Motif ID: HLF.p2

Z-value: 1.499


Transcription factors associated with HLF.p2:

Gene SymbolEntrez IDGene Name
Hlf 217082 hepatic leukemia factor

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hlfchr11_-_90250949-0.073.4e-01Click!


Activity profile for motif HLF.p2.

activity profile for motif HLF.p2


Sorted Z-values histogram for motif HLF.p2

Sorted Z-values for motif HLF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HLF.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_95721654 25.652 Ces1d
carboxylesterase 1D
chr9_-_71011053 23.623 NM_022026
Aqp9
aquaporin 9
chr3_-_144347983 23.173


chr2_-_129196855 21.323 NM_008361
Il1b
interleukin 1 beta
chr8_-_95721702 20.324 NM_053200
Ces1d
carboxylesterase 1D
chr2_+_24200807 20.030 NM_001159562
Il1rn
interleukin 1 receptor antagonist
chr2_+_24200890 18.772 NM_001039701
Il1rn
interleukin 1 receptor antagonist
chr10_+_23571267 17.055 NM_011979
Vnn3
vanin 3
chr7_+_27092187 17.037 NM_009997
Cyp2a4
cytochrome P450, family 2, subfamily a, polypeptide 4
chr10_+_100055019 16.352 NM_001081246
1700017N19Rik
RIKEN cDNA 1700017N19 gene
chr10_-_24647173 15.283 Arg1
arginase, liver
chr4_+_43996375 15.256 NM_001002787
Ccin
calicin
chr18_-_36886051 14.575 Cd14
CD14 antigen
chr7_+_27620380 14.573 Cyp2a4
Cyp2a5
cytochrome P450, family 2, subfamily a, polypeptide 4
cytochrome P450, family 2, subfamily a, polypeptide 5
chr4_+_56756283 13.910 NM_009611
Actl7a
actin-like 7a
chr11_-_83391984 13.902 Ccl9
chemokine (C-C motif) ligand 9
chr10_-_61970481 13.758 NM_011157
Srgn
serglycin
chr2_+_24200925 13.268 Il1rn
interleukin 1 receptor antagonist
chr4_-_127938134 12.707 NM_027036
Hmgb4
high-mobility group box 4
chr7_-_53971038 12.587 NM_011315
Saa3
serum amyloid A 3
chr2_-_58012447 12.327 NM_139200
Cytip
cytohesin 1 interacting protein
chr18_-_36886307 11.946 NM_009841
Cd14
CD14 antigen
chr5_+_88408469 11.916 NM_027631
4931407G18Rik
RIKEN cDNA 4931407G18 gene
chr7_-_31524374 11.636 NM_008085
Gapdhs
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr18_-_36886375 11.359 Cd14
CD14 antigen
chr9_-_106463955 11.322 NM_026645
Iqcf3
IQ motif containing F3
chr2_+_24201033 11.233 Il1rn
interleukin 1 receptor antagonist
chr13_-_74946095 10.826 Cast
calpastatin
chr5_-_123496828 10.664 NM_029112
Morn3
MORN repeat containing 3
chr7_-_31729018 10.500 NM_032541
Hamp
hepcidin antimicrobial peptide
chr16_+_22951183 10.426 Hrg
histidine-rich glycoprotein
chr11_+_83476085 10.129 NM_013652
Ccl4
chemokine (C-C motif) ligand 4
chr17_+_33569840 9.929 NM_183282
Actl9
actin-like 9
chrX_+_104871850 9.850 NM_145224
Tbx22
T-box 22
chr3_-_94240497 9.752 NM_016901
Oaz3
ornithine decarboxylase antizyme 3
chr15_-_76137667 9.652 NM_153122
Oplah
5-oxoprolinase (ATP-hydrolysing)
chr7_+_52877180 9.370 NM_001018013
Izumo1
izumo sperm-egg fusion 1
chr1_+_177628723 9.296 NM_029453
Wdr64
WD repeat domain 64
chr3_-_58934492 9.180 NM_001008497
NM_133200
P2ry14

purinergic receptor P2Y, G-protein coupled, 14

chr16_-_23029154 9.140 NM_001102409
NM_001102410
NM_201375
Kng2


kininogen 2


chr1_-_152011986 8.766


chr14_-_64704225 8.714 NM_001081063
Prss55
protease, serine, 55
chr2_+_148624569 8.485 NM_009978
Cst8
cystatin 8 (cystatin-related epididymal spermatogenic)
chr4_-_86204177 8.281 NM_001081096
Fam154a
family with sequence similarity 154, member A
chr17_+_34781733 8.186 NM_019873
Fkbpl
FK506 binding protein-like
chr6_+_41634429 8.167 NM_029671
1700034O15Rik
RIKEN cDNA 1700034O15 gene
chr6_-_40469482 8.117 NM_026317
Prss37
protease, serine, 37
chr12_+_99506844 8.090 NM_008152
Gpr65
G-protein coupled receptor 65
chr12_-_82480450 8.045 NM_001038995
Gm4787
predicted gene 4787
chr9_+_43552516 8.041 NM_021424
Pvrl1
poliovirus receptor-related 1
chr7_+_51751957 7.930 NM_028169
Fam71e1
family with sequence similarity 71, member E1
chr4_+_63005581 7.906 NM_008768
Orm1
orosomucoid 1
chr16_+_22951144 7.773 NM_053176
Hrg
histidine-rich glycoprotein
chr13_-_55516542 7.698 NM_029303
Pfn3
profilin 3
chr6_+_126803115 7.478 NM_009650
Akap3
A kinase (PRKA) anchor protein 3
chr6_+_124758692 7.098 Spsb2
splA/ryanodine receptor domain and SOCS box containing 2
chr7_+_109358966 6.775 Pgap2
post-GPI attachment to proteins 2
chr8_-_120195414 6.710 NM_028725
Sdr42e1
short chain dehydrogenase/reductase family 42E, member 1
chr5_-_92757021 6.707 NM_008599
Cxcl9
chemokine (C-X-C motif) ligand 9
chr7_-_31709187 6.658 NM_183257
Hamp2
hepcidin antimicrobial peptide 2
chr6_+_124758919 6.598 NM_013539
Spsb2
splA/ryanodine receptor domain and SOCS box containing 2
chr2_+_172298047 6.513 NM_029608
1700029J11Rik
RIKEN cDNA 1700029J11 gene
chr6_-_86619001 6.506 NM_010751
Mxd1
MAX dimerization protein 1
chr4_-_56754248 6.505 NM_025271
Actl7b
actin-like 7b
chr3_-_107357915 6.480 NM_026261
Ubl4b
ubiquitin-like 4B
chr18_-_35658485 6.426 NM_030749
Sil1
endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae)
chr1_-_56694278 6.358 NM_027661
Hsfy2
heat shock transcription factor, Y linked 2
chr14_+_22838933 6.300 NM_028275
1700112E06Rik
RIKEN cDNA 1700112E06 gene
chr10_+_57365674 6.194 NM_001039052
NM_001039053
Pkib

protein kinase inhibitor beta, cAMP dependent, testis specific

chr2_+_129626252 6.113 NM_001038635
NM_183262
Stk35

serine/threonine kinase 35

chrX_+_115540835 6.062 NM_001142750
NM_153109
Tgif2lx2
Tgif2lx1
TGFB-induced factor homeobox 2-like, X-linked 2
TGFB-induced factor homeobox 2-like, X-linked 1
chr5_-_124315478 5.955 NM_030701
Niacr1
niacin receptor 1
chrX_+_10885885 5.931 NM_001111037
Gm14483
predicted gene 14483
chrX_+_10876382 5.914 NM_001111037
Gm14483
predicted gene 14483
chr7_-_148202806 5.910 Ifitm6
interferon induced transmembrane protein 6
chr17_-_56261311 5.889 NM_029796
Lrg1
leucine-rich alpha-2-glycoprotein 1
chr11_-_118203813 5.864 NM_021440
BC100451
cDNA sequence BC100451
chr8_-_81772468 5.799 NM_026315
1700011L22Rik
RIKEN cDNA 1700011L22 gene
chr16_-_23029138 5.785 Kng2
kininogen 2
chr1_+_109407998 5.773 NM_001174170
NM_011111
Serpinb2

serine (or cysteine) peptidase inhibitor, clade B, member 2

chr11_-_83392129 5.678 NM_011338
Ccl9
chemokine (C-C motif) ligand 9
chr15_-_103140868 5.592 NM_030720
Gpr84
G protein-coupled receptor 84
chr2_-_17918493 5.580 NM_026627
H2afb1
H2A histone family, member B1
chr16_-_36334417 5.534 NM_001001332
BC117090
cDNA sequence BC1179090
chr12_-_111920809 5.526 NM_025488
1700001K19Rik
RIKEN cDNA 1700001K19 gene
chr1_-_73062445 5.481 NM_009407
Tnp1
transition protein 1
chr12_-_112217151 5.472 NM_175207
Ankrd9
ankyrin repeat domain 9
chrX_-_115594254 5.468 NM_001142750
NM_153109
Tgif2lx2
Tgif2lx1
TGFB-induced factor homeobox 2-like, X-linked 2
TGFB-induced factor homeobox 2-like, X-linked 1
chr19_-_34821529 5.444 NM_172838
Slc16a12
solute carrier family 16 (monocarboxylic acid transporters), member 12
chr3_+_95032637 5.415 Cdc42se1
CDC42 small effector 1
chr7_+_31561419 5.327 NM_028618
Dmkn
dermokine
chr6_+_30462285 5.223 NM_029373
1700025E21Rik
RIKEN cDNA 1700025E21 gene
chr17_-_74299469 5.214 NM_011723
Xdh
xanthine dehydrogenase
chr11_-_83462722 5.214 NM_011337
Ccl3
chemokine (C-C motif) ligand 3
chr16_-_38433223 5.087 NM_134102
Pla1a
phospholipase A1 member A
chr18_+_83084023 5.072 NM_001177464
Zfp516
zinc finger protein 516
chr3_-_92392895 5.070 NM_008574
Smcp
sperm mitochondria-associated cysteine-rich protein
chr1_-_142079842 4.989 NM_009888
Cfh
complement component factor h
chrX_+_132758579 4.986 NM_001127169
Tceal7
transcription elongation factor A (SII)-like 7
chr12_-_29267347 4.973 NM_053156
Allc
allantoicase
chr4_+_43455122 4.957 NM_011571
Tesk1
testis specific protein kinase 1
chr14_-_69151731 4.895 NM_007402
Adam7
a disintegrin and metallopeptidase domain 7
chr17_+_35400983 4.883 H2-D1
histocompatibility 2, D region locus 1
chr18_+_44264117 4.860 NM_030061
Spink12
serine peptidase inhibitor, Kazal type 11
chr1_+_19198994 4.723 NM_009334
Tcfap2b
transcription factor AP-2 beta
chr16_+_23058457 4.683 Kng1
kininogen 1
chr9_-_57950031 4.635 NM_029212
Ccdc33
coiled-coil domain containing 33
chr7_-_127039189 4.618 NM_001163703
Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr16_-_23029075 4.598 Kng2
kininogen 2
chr1_+_74421706 4.452 NM_013612
Slc11a1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
chr11_-_99354449 4.440 Krt23
keratin 23
chrX_+_13788273 4.422 NM_001034100
Gm5382
predicted gene 5382
chrY_+_1855008 4.409 NM_001113395
NM_001177569
Gm16501
Gm6026
predicted gene 16501
predicted gene 6026
chr16_+_36277233 4.407 NM_001082543
Stfa1
stefin A1
chr7_+_134439804 4.377 NM_008400
Itgal
integrin alpha L
chr15_-_101510717 4.355 NM_010669
Krt6b
keratin 6B
chr11_-_59850365 4.355 Pemt
phosphatidylethanolamine N-methyltransferase
chr6_-_87759747 4.291 NM_133717
Rab43
RAB43, member RAS oncogene family
chr9_+_64027101 4.277 NM_183316
Snapc5
small nuclear RNA activating complex, polypeptide 5
chr16_+_8830175 4.260 NM_001081400
1810013L24Rik
RIKEN cDNA 1810013L24 gene
chr16_-_88896693 4.252 NM_010676
Krtap8-2
keratin associated protein 8-2
chr9_+_124016886 4.178 NM_009915
Ccr2
chemokine (C-C motif) receptor 2
chr17_-_56651788 4.166 NM_011483
Znrf4
zinc and ring finger 4
chr7_-_148202779 4.159 NM_001033632
Ifitm6
interferon induced transmembrane protein 6
chr6_-_142421466 4.155 NM_145572
Gys2
glycogen synthase 2
chr2_-_84265422 4.134 NM_018782
Calcrl
calcitonin receptor-like
chr6_-_135204232 3.999 NM_001080553
NM_010352
Gsg1

germ cell-specific gene 1

chr16_+_32496350 3.987 NM_199309
Zdhhc19
zinc finger, DHHC domain containing 19
chr18_+_56748001 3.965 NM_026099
1700065I17Rik
RIKEN cDNA 1700065I17 gene
chr5_-_124482223 3.887 NM_177876
Vps37b
vacuolar protein sorting 37B (yeast)
chr16_+_57549340 3.839 NM_001177871
Filip1l
filamin A interacting protein 1-like
chr19_+_5335740 3.810 NM_139301
Catsper1
cation channel, sperm associated 1
chr11_-_99354417 3.808 NM_033373
Krt23
keratin 23
chr4_+_33149973 3.798 NM_008076
Gabrr2
gamma-aminobutyric acid (GABA) C receptor, subunit rho 2
chr2_-_164571430 3.758 Wfdc3
WAP four-disulfide core domain 3
chr16_+_22892125 3.747 Ahsg
alpha-2-HS-glycoprotein
chr16_-_36367622 3.722 NM_001082546
BC100530
BC117090
cDNA sequence BC100530
cDNA sequence BC1179090
chr15_-_81238649 3.712 NM_021317
Dnajb7
DnaJ (Hsp40) homolog, subfamily B, member 7
chr11_-_83406475 3.693 NM_009139
Ccl6
chemokine (C-C motif) ligand 6
chr11_-_59850340 3.692 NM_008819
Pemt
phosphatidylethanolamine N-methyltransferase
chr9_+_107982741 3.644 NM_008243
Mst1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr16_+_22892112 3.633 NM_013465
Ahsg
alpha-2-HS-glycoprotein
chr11_+_62764694 3.607 NM_025496
Cdrt4
CMT1A duplicated region transcript 4
chr18_+_40418014 3.547 NM_026135
Kctd16
potassium channel tetramerisation domain containing 16
chr6_-_142271469 3.526 NM_130861
Slco1a5
solute carrier organic anion transporter family, member 1a5
chr15_+_54242324 3.516 NM_173422
Colec10
collectin sub-family member 10
chrX_+_13044797 3.509 NM_173415
Nyx
nyctalopin
chrX_+_10889059 3.501 NM_001025260
Gm14484
predicted gene 14484
chr3_-_127256215 3.467 NM_138593
Larp7
La ribonucleoprotein domain family, member 7
chr18_+_52491189 3.439 NM_026286
Ftmt
ferritin mitochondrial
chr12_-_88579550 3.391 NM_027744
4933437F05Rik
RIKEN cDNA 4933437F05 gene
chr11_+_3964839 3.358 NM_001029937
Sec14l3
SEC14-like 3 (S. cerevisiae)
chr10_+_121176978 3.353 NM_173022
BC048403
cDNA sequence BC048403
chr17_+_37079857 3.352 Rnf39
ring finger protein 39
chr8_-_42127124 3.341 Mtus1
mitochondrial tumor suppressor 1
chr18_-_80909796 3.326 NM_001164109
NM_001164110
NM_198429
Nfatc1


nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1


chr3_+_67178016 3.293 NM_001039543
NM_010801
Mlf1

myeloid leukemia factor 1

chr1_-_195068455 3.287 NM_001044751
Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
chr7_-_87550315 3.244 NM_001081454
Furin
furin (paired basic amino acid cleaving enzyme)
chr4_+_51229549 3.221 NM_001162865
Cylc2
cylicin, basic protein of sperm head cytoskeleton 2
chr13_+_35016277 3.215 NM_025750
4933417A18Rik
RIKEN cDNA 4933417A18 gene
chr11_+_67051128 3.212 Myh4
myosin, heavy polypeptide 4, skeletal muscle
chr14_-_56721304 3.187 NM_007800
Ctsg
cathepsin G
chr13_-_93346126 3.165 NM_030237
Spz1
spermatogenic leucine zipper 1
chr6_-_97409251 3.160 Frmd4b
FERM domain containing 4B
chr19_-_7877136 3.149 NM_146232
BC014805
cDNA sequence BC014805
chr6_-_142421335 3.071 Gys2
glycogen synthase 2
chr4_-_150418704 3.029 NM_011067
Per3
period homolog 3 (Drosophila)
chr8_-_127093601 2.995 NM_007428
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr17_-_33204849 2.991 NM_001009544
4921501E09Rik
RIKEN cDNA 4921501E09 gene
chr5_-_66489416 2.989 NM_139065
Rbm47
RNA binding motif protein 47
chr2_+_18620627 2.966 NM_001001334
BC061194
cDNA sequence BC061194
chr8_-_46347384 2.931 NM_028066
F11
coagulation factor XI
chr10_-_106931783 2.922 NM_008657
Myf6
myogenic factor 6
chr14_-_37862119 2.921 NM_021340
Rgr
retinal G protein coupled receptor
chr8_-_46347363 2.919 F11
coagulation factor XI
chr14_+_64712532 2.913 NM_001193631
Prss51
protease, serine, 51
chr15_-_58046380 2.911 Fbxo32
F-box protein 32
chr7_-_53922712 2.911 NM_001136084
Tph1
tryptophan hydroxylase 1
chr4_-_58021900 2.908 NM_026132
Txndc8
thioredoxin domain containing 8
chr19_-_38199112 2.899 Rbp4
retinol binding protein 4, plasma
chrX_+_8860889 2.863 NM_029588
1700012L04Rik
RIKEN cDNA 1700012L04 gene
chrY_-_1976583 2.852 NM_001113395
NM_001177569
Gm16501
Gm6026
predicted gene 16501
predicted gene 6026
chr7_-_52870858 2.819 NM_020013
Fgf21
fibroblast growth factor 21
chr10_+_97028409 2.806 Lum
lumican
chr14_+_70977443 2.774 NM_153136
Nudt18
nudix (nucleoside diphosphate linked moiety X)-type motif 18
chr11_-_103500187 2.759 NM_027083
Lyzl6
lysozyme-like 6
chr7_+_26682681 2.754 NM_009999
Cyp2b10
cytochrome P450, family 2, subfamily b, polypeptide 10
chr7_-_105268002 2.751 NM_008663
Myo7a
myosin VIIA
chr16_+_22892156 2.739 Ahsg
alpha-2-HS-glycoprotein
chr17_+_37079995 2.735 NM_001099632
Rnf39
ring finger protein 39
chr7_+_74792295 2.733 NM_001168475
NM_001168476
NM_001168477
NM_025905
Ttc23



tetratricopeptide repeat domain 23



chr16_+_23058492 2.728 Kng1
kininogen 1
chr12_-_82068951 2.722 Slc10a1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
chr7_-_133974985 2.700 NM_183131
4930451I11Rik
RIKEN cDNA 4930451I11 gene
chr6_-_113433154 2.698 Il17rc
interleukin 17 receptor C
chr6_+_90416405 2.695 Klf15
Kruppel-like factor 15
chr14_-_51875785 2.690 NM_053113
Ear11
eosinophil-associated, ribonuclease A family, member 11
chr4_+_40216581 2.682 2010003O02Rik
RIKEN cDNA 2010003O02 gene
chrX_+_89735287 2.677 NM_001034103
Gm5941
predicted gene 5941

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.34 3.05e-02 GO:0006952 defense response
2.58 3.39e-02 GO:0006955 immune response
3.20 3.58e-02 GO:0006954 inflammatory response
2.54 4.39e-02 GO:0009611 response to wounding

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.52 3.75e-06 GO:0005615 extracellular space
1.99 1.43e-03 GO:0044421 extracellular region part
1.65 3.21e-03 GO:0005576 extracellular region
3.85 6.49e-03 GO:0005882 intermediate filament

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
11.80 9.58e-09 GO:0004869 cysteine-type endopeptidase inhibitor activity
5.53 2.33e-08 GO:0004866 endopeptidase inhibitor activity
5.33 4.85e-08 GO:0061135 endopeptidase regulator activity
5.23 6.91e-08 GO:0030414 peptidase inhibitor activity
3.95 8.17e-07 GO:0004857 enzyme inhibitor activity
4.48 1.33e-06 GO:0061134 peptidase regulator activity
7.49 3.61e-02 GO:0008009 chemokine activity