Motif ID: IKZF2.p2

Z-value: 1.140


Transcription factors associated with IKZF2.p2:

Gene SymbolEntrez IDGene Name
Ikzf2 22779 IKAROS family zinc finger 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ikzf2chr1_-_697323730.172.1e-02Click!


Activity profile for motif IKZF2.p2.

activity profile for motif IKZF2.p2


Sorted Z-values histogram for motif IKZF2.p2

Sorted Z-values for motif IKZF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_72091188 20.622 NM_008069
Gabrb1
gamma-aminobutyric acid (GABA) A receptor, subunit beta 1
chr8_+_56122680 16.029 Gpm6a
glycoprotein m6a
chrX_+_132806184 14.893 Ngfrap1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr17_-_90436488 14.527 Nrxn1
neurexin I
chr6_-_126658429 13.899


chr9_-_49311823 12.943 Ncam1
neural cell adhesion molecule 1
chrX_+_131252542 12.802 Armcx1
armadillo repeat containing, X-linked 1
chrX_+_131252456 12.149 NM_001166377
NM_001166378
NM_001166379
NM_001166380
NM_030066
Armcx1




armadillo repeat containing, X-linked 1




chr9_-_117160916 11.660 Rbms3
RNA binding motif, single stranded interacting protein
chr9_-_117161234 11.652 Rbms3
RNA binding motif, single stranded interacting protein
chr9_-_117161564 10.645 NM_001172122
NM_001172123
NM_001172124
NM_001172126
NM_178660
Rbms3




RNA binding motif, single stranded interacting protein




chr4_+_104829963 9.883 Ppap2b
phosphatidic acid phosphatase type 2B
chr4_+_104829867 9.273 Ppap2b
phosphatidic acid phosphatase type 2B
chr9_-_21820860 8.973 Elavl3
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
chr16_-_36334417 8.859 NM_001001332
BC117090
cDNA sequence BC1179090
chr2_+_121183509 8.489 Ckmt1
creatine kinase, mitochondrial 1, ubiquitous
chr11_-_79317583 8.190 NM_019409
Omg
oligodendrocyte myelin glycoprotein
chr11_-_79317471 8.119 Omg
oligodendrocyte myelin glycoprotein
chr6_+_30756073 7.736 Copg2as2
coatomer protein complex, subunit gamma 2, antisense 2
chr4_+_104829951 7.652 NM_080555
Ppap2b
phosphatidic acid phosphatase type 2B
chr2_+_97307652 7.051 NM_178725
Lrrc4c
leucine rich repeat containing 4C
chr2_+_177876635 6.722 NM_028806
Phactr3
phosphatase and actin regulator 3
chr11_-_55233354 6.651 Sparc
secreted acidic cysteine rich glycoprotein
chr19_+_23241546 6.577 Klf9
Kruppel-like factor 9
chr1_+_45368443 6.446 Col3a1
collagen, type III, alpha 1
chr6_-_36759929 6.370 Ptn
pleiotrophin
chr2_+_135883963 6.304 6330527O06Rik
RIKEN cDNA 6330527O06 gene
chr7_+_138087002 6.265 Htra1
HtrA serine peptidase 1
chrX_+_140127827 6.239 NM_001195046
NM_001195047
Pak3

p21 protein (Cdc42/Rac)-activated kinase 3

chrX_+_10173557 6.220


chrX_+_102318792 6.166 Magee1
melanoma antigen, family E, 1
chr6_-_60779848 6.160 NM_009221
Snca
synuclein, alpha
chr8_+_56040445 6.042 Gpm6a
glycoprotein m6a
chr15_+_3220999 5.978 Sepp1
selenoprotein P, plasma, 1
chr18_-_25637339 5.924 Celf4
CUGBP, Elav-like family member 4
chr9_+_111277323 5.918 Trank1
tetratricopeptide repeat and ankyrin repeat containing 1
chr9_-_49607164 5.917 NM_001081445
NM_001113204
NM_010875
Ncam1


neural cell adhesion molecule 1


chr2_+_135883662 5.821 NM_029530
6330527O06Rik
RIKEN cDNA 6330527O06 gene
chr2_+_177876710 5.764 Phactr3
phosphatase and actin regulator 3
chr15_-_79656745 5.710 Cbx6
chromobox homolog 6
chr15_+_3220994 5.670 Sepp1
selenoprotein P, plasma, 1
chr7_-_149838254 5.570 Igf2
insulin-like growth factor 2
chr2_-_140485267 5.537 Flrt3
fibronectin leucine rich transmembrane protein 3
chr10_+_69487700 5.510 Ank3
ankyrin 3, epithelial
chrX_+_54032858 5.490 NM_001077362
Fhl1
four and a half LIM domains 1
chr18_+_37925233 5.444 NM_033595
Pcdhga12
protocadherin gamma subfamily A, 12
chr15_+_3220766 5.430 NM_001042613
NM_001042614
NM_009155
Sepp1


selenoprotein P, plasma, 1


chrX_+_54032914 5.412 Fhl1
four and a half LIM domains 1
chr18_+_37925619 5.333 Pcdhga12
protocadherin gamma subfamily A, 12
chr10_+_34018323 5.294 Tspyl4
TSPY-like 4
chr18_+_23656024 5.260 Dtna
dystrobrevin alpha
chr5_+_104868321 5.191 Spp1
secreted phosphoprotein 1
chr8_+_56040080 5.189 NM_153581
Gpm6a
glycoprotein m6a
chr5_+_89012596 5.135 NM_027530
Rufy3
RUN and FYVE domain containing 3
chr16_-_36367622 5.093 NM_001082546
BC100530
BC117090
cDNA sequence BC100530
cDNA sequence BC1179090
chr1_-_170085342 5.091 Pbx1
pre B-cell leukemia transcription factor 1
chr18_+_37821598 4.969 NM_033584
Pcdhga1
protocadherin gamma subfamily A, 1
chr4_-_63681749 4.969 NM_011607
Tnc
tenascin C
chr15_-_101510717 4.928 NM_010669
Krt6b
keratin 6B
chr5_+_29761203 4.913 NM_001033457
Nom1
nucleolar protein with MIF4G domain 1
chr1_+_12708582 4.858 NM_172294
Sulf1
sulfatase 1
chr15_-_8660729 4.770 NM_148938
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_-_52414072 4.735 NM_146123
Cacnb4
calcium channel, voltage-dependent, beta 4 subunit
chr15_+_97962651 4.723


chr12_+_25265583 4.718 NM_145890
Grhl1
grainyhead-like 1 (Drosophila)
chr7_+_107423813 4.688 Pgm2l1
phosphoglucomutase 2-like 1
chr2_+_145068346 4.641 NM_053195
Slc24a3
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr14_+_14286471 4.641 NM_001163032
Synpr
synaptoporin
chr8_+_96696512 4.616 NM_008630
Mt2
metallothionein 2
chr5_-_104542598 4.614 Sparcl1
SPARC-like 1
chr8_-_48374715 4.562 Stox2
storkhead box 2
chr10_+_96944961 4.554 NM_007833
Dcn
decorin
chr11_-_55233366 4.525 Sparc
secreted acidic cysteine rich glycoprotein
chr5_-_104542641 4.519 Sparcl1
SPARC-like 1
chr8_-_49760037 4.431 NM_001145937
NM_011857
Odz3

odd Oz/ten-m homolog 3 (Drosophila)

chr1_-_171677653 4.411 NM_009062
Rgs4
regulator of G-protein signaling 4
chr6_+_3954259 4.405 Gng11
guanine nucleotide binding protein (G protein), gamma 11
chr9_+_75192367 4.334 Gnb5
guanine nucleotide binding protein (G protein), beta 5
chr7_-_110976314 4.312 Hbb-b1
Hbb-b2
hemoglobin, beta adult major chain
hemoglobin, beta adult minor chain
chr5_-_104542729 4.268 Sparcl1
SPARC-like 1
chr16_+_36277233 4.253 NM_001082543
Stfa1
stefin A1
chr17_+_75784448 4.236 Ltbp1
latent transforming growth factor beta binding protein 1
chr18_-_31476527 4.220 Rit2
Ras-like without CAAX 2
chr3_+_14886253 4.188 NM_009801
Car2
carbonic anhydrase 2
chr7_-_110976499 4.172 Hbb-b1
hemoglobin, beta adult major chain
chr8_-_105308910 4.150 NM_009866
Cdh11
cadherin 11
chr7_-_107805466 4.137 NM_001163186
NM_001163187
Plekhb1

pleckstrin homology domain containing, family B (evectins) member 1

chr10_+_40657980 4.131 Wasf1
WASP family 1
chr4_+_104830022 4.123 Ppap2b
phosphatidic acid phosphatase type 2B
chr7_-_110976438 4.102 Hbb-b1
hemoglobin, beta adult major chain
chr6_+_3953944 4.071 NM_025331
Gng11
guanine nucleotide binding protein (G protein), gamma 11
chr18_-_25637786 4.004 Celf4
CUGBP, Elav-like family member 4
chr10_+_97028134 4.003 NM_008524
Lum
lumican
chr15_-_98783909 3.988 NM_011653
Tuba1a
tubulin, alpha 1A
chr11_-_102331042 3.986 NM_010575
Itga2b
integrin alpha 2b
chr6_+_3954225 3.979 Gng11
guanine nucleotide binding protein (G protein), gamma 11
chr13_+_49704471 3.948 Ogn
osteoglycin
chr11_-_11832366 3.944 Grb10
growth factor receptor bound protein 10
chr9_+_40590943 3.864 9030425E11Rik
RIKEN cDNA 9030425E11 gene
chr16_+_35002066 3.827 Mylk
myosin, light polypeptide kinase
chr13_+_49703402 3.816 NM_008760
Ogn
osteoglycin
chr14_+_76362274 3.809 Kctd4
potassium channel tetramerisation domain containing 4
chr7_-_107805365 3.808 Plekhb1
pleckstrin homology domain containing, family B (evectins) member 1
chr14_+_28435613 3.795 NM_177814
Erc2
ELKS/RAB6-interacting/CAST family member 2
chr6_-_121423633 3.794 Iqsec3
IQ motif and Sec7 domain 3
chr10_+_97028409 3.788 Lum
lumican
chr11_+_44431601 3.781 NM_007897
Ebf1
early B-cell factor 1
chr6_-_92517359 3.776 NM_001134461
Prickle2
prickle homolog 2 (Drosophila)
chr10_+_98453513 3.767 Atp2b1
ATPase, Ca++ transporting, plasma membrane 1
chr4_-_138419379 3.765 NM_001122954
Pla2g5
phospholipase A2, group V
chr14_-_20796411 3.752 NM_001038637
NM_010315
Gng2

guanine nucleotide binding protein (G protein), gamma 2

chr18_-_31476721 3.739 NM_009065
Rit2
Ras-like without CAAX 2
chr10_+_97028456 3.723 Lum
lumican
chr1_+_17135421 3.716 NM_010267
Gdap1
ganglioside-induced differentiation-associated-protein 1
chr10_-_70055559 3.711 NM_001162846
Phyhipl
phytanoyl-CoA hydroxylase interacting protein-like
chrX_-_149471740 3.711 NM_023788
Mageh1
melanoma antigen, family H, 1
chrX_-_132749976 3.627 NM_009052
Bex1
brain expressed gene 1
chr19_-_5799376 3.598 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr7_-_110976439 3.598 Hbb-b1
hemoglobin, beta adult major chain
chr7_-_133939596 3.594


chr7_-_147268150 3.579 NM_001190386
Caly
calcyon neuron-specific vesicular protein
chr1_+_155756310 3.564 Glul
glutamate-ammonia ligase (glutamine synthetase)
chr12_+_90191833 3.513 NM_172544
Nrxn3
neurexin III
chr8_-_67071497 3.484


chrX_+_133357268 3.484 NM_011123
Plp1
proteolipid protein (myelin) 1
chr4_+_114761312 3.475 NM_001164557
NM_001164558
NM_026018
Pdzk1ip1


PDZK1 interacting protein 1


chr11_+_87391881 3.468 Sept4
septin 4
chr11_-_30839546 3.463 Erlec1
endoplasmic reticulum lectin 1
chr7_-_147268395 3.452 NM_001190385
NM_026769
Caly

calcyon neuron-specific vesicular protein

chr1_-_45559866 3.441 Col5a2
collagen, type V, alpha 2
chr9_+_7558476 3.438 Mmp8
matrix metallopeptidase 8
chr8_-_48374755 3.419 NM_001114311
Stox2
storkhead box 2
chr9_+_7558428 3.411 NM_008611
Mmp8
matrix metallopeptidase 8
chr1_+_45368382 3.397 NM_009930
Col3a1
collagen, type III, alpha 1
chr6_+_121586190 3.386 NM_175628
A2m
alpha-2-macroglobulin
chr9_-_54509453 3.370 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr11_-_55233339 3.369 Sparc
secreted acidic cysteine rich glycoprotein
chr6_+_141472906 3.365 NM_001177772
NM_021471
Slco1c1

solute carrier organic anion transporter family, member 1c1

chr18_+_80315134 3.334 Pard6g
par-6 partitioning defective 6 homolog gamma (C. elegans)
chr3_-_92674126 3.320 NM_025621
2310050C09Rik
RIKEN cDNA 2310050C09 gene
chr10_+_96945057 3.312 Dcn
decorin
chr4_+_128820458 3.310 Fndc5
fibronectin type III domain containing 5
chr12_+_96930429 3.289 NM_201518
Flrt2
fibronectin leucine rich transmembrane protein 2
chrX_-_16394443 3.280 NM_172778
Maob
monoamine oxidase B
chr6_-_60778740 3.278 NM_001042451
Snca
synuclein, alpha
chr1_+_152166546 3.270 NM_001159730
NM_024458
Pdc

phosducin

chr15_-_54751515 3.267 NM_001136077
NM_015744
Enpp2

ectonucleotide pyrophosphatase/phosphodiesterase 2

chr7_+_4071087 3.251 NM_001001454
NM_001109765
NM_021324
Ttyh1


tweety homolog 1 (Drosophila)


chr5_-_139606339 3.229 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr9_-_52484889 3.211 AI593442
expressed sequence AI593442
chr3_-_126646303 3.197 NM_001034168
Ank2
ankyrin 2, brain
chr11_-_103733519 3.197 Nsf
N-ethylmaleimide sensitive fusion protein
chr3_+_136598184 3.179 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr6_-_127075853 3.166 Ccnd2
cyclin D2
chr6_+_56828743 3.146 Fkbp9
FK506 binding protein 9
chr17_+_73186891 3.145 Ypel5
yippee-like 5 (Drosophila)
chr4_+_101180625 3.131 Dnajc6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr16_-_36131169 3.129 NM_001033239
Csta
cystatin A
chr1_+_43787692 3.122 1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr4_+_114761644 3.079 Pdzk1ip1
PDZK1 interacting protein 1
chr17_+_73186929 3.062 Ypel5
yippee-like 5 (Drosophila)
chr1_+_43787442 3.061 NM_024283
1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr11_+_67013553 3.035 NM_030679
Myh1
myosin, heavy polypeptide 1, skeletal muscle, adult
chr19_-_5800268 3.024


chr14_-_52530382 3.016 Ndrg2
N-myc downstream regulated gene 2
chr7_-_54444724 3.014 NM_205821
Mrgpra6
MAS-related GPR, member A6
chrX_-_147241307 3.013 Maged2
melanoma antigen, family D, 2
chr2_-_62411970 2.983 NM_007986
Fap
fibroblast activation protein
chr18_+_82754829 2.962 Mbp
myelin basic protein
chr1_+_155500166 2.948 NM_026380
Rgs8
regulator of G-protein signaling 8
chr11_+_119862650 2.942 Baiap2
brain-specific angiogenesis inhibitor 1-associated protein 2
chr13_-_3803547 2.942 NM_027416
Calml3
calmodulin-like 3
chr3_+_13471681 2.936 Ralyl
RALY RNA binding protein-like
chr1_-_42751652 2.933 2610017I09Rik
RIKEN cDNA 2610017I09 gene
chr11_-_30119771 2.921 NM_175836
Spnb2
spectrin beta 2
chr17_+_72131286 2.915 NM_030179
Clip4
CAP-GLY domain containing linker protein family, member 4
chr11_-_83880574 2.914 Dusp14
dual specificity phosphatase 14
chr11_+_94812919 2.904 Col1a1
collagen, type I, alpha 1
chr2_+_177876858 2.892 Phactr3
phosphatase and actin regulator 3
chr10_+_90292388 2.883 Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr14_+_13073221 2.875 Ptprg
protein tyrosine phosphatase, receptor type, G
chr9_+_72859850 2.857 Ccpg1
cell cycle progression 1
chr14_-_9142289 2.842 NM_183187
Fam107a
family with sequence similarity 107, member A
chr2_-_140497204 2.825 NM_001172160
NM_178382
Flrt3

fibronectin leucine rich transmembrane protein 3

chr18_-_25912453 2.815 NM_001146292
NM_001146293
NM_001146294
NM_001146295
NM_001174074
NM_133195
Celf4





CUGBP, Elav-like family member 4





chr1_-_45559700 2.807 Col5a2
collagen, type V, alpha 2
chr17_+_75578120 2.776 NM_206958
Ltbp1
latent transforming growth factor beta binding protein 1
chr14_+_55555300 2.772 NM_026066
Cmtm5
CKLF-like MARVEL transmembrane domain containing 5
chrX_-_132738383 2.735 NM_177919
Tceal5
transcription elongation factor A (SII)-like 5
chr12_+_89961317 2.690 NM_001198587
Nrxn3
neurexin III
chr18_+_37644674 2.681 NM_053142
Pcdhb17
protocadherin beta 17
chr7_+_4071171 2.681 Ttyh1
tweety homolog 1 (Drosophila)
chr9_-_54509658 2.680 NM_053178
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr7_-_88851823 2.671 Homer2
homer homolog 2 (Drosophila)
chr1_+_24184448 2.660 NM_007740
Col9a1
collagen, type IX, alpha 1
chr18_-_43552694 2.657 NM_009468
Dpysl3
dihydropyrimidinase-like 3
chr4_+_134024234 2.652 NM_019641
Stmn1
stathmin 1
chr14_-_56143027 2.652 NM_008736
Nrl
neural retina leucine zipper gene
chr11_+_98629709 2.647


chr8_-_70342105 2.643 NM_027626
Psd3
pleckstrin and Sec7 domain containing 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.92 4.89e-07 GO:0007155 cell adhesion
1.90 7.90e-07 GO:0022610 biological adhesion
1.30 1.76e-04 GO:0032502 developmental process
1.52 3.00e-04 GO:0007399 nervous system development
1.32 3.93e-04 GO:0048856 anatomical structure development
1.34 5.48e-04 GO:0048731 system development
1.29 9.85e-04 GO:0007275 multicellular organismal development
1.27 1.54e-03 GO:0051179 localization
1.74 5.51e-03 GO:0048585 negative regulation of response to stimulus
1.36 9.30e-03 GO:0065008 regulation of biological quality
1.62 1.07e-02 GO:0007154 cell communication
3.00 1.62e-02 GO:0008585 female gonad development
2.82 1.72e-02 GO:0031589 cell-substrate adhesion
1.46 1.88e-02 GO:0010646 regulation of cell communication
3.16 2.17e-02 GO:0061039 ovum-producing ovary development
1.50 2.69e-02 GO:0042592 homeostatic process
1.54 3.24e-02 GO:0048699 generation of neurons
1.51 3.77e-02 GO:0022008 neurogenesis
1.82 4.78e-02 GO:0019226 transmission of nerve impulse
1.82 4.78e-02 GO:0035637 multicellular organismal signaling
2.89 4.99e-02 GO:0042698 ovulation cycle

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.66 7.25e-08 GO:0042995 cell projection
1.29 2.21e-06 GO:0071944 cell periphery
1.85 2.96e-06 GO:0043005 neuron projection
1.29 3.20e-06 GO:0005886 plasma membrane
1.91 4.47e-06 GO:0045202 synapse
1.44 6.43e-06 GO:0005576 extracellular region
1.59 5.69e-05 GO:0005626 insoluble fraction
1.50 8.49e-05 GO:0000267 cell fraction
1.70 1.30e-04 GO:0030054 cell junction
1.55 1.39e-04 GO:0044421 extracellular region part
1.57 2.44e-04 GO:0005624 membrane fraction
2.05 2.51e-04 GO:0005578 proteinaceous extracellular matrix
1.37 3.53e-04 GO:0044459 plasma membrane part
1.92 6.38e-04 GO:0044456 synapse part
1.91 1.17e-03 GO:0031012 extracellular matrix
1.57 2.36e-03 GO:0005615 extracellular space
1.98 3.06e-03 GO:0030424 axon
1.12 6.70e-03 GO:0005737 cytoplasm
1.09 9.40e-03 GO:0044424 intracellular part
1.09 1.06e-02 GO:0005622 intracellular
1.70 1.20e-02 GO:0044463 cell projection part
6.14 1.69e-02 GO:0005583 fibrillar collagen
2.68 2.28e-02 GO:0030426 growth cone
2.34 2.69e-02 GO:0044420 extracellular matrix part
1.42 3.08e-02 GO:0005794 Golgi apparatus
2.58 3.86e-02 GO:0030427 site of polarized growth

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.30 6.46e-12 GO:0005515 protein binding
1.14 4.88e-07 GO:0005488 binding
1.56 1.00e-03 GO:0030234 enzyme regulator activity
1.53 3.22e-03 GO:0019899 enzyme binding
2.61 6.90e-03 GO:0019838 growth factor binding
1.64 1.44e-02 GO:0005509 calcium ion binding
9.51 1.96e-02 GO:0031994 insulin-like growth factor I binding
1.87 3.35e-02 GO:0004857 enzyme inhibitor activity