Motif ID: HOX{A4,D4}.p2

Z-value: 1.367


Transcription factors associated with HOX{A4,D4}.p2:

Gene SymbolEntrez IDGene Name
Hoxa4 15401 homeobox A4
Hoxd4 15436 homeobox D4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hoxd4chr2_+_74560034-0.206.3e-03Click!
Hoxa4chr6_-_521416970.018.5e-01Click!


Activity profile for motif HOX{A4,D4}.p2.

activity profile for motif HOX{A4,D4}.p2


Sorted Z-values histogram for motif HOX{A4,D4}.p2

Sorted Z-values for motif HOX{A4,D4}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A4,D4}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_69487700 31.171 Ank3
ankyrin 3, epithelial
chr5_-_122906470 28.190 Atp2a2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
chrX_+_133357268 24.343 NM_011123
Plp1
proteolipid protein (myelin) 1
chr17_+_71168939 23.795 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr11_+_56825307 21.677 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr16_+_7069971 21.595 Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr11_+_56825258 21.243 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr5_-_122907002 20.888 Atp2a2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
chr7_-_107810868 20.027 NM_001163182
NM_013746
Plekhb1

pleckstrin homology domain containing, family B (evectins) member 1

chr12_+_110784600 19.877 Meg3
maternally expressed 3
chr11_+_56825192 19.766 NM_001113325
NM_008165
Gria1

glutamate receptor, ionotropic, AMPA1 (alpha 1)

chr16_+_7069927 19.580 NM_183188
Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr12_+_91570569 19.105 Nrxn3
neurexin III
chr12_+_30219769 18.605 NM_001093776
Myt1l
myelin transcription factor 1-like
chr2_+_177910053 18.451 NM_001177791
Phactr3
phosphatase and actin regulator 3
chr4_+_101180625 17.882 Dnajc6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr10_+_69488049 17.857 Ank3
ankyrin 3, epithelial
chr9_-_91255831 17.552 Zic1
zinc finger protein of the cerebellum 1
chr5_+_89012596 17.420 NM_027530
Rufy3
RUN and FYVE domain containing 3
chr13_+_42775991 17.223 NM_198419
Phactr1
phosphatase and actin regulator 1
chr12_+_30213224 16.617 NM_001093775
NM_001093778
NM_008666
Myt1l


myelin transcription factor 1-like


chr13_+_46597271 16.606 NM_026056
Cap2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr1_-_42724504 15.463 2610017I09Rik
RIKEN cDNA 2610017I09 gene
chr14_+_28689289 15.444 Erc2
ELKS/RAB6-interacting/CAST family member 2
chr13_+_58909254 15.088 Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr13_+_42776161 14.886 Phactr1
phosphatase and actin regulator 1
chr7_-_20284370 14.833 Apoe
apolipoprotein E
chr10_-_63552994 14.816 NM_178678
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr3_+_68376319 14.414 Schip1
schwannomin interacting protein 1
chr5_+_89012537 14.200 Rufy3
RUN and FYVE domain containing 3
chr5_+_89012547 14.164 Rufy3
RUN and FYVE domain containing 3
chr7_-_20284500 14.047 NM_009696
Apoe
apolipoprotein E
chr14_-_109313298 13.931 Slitrk1
SLIT and NTRK-like family, member 1
chr2_+_97306600 13.303


chr3_+_67696141 13.220 NM_001113419
NM_177585
Iqcj-schip1
Iqcj
IQ motif containing J-schwannomin interacting protein 1 read-through transcript
IQ motif containing J
chr5_+_90889913 13.205 NM_009654
Alb
albumin
chrX_-_35605544 12.861 Fam70a
family with sequence similarity 70, member A
chr3_+_68376289 12.848 NM_013928
Schip1
schwannomin interacting protein 1
chr5_+_90889937 12.700 Alb
albumin
chr14_-_109313333 12.396 Slitrk1
SLIT and NTRK-like family, member 1
chr14_-_109313447 12.359 NM_199065
Slitrk1
SLIT and NTRK-like family, member 1
chr15_+_4325490 12.219 NM_177355
Plcxd3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr18_+_61123204 12.050 NM_009792
Camk2a
calcium/calmodulin-dependent protein kinase II alpha
chr18_+_37925233 11.968 NM_033595
Pcdhga12
protocadherin gamma subfamily A, 12
chr16_-_42340613 11.726 NM_008083
Gap43
growth associated protein 43
chr18_+_37834003 11.693 Pcdhga3
protocadherin gamma subfamily A, 3
chr7_+_31092787 11.547 Clip3
CAP-GLY domain containing linker protein 3
chr2_+_61884596 11.544 NM_033552
Slc4a10
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
chr13_+_58909236 11.479 Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr6_-_13785233 11.468 Gpr85
G protein-coupled receptor 85
chrX_+_155897136 11.201 Mtap7d2
MAP7 domain containing 2
chr13_+_58909168 11.136 NM_001025074
Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr3_+_114783882 11.111 NM_153157
Olfm3
olfactomedin 3
chr10_-_31410391 11.046 Nkain2
Na+/K+ transporting ATPase interacting 2
chr8_+_12984287 10.696 Mcf2l
mcf.2 transforming sequence-like
chr4_+_101223198 10.614 NM_001164583
Dnajc6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr9_-_73781373 10.570 NM_001081153
Unc13c
unc-13 homolog C (C. elegans)
chr8_+_12949417 10.538 NM_001159485
NM_001159486
Mcf2l

mcf.2 transforming sequence-like

chr18_-_43219062 10.348 NM_028392
Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr4_-_60594959 10.323 NM_001122647
Mup10
LOC100048884
Mup1
major urinary protein 10
novel member of the major urinary protein (Mup) gene family
major urinary protein 1
chr9_-_49607164 10.172 NM_001081445
NM_001113204
NM_010875
Ncam1


neural cell adhesion molecule 1


chr12_+_110783593 10.008 Meg3
maternally expressed 3
chr6_-_102414660 9.979 NM_008779
Cntn3
contactin 3
chr6_-_92484838 9.963 NM_001134459
Prickle2
prickle homolog 2 (Drosophila)
chr2_+_97307652 9.650 NM_178725
Lrrc4c
leucine rich repeat containing 4C
chr12_+_90191833 9.585 NM_172544
Nrxn3
neurexin III
chr8_-_87461251 9.304 NM_019945
Mast1
microtubule associated serine/threonine kinase 1
chr3_+_17695743 9.259 6430547I21Rik
RIKEN cDNA 6430547I21 gene
chr5_-_84846256 9.156 Epha5
Eph receptor A5
chr11_+_98629709 9.132


chr11_+_87394647 9.129 Sept4
septin 4
chr18_-_32109233 9.092 NM_001025381
Gpr17
G protein-coupled receptor 17
chr13_+_58909632 9.070 Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr10_+_126857922 9.038 NM_001168293
NM_027900
R3hdm2

R3H domain containing 2

chr4_+_138012860 9.026 Camk2n1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr11_+_29607599 9.015 Rtn4
reticulon 4
chr4_-_60889249 8.950 NM_001134674
Mup13
Mup19
Mup1
major urinary protein 13
major urinary protein 19
major urinary protein 1
chr6_+_104443037 8.906 NM_017383
Cntn6
contactin 6
chr12_+_39506844 8.897 NM_007960
Etv1
ets variant gene 1
chr2_-_25325248 8.831 NM_008963
Ptgds
prostaglandin D2 synthase (brain)
chr3_-_146432922 8.816 Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr16_+_96689206 8.694 NM_008791
Pcp4
Purkinje cell protein 4
chr12_+_110806715 8.687 Meg3
maternally expressed 3
chr2_-_25325196 8.606 Ptgds
prostaglandin D2 synthase (brain)
chr15_-_8660729 8.601 NM_148938
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr19_+_27291897 8.581 Vldlr
very low density lipoprotein receptor
chr12_+_101447413 8.482 Calm1
calmodulin 1
chr18_+_37925619 8.410 Pcdhga12
protocadherin gamma subfamily A, 12
chr9_-_83003967 8.406


chr16_+_96689373 8.197 Pcp4
Purkinje cell protein 4
chr12_+_118896501 8.158 Rapgef5
Rap guanine nucleotide exchange factor (GEF) 5
chr4_-_109960078 8.156 NM_001038698
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chrX_-_40627962 8.128 NM_011855
Odz1
odd Oz/ten-m homolog 1 (Drosophila)
chrX_-_35605626 8.105 NM_172930
Fam70a
family with sequence similarity 70, member A
chrX_+_155897056 8.082 Mtap7d2
MAP7 domain containing 2
chr15_-_58614642 7.976 Tmem65
transmembrane protein 65
chr2_-_77357674 7.939 NM_001113400
Zfp385b
zinc finger protein 385B
chr18_-_31476721 7.912 NM_009065
Rit2
Ras-like without CAAX 2
chr12_+_101447480 7.870 Calm1
calmodulin 1
chrX_+_10173557 7.727


chr3_-_146444377 7.674 NM_001164200
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr3_-_117063793 7.574 NM_177664
D3Bwg0562e
DNA segment, Chr 3, Brigham & Women's Genetics 0562 expressed
chr1_-_182123596 7.548 NM_001163290
Adck3
aarF domain containing kinase 3
chrX_-_100381973 7.449 NM_008671
Nap1l2
nucleosome assembly protein 1-like 2
chr18_+_37849488 7.410 NM_033575
Pcdhgb2
protocadherin gamma subfamily B, 2
chr11_+_87394543 7.398 Sept4
septin 4
chr8_+_116729508 7.374 NM_173016
Vat1l
vesicle amine transport protein 1 homolog-like (T. californica)
chr18_+_37979242 7.360 Pcdhgc5
protocadherin gamma subfamily C, 5
chr5_-_121459496 7.217 NM_011286
Rph3a
rabphilin 3A
chr3_-_80606500 7.171 Gria2
glutamate receptor, ionotropic, AMPA2 (alpha 2)
chr9_-_112134984 7.117 NM_001177616
Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr4_-_86876328 7.112 NM_172426
Slc24a2
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
chr5_+_90890764 7.074 Alb
albumin
chr18_+_37595274 7.069 NM_053137
Pcdhb12
protocadherin beta 12
chr14_-_104213981 7.045


chr11_+_87394609 7.022 NM_011129
Sept4
septin 4
chr15_-_73640331 6.976 Ndufb4
NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4
chr10_+_5151833 6.950 NM_001079686
Syne1
synaptic nuclear envelope 1
chr9_+_21742717 6.948 NM_144935
BC018242
cDNA sequence BC018242
chr13_+_20277293 6.826 NM_080288
Elmo1
engulfment and cell motility 1, ced-12 homolog (C. elegans)
chr1_-_5060365 6.799 NM_001177795
Rgs20
regulator of G-protein signaling 20
chr8_-_87461220 6.740 Mast1
microtubule associated serine/threonine kinase 1
chr16_-_84955488 6.716 App
amyloid beta (A4) precursor protein
chr10_+_59763520 6.695 Psap
prosaposin
chr12_-_32398730 6.631 NM_175191
Gpr22
G protein-coupled receptor 22
chr12_+_109843975 6.620 NM_001163395
Evl
Ena-vasodilator stimulated phosphoprotein
chr19_-_55177562 6.608 Gpam
glycerol-3-phosphate acyltransferase, mitochondrial
chr16_-_84955086 6.542 App
amyloid beta (A4) precursor protein
chr6_+_77193078 6.532 Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr11_-_79317471 6.509 Omg
oligodendrocyte myelin glycoprotein
chr18_+_37979199 6.509 NM_033583
Pcdhgb4
Pcdhgc5
protocadherin gamma subfamily B, 4
protocadherin gamma subfamily C, 5
chr1_+_34364633 6.482 Dst
dystonin
chr15_+_91958558 6.420 NM_007727
Cntn1
contactin 1
chr14_+_65885454 6.408 NM_015795
Fbxo16
F-box protein 16
chr12_+_50484907 6.368 Foxg1
forkhead box G1
chr19_+_8915018 6.213 Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chrX_+_132424640 6.197 Bhlhb9
basic helix-loop-helix domain containing, class B9
chr2_+_155215225 6.162 Trp53inp2
transformation related protein 53 inducible nuclear protein 2
chr14_+_66963139 6.150 NM_019675
Stmn4
stathmin-like 4
chr15_-_37389073 6.079 NM_001170867
NM_001170868
Ncald

neurocalcin delta

chr8_+_115093942 6.075 NM_130457
Cntnap4
contactin associated protein-like 4
chr4_+_101180580 6.046 NM_001164584
NM_001164585
Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr14_-_31304341 6.000 NM_028981
Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr18_-_31606908 5.981 NM_009308
Syt4
synaptotagmin IV
chr3_+_136598184 5.975 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr16_+_96689322 5.837


chr19_+_56798916 5.800 Adrb1
adrenergic receptor, beta 1
chr6_+_115189004 5.787 Syn2
synapsin II
chr6_+_77192839 5.771 Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr2_-_73498303 5.754 NM_001166604
NM_175752
Chn1

chimerin (chimaerin) 1

chr12_+_110800212 5.751 Meg3
maternally expressed 3
chr10_+_84218792 5.714 NM_001024918
Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr2_+_59192308 5.697 Pkp4
plakophilin 4
chr18_-_42900793 5.678 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr5_-_139606339 5.678 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr6_+_124948627 5.621 NM_001145926
C530028O21Rik
RIKEN cDNA C530028O21 gene
chr14_-_55613384 5.569 NM_080728
Myh7
myosin, heavy polypeptide 7, cardiac muscle, beta
chr7_+_148817700 5.558 Ap2a2
adaptor protein complex AP-2, alpha 2 subunit
chr2_-_148558110 5.537 NM_019632
Napb
N-ethylmaleimide sensitive fusion protein attachment protein beta
chr3_-_19595395 5.527 NM_205769
Crh
corticotropin releasing hormone
chr6_+_134932018 5.522 NM_001109914
Apold1
apolipoprotein L domain containing 1
chrX_+_20265093 5.499 Cdk16
cyclin-dependent kinase 16
chr7_-_31840647 5.430 NM_019503
NM_052992
Fxyd1

FXYD domain-containing ion transport regulator 1

chr10_+_98486068 5.409 Atp2b1
ATPase, Ca++ transporting, plasma membrane 1
chrX_+_139997806 5.361 NM_008778
Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr13_+_83803830 5.352 Mef2c
myocyte enhancer factor 2C
chr14_-_80171003 5.348 NM_001042726
NM_021543
Pcdh8

protocadherin 8

chrX_+_133371611 5.321 Plp1
proteolipid protein (myelin) 1
chr2_-_23904343 5.270 Hnmt
histamine N-methyltransferase
chr5_+_137506122 5.270 NM_001039385
Vgf
VGF nerve growth factor inducible
chr17_-_43803963 5.258 NM_028711
Slc25a27
solute carrier family 25, member 27
chrX_-_100381703 5.252 Nap1l2
nucleosome assembly protein 1-like 2
chr9_-_107571294 5.110 Slc38a3
solute carrier family 38, member 3
chr4_-_136441982 5.100 NM_009777
C1qb
complement component 1, q subcomponent, beta polypeptide
chr12_+_39510297 5.095 NM_001163154
Etv1
ets variant gene 1
chr8_+_56122680 5.066 Gpm6a
glycoprotein m6a
chr3_-_84024766 5.058 NM_030706
Trim2
tripartite motif-containing 2
chr12_+_110783786 5.012 Meg3
maternally expressed 3
chr2_+_20211539 5.004 NM_001081006
Etl4
enhancer trap locus 4
chr18_+_37460452 4.987 NM_053128
Pcdhb3
protocadherin beta 3
chr19_-_7500486 4.973


chr12_-_4344470 4.970 Ncoa1
nuclear receptor coactivator 1
chr6_-_92431385 4.970 NM_001134460
Prickle2
prickle homolog 2 (Drosophila)
chr19_+_27291507 4.960 NM_001161420
NM_013703
Vldlr

very low density lipoprotein receptor

chr7_-_67285104 4.937 NM_001082962
Snrpn
small nuclear ribonucleoprotein N
chr1_-_67085404 4.927 NM_001190984
NM_001190985
NM_021295
Lancl1


LanC (bacterial lantibiotic synthetase component C)-like 1


chr7_-_31840594 4.901 Fxyd1
FXYD domain-containing ion transport regulator 1
chr6_+_58783693 4.876 NM_028705
Herc3
hect domain and RLD 3
chr5_+_89012600 4.873 Rufy3
RUN and FYVE domain containing 3
chrM_+_12383 4.852


chrX_-_161764912 4.851 NM_183427
Glra2
glycine receptor, alpha 2 subunit
chr5_-_115636064 4.835 NM_013879
Cabp1
calcium binding protein 1
chr9_-_107571304 4.799 Slc38a3
solute carrier family 38, member 3
chr1_+_169548381 4.771 NM_001159731
Rxrg
retinoid X receptor gamma
chr9_-_55983967 4.715 Tspan3
tetraspanin 3
chr8_+_114062242 4.642 NM_001168623
Znrf1
zinc and ring finger 1
chr9_-_60535274 4.641 NM_001146047
Lrrc49
leucine rich repeat containing 49
chr3_-_80606704 4.628 NM_001039195
NM_001083806
NM_013540
Gria2


glutamate receptor, ionotropic, AMPA2 (alpha 2)


chr5_+_107926763 4.608 NM_001007574
NM_001168557
A830010M20Rik

RIKEN cDNA A830010M20 gene

chr6_+_8900018 4.602 NM_008751
Nxph1
neurexophilin 1

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.87 1.17e-07 GO:0000267 cell fraction
2.38 5.49e-07 GO:0045202 synapse
1.95 6.25e-07 GO:0005626 insoluble fraction
1.41 1.27e-06 GO:0071944 cell periphery
1.93 3.56e-06 GO:0005624 membrane fraction
1.39 4.92e-06 GO:0005886 plasma membrane
2.12 1.95e-05 GO:0043005 neuron projection
2.40 9.54e-05 GO:0044297 cell body
1.61 1.04e-04 GO:0005856 cytoskeleton
2.37 1.75e-04 GO:0044456 synapse part
2.39 2.02e-04 GO:0043025 neuronal cell body
2.49 2.18e-04 GO:0030425 dendrite
2.41 1.73e-03 GO:0030424 axon
1.68 2.62e-03 GO:0044430 cytoskeletal part
1.16 1.14e-02 GO:0005737 cytoplasm
1.56 1.50e-02 GO:0042995 cell projection
1.52 2.07e-02 GO:0031090 organelle membrane
2.78 4.16e-02 GO:0043292 contractile fiber

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.29 1.34e-05 GO:0005515 protein binding
2.12 1.12e-04 GO:0008092 cytoskeletal protein binding
1.14 7.35e-04 GO:0005488 binding
2.09 4.45e-02 GO:0003779 actin binding