Motif ID: HNF4A_NR2F1,2.p2

Z-value: 3.682


Transcription factors associated with HNF4A_NR2F1,2.p2:

Gene SymbolEntrez IDGene Name
Hnf4a 15378 hepatic nuclear factor 4, alpha
Nr2f1 13865 nuclear receptor subfamily 2, group F, member 1
Nr2f2 11819 nuclear receptor subfamily 2, group F, member 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hnf4achr2_+_1633728890.801.3e-41Click!
Nr2f2chr7_-_775052480.273.0e-04Click!
Nr2f1chr13_-_78338131-0.121.1e-01Click!


Activity profile for motif HNF4A_NR2F1,2.p2.

activity profile for motif HNF4A_NR2F1,2.p2


Sorted Z-values histogram for motif HNF4A_NR2F1,2.p2

Sorted Z-values for motif HNF4A_NR2F1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A_NR2F1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_23146608 66.772 NM_009605
Adipoq
adiponectin, C1Q and collagen domain containing
chr16_+_23146631 65.661 Adipoq
adiponectin, C1Q and collagen domain containing
chr16_+_5007426 62.376 Gm5480
predicted gene 5480
chr2_+_172978566 58.944 NM_011044
Pck1
phosphoenolpyruvate carboxykinase 1, cytosolic
chr3_+_122598292 52.638 NM_007980
Fabp2
fatty acid binding protein 2, intestinal
chr14_-_56377206 49.852 Cideb
cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
chr14_-_56377231 49.796 Cideb
cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
chr14_-_56377278 49.458 Cideb
cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
chr14_-_56377260 49.111 NM_009894
Cideb
cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
chr11_-_73137838 44.509 Aspa
aspartoacylase
chr17_-_43639675 43.356 NM_008585
Mep1a
meprin 1 alpha
chr9_+_46036703 42.983 NM_009692
Apoa1
apolipoprotein A-I
chr18_+_21230844 40.793 NM_008586
Mep1b
meprin 1 beta
chr11_-_77707282 39.019 NM_008952
Pipox
pipecolic acid oxidase
chr12_+_37968225 38.968 NM_178767
Tmem195
transmembrane protein 195
chr9_+_46036788 38.562 Apoa1
apolipoprotein A-I
chr4_-_129851289 37.499 Tinagl1
tubulointerstitial nephritis antigen-like 1
chr9_+_46036799 36.528 Apoa1
apolipoprotein A-I
chr1_+_74455956 35.825 NM_009509
Vil1
villin 1
chr7_+_150659707 34.871 Slc22a18
solute carrier family 22 (organic cation transporter), member 18

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 94 entries
Enrichment   P-value GO Accession GO Term
7.56 1.70e-02 GO:0042737 drug catabolic process
6.08 9.67e-03 GO:0046627 negative regulation of insulin receptor signaling pathway
4.91 3.24e-02 GO:0046470 phosphatidylcholine metabolic process
4.91 3.24e-02 GO:0071825 protein-lipid complex subunit organization
4.91 3.24e-02 GO:0071827 plasma lipoprotein particle organization
4.73 9.65e-04 GO:0097006 regulation of plasma lipoprotein particle levels
4.39 7.14e-03 GO:0042439 ethanolamine-containing compound metabolic process
3.93 2.90e-03 GO:0019395 fatty acid oxidation
3.93 2.90e-03 GO:0034440 lipid oxidation
3.88 1.66e-02 GO:0009062 fatty acid catabolic process
3.88 1.66e-02 GO:0043648 dicarboxylic acid metabolic process
3.77 1.16e-02 GO:0042632 cholesterol homeostasis
3.77 1.16e-02 GO:0055092 sterol homeostasis
3.71 4.47e-05 GO:0006641 triglyceride metabolic process
3.60 4.45e-02 GO:0072329 monocarboxylic acid catabolic process
3.48 2.48e-03 GO:0055088 lipid homeostasis
3.47 1.31e-05 GO:0044242 cellular lipid catabolic process
3.42 6.97e-05 GO:0006638 neutral lipid metabolic process
3.37 1.84e-04 GO:0006639 acylglycerol metabolic process
3.18 5.89e-05 GO:0018904 organic ether metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 56 entries
Enrichment   P-value GO Accession GO Term
6.87 5.76e-03 GO:0042627 chylomicron
6.60 3.03e-05 GO:0034361 very-low-density lipoprotein particle
6.60 3.03e-05 GO:0034385 triglyceride-rich lipoprotein particle
3.71 3.62e-02 GO:0032994 protein-lipid complex
3.71 3.62e-02 GO:0034358 plasma lipoprotein particle
3.60 4.98e-02 GO:0005793 ER-Golgi intermediate compartment
3.48 3.33e-04 GO:0005903 brush border
2.89 1.13e-07 GO:0005759 mitochondrial matrix
2.75 2.36e-04 GO:0005777 peroxisome
2.75 2.36e-04 GO:0042579 microbody
2.61 1.28e-12 GO:0005743 mitochondrial inner membrane
2.58 1.09e-02 GO:0030017 sarcomere
2.51 4.08e-11 GO:0042598 vesicular fraction
2.51 9.87e-11 GO:0005792 microsome
2.48 2.53e-11 GO:0019866 organelle inner membrane
2.37 1.81e-16 GO:0044429 mitochondrial part
2.36 6.87e-05 GO:0016324 apical plasma membrane
2.34 9.59e-12 GO:0031966 mitochondrial membrane
2.32 6.41e-12 GO:0005740 mitochondrial envelope
2.27 4.33e-02 GO:0030016 myofibril

Gene overrepresentation in function category:

Showing 1 to 20 of 41 entries
Enrichment   P-value GO Accession GO Term
5.82 4.66e-02 GO:0004602 glutathione peroxidase activity
5.14 4.77e-03 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
5.04 8.80e-05 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
5.02 2.71e-04 GO:0070330 aromatase activity
4.32 2.68e-05 GO:0016209 antioxidant activity
4.18 7.88e-03 GO:0004601 peroxidase activity
4.18 7.88e-03 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor
3.84 2.25e-05 GO:0033293 monocarboxylic acid binding
3.51 3.02e-02 GO:0005504 fatty acid binding
3.19 1.37e-07 GO:0046906 tetrapyrrole binding
3.12 3.81e-02 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
3.10 1.72e-06 GO:0020037 heme binding
3.09 1.12e-06 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
3.07 6.60e-06 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
3.00 4.20e-03 GO:0050660 flavin adenine dinucleotide binding
2.94 2.06e-09 GO:0050662 coenzyme binding
2.93 2.91e-06 GO:0004497 monooxygenase activity
2.83 2.35e-04 GO:0004091 carboxylesterase activity
2.75 1.78e-11 GO:0048037 cofactor binding
2.72 2.18e-04 GO:0009055 electron carrier activity