Motif ID: HNF4A_NR2F1,2.p2

Z-value: 3.682


Transcription factors associated with HNF4A_NR2F1,2.p2:

Gene SymbolEntrez IDGene Name
Hnf4a 15378 hepatic nuclear factor 4, alpha
Nr2f1 13865 nuclear receptor subfamily 2, group F, member 1
Nr2f2 11819 nuclear receptor subfamily 2, group F, member 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hnf4achr2_+_1633728890.801.3e-41Click!
Nr2f2chr7_-_775052480.273.0e-04Click!
Nr2f1chr13_-_78338131-0.121.1e-01Click!


Activity profile for motif HNF4A_NR2F1,2.p2.

activity profile for motif HNF4A_NR2F1,2.p2


Sorted Z-values histogram for motif HNF4A_NR2F1,2.p2

Sorted Z-values for motif HNF4A_NR2F1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A_NR2F1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_23146608 66.772 NM_009605
Adipoq
adiponectin, C1Q and collagen domain containing
chr16_+_23146631 65.661 Adipoq
adiponectin, C1Q and collagen domain containing
chr16_+_5007426 62.376 Gm5480
predicted gene 5480
chr2_+_172978566 58.944 NM_011044
Pck1
phosphoenolpyruvate carboxykinase 1, cytosolic
chr3_+_122598292 52.638 NM_007980
Fabp2
fatty acid binding protein 2, intestinal
chr14_-_56377206 49.852 Cideb
cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
chr14_-_56377231 49.796 Cideb
cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
chr14_-_56377278 49.458 Cideb
cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
chr14_-_56377260 49.111 NM_009894
Cideb
cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
chr11_-_73137838 44.509 Aspa
aspartoacylase
chr17_-_43639675 43.356 NM_008585
Mep1a
meprin 1 alpha
chr9_+_46036703 42.983 NM_009692
Apoa1
apolipoprotein A-I
chr18_+_21230844 40.793 NM_008586
Mep1b
meprin 1 beta
chr11_-_77707282 39.019 NM_008952
Pipox
pipecolic acid oxidase
chr12_+_37968225 38.968 NM_178767
Tmem195
transmembrane protein 195
chr9_+_46036788 38.562 Apoa1
apolipoprotein A-I
chr4_-_129851289 37.499 Tinagl1
tubulointerstitial nephritis antigen-like 1
chr9_+_46036799 36.528 Apoa1
apolipoprotein A-I
chr1_+_74455956 35.825 NM_009509
Vil1
villin 1
chr7_+_150659707 34.871 Slc22a18
solute carrier family 22 (organic cation transporter), member 18
chr7_+_150659625 33.958 NM_008767
Slc22a18
solute carrier family 22 (organic cation transporter), member 18
chr15_+_82282806 33.088 NM_010006
Cyp2d9
cytochrome P450, family 2, subfamily d, polypeptide 9
chr6_+_71149869 32.949 NM_017399
Fabp1
fatty acid binding protein 1, liver
chr4_-_61179982 31.676 Mup1
major urinary protein 1
chr9_-_15105965 31.620 NM_133732
4931406C07Rik
RIKEN cDNA 4931406C07 gene
chrX_+_136343083 31.156 Cldn2
claudin 2
chr3_+_94736993 30.992 NM_009150
Selenbp1
selenium binding protein 1
chr10_-_88969371 30.980 NM_001163700
NM_009108
Nr1h4

nuclear receptor subfamily 1, group H, member 4

chr19_+_23239333 30.774 Klf9
Kruppel-like factor 9
chr1_+_162917586 30.753 Serpinc1
serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
chr4_-_60235470 30.511 NM_001134676
Mup8
major urinary protein 8
chr17_-_34999458 30.151 NM_001142706
NM_008198
Cfb

complement factor B

chr1_+_162917640 30.101 Serpinc1
serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
chr3_+_107680147 30.001 NM_133867
Eps8l3
EPS8-like 3
chr3_+_94736974 29.665 Selenbp1
selenium binding protein 1
chr9_-_15105864 29.583 4931406C07Rik
RIKEN cDNA 4931406C07 gene
chr10_-_128397928 28.794 NM_027853
Mettl7b
methyltransferase like 7B
chr17_+_24879324 28.480 Sepx1
selenoprotein X 1
chr11_-_73138102 28.433 NM_023113
Aspa
aspartoacylase
chr8_+_107450138 27.801 NM_001163756
NM_172759
Ces2e

carboxylesterase 2E

chr7_-_106844083 27.722 Slco2b1
solute carrier organic anion transporter family, member 2b1
chr17_-_34999068 27.625 Cfb
complement factor B
chr7_-_31840647 27.569 NM_019503
NM_052992
Fxyd1

FXYD domain-containing ion transport regulator 1

chr11_+_32183671 27.411 NM_001083955
NM_008218
Hba-a2
Hba-a1
hemoglobin alpha, adult chain 2
hemoglobin alpha, adult chain 1
chr15_+_3220766 27.232 NM_001042613
NM_001042614
NM_009155
Sepp1


selenoprotein P, plasma, 1


chr11_+_32196488 27.141 NM_001083955
NM_008218
Hba-a2
Hba-a1
hemoglobin alpha, adult chain 2
hemoglobin alpha, adult chain 1
chr15_+_3220999 27.002 Sepp1
selenoprotein P, plasma, 1
chr11_+_58192533 26.968 NM_001083884
NM_027339
2210415F13Rik

RIKEN cDNA 2210415F13 gene

chr15_-_3421486 26.340 NM_001048147
Ghr
growth hormone receptor
chr3_+_94497485 26.280 NM_019414
Selenbp2
selenium binding protein 2
chr13_-_41923709 25.624 9530008L14Rik
RIKEN cDNA 9530008L14 gene
chr15_+_3220994 25.542 Sepp1
selenoprotein P, plasma, 1
chr19_+_4594318 25.163 NM_008797
Pcx
pyruvate carboxylase
chr17_-_35018943 24.807 C2
complement component 2 (within H-2S)
chr1_-_45982242 24.723 NM_016917
Slc40a1
solute carrier family 40 (iron-regulated transporter), member 1
chr6_+_72306146 23.824 Tmem150a
transmembrane protein 150A
chr3_-_129035406 23.795 NM_007934
Enpep
glutamyl aminopeptidase
chr11_-_3831515 23.745 Tcn2
transcobalamin 2
chr8_+_58773321 23.658 NM_008278
Hpgd
hydroxyprostaglandin dehydrogenase 15 (NAD)
chr17_-_34960292 23.460 NM_011413
C4a
complement component 4A (Rodgers blood group)
chr19_-_44482138 23.451 NM_009127
Scd1
stearoyl-Coenzyme A desaturase 1
chr9_-_46043339 23.110 NM_023114
Apoc3
apolipoprotein C-III
chr19_-_44482033 23.064 Scd1
stearoyl-Coenzyme A desaturase 1
chr7_-_31840594 22.999 Fxyd1
FXYD domain-containing ion transport regulator 1
chr17_-_34880784 22.830 NM_009780
C4b
complement component 4B (Childo blood group)
chr7_+_50699457 22.795 NM_026695
Etfb
electron transferring flavoprotein, beta polypeptide
chr1_-_122017495 22.656 NM_001037999
Dbi
diazepam binding inhibitor
chr11_-_83406475 22.434 NM_009139
Ccl6
chemokine (C-C motif) ligand 6
chr6_-_124492297 22.302 NM_144938
NM_001097617
C1s

complement component 1, s subcomponent

chr15_+_101933364 22.278 NM_153533
Tenc1
tensin like C1 domain-containing phosphatase
chr19_+_46206383 21.904 NM_007703
Elovl3
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3
chr16_+_8513513 21.758 NM_001170978
NM_172961
Abat

4-aminobutyrate aminotransferase

chr19_-_44481898 21.509 Scd1
stearoyl-Coenzyme A desaturase 1
chr17_-_57354126 21.442 C3
complement component 3
chr6_-_128476708 21.068 NM_007376
Pzp
pregnancy zone protein
chr6_+_90424727 20.978 Klf15
Kruppel-like factor 15
chr6_+_138089041 20.190 NM_019946
Mgst1
microsomal glutathione S-transferase 1
chr7_+_148106800 20.130 NM_001081389
Nlrp6
NLR family, pyrin domain containing 6
chr13_-_94407590 20.047 NM_016668
Bhmt
betaine-homocysteine methyltransferase
chr8_+_11443165 19.567 Col4a2
collagen, type IV, alpha 2
chr19_-_44471675 19.474 Scd1
stearoyl-Coenzyme A desaturase 1
chr2_+_122090555 19.474 Sord
sorbitol dehydrogenase
chr3_+_98084352 19.155 NM_008256
Hmgcs2
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
chr1_+_159456274 19.023 NM_001159986
Sec16b
SEC16 homolog B (S. cerevisiae)
chr1_-_157659936 18.936 NM_001024945
NM_023268
Qsox1

quiescin Q6 sulfhydryl oxidase 1

chr19_-_39961258 18.887 NM_001104525
Cyp2c69
cytochrome P450, family 2, subfamily c, polypeptide 69
chr3_+_90346956 18.867 S100a16
S100 calcium binding protein A16
chr3_+_59835700 18.816 NM_023383
Aadac
arylacetamide deacetylase (esterase)
chr9_-_21940154 18.749 NM_001102405
Acp5
acid phosphatase 5, tartrate resistant
chr19_-_39887217 18.588 NM_010004
Cyp2c40
cytochrome P450, family 2, subfamily c, polypeptide 40
chr10_-_80555271 18.573 Creb3l3
cAMP responsive element binding protein 3-like 3
chr16_+_33794452 18.431 Muc13
mucin 13, epithelial transmembrane
chr12_-_104976382 18.427 NM_009244
Serpina1b
serine (or cysteine) preptidase inhibitor, clade A, member 1B
chr4_-_61335031 18.302 Mup10
LOC100048884
Mup19
Mup1
Mup2
major urinary protein 10
novel member of the major urinary protein (Mup) gene family
major urinary protein 19
major urinary protein 1
major urinary protein 2
chr11_+_101229029 18.296 NM_008061
G6pc
glucose-6-phosphatase, catalytic
chr2_-_110145819 18.257 Bbox1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase)
chr11_-_3831963 18.112 NM_001130459
NM_015749
NM_001130458
Tcn2


transcobalamin 2


chr5_-_136220001 18.110 NM_172541
Tmem120a
transmembrane protein 120A
chr5_-_146821173 17.977 NM_019792
Cyp3a25
cytochrome P450, family 3, subfamily a, polypeptide 25
chr7_-_52830518 17.930 0610005C13Rik
RIKEN cDNA 0610005C13 gene
chr5_+_146890818 17.832 NM_001105160
Cyp3a59
cytochrome P450, subfamily 3A, polypeptide 59
chr11_+_98308147 17.776 NM_010346
Grb7
growth factor receptor bound protein 7
chr7_-_26181005 17.695 NM_010719
Lipe
lipase, hormone sensitive
chr17_-_35019039 17.682 NM_013484
C2
complement component 2 (within H-2S)
chr19_-_44472087 17.227 Scd1
stearoyl-Coenzyme A desaturase 1
chr3_-_89084872 17.225 NM_001162425
Efna1
ephrin A1
chr10_-_80555389 17.138 Creb3l3
cAMP responsive element binding protein 3-like 3
chr11_+_98308333 17.119 Grb7
growth factor receptor bound protein 7
chr7_+_27620354 17.090 NM_007812
Cyp2a5
cytochrome P450, family 2, subfamily a, polypeptide 5
chr5_-_115569276 17.088 NM_007383
Acads
acyl-Coenzyme A dehydrogenase, short chain
chr19_+_39361574 17.077 NM_007815
Cyp2c29
cytochrome P450, family 2, subfamily c, polypeptide 29
chr2_+_121183509 16.905 Ckmt1
creatine kinase, mitochondrial 1, ubiquitous
chr15_+_98929891 16.873 NM_176835
Dnajc22
DnaJ (Hsp40) homolog, subfamily C, member 22
chr3_+_118265066 16.804 NM_170778
Dpyd
dihydropyrimidine dehydrogenase
chr17_-_46575402 16.764 NM_144856
Slc22a7
solute carrier family 22 (organic anion transporter), member 7
chr19_+_39081508 16.751 NM_028089
Cyp2c55
cytochrome P450, family 2, subfamily c, polypeptide 55
chr1_+_173155414 16.742 Apoa2
apolipoprotein A-II
chr6_+_48791616 16.697 NM_001098271
Tmem176a
transmembrane protein 176A
chr7_+_51480806 16.666 NM_010639
Klk1
kallikrein 1
chr10_+_127213437 16.596 NM_153133
Rdh9
retinol dehydrogenase 9
chr16_+_31422377 16.543 NM_175177
Bdh1
3-hydroxybutyrate dehydrogenase, type 1
chr3_+_90345082 16.522 NM_026416
S100a16
S100 calcium binding protein A16
chr15_-_82237600 16.432 NM_010005
Cyp2d10
cytochrome P450, family 2, subfamily d, polypeptide 10
chr19_-_8206403 16.302 NM_001013820
Gm5631
predicted gene 5631
chr10_-_6806261 16.058 NM_027391
Iyd
iodotyrosine deiodinase
chr13_-_94407455 16.041 Bhmt
betaine-homocysteine methyltransferase
chr7_+_27620380 15.961 Cyp2a4
Cyp2a5
cytochrome P450, family 2, subfamily a, polypeptide 4
cytochrome P450, family 2, subfamily a, polypeptide 5
chr17_-_35268696 15.949 NM_018816
Apom
apolipoprotein M
chr19_-_8479532 15.937 NM_177002
C730048C13Rik
RIKEN cDNA C730048C13 gene
chr2_+_169459145 15.889 NM_080455
Tshz2
teashirt zinc finger family member 2
chr9_-_121825407 15.790 Cyp8b1
cytochrome P450, family 8, subfamily b, polypeptide 1
chr2_-_13413502 15.704 NM_001081084
Cubn
cubilin (intrinsic factor-cobalamin receptor)
chr19_+_12707680 15.631 NM_145935
Glyat
glycine-N-acyltransferase
chr10_+_58866370 15.565 NM_023530
Pla2g12b
phospholipase A2, group XIIB
chr17_-_31266539 15.474 NM_011575
Tff3
trefoil factor 3, intestinal
chr7_+_29618812 15.471 NM_010706
Lgals4
Lgals6
lectin, galactose binding, soluble 4
lectin, galactose binding, soluble 6
chr16_-_21787906 15.280 NM_023737
Ehhadh
enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase
chr7_+_27904997 15.279 Cyp2f2
cytochrome P450, family 2, subfamily f, polypeptide 2
chr7_+_127317371 15.223 NM_028085
Anks4b
ankyrin repeat and sterile alpha motif domain containing 4B
chr9_-_121825422 15.132 NM_010012
Cyp8b1
cytochrome P450, family 8, subfamily b, polypeptide 1
chr17_-_46575337 15.125 Slc22a7
solute carrier family 22 (organic anion transporter), member 7
chr2_-_110145870 15.014 NM_130452
Bbox1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase)
chr10_+_81022283 14.921 Aes
amino-terminal enhancer of split
chr6_+_124613114 14.884 NM_145130
Lpcat3
lysophosphatidylcholine acyltransferase 3
chr1_+_173155184 14.862 NM_013474
Apoa2
apolipoprotein A-II
chr5_-_87964170 14.857 Sult1b1
sulfotransferase family 1B, member 1
chr7_+_51720804 14.779 NM_026690
Aspdh
aspartate dehydrogenase domain containing
chrX_+_9829439 14.773 NM_008769
Otc
ornithine transcarbamylase
chrX_+_20126893 14.771 NM_009060
Rgn
regucalcin
chr11_-_100007218 14.727 NM_008471
Krt19
keratin 19
chr9_+_62705890 14.714 NM_001102468
NM_138304
Calml4

calmodulin-like 4

chr15_+_101980990 14.626 NM_146064
Soat2
sterol O-acyltransferase 2
chr3_-_137794277 14.567 NM_008642
Mttp
microsomal triglyceride transfer protein
chr5_-_104406333 14.409 Hsd17b13
hydroxysteroid (17-beta) dehydrogenase 13
chr7_+_147279293 14.326 NM_009475
Prap1
proline-rich acidic protein 1
chr10_-_25255955 14.307 NM_001195596
2010003K15Rik
RIKEN cDNA 2010003K15 gene
chr14_+_32031041 14.297 NM_001025379
Sema3g
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr15_-_96850752 14.264 Slc38a4
solute carrier family 38, member 4
chr16_+_33794122 14.239 NM_010739
Muc13
mucin 13, epithelial transmembrane
chr19_-_39815529 14.139 Cyp2c68
cytochrome P450, family 2, subfamily c, polypeptide 68
chr18_+_85020800 14.135 NM_025797
Cyb5
cytochrome b-5
chr16_-_21787868 14.089 Ehhadh
enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase
chr1_-_88998180 14.052 NM_001081082
Alpi
alkaline phosphatase, intestinal
chr15_+_6395353 14.047 C9
complement component 9
chr10_+_81022229 14.037 Aes
amino-terminal enhancer of split
chr4_+_97444312 14.029 NM_001122953
NM_010905
Nfia

nuclear factor I/A

chr12_-_86715324 13.980 Tmed10
transmembrane emp24-like trafficking protein 10 (yeast)
chr7_-_142720274 13.944 NM_178669
Clrn3
clarin 3
chr18_+_85020742 13.891 Cyb5
cytochrome b-5
chr7_-_26180629 13.812 Lipe
lipase, hormone sensitive
chr3_-_79432487 13.751 NM_025794
Etfdh
electron transferring flavoprotein, dehydrogenase
chr3_-_121518046 13.696 NM_008991
Abcd3
ATP-binding cassette, sub-family D (ALD), member 3
chr10_+_81022304 13.675 NM_010347
Aes
amino-terminal enhancer of split
chr9_-_103119803 13.663 Trf
transferrin
chrX_+_93650774 13.635 NM_001159628
NM_010417
Heph

hephaestin

chr9_+_46048812 13.617 NM_007468
Apoa4
apolipoprotein A-IV
chr8_-_95753501 13.596 NM_133660
Ces1e
carboxylesterase 1E
chr12_+_7984451 13.530 NM_009693
Apob
apolipoprotein B
chr3_+_137949734 13.478 Adh1
alcohol dehydrogenase 1 (class I)
chr17_+_57201623 13.475 NM_177638
Crb3
crumbs homolog 3 (Drosophila)
chr4_-_137923869 13.423 NM_028176
Cda
cytidine deaminase
chr17_-_26005645 13.361 Fam195a
family with sequence similarity 195, member A
chr2_-_25356025 13.236 NM_027062
C8g
complement component 8, gamma polypeptide
chr9_+_107479247 13.229 NM_008317
Hyal1
hyaluronoglucosaminidase 1
chr18_+_20716598 13.215 NM_007883
Dsg2
desmoglein 2
chr11_-_4604308 13.147 NM_197979
Uqcr10
ubiquinol-cytochrome c reductase, complex III subunit X
chr9_+_46048993 13.056 Apoa4
apolipoprotein A-IV
chr16_-_20716708 13.040 NM_009900
Clcn2
chloride channel 2
chr8_-_13200534 13.008 NM_025768
Grtp1
GH regulated TBC protein 1
chr12_-_85741801 13.001 Entpd5
ectonucleoside triphosphate diphosphohydrolase 5
chr11_-_53236630 12.937 NM_153069
Leap2
liver-expressed antimicrobial peptide 2
chr8_+_46035561 12.908 NM_001081286
Fat1
FAT tumor suppressor homolog 1 (Drosophila)
chr18_+_74893369 12.908 Myo5b
myosin VB
chr7_-_52359079 12.905 NM_010189
Fcgrt
Fc receptor, IgG, alpha chain transporter
chr17_-_84246141 12.877 Haao
3-hydroxyanthranilate 3,4-dioxygenase
chr16_-_23029138 12.855 Kng2
kininogen 2
chr9_+_46049140 12.813 Apoa4
apolipoprotein A-IV
chr8_+_11313002 12.812 Col4a2
collagen, type IV, alpha 2
chr10_-_79446784 12.791 ORF61
open reading frame 61
chr15_-_89011113 12.719 NM_138749
Plxnb2
plexin B2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.01 5.82e-29 GO:0044281 small molecule metabolic process
2.74 9.68e-29 GO:0006082 organic acid metabolic process
2.71 5.10e-28 GO:0042180 cellular ketone metabolic process
2.71 3.25e-27 GO:0019752 carboxylic acid metabolic process
2.71 3.25e-27 GO:0043436 oxoacid metabolic process
2.51 6.06e-27 GO:0055114 oxidation-reduction process
1.34 1.61e-25 GO:0008152 metabolic process
2.21 8.37e-19 GO:0006629 lipid metabolic process
2.42 6.11e-18 GO:0044255 cellular lipid metabolic process
3.02 1.16e-17 GO:0032787 monocarboxylic acid metabolic process
1.51 4.77e-13 GO:0006810 transport
1.50 1.17e-12 GO:0051234 establishment of localization
1.28 1.45e-12 GO:0044237 cellular metabolic process
3.02 1.47e-12 GO:0006631 fatty acid metabolic process
1.44 5.29e-12 GO:0051179 localization
1.26 6.83e-11 GO:0044238 primary metabolic process
2.42 8.13e-11 GO:0006066 alcohol metabolic process
2.25 4.16e-10 GO:0044283 small molecule biosynthetic process
1.55 7.18e-09 GO:0042221 response to chemical stimulus
2.96 4.80e-08 GO:0016042 lipid catabolic process
2.69 2.85e-07 GO:0046486 glycerolipid metabolic process
2.24 2.92e-07 GO:0044106 cellular amine metabolic process
2.65 3.23e-07 GO:0016053 organic acid biosynthetic process
2.65 3.23e-07 GO:0046394 carboxylic acid biosynthetic process
2.56 7.45e-07 GO:0051186 cofactor metabolic process
1.59 1.22e-06 GO:0009056 catabolic process
2.73 2.26e-06 GO:0006732 coenzyme metabolic process
2.01 6.64e-06 GO:0009308 amine metabolic process
3.47 1.31e-05 GO:0044242 cellular lipid catabolic process
3.06 1.73e-05 GO:0016054 organic acid catabolic process
3.06 1.73e-05 GO:0046395 carboxylic acid catabolic process
2.50 2.74e-05 GO:0008202 steroid metabolic process
2.34 4.03e-05 GO:0006091 generation of precursor metabolites and energy
3.71 4.47e-05 GO:0006641 triglyceride metabolic process
3.18 5.89e-05 GO:0018904 organic ether metabolic process
3.42 6.97e-05 GO:0006638 neutral lipid metabolic process
2.02 7.54e-05 GO:0071702 organic substance transport
2.00 1.06e-04 GO:0009725 response to hormone stimulus
1.99 1.48e-04 GO:0044262 cellular carbohydrate metabolic process
3.14 1.50e-04 GO:0006662 glycerol ether metabolic process
3.37 1.84e-04 GO:0006639 acylglycerol metabolic process
2.49 3.24e-04 GO:0043434 response to peptide hormone stimulus
1.82 3.70e-04 GO:0005975 carbohydrate metabolic process
1.72 3.95e-04 GO:0046483 heterocycle metabolic process
1.89 4.81e-04 GO:0009719 response to endogenous stimulus
1.95 5.87e-04 GO:0008610 lipid biosynthetic process
1.80 6.94e-04 GO:0044282 small molecule catabolic process
2.41 7.36e-04 GO:0005996 monosaccharide metabolic process
1.68 9.65e-04 GO:0070887 cellular response to chemical stimulus
4.73 9.65e-04 GO:0097006 regulation of plasma lipoprotein particle levels
2.43 1.28e-03 GO:0006979 response to oxidative stress
2.06 1.64e-03 GO:0006520 cellular amino acid metabolic process
2.47 1.88e-03 GO:0010876 lipid localization
3.48 2.48e-03 GO:0055088 lipid homeostasis
2.43 2.61e-03 GO:0014706 striated muscle tissue development
3.93 2.90e-03 GO:0019395 fatty acid oxidation
3.93 2.90e-03 GO:0034440 lipid oxidation
1.36 4.04e-03 GO:0065008 regulation of biological quality
1.91 4.70e-03 GO:0044271 cellular nitrogen compound biosynthetic process
1.49 5.11e-03 GO:0044248 cellular catabolic process
2.73 5.24e-03 GO:0006006 glucose metabolic process
2.14 5.50e-03 GO:0071495 cellular response to endogenous stimulus
1.28 5.56e-03 GO:0048518 positive regulation of biological process
2.32 5.86e-03 GO:0007517 muscle organ development
2.46 5.95e-03 GO:0006869 lipid transport
4.39 7.14e-03 GO:0042439 ethanolamine-containing compound metabolic process
1.29 7.45e-03 GO:0048522 positive regulation of cellular process
1.47 7.57e-03 GO:0010033 response to organic substance
6.08 9.67e-03 GO:0046627 negative regulation of insulin receptor signaling pathway
2.16 9.99e-03 GO:0032870 cellular response to hormone stimulus
3.77 1.16e-02 GO:0042632 cholesterol homeostasis
3.77 1.16e-02 GO:0055092 sterol homeostasis
1.43 1.25e-02 GO:0033036 macromolecule localization
2.40 1.50e-02 GO:0019318 hexose metabolic process
2.25 1.61e-02 GO:0060537 muscle tissue development
2.58 1.63e-02 GO:0006575 cellular modified amino acid metabolic process
3.88 1.66e-02 GO:0009062 fatty acid catabolic process
3.88 1.66e-02 GO:0043648 dicarboxylic acid metabolic process
7.56 1.70e-02 GO:0042737 drug catabolic process
1.46 1.84e-02 GO:0032879 regulation of localization
1.97 1.87e-02 GO:0061061 muscle structure development
2.15 2.01e-02 GO:0010035 response to inorganic substance
2.80 2.09e-02 GO:0030258 lipid modification
2.57 2.54e-02 GO:0045017 glycerolipid biosynthetic process
4.91 3.24e-02 GO:0046470 phosphatidylcholine metabolic process
4.91 3.24e-02 GO:0071825 protein-lipid complex subunit organization
4.91 3.24e-02 GO:0071827 plasma lipoprotein particle organization
2.20 3.72e-02 GO:0015849 organic acid transport
2.70 3.81e-02 GO:0006576 cellular biogenic amine metabolic process
1.54 4.04e-02 GO:0055085 transmembrane transport
1.59 4.06e-02 GO:0016192 vesicle-mediated transport
1.67 4.29e-02 GO:0071310 cellular response to organic substance
3.60 4.45e-02 GO:0072329 monocarboxylic acid catabolic process
2.54 4.74e-02 GO:0006633 fatty acid biosynthetic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.60 7.91e-51 GO:0044444 cytoplasmic part
1.40 1.56e-42 GO:0005737 cytoplasm
2.08 2.68e-31 GO:0005739 mitochondrion
1.23 1.89e-25 GO:0005622 intracellular
1.24 2.78e-25 GO:0044424 intracellular part
2.08 2.81e-21 GO:0005783 endoplasmic reticulum
1.28 3.27e-21 GO:0043227 membrane-bounded organelle
1.28 1.09e-20 GO:0043231 intracellular membrane-bounded organelle
1.25 1.56e-20 GO:0043226 organelle
1.25 3.44e-20 GO:0043229 intracellular organelle
1.94 7.19e-19 GO:0031090 organelle membrane
2.37 1.81e-16 GO:0044429 mitochondrial part
1.84 5.48e-15 GO:0000267 cell fraction
2.61 1.28e-12 GO:0005743 mitochondrial inner membrane
1.88 2.30e-12 GO:0005626 insoluble fraction
2.32 6.41e-12 GO:0005740 mitochondrial envelope
2.34 9.59e-12 GO:0031966 mitochondrial membrane
2.05 1.92e-11 GO:0031967 organelle envelope
1.86 2.20e-11 GO:0005624 membrane fraction
2.48 2.53e-11 GO:0019866 organelle inner membrane
2.51 4.08e-11 GO:0042598 vesicular fraction
2.02 5.49e-11 GO:0031975 envelope
2.51 9.87e-11 GO:0005792 microsome
1.09 7.62e-10 GO:0005623 cell
1.09 7.62e-10 GO:0044464 cell part
1.84 1.88e-09 GO:0012505 endomembrane system
2.89 1.13e-07 GO:0005759 mitochondrial matrix
1.62 3.91e-06 GO:0005794 Golgi apparatus
1.40 2.56e-05 GO:0005576 extracellular region
6.60 3.03e-05 GO:0034361 very-low-density lipoprotein particle
6.60 3.03e-05 GO:0034385 triglyceride-rich lipoprotein particle
2.16 5.86e-05 GO:0045177 apical part of cell
2.36 6.87e-05 GO:0016324 apical plasma membrane
2.03 7.25e-05 GO:0044432 endoplasmic reticulum part
1.14 1.45e-04 GO:0016020 membrane
2.75 2.36e-04 GO:0005777 peroxisome
2.75 2.36e-04 GO:0042579 microbody
3.48 3.33e-04 GO:0005903 brush border
1.21 6.28e-04 GO:0044422 organelle part
2.01 6.94e-04 GO:0005789 endoplasmic reticulum membrane
1.96 1.14e-03 GO:0042175 nuclear membrane-endoplasmic reticulum network
1.82 2.06e-03 GO:0005625 soluble fraction
1.92 2.14e-03 GO:0015629 actin cytoskeleton
1.46 3.93e-03 GO:0044421 extracellular region part
1.20 4.84e-03 GO:0044446 intracellular organelle part
6.87 5.76e-03 GO:0042627 chylomicron
1.52 8.00e-03 GO:0005615 extracellular space
2.58 1.09e-02 GO:0030017 sarcomere
1.96 1.21e-02 GO:0016323 basolateral plasma membrane
1.29 1.99e-02 GO:0044459 plasma membrane part
1.79 2.08e-02 GO:0044431 Golgi apparatus part
3.71 3.62e-02 GO:0032994 protein-lipid complex
3.71 3.62e-02 GO:0034358 plasma lipoprotein particle
2.06 4.24e-02 GO:0000139 Golgi membrane
2.27 4.33e-02 GO:0030016 myofibril
3.60 4.98e-02 GO:0005793 ER-Golgi intermediate compartment

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.43 1.11e-23 GO:0003824 catalytic activity
2.37 1.44e-21 GO:0016491 oxidoreductase activity
2.75 1.78e-11 GO:0048037 cofactor binding
1.16 1.09e-10 GO:0005488 binding
2.94 2.06e-09 GO:0050662 coenzyme binding
2.70 5.80e-08 GO:0005506 iron ion binding
3.19 1.37e-07 GO:0046906 tetrapyrrole binding
3.09 1.12e-06 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
3.10 1.72e-06 GO:0020037 heme binding
2.93 2.91e-06 GO:0004497 monooxygenase activity
3.07 6.60e-06 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
1.21 1.53e-05 GO:0005515 protein binding
3.84 2.25e-05 GO:0033293 monocarboxylic acid binding
4.32 2.68e-05 GO:0016209 antioxidant activity
2.54 3.08e-05 GO:0031406 carboxylic acid binding
1.27 5.45e-05 GO:0043167 ion binding
5.04 8.80e-05 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
1.88 1.72e-04 GO:0008289 lipid binding
1.26 1.91e-04 GO:0043169 cation binding
2.72 2.18e-04 GO:0009055 electron carrier activity
2.10 2.23e-04 GO:0004857 enzyme inhibitor activity
2.83 2.35e-04 GO:0004091 carboxylesterase activity
5.02 2.71e-04 GO:0070330 aromatase activity
1.26 2.75e-04 GO:0046872 metal ion binding
1.62 3.64e-04 GO:0046983 protein dimerization activity
1.37 6.41e-04 GO:0016740 transferase activity
2.35 2.19e-03 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
1.53 4.10e-03 GO:0042802 identical protein binding
3.00 4.20e-03 GO:0050660 flavin adenine dinucleotide binding
5.14 4.77e-03 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
1.66 5.27e-03 GO:0005509 calcium ion binding
1.68 6.94e-03 GO:0042803 protein homodimerization activity
4.18 7.88e-03 GO:0004601 peroxidase activity
4.18 7.88e-03 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor
2.35 1.61e-02 GO:0019842 vitamin binding
1.80 2.05e-02 GO:0022804 active transmembrane transporter activity
1.27 2.88e-02 GO:0000166 nucleotide binding
3.51 3.02e-02 GO:0005504 fatty acid binding
1.40 3.06e-02 GO:0005215 transporter activity
3.12 3.81e-02 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
5.82 4.66e-02 GO:0004602 glutathione peroxidase activity