Motif ID: HSF1,2.p2

Z-value: 2.313


Transcription factors associated with HSF1,2.p2:

Gene SymbolEntrez IDGene Name
Hsf1 15499 heat shock factor 1
Hsf2 15500 heat shock factor 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hsf2chr10_+_57206184-0.063.9e-01Click!
Hsf1chr15_+_76307820-0.037.3e-01Click!


Activity profile for motif HSF1,2.p2.

activity profile for motif HSF1,2.p2


Sorted Z-values histogram for motif HSF1,2.p2

Sorted Z-values for motif HSF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HSF1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_136363914 72.362 Hspb1
heat shock protein 1
chr11_-_55208276 50.467


chrX_+_54032914 43.227 Fhl1
four and a half LIM domains 1
chr1_-_172018982 41.571 NM_022563
 Ddr2
discoidin domain receptor family, member 2
chrX_+_54032858 40.579 NM_001077362
 Fhl1
four and a half LIM domains 1
chr1_-_66981900 40.150 NM_001113387
 Myl1
myosin, light polypeptide 1
chr5_+_136363810 38.667 Hspb1
heat shock protein 1
chr14_-_46149660 38.317 NM_146054
 Fermt2
fermitin family homolog 2 (Drosophila)
chr7_-_74879894 35.907 Synm
synemin, intermediate filament protein
chr4_+_41774206 34.150 NM_011335
NM_001193668
NM_001193666
NM_023052
 Ccl21b
Gm10591
Gm13304
Ccl21a
Ccl21c
chemokine (C-C motif) ligand 21B (leucine)
predicted gene 10591
predicted gene 13304
chemokine (C-C motif) ligand 21A (serine)
chemokine (C-C motif) ligand 21C (leucine)
chr5_+_136363769 33.460 NM_013560
 Hspb1
heat shock protein 1
chr1_+_166726827 31.212 NM_019759
 Dpt
dermatopontin
chr7_+_147949708 31.165 NM_021282
 Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr7_+_147949637 30.387 Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr4_-_82151004 29.701 Nfib
nuclear factor I/B
chr1_-_45559904 28.665 Col5a2
collagen, type V, alpha 2
chr15_-_76881097 27.973 NM_013593
 Mb
myoglobin
chr5_+_17080553 27.678 NM_013657
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr1_-_45559866 27.554 Col5a2
collagen, type V, alpha 2
chr5_-_116872852 27.256 NM_030704
 Hspb8
heat shock protein 8

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 94 entries
Enrichment   P-value GO Accession GO Term
5.69 1.05e-02 GO:0030199 collagen fibril organization
5.25 8.67e-03 GO:0044259 multicellular organismal macromolecule metabolic process
5.10 3.29e-02 GO:0032963 collagen metabolic process
5.05 6.79e-04 GO:0007266 Rho protein signal transduction
4.67 1.26e-02 GO:0010464 regulation of mesenchymal cell proliferation
4.65 3.32e-02 GO:0002053 positive regulation of mesenchymal cell proliferation
4.52 4.49e-02 GO:0044236 multicellular organismal metabolic process
4.33 3.04e-02 GO:0043588 skin development
4.09 2.61e-02 GO:0031016 pancreas development
3.53 2.04e-02 GO:0006641 triglyceride metabolic process
3.46 7.72e-03 GO:0006639 acylglycerol metabolic process
3.37 1.14e-02 GO:0006638 neutral lipid metabolic process
3.18 8.83e-03 GO:0006662 glycerol ether metabolic process
3.13 4.46e-04 GO:0003012 muscle system process
3.11 1.25e-02 GO:0018904 organic ether metabolic process
3.04 6.40e-03 GO:0006936 muscle contraction
2.93 2.70e-03 GO:0030324 lung development
2.89 3.66e-03 GO:0030323 respiratory tube development
2.80 1.71e-03 GO:0006457 protein folding
2.80 4.21e-02 GO:0030278 regulation of ossification

Gene overrepresentation in compartment category:

Showing 1 to 20 of 45 entries
Enrichment   P-value GO Accession GO Term
6.82 4.18e-02 GO:0005583 fibrillar collagen
4.75 2.39e-02 GO:0009925 basal plasma membrane
3.67 2.50e-07 GO:0044420 extracellular matrix part
3.58 2.40e-07 GO:0043292 contractile fiber
3.52 8.97e-06 GO:0044449 contractile fiber part
3.47 5.44e-04 GO:0005604 basement membrane
3.24 5.07e-05 GO:0030016 myofibril
3.21 1.03e-03 GO:0030017 sarcomere
3.21 3.35e-03 GO:0042383 sarcolemma
2.93 7.63e-03 GO:0016327 apicolateral plasma membrane
2.83 1.99e-02 GO:0043296 apical junction complex
2.76 4.65e-09 GO:0005578 proteinaceous extracellular matrix
2.66 2.60e-09 GO:0031012 extracellular matrix
2.41 3.03e-04 GO:0016323 basolateral plasma membrane
2.13 5.47e-03 GO:0045177 apical part of cell
2.13 1.21e-02 GO:0005911 cell-cell junction
2.11 2.48e-03 GO:0015629 actin cytoskeleton
2.08 1.26e-09 GO:0005615 extracellular space
2.06 6.14e-13 GO:0044421 extracellular region part
1.94 2.23e-02 GO:0048471 perinuclear region of cytoplasm

Gene overrepresentation in function category:

Showing 1 to 19 of 19 entries
Enrichment   P-value GO Accession GO Term
9.86 1.06e-04 GO:0048407 platelet-derived growth factor binding
5.63 2.51e-02 GO:0001968 fibronectin binding
5.10 7.53e-03 GO:0005201 extracellular matrix structural constituent
4.22 4.75e-02 GO:0050840 extracellular matrix binding
3.76 1.97e-03 GO:0005178 integrin binding
3.38 6.44e-05 GO:0019838 growth factor binding
2.96 2.93e-02 GO:0051082 unfolded protein binding
2.53 6.70e-03 GO:0001871 pattern binding
2.53 6.70e-03 GO:0030247 polysaccharide binding
2.18 1.30e-05 GO:0005198 structural molecule activity
1.95 6.51e-05 GO:0008092 cytoskeletal protein binding
1.88 2.11e-02 GO:0032403 protein complex binding
1.86 9.48e-04 GO:0005509 calcium ion binding
1.82 3.93e-02 GO:0030246 carbohydrate binding
1.76 8.21e-03 GO:0019904 protein domain specific binding
1.73 2.91e-06 GO:0005102 receptor binding
1.53 3.81e-02 GO:0019899 enzyme binding
1.44 1.82e-20 GO:0005515 protein binding
1.21 1.66e-13 GO:0005488 binding