIF1A.p2

Z-value: 1.740


Transcription factors associated with HIF1A.p2:

Gene SymbolEntrez IDGene Name
Hif1a 15251 hypoxia inducible factor 1, alpha subunit

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hif1achr12_+_75002361,
chr12_+_75028976
0.281.7e-04Click!


Activity profile for motif HIF1A.p2.

activity profile for motif HIF1A.p2


Sorted Z-values histogram for motif HIF1A.p2

Sorted Z-values for motif HIF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIF1A.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_125075222 23.840 NM_001037298
Fam38a
family with sequence similarity 38, member A
chr10_+_43198945 21.892 NM_199028
Bend3
BEN domain containing 3
chr11_-_115971327 19.821 NM_172570
Trim47
tripartite motif-containing 47
chr8_+_49195311 14.709 NM_178788
NM_001161515
Dctd

dCMP deaminase

chr2_-_13977688 14.572 Ptpla
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a
chr9_-_58160063 14.566 Loxl1
lysyl oxidase-like 1
chr19_+_7049425 13.520 NM_008889
Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr7_+_54101157 13.468 NM_010699
Ldha
lactate dehydrogenase A
chr12_+_33505307 13.392 Nampt
nicotinamide phosphoribosyltransferase
chr19_+_7049639 12.923 Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr12_+_33505364 12.777 Nampt
nicotinamide phosphoribosyltransferase
chr9_+_107490100 12.304 Ifrd2
interferon-related developmental regulator 2
chr4_-_118966945 12.234 NM_011732
Ybx1
Y box protein 1
chr14_-_45938164 11.916 Ero1l
ERO1-like (S. cerevisiae)
chr17_+_35137995 11.835 Vars
valyl-tRNA synthetase
chr10_-_68815606 11.724 NM_007659
Cdk1
cyclin-dependent kinase 1
chr7_+_54101226 11.163 Ldha
lactate dehydrogenase A
chr1_-_55144637 11.081 Hspd1
heat shock protein 1 (chaperonin)
chr2_-_169956719 10.922 NM_001033299
Zfp217
zinc finger protein 217
chr11_+_3190334 10.635 NM_019574
Patz1
POZ (BTB) and AT hook containing zinc finger 1
chr1_-_55144687 10.571 NM_010477
Hspd1
heat shock protein 1 (chaperonin)
chr2_+_27741864 10.569 NM_015734
Col5a1
collagen, type V, alpha 1
chr1_+_55145132 10.523 Hspe1
heat shock protein 1 (chaperonin 10)
chr9_+_107489981 10.491 NM_025903
Ifrd2
interferon-related developmental regulator 2
chr2_-_179777080 10.373 NM_011969
Psma7
proteasome (prosome, macropain) subunit, alpha type 7
chr14_-_31832274 10.356 NM_153547
Gnl3
guanine nucleotide binding protein-like 3 (nucleolar)
chr1_-_75176703 10.223 NM_023732
Abcb6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr8_-_72498125 10.035 Gatad2a
GATA zinc finger domain containing 2A
chr8_+_34842304 9.996 NM_001167921
Gtf2e2
general transcription factor II E, polypeptide 2 (beta subunit)
chr2_-_13977502 9.609 Ptpla
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a
chr11_-_102680467 9.568 NM_001159382
Gjc1
gap junction protein, gamma 1
chr16_+_32608981 9.448 NM_011638
Tfrc
transferrin receptor
chr10_-_119913990 9.374 NM_010441
Hmga2
high mobility group AT-hook 2
chr4_-_131901576 9.318 NM_001197082
NM_133878
Rcc1

regulator of chromosome condensation 1

chr16_-_22163264 9.156 NM_183029
Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr14_-_45938187 8.998 NM_015774
Ero1l
ERO1-like (S. cerevisiae)
chr3_+_121948541 8.955 Gclm
glutamate-cysteine ligase, modifier subunit
chr1_-_75176965 8.945 Abcb6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr7_-_59117613 8.838 NM_001115087
Fancf
Fanconi anemia, complementation group F
chr14_-_31832165 8.828 Gnl3
guanine nucleotide binding protein-like 3 (nucleolar)
chr17_-_35137799 8.748 D17H6S56E-5
DNA segment, Chr 17, human D6S56E 5
chr17_-_26232411 8.706 NM_019731
Nme4
non-metastatic cells 4, protein expressed in
chr1_-_33814537 8.567 Bag2
BCL2-associated athanogene 2
chr12_+_17551678 8.538 NM_013614
Odc1
ornithine decarboxylase, structural 1
chr14_-_45938236 8.511 Ero1l
ERO1-like (S. cerevisiae)
chr5_+_129526383 8.483 Ran
RAN, member RAS oncogene family
chr10_-_83996516 8.455 Ckap4
cytoskeleton-associated protein 4
chr2_-_73052484 8.340 NM_025942
NM_030091
Ola1

Obg-like ATPase 1

chr19_+_47654060 8.325 Slk
STE20-like kinase (yeast)
chr10_+_17443024 8.221 NM_010828
Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr4_-_118966829 8.015 Ybx1
Y box protein 1
chr4_+_107040634 7.923 Tmem48
transmembrane protein 48
chr9_-_43047862 7.830 NM_178644
Oaf
OAF homolog (Drosophila)
chr2_-_13977563 7.830 NM_001012396
NM_013935
Ptpla

protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a

chr7_-_112884943 7.729 Rrp8
ribosomal RNA processing 8, methyltransferase, homolog (yeast)
chr18_-_52689504 7.702 Lox
lysyl oxidase
chr8_+_109417539 7.622 NM_011574
Cirh1a
cirrhosis, autosomal recessive 1A (human)
chr11_-_115971521 7.615 Trim47
tripartite motif-containing 47
chr17_+_46633703 7.606 NM_207161
BC048355
cDNA sequence BC048355
chr5_+_129526060 7.551 Ran
RAN, member RAS oncogene family
chr1_-_145549758 7.546 NM_145991
Cdc73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr14_-_32643594 7.512 NM_001024604
Ankrd28
ankyrin repeat domain 28
chr18_+_35713033 7.500 Matr3
matrin 3
chr7_-_112885071 7.426 Rrp8
ribosomal RNA processing 8, methyltransferase, homolog (yeast)
chr19_+_36908807 7.425 Tnks2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr7_-_112884969 7.386 NM_025897
Rrp8
ribosomal RNA processing 8, methyltransferase, homolog (yeast)
chr9_-_58160769 7.381 Loxl1
lysyl oxidase-like 1
chr8_-_123112974 7.371 NM_178856
Gins2
GINS complex subunit 2 (Psf2 homolog)
chr17_-_23814415 7.214 NM_001161746
NM_013749
Tnfrsf12a

tumor necrosis factor receptor superfamily, member 12a

chr1_-_75176926 7.176 Abcb6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr10_-_83996632 6.993 NM_175451
Ckap4
cytoskeleton-associated protein 4
chr11_+_68859125 6.910 NM_011496
Aurkb
aurora kinase B
chr2_+_162880370 6.890 NM_008652
Mybl2
myeloblastosis oncogene-like 2
chrX_-_165111764 6.794 NM_010832
Msl3
male-specific lethal 3 homolog (Drosophila)
chr2_+_22751003 6.782 NM_019501
Pdss1
prenyl (solanesyl) diphosphate synthase, subunit 1
chr9_+_92437056 6.745 NM_001142916
NM_011961
Plod2

procollagen lysine, 2-oxoglutarate 5-dioxygenase 2

chr5_-_23289370 6.732 NM_178403
Pus7
pseudouridylate synthase 7 homolog (S. cerevisiae)
chr15_+_9001154 6.729 1110020G09Rik
RIKEN cDNA 1110020G09 gene
chr4_+_154937946 6.717 Nadk
NAD kinase
chr8_+_34842810 6.707 NM_001167922
Gtf2e2
general transcription factor II E, polypeptide 2 (beta subunit)
chr8_-_123112925 6.704 Gins2
GINS complex subunit 2 (Psf2 homolog)
chr4_+_154937914 6.680 NM_001159637
Nadk
NAD kinase
chr12_+_33505175 6.661 NM_021524
Nampt
nicotinamide phosphoribosyltransferase
chr9_-_88417710 6.656 Snhg5
small nucleolar RNA host gene 5
chr5_-_145726643 6.648 NM_001038627
NM_029438
Smurf1

SMAD specific E3 ubiquitin protein ligase 1

chr5_+_129525943 6.637 NM_009391
Ran
RAN, member RAS oncogene family
chr17_-_23814399 6.633 Tnfrsf12a
tumor necrosis factor receptor superfamily, member 12a
chr6_-_6167034 6.583 Slc25a13
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
chr6_-_6167113 6.576 NM_001177572
NM_015829
Slc25a13

solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13

chr16_+_44724394 6.573 NM_145972
BC027231
cDNA sequence BC027231
chr12_-_77470450 6.572 NM_001172104
NM_028356
Zbtb25

zinc finger and BTB domain containing 25

chr6_-_6167086 6.547 Slc25a13
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
chr1_-_155179844 6.487 NM_010683
Lamc1
laminin, gamma 1
chr18_-_52689185 6.462 Lox
lysyl oxidase
chr2_-_144096582 6.426 Snx5
sorting nexin 5
chr11_-_57981970 6.420 Gemin5
gem (nuclear organelle) associated protein 5
chr2_+_22751081 6.394 Pdss1
prenyl (solanesyl) diphosphate synthase, subunit 1
chr1_-_33814590 6.389 NM_145392
Bag2
BCL2-associated athanogene 2
chr4_+_11118500 6.370 NM_001037134
Ccne2
cyclin E2
chr6_+_108778985 6.355 Edem1
ER degradation enhancer, mannosidase alpha-like 1
chr2_-_144096164 6.334 Snx5
sorting nexin 5
chr11_-_84326869 6.305 NM_019816
Aatf
apoptosis antagonizing transcription factor
chr17_-_56766191 6.245 NM_028782
Lonp1
lon peptidase 1, mitochondrial
chr17_-_50329593 6.241 NM_181397
Rftn1
raftlin lipid raft linker 1
chr5_+_123526279 6.209 NM_001039723
Tmem120b
transmembrane protein 120B
chr11_+_97177029 6.208 NM_025927
Mrpl45
mitochondrial ribosomal protein L45
chr6_-_88848650 6.200 NM_008564
Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr5_-_111082387 6.200 NM_153570
Noc4l
nucleolar complex associated 4 homolog (S. cerevisiae)
chr1_-_145549903 6.189 Cdc73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr14_+_70009282 6.148 NM_033325
Loxl2
lysyl oxidase-like 2
chrX_+_93291377 6.131 NM_010833
Msn
moesin
chr19_+_47654508 6.108 NM_001164639
NM_009289
Slk

STE20-like kinase (yeast)

chr13_-_99660903 6.107 NM_001048267
Tnpo1
transportin 1
chr8_+_67471046 6.055 NM_001163747
NM_028427
Tmem192

transmembrane protein 192

chr8_+_86521498 6.024 NM_001081415
Samd1
sterile alpha motif domain containing 1
chr5_+_64484146 6.009 NM_025700
Pgm1
phosphoglucomutase 1
chr4_+_122960059 5.976 NM_130881
Pabpc4
poly(A) binding protein, cytoplasmic 4
chr10_+_68675404 5.955 NM_001081347
Rhobtb1
Rho-related BTB domain containing 1
chr17_+_35035898 5.923 NM_145830
Ehmt2
euchromatic histone lysine N-methyltransferase 2
chr8_+_131209787 5.784 Itgb1
integrin beta 1 (fibronectin receptor beta)
chr5_+_34000745 5.774 NM_001040435
Tacc3
transforming, acidic coiled-coil containing protein 3
chr14_-_62058627 5.757 NM_008466
Kpna3
karyopherin (importin) alpha 3
chr15_-_99705812 5.738 NM_001113545
Lima1
LIM domain and actin binding 1
chr5_+_129526311 5.730 Ran
RAN, member RAS oncogene family
chr8_-_87956665 5.723 NM_025722
4921524J17Rik
RIKEN cDNA 4921524J17 gene
chr6_-_131243197 5.702 NM_025564
Magohb
mago-nashi homolog B (Drosophila)
chr13_+_109106530 5.656 NM_178683
Depdc1b
DEP domain containing 1B
chr8_+_120022149 5.595 NM_172285
Plcg2
phospholipase C, gamma 2
chr10_+_79317316 5.525 NM_001077363
NM_008956
Ptbp1

polypyrimidine tract binding protein 1

chr8_-_124431581 5.476 NM_011404
Slc7a5
solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
chr7_-_26035683 5.474 NM_010155
Erf
Ets2 repressor factor
chr8_+_131209680 5.470 Itgb1
integrin beta 1 (fibronectin receptor beta)
chr11_+_120810346 5.424 NM_001038653
NM_001038654
Slc16a3

solute carrier family 16 (monocarboxylic acid transporters), member 3

chr4_+_101092307 5.423 NM_009647
Ak4
adenylate kinase 4
chr9_-_107888185 5.419 6230427J02Rik
RIKEN cDNA 6230427J02 gene
chr1_+_16655263 5.402 NM_026392
NM_027415
Tmem70

transmembrane protein 70

chr1_-_95375363 5.397 Hdlbp
high density lipoprotein (HDL) binding protein
chr11_-_88725877 5.380 NM_001042541
Akap1
A kinase (PRKA) anchor protein 1
chr7_-_52241669 5.378 NM_019830
Prmt1
protein arginine N-methyltransferase 1
chr4_+_46502141 5.353 NM_053179
Nans
N-acetylneuraminic acid synthase (sialic acid synthase)
chr2_-_174264400 5.338 NM_022325
Ctsz
cathepsin Z
chr9_-_96264446 5.324 Atp1b3
ATPase, Na+/K+ transporting, beta 3 polypeptide
chr8_-_124431559 5.317 Slc7a5
solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
chr11_+_117710532 5.306 NM_001012273
NM_009689
Birc5

baculoviral IAP repeat-containing 5

chr1_-_155396839 5.291 NM_028749
F630010C12Rik
Npl
RIKEN cDNA F630010C12 gene
N-acetylneuraminate pyruvate lyase
chr11_+_74462965 5.222 NM_001081158
1300001I01Rik
RIKEN cDNA 1300001I01 gene
chr2_+_27370649 5.209 NM_080848
Wdr5
WD repeat domain 5
chr7_+_28233013 5.194 Blvrb
biliverdin reductase B (flavin reductase (NADPH))
chr1_-_38186482 5.185 NM_019570
Rev1
REV1 homolog (S. cerevisiae)
chr11_-_102680999 5.164 NM_001159383
Gjc1
gap junction protein, gamma 1
chr9_+_50665024 5.134 NM_001034085
NM_028614
Ppp2r1b

protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform

chr18_-_52689279 5.042 NM_010728
Lox
lysyl oxidase
chr10_-_81063566 5.025 NM_053254
Tle6
transducin-like enhancer of split 6, homolog of Drosophila E(spl)
chr4_+_149611305 5.015 NM_023119
Eno1
enolase 1, alpha non-neuron
chr15_+_61869529 4.946 Pvt1
plasmacytoma variant translocation 1
chr4_+_147965596 4.938 NM_009272
Srm
spermidine synthase
chr1_+_93698037 4.930 NM_007855
Twist2
twist homolog 2 (Drosophila)
chr18_+_46757333 4.927 NM_010120
Eif1a
eukaryotic translation initiation factor 1A
chr1_+_137662648 4.891 NM_013750
Phlda3
pleckstrin homology-like domain, family A, member 3
chr6_+_29222698 4.881 2310016C08Rik
RIKEN cDNA 2310016C08 gene
chr16_+_20141134 4.880 NM_001033237
NM_001145930
NM_001145931
Yeats2


YEATS domain containing 2


chr2_-_31939210 4.877 NM_175511
Fam78a
family with sequence similarity 78, member A
chr10_-_75322897 4.804 Mif
macrophage migration inhibitory factor
chr10_-_60610398 4.796 NM_009163
Sgpl1
sphingosine phosphate lyase 1
chr16_+_14361637 4.795 NM_008576
Abcc1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
chr17_+_35137851 4.794 NM_011690
Vars
valyl-tRNA synthetase
chr12_-_40764514 4.794 Arl4a
ADP-ribosylation factor-like 4A
chr3_+_121948693 4.791 Gclm
glutamate-cysteine ligase, modifier subunit
chr3_-_8923789 4.772 NM_025434
Mrps28
mitochondrial ribosomal protein S28
chr6_-_52108249 4.769 NM_010449
Hoxa1
homeobox A1
chr5_-_111082269 4.768 Noc4l
nucleolar complex associated 4 homolog (S. cerevisiae)
chr10_+_121176978 4.752 NM_173022
BC048403
cDNA sequence BC048403
chr3_+_121948399 4.750 NM_008129
Gclm
glutamate-cysteine ligase, modifier subunit
chr3_-_142544883 4.720 NM_178654
Pkn2
protein kinase N2
chr7_+_105851755 4.719 NM_028410
Prkrir
protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
chr12_+_52449216 4.713 NM_001015099
NM_001167963
NM_001167964
G2e3


G2/M-phase specific E3 ubiquitin ligase


chr8_+_131209614 4.699 Itgb1
integrin beta 1 (fibronectin receptor beta)
chr14_+_70008874 4.696 Loxl2
lysyl oxidase-like 2
chr11_+_100931369 4.693 NM_013792
Naglu
alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)
chr10_-_75322941 4.691 NM_010798
Mif
macrophage migration inhibitory factor
chr10_-_127648817 4.655 NM_025716
Spryd4
SPRY domain containing 4
chr12_+_77471506 4.648 Zbtb1
zinc finger and BTB domain containing 1
chr6_+_29222664 4.630 2310016C08Rik
RIKEN cDNA 2310016C08 gene
chr2_+_172847371 4.630 NM_019547
Rbm38
RNA binding motif protein 38
chrX_+_103382432 4.629 NM_008828
Pgk1
phosphoglycerate kinase 1
chr11_-_116713532 4.615 Srsf2
serine/arginine-rich splicing factor 2
chr12_-_32746061 4.604 NM_011158
Prkar2b
protein kinase, cAMP dependent regulatory, type II beta
chr4_-_41688124 4.602 NM_011014
Sigmar1
sigma non-opioid intracellular receptor 1
chr14_+_31832340 4.585 Pbrm1
polybromo 1
chr6_+_17015159 4.576 Tes
testis derived transcript
chr16_+_70314331 4.561 NM_028803
Gbe1
glucan (1,4-alpha-), branching enzyme 1
chr17_-_46168654 4.549 Vegfa
vascular endothelial growth factor A
chr18_+_67448839 4.541 NM_053261
Impa2
inositol (myo)-1(or 4)-monophosphatase 2
chr5_-_90652790 4.539 Cox18
COX18 cytochrome c oxidase assembly homolog (S. cerevisiae)
chr15_-_94373918 4.531 NM_172437
Pus7l
pseudouridylate synthase 7 homolog (S. cerevisiae)-like
chr6_+_29383152 4.512 NM_001081185
Flnc
filamin C, gamma
chr2_+_92024338 4.504 NM_138755
Phf21a
PHD finger protein 21A
chr12_+_17551771 4.493 Odc1
ornithine decarboxylase, structural 1
chr4_-_133801438 4.487 NM_024215
Zfp593
zinc finger protein 593
chr5_-_111209468 4.483 NM_001025561
NM_019700
NM_001025562
Pus1


pseudouridine synthase 1



Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.56 6.94e-42 GO:0044237 cellular metabolic process
1.70 2.75e-41 GO:0044260 cellular macromolecule metabolic process
1.47 1.51e-37 GO:0008152 metabolic process
1.52 1.72e-36 GO:0044238 primary metabolic process
1.61 4.86e-36 GO:0043170 macromolecule metabolic process
1.84 4.10e-35 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.77 4.23e-35 GO:0006807 nitrogen compound metabolic process
1.78 1.78e-34 GO:0034641 cellular nitrogen compound metabolic process
1.91 4.24e-31 GO:0010467 gene expression
1.88 4.28e-31 GO:0090304 nucleic acid metabolic process
1.92 7.44e-29 GO:0016070 RNA metabolic process
1.81 2.85e-26 GO:0010468 regulation of gene expression
1.74 3.41e-26 GO:0044249 cellular biosynthetic process
1.72 1.62e-25 GO:0009058 biosynthetic process
1.68 5.00e-25 GO:0060255 regulation of macromolecule metabolic process
1.82 5.25e-25 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.79 4.54e-24 GO:0010556 regulation of macromolecule biosynthetic process
1.82 1.10e-23 GO:0009059 macromolecule biosynthetic process
1.82 1.26e-23 GO:0034645 cellular macromolecule biosynthetic process
1.64 2.24e-23 GO:0031323 regulation of cellular metabolic process
1.75 3.70e-23 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.82 3.88e-23 GO:0051252 regulation of RNA metabolic process
1.75 5.55e-23 GO:0051171 regulation of nitrogen compound metabolic process
1.75 5.80e-23 GO:0031326 regulation of cellular biosynthetic process
1.74 6.24e-23 GO:0009889 regulation of biosynthetic process
1.83 6.97e-23 GO:0006355 regulation of transcription, DNA-dependent
1.63 8.00e-23 GO:0080090 regulation of primary metabolic process
1.58 1.06e-22 GO:0019222 regulation of metabolic process
1.92 5.44e-20 GO:0032774 RNA biosynthetic process
1.91 9.65e-20 GO:0006351 transcription, DNA-dependent
1.71 6.33e-16 GO:0071841 cellular component organization or biogenesis at cellular level
1.56 4.21e-14 GO:0071840 cellular component organization or biogenesis
1.18 1.06e-13 GO:0009987 cellular process
1.66 9.88e-13 GO:0071842 cellular component organization at cellular level
1.82 2.87e-12 GO:0006996 organelle organization
2.00 6.51e-12 GO:0010605 negative regulation of macromolecule metabolic process
2.85 9.16e-12 GO:0016568 chromatin modification
1.99 1.22e-11 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.48 2.70e-11 GO:0032502 developmental process
1.52 2.79e-11 GO:0016043 cellular component organization
1.61 5.42e-11 GO:0048523 negative regulation of cellular process
2.63 9.63e-11 GO:0006325 chromatin organization
1.49 1.03e-10 GO:0007275 multicellular organismal development
1.90 1.54e-10 GO:0009892 negative regulation of metabolic process
1.56 2.77e-10 GO:0048519 negative regulation of biological process
1.57 4.23e-10 GO:0044267 cellular protein metabolic process
2.12 1.00e-09 GO:0010629 negative regulation of gene expression
2.32 1.48e-09 GO:0051276 chromosome organization
1.50 1.67e-09 GO:0048856 anatomical structure development
1.86 1.31e-08 GO:0031324 negative regulation of cellular metabolic process
2.00 3.61e-08 GO:0010558 negative regulation of macromolecule biosynthetic process
1.50 3.65e-08 GO:0048731 system development
2.68 3.91e-08 GO:0018193 peptidyl-amino acid modification
2.08 4.01e-08 GO:0006915 apoptosis
2.02 4.12e-08 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
2.02 4.69e-08 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.07 4.69e-08 GO:0012501 programmed cell death
2.21 4.73e-08 GO:0009792 embryo development ending in birth or egg hatching
2.22 5.82e-08 GO:0043009 chordate embryonic development
1.99 1.12e-07 GO:0051172 negative regulation of nitrogen compound metabolic process
1.90 1.76e-07 GO:0009790 embryo development
1.93 2.49e-07 GO:0031327 negative regulation of cellular biosynthetic process
1.96 3.56e-07 GO:0016265 death
1.91 4.44e-07 GO:0009890 negative regulation of biosynthetic process
2.02 4.75e-07 GO:0051253 negative regulation of RNA metabolic process
2.03 4.94e-07 GO:0045892 negative regulation of transcription, DNA-dependent
2.98 5.31e-07 GO:0016570 histone modification
1.56 5.44e-07 GO:0048513 organ development
1.43 6.61e-07 GO:0019538 protein metabolic process
2.93 8.90e-07 GO:0016569 covalent chromatin modification
1.56 9.51e-07 GO:0043412 macromolecule modification
1.94 9.81e-07 GO:0008219 cell death
2.08 1.26e-06 GO:0006396 RNA processing
1.84 2.07e-06 GO:0007049 cell cycle
2.41 4.58e-06 GO:0001701 in utero embryonic development
1.61 5.58e-06 GO:0009653 anatomical structure morphogenesis
3.63 7.12e-06 GO:0018205 peptidyl-lysine modification
1.54 8.15e-06 GO:0006464 protein modification process
2.73 2.01e-05 GO:0071843 cellular component biogenesis at cellular level
1.47 2.39e-05 GO:0030154 cell differentiation
2.73 4.81e-05 GO:0022613 ribonucleoprotein complex biogenesis
2.09 5.42e-05 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.45 5.96e-05 GO:0048869 cellular developmental process
1.71 1.09e-04 GO:0009888 tissue development
3.94 1.86e-04 GO:0016573 histone acetylation
1.92 2.00e-04 GO:0048646 anatomical structure formation involved in morphogenesis
1.92 2.49e-04 GO:0072358 cardiovascular system development
1.92 2.49e-04 GO:0072359 circulatory system development
3.70 2.82e-04 GO:0050657 nucleic acid transport
3.70 2.82e-04 GO:0050658 RNA transport
3.70 2.82e-04 GO:0051236 establishment of RNA localization
3.82 3.15e-04 GO:0006475 internal protein amino acid acetylation
3.82 3.15e-04 GO:0018393 internal peptidyl-lysine acetylation
2.15 3.37e-04 GO:0051301 cell division
3.77 4.06e-04 GO:0018394 peptidyl-lysine acetylation
1.62 4.06e-04 GO:0050793 regulation of developmental process
2.97 4.09e-04 GO:0042254 ribosome biogenesis
1.66 4.71e-04 GO:0051173 positive regulation of nitrogen compound metabolic process
1.64 5.00e-04 GO:0031328 positive regulation of cellular biosynthetic process
3.56 5.76e-04 GO:0006403 RNA localization
2.25 6.13e-04 GO:0001501 skeletal system development
1.62 7.50e-04 GO:0009891 positive regulation of biosynthetic process
1.96 1.03e-03 GO:0022403 cell cycle phase
3.28 1.41e-03 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
1.69 1.53e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.69 1.58e-03 GO:0051254 positive regulation of RNA metabolic process
1.64 1.59e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.48 1.68e-03 GO:0006473 protein acetylation
1.35 1.73e-03 GO:0048522 positive regulation of cellular process
1.59 2.06e-03 GO:0044085 cellular component biogenesis
1.76 2.25e-03 GO:0009887 organ morphogenesis
1.79 2.51e-03 GO:0022402 cell cycle process
1.53 2.51e-03 GO:0007399 nervous system development
1.79 2.89e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.52 3.31e-03 GO:0033036 macromolecule localization
1.98 3.60e-03 GO:0007389 pattern specification process
1.49 4.41e-03 GO:0031325 positive regulation of cellular metabolic process
3.54 4.63e-03 GO:0051028 mRNA transport
1.47 4.82e-03 GO:0009893 positive regulation of metabolic process
1.60 5.45e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
1.62 5.63e-03 GO:0010628 positive regulation of gene expression
3.10 6.94e-03 GO:0043543 protein acylation
1.93 7.59e-03 GO:0000278 mitotic cell cycle
1.84 8.48e-03 GO:0051726 regulation of cell cycle
3.39 9.01e-03 GO:0006479 protein methylation
3.39 9.01e-03 GO:0008213 protein alkylation
2.62 9.16e-03 GO:0006913 nucleocytoplasmic transport
1.47 1.13e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.41 1.28e-02 GO:0044281 small molecule metabolic process
2.56 1.39e-02 GO:0051169 nuclear transport
1.95 1.40e-02 GO:0016071 mRNA metabolic process
1.58 2.07e-02 GO:0048468 cell development
1.29 2.11e-02 GO:0048518 positive regulation of biological process
2.04 2.24e-02 GO:0006397 mRNA processing
2.45 2.26e-02 GO:0048705 skeletal system morphogenesis
2.33 2.36e-02 GO:0034470 ncRNA processing
2.05 2.53e-02 GO:0007507 heart development
2.15 2.80e-02 GO:0034660 ncRNA metabolic process
1.95 2.90e-02 GO:0035295 tube development
2.10 3.00e-02 GO:0010608 posttranscriptional regulation of gene expression
1.92 3.24e-02 GO:0000279 M phase
2.04 3.43e-02 GO:0008380 RNA splicing
2.10 3.71e-02 GO:0048514 blood vessel morphogenesis
1.54 4.56e-02 GO:2000026 regulation of multicellular organismal development
1.93 4.59e-02 GO:0001944 vasculature development

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.44 1.83e-73 GO:0005622 intracellular
1.45 3.07e-73 GO:0044424 intracellular part
1.57 1.05e-69 GO:0043231 intracellular membrane-bounded organelle
1.57 1.31e-69 GO:0043227 membrane-bounded organelle
1.50 4.66e-67 GO:0043226 organelle
1.51 5.42e-67 GO:0043229 intracellular organelle
1.77 1.90e-55 GO:0005634 nucleus
2.10 2.62e-30 GO:0044428 nuclear part
1.37 1.29e-27 GO:0005737 cytoplasm
1.17 1.54e-26 GO:0005623 cell
1.17 1.54e-26 GO:0044464 cell part
2.01 1.67e-24 GO:0031974 membrane-enclosed lumen
2.02 2.16e-24 GO:0070013 intracellular organelle lumen
2.01 2.84e-24 GO:0043233 organelle lumen
2.09 1.17e-23 GO:0031981 nuclear lumen
1.55 3.34e-22 GO:0044446 intracellular organelle part
1.53 3.23e-21 GO:0044422 organelle part
1.36 2.14e-14 GO:0044444 cytoplasmic part
2.02 5.69e-14 GO:0005654 nucleoplasm
1.73 2.86e-11 GO:0005739 mitochondrion
2.11 2.17e-10 GO:0044451 nucleoplasm part
1.49 8.58e-09 GO:0043228 non-membrane-bounded organelle
1.49 8.58e-09 GO:0043232 intracellular non-membrane-bounded organelle
1.39 2.63e-08 GO:0032991 macromolecular complex
2.37 2.91e-08 GO:0005730 nucleolus
1.55 3.82e-06 GO:0005829 cytosol
1.35 5.08e-05 GO:0043234 protein complex
7.15 9.17e-05 GO:0031519 PcG protein complex
1.91 1.36e-04 GO:0030529 ribonucleoprotein complex
1.77 1.77e-04 GO:0031967 organelle envelope
2.48 2.83e-04 GO:0005635 nuclear envelope
1.75 3.21e-04 GO:0031975 envelope
7.19 3.55e-04 GO:0032592 integral to mitochondrial membrane
1.89 1.04e-03 GO:0044427 chromosomal part
1.84 1.44e-03 GO:0005694 chromosome
2.41 2.32e-03 GO:0005840 ribosome
3.39 4.61e-03 GO:0000123 histone acetyltransferase complex
2.13 1.15e-02 GO:0000785 chromatin
3.23 1.60e-02 GO:0000792 heterochromatin
2.10 2.09e-02 GO:0000228 nuclear chromosome
3.70 2.26e-02 GO:0005643 nuclear pore
2.52 2.82e-02 GO:0005819 spindle
2.85 2.83e-02 GO:0016585 chromatin remodeling complex
5.17 2.92e-02 GO:0001739 sex chromatin
2.66 2.95e-02 GO:0000790 nuclear chromatin
2.43 3.49e-02 GO:0031301 integral to organelle membrane
4.94 4.30e-02 GO:0000803 sex chromosome
1.43 4.35e-02 GO:0005783 endoplasmic reticulum

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.90 7.02e-32 GO:0003676 nucleic acid binding
1.25 5.51e-23 GO:0005488 binding
1.82 4.86e-17 GO:0003677 DNA binding
2.15 8.53e-12 GO:0003723 RNA binding
1.29 2.70e-09 GO:0005515 protein binding
1.84 3.01e-08 GO:0030528 transcription regulator activity
1.50 5.94e-08 GO:0000166 nucleotide binding
1.65 1.23e-07 GO:0008270 zinc ion binding
1.28 1.43e-07 GO:0003824 catalytic activity
2.43 2.94e-07 GO:0016564 transcription repressor activity
1.54 6.87e-07 GO:0016740 transferase activity
1.55 1.10e-06 GO:0046914 transition metal ion binding
1.84 1.54e-06 GO:0001071 nucleic acid binding transcription factor activity
1.84 1.54e-06 GO:0003700 sequence-specific DNA binding transcription factor activity
1.89 3.25e-06 GO:0043565 sequence-specific DNA binding
1.47 4.10e-05 GO:0035639 purine ribonucleoside triphosphate binding
1.46 4.25e-05 GO:0032553 ribonucleotide binding
1.45 6.54e-05 GO:0032555 purine ribonucleotide binding
1.45 8.70e-05 GO:0017076 purine nucleotide binding
1.50 1.39e-04 GO:0005524 ATP binding
1.49 1.56e-04 GO:0032559 adenyl ribonucleotide binding
1.48 2.12e-04 GO:0030554 adenyl nucleotide binding
1.58 1.21e-03 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.27 2.04e-03 GO:0046872 metal ion binding
1.27 2.09e-03 GO:0043169 cation binding
2.02 2.43e-03 GO:0008134 transcription factor binding
1.26 2.86e-03 GO:0043167 ion binding
2.27 3.42e-03 GO:0003682 chromatin binding
1.82 1.09e-02 GO:0016874 ligase activity
3.59 1.30e-02 GO:0008276 protein methyltransferase activity
2.80 1.40e-02 GO:0016566 specific transcriptional repressor activity
4.27 1.70e-02 GO:0019205 nucleobase, nucleoside, nucleotide kinase activity
1.54 1.95e-02 GO:0016301 kinase activity
2.26 4.57e-02 GO:0008168 methyltransferase activity