Motif ID: HMGA1,2.p2

Z-value: 1.428


Transcription factors associated with HMGA1,2.p2:

Gene SymbolEntrez IDGene Name
Hmga1 15361 high mobility group AT-hook 1
Hmga2 15364 high mobility group AT-hook 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmga1chr17_+_27693821-0.222.3e-03Click!
Hmga2chr10_-_1199132040.036.5e-01Click!


Activity profile for motif HMGA1,2.p2.

activity profile for motif HMGA1,2.p2


Sorted Z-values histogram for motif HMGA1,2.p2

Sorted Z-values for motif HMGA1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMGA1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_45402907 62.425 Col3a1
collagen, type III, alpha 1
chr1_+_45368443 40.100 Col3a1
collagen, type III, alpha 1
chr1_+_45390415 31.580 Col3a1
collagen, type III, alpha 1
chr1_+_45401303 30.732 Col3a1
collagen, type III, alpha 1
chr6_+_4490515 27.579 Col1a2
collagen, type I, alpha 2
chr10_+_96944961 26.957 NM_007833
 Dcn
decorin
chr6_+_4484651 21.361 Col1a2
collagen, type I, alpha 2
chr5_-_17394564 19.771 Cd36
CD36 antigen
chr3_-_10208575 17.049 NM_024406
 Fabp4
fatty acid binding protein 4, adipocyte
chr12_+_110783593 16.842 Meg3
maternally expressed 3
chr8_-_87297283 16.411 Nfix
nuclear factor I/X
chr1_+_45368382 15.688 NM_009930
 Col3a1
collagen, type III, alpha 1
chr1_-_172018982 14.341 NM_022563
 Ddr2
discoidin domain receptor family, member 2
chr1_-_66991625 14.132 NM_021285
 Myl1
myosin, light polypeptide 1
chr15_-_3421486 13.937 NM_001048147
 Ghr
growth hormone receptor
chr9_-_117161564 13.793 NM_001172122
NM_001172123
NM_001172124
NM_001172126
NM_178660
 Rbms3




RNA binding motif, single stranded interacting protein




chr5_-_17355533 13.092 NM_001159556
NM_001159557
 Cd36

CD36 antigen

chr6_+_4483741 12.861 Col1a2
collagen, type I, alpha 2
chr12_+_110783786 12.771 Meg3
maternally expressed 3
chr1_-_66991580 12.702 Myl1
myosin, light polypeptide 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 41 entries
Enrichment   P-value GO Accession GO Term
2.63 9.54e-04 GO:0042060 wound healing
2.62 1.91e-02 GO:0030198 extracellular matrix organization
2.46 2.22e-03 GO:0043062 extracellular structure organization
2.07 1.04e-08 GO:0007155 cell adhesion
2.05 1.72e-08 GO:0022610 biological adhesion
2.03 4.36e-03 GO:0032787 monocarboxylic acid metabolic process
1.93 2.64e-03 GO:0009611 response to wounding
1.92 3.04e-08 GO:0055114 oxidation-reduction process
1.91 3.19e-02 GO:0001944 vasculature development
1.90 4.49e-02 GO:0046903 secretion
1.80 1.38e-04 GO:0006082 organic acid metabolic process
1.78 3.95e-04 GO:0019752 carboxylic acid metabolic process
1.78 3.95e-04 GO:0043436 oxoacid metabolic process
1.76 6.36e-04 GO:0042180 cellular ketone metabolic process
1.71 3.14e-02 GO:0072358 cardiovascular system development
1.71 3.14e-02 GO:0072359 circulatory system development
1.60 2.99e-09 GO:0065008 regulation of biological quality
1.60 2.97e-03 GO:2000026 regulation of multicellular organismal development
1.56 4.78e-02 GO:0048699 generation of neurons
1.55 2.58e-02 GO:0022008 neurogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 41 entries
Enrichment   P-value GO Accession GO Term
8.01 2.02e-03 GO:0060076 excitatory synapse
4.84 6.54e-03 GO:0005581 collagen
3.12 1.02e-05 GO:0044420 extracellular matrix part
2.70 3.60e-02 GO:0030427 site of polarized growth
2.48 7.14e-08 GO:0005578 proteinaceous extracellular matrix
2.38 5.66e-03 GO:0005938 cell cortex
2.31 2.63e-02 GO:0019717 synaptosome
2.26 1.41e-06 GO:0031012 extracellular matrix
2.16 1.47e-13 GO:0005615 extracellular space
2.15 2.11e-05 GO:0043025 neuronal cell body
2.14 5.75e-05 GO:0005792 microsome
2.12 5.48e-05 GO:0042598 vesicular fraction
2.08 4.66e-05 GO:0044297 cell body
2.07 9.35e-16 GO:0044421 extracellular region part
2.07 3.28e-02 GO:0016324 apical plasma membrane
2.02 2.02e-03 GO:0005773 vacuole
2.01 7.31e-13 GO:0005624 membrane fraction
2.01 6.79e-03 GO:0045177 apical part of cell
1.99 4.85e-13 GO:0005626 insoluble fraction
1.90 2.52e-14 GO:0000267 cell fraction

Gene overrepresentation in function category:

Showing 1 to 20 of 25 entries
Enrichment   P-value GO Accession GO Term
7.34 7.20e-03 GO:0005161 platelet-derived growth factor receptor binding
4.19 4.40e-02 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
3.59 4.67e-02 GO:0043498 cell surface binding
2.76 4.32e-03 GO:0019838 growth factor binding
2.71 8.84e-03 GO:0008201 heparin binding
2.63 1.79e-03 GO:0004497 monooxygenase activity
2.59 1.66e-03 GO:0005539 glycosaminoglycan binding
2.52 4.49e-02 GO:0004867 serine-type endopeptidase inhibitor activity
2.40 5.38e-03 GO:0001871 pattern binding
2.40 5.38e-03 GO:0030247 polysaccharide binding
2.29 1.32e-02 GO:0004866 endopeptidase inhibitor activity
2.21 2.69e-02 GO:0061135 endopeptidase regulator activity
2.17 3.78e-02 GO:0030414 peptidase inhibitor activity
2.05 4.92e-02 GO:0061134 peptidase regulator activity
1.95 4.37e-04 GO:0030246 carbohydrate binding
1.90 7.59e-08 GO:0016491 oxidoreductase activity
1.88 3.76e-03 GO:0032403 protein complex binding
1.64 3.15e-02 GO:0008092 cytoskeletal protein binding
1.63 4.21e-02 GO:0005509 calcium ion binding
1.56 2.80e-03 GO:0019899 enzyme binding