Motif ID: IRF1,2,7.p3

Z-value: 7.114


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
Irf1 16362 interferon regulatory factor 1
Irf2 16363 interferon regulatory factor 2
Irf7 54123 interferon regulatory factor 7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf7chr7_-_1484522990.886.0e-61Click!
Irf1chr11_+_535835150.825.4e-45Click!
Irf2chr8_+_478250720.707.4e-28Click!


Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_121195885 260.099 NM_011909
Usp18
ubiquitin specific peptidase 18
chr5_-_121357467 210.385 NM_145211
Oas1a
2'-5' oligoadenylate synthetase 1A
chr4_-_155574875 188.343 NM_015783
Isg15
ISG15 ubiquitin-like modifier
chr1_-_175465858 180.573 BC094916
cDNA sequence BC094916
chr3_+_142283605 168.413 NM_010260
Gbp2
guanylate binding protein 2
chr5_-_121337533 166.687 NM_011852
Oas1g
2'-5' oligoadenylate synthetase 1G
chr1_-_175810248 161.412 NM_001170853
Mndal
myeloid nuclear differentiation antigen like
chr11_+_48900507 156.137 NM_008330
Ifi47
Olfr56
interferon gamma inducible protein 47
olfactory receptor 56
chr6_+_57531124 155.955 Herc6
hect domain and RLD 6
chr19_+_34658016 155.756 NM_010501
Ifit3
interferon-induced protein with tetratricopeptide repeats 3
chr16_+_23609986 152.536 NM_023386
Rtp4
receptor transporter protein 4
chr7_-_148452299 146.294 NM_016850
Irf7
interferon regulatory factor 7
chr17_-_34324234 141.784 NM_013585
Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr19_-_11124897 136.766 NM_001177351
AW112010
expressed sequence AW112010
chr19_+_34682418 134.103 NM_001005858
I830012O16Rik
RIKEN cDNA I830012O16 gene
chr8_-_108462291 133.754 NM_013640
Psmb10
proteasome (prosome, macropain) subunit, beta type 10
chr11_-_48877704 133.166 NM_001145164
Tgtp2
T-cell specific GTPase 2
chr6_+_57530968 132.062 NM_025992
Herc6
hect domain and RLD 6
chr11_+_58013057 129.284 NM_018738
Igtp
interferon gamma induced GTPase
chr11_-_48877544 128.528 Tgtp2
Tgtp1
T-cell specific GTPase 2
T-cell specific GTPase 1
chr18_+_60542336 127.268 Iigp1
interferon inducible GTPase 1
chr2_-_173044305 126.806 NM_001139519
NM_021394
Zbp1

Z-DNA binding protein 1

chr17_+_34324700 125.765 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr2_+_121973414 123.730 NM_009735
B2m
beta-2 microglobulin
chrX_-_9046362 123.077 NM_007807
Cybb
cytochrome b-245, beta polypeptide
chr16_+_35939047 120.105 Parp9
poly (ADP-ribose) polymerase family, member 9
chr9_-_88626613 119.348 NM_007536
Bcl2a1d
B-cell leukemia/lymphoma 2 related protein A1d
chr10_-_33847745 119.310 NM_175449
Fam26f
family with sequence similarity 26, member F
chr17_+_34324636 118.782 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr11_-_78798332 112.710 NM_001159301
NM_010708
Lgals9

lectin, galactose binding, soluble 9

chr19_+_34715368 112.651 NM_008331
Ifit1
interferon-induced protein with tetratricopeptide repeats 1
chr8_-_74061134 112.620 NM_198095
Bst2
bone marrow stromal cell antigen 2
chr8_-_108461909 112.346 Psmb10
proteasome (prosome, macropain) subunit, beta type 10
chr11_-_70273251 112.206 Cxcl16
chemokine (C-X-C motif) ligand 16
chr11_-_70273190 108.256 Cxcl16
chemokine (C-X-C motif) ligand 16
chr11_-_48805585 108.184 NM_001145164
NM_011579
Tgtp2
Tgtp1
Gm12185
T-cell specific GTPase 2
T-cell specific GTPase 1
predicted gene 12185
chr11_-_70272909 107.749 Cxcl16
chemokine (C-X-C motif) ligand 16
chr5_-_92777875 107.556 NM_021274
Cxcl10
chemokine (C-X-C motif) ligand 10
chr19_+_29441927 107.475 NM_021893
Cd274
CD274 antigen
chr11_-_70273434 107.255 Cxcl16
chemokine (C-X-C motif) ligand 16
chr8_-_113862056 106.020 Mlkl
mixed lineage kinase domain-like
chr8_+_64406883 105.593 NM_001081215
Ddx60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr5_-_105668551 102.011 NM_001039646
Gbp10
guanylate-binding protein 10
chr2_-_51828440 101.327 Nmi
N-myc (and STAT) interactor
chr19_+_34644768 100.347 Ifit2
interferon-induced protein with tetratricopeptide repeats 2
chr9_-_88626434 99.231 Bcl2a1d
B-cell leukemia/lymphoma 2 related protein A1d
chr14_+_103446193 98.897 Irg1
immunoresponsive gene 1
chr3_+_142193286 98.617 NM_001083312
NM_145545
Gbp6

guanylate binding protein 6

chr9_+_5298516 98.307 NM_009807
Casp1
caspase 1
chr1_-_175842977 97.888 NM_001033450
Ifi204
Mnda
interferon activated gene 204
myeloid cell nuclear differentiation antigen
chr6_-_38304508 97.756 Zc3hav1
zinc finger CCCH type, antiviral 1
chr11_-_70273333 96.961 Cxcl16
chemokine (C-X-C motif) ligand 16
chr1_+_87546558 96.433 NM_013673
Sp100
nuclear antigen Sp100
chr16_-_35939034 96.430 NM_001013371
Dtx3l
deltex 3-like (Drosophila)
chr5_-_134705423 96.293 NM_010876
Ncf1
neutrophil cytosolic factor 1
chr17_+_34335139 96.177 NM_010724
Psmb8
proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
chr19_+_29446941 95.975 Cd274
CD274 antigen
chr5_-_121227617 95.386 NM_145226
Oas3
2'-5' oligoadenylate synthetase 3
chr11_+_101443690 94.659 Tmem106a
transmembrane protein 106A
chr19_+_12873063 94.030 NM_134152
Lpxn
leupaxin
chr5_+_115347505 93.641 Oasl2
2'-5' oligoadenylate synthetase-like 2
chr3_+_142223027 93.343 Gbp3
guanylate binding protein 3
chr2_-_62484264 92.735 NM_001164477
NM_027835
Ifih1

interferon induced with helicase C domain 1

chr7_-_109713935 91.976 NM_001082552
NM_009277
Trim21

tripartite motif-containing 21

chr11_-_82834223 90.921 NM_001167743
NM_181545
Slfn8

schlafen 8

chr7_-_111656285 89.860 NM_001167828
NM_199146
Trim30a
Trim30d

tripartite motif-containing 30A
tripartite motif-containing 30D

chr15_+_75692745 89.502 NM_026960
Gsdmd
gasdermin D
chr14_+_78304045 89.069 NM_029495
NM_178825
Epsti1

epithelial stromal interaction 1 (breast)

chr11_-_70273453 88.834 NM_023158
Cxcl16
chemokine (C-X-C motif) ligand 16
chr1_-_175872522 88.440 NM_008328
NM_001045481
Ifi203

interferon activated gene 203

chr13_-_100972022 86.322 NM_001126182
NM_010872
Naip2

NLR family, apoptosis inhibitory protein 2

chr14_+_103446209 84.314 NM_008392
Irg1
immunoresponsive gene 1
chr6_-_3349415 84.259 Samd9l
sterile alpha motif domain containing 9-like
chr8_-_84927109 84.169 Il15
interleukin 15
chr17_+_34324496 82.580 NM_001161730
NM_013683
Tap1

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

chr11_-_48684659 82.433 NM_008326
Irgm1
immunity-related GTPase family M member 1
chr1_-_175696989 82.348 NM_008329
Ifi204
interferon activated gene 204
chr19_-_34673889 82.342 NM_001110517
Gm14446
predicted gene 14446
chr17_+_57498108 82.284 NM_010130
Emr1
EGF-like module containing, mucin-like, hormone receptor-like sequence 1
chr5_-_105722663 82.138 NM_194336
Mpa2l
Gbp4
macrophage activation 2 like
guanylate binding protein 4
chr3_+_142223007 82.008 NM_018734
Gbp3
guanylate binding protein 3
chr1_-_175671849 81.880 AI607873
expressed sequence AI607873
chr13_-_101017247 80.681 NM_010870
Naip5
NLR family, apoptosis inhibitory protein 5
chr6_+_29479250 80.446 Irf5
interferon regulatory factor 5
chr5_+_86500770 80.174 NM_019992
Stap1
signal transducing adaptor family member 1
chr14_-_59916342 80.068 NM_172603
Phf11
PHD finger protein 11
chr13_+_37437194 79.870 NM_010745
Ly86
lymphocyte antigen 86
chr1_+_175603760 79.369 NM_001162938
Pydc3
pyrin domain containing 3
chr19_+_12873115 78.669 Lpxn
leupaxin
chr1_+_52176281 78.318 NM_009283
Stat1
signal transducer and activator of transcription 1
chr6_-_3295980 77.492 9530028C05
hypothetical protein 9530028C05
chr17_-_36157472 76.949 NM_008207
H2-T24
histocompatibility 2, T region locus 24
chr7_+_111392968 76.456 NM_030684
Trim34a
tripartite motif-containing 34A
chr14_-_59984246 76.152 NM_199015
D14Ertd668e
DNA segment, Chr 14, ERATO Doi 668, expressed
chr19_+_56471731 74.804 Casp7
caspase 7
chr17_+_34341467 74.516 Tap2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr18_+_60963495 73.792 NM_001042605
NM_010545
Cd74

CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)

chr11_+_101443529 73.584 NM_144830
Tmem106a
transmembrane protein 106A
chr11_+_101309725 73.421 NM_027320
Ifi35
interferon-induced protein 35
chr19_-_34676457 73.302 NM_001101605
Gm14446
predicted gene 14446
chr19_+_56471580 72.825 NM_007611
Casp7
caspase 7
chr3_-_151412812 72.602 NM_133871
Ifi44
interferon-induced protein 44
chr2_-_51790671 72.353 Rbm43
RNA binding motif protein 43
chr17_+_34341417 72.039 NM_011530
Tap2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_+_34056367 71.286 NM_001025313
NM_009318
Tapbp

TAP binding protein

chr6_-_39067918 71.131 Parp12
poly (ADP-ribose) polymerase family, member 12
chr15_+_78156227 70.788 NM_007780
Csf2rb
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr16_-_97684510 70.656 NM_010846
Mx1
myxovirus (influenza virus) resistance 1
chr2_-_51790406 70.502 NM_001141981
NM_030243
Rbm43

RNA binding motif protein 43

chr8_-_84926440 70.362 NM_008357
Il15
interleukin 15
chr9_-_110959315 69.438 Ccrl2
chemokine (C-C motif) receptor-like 2
chr10_-_87819740 68.317 Dram1
DNA-damage regulated autophagy modulator 1
chr6_-_38304558 67.379 NM_028421
NM_028864
Zc3hav1

zinc finger CCCH type, antiviral 1

chr6_-_39068241 67.219 Parp12
poly (ADP-ribose) polymerase family, member 12
chr15_-_76073582 66.320 Parp10
poly (ADP-ribose) polymerase family, member 10
chr1_+_173319048 66.115 NM_001005508
Arhgap30
Rho GTPase activating protein 30
chr15_-_76073789 65.547 Parp10
poly (ADP-ribose) polymerase family, member 10
chr17_+_34056798 65.523 Tapbp
TAP binding protein
chr4_-_40186722 65.248 NM_172689
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr5_+_115347750 65.184 Oasl2
2'-5' oligoadenylate synthetase-like 2
chr15_-_76073869 64.852 NM_001163575
NM_001163576
Parp10

poly (ADP-ribose) polymerase family, member 10

chr9_-_37063214 64.594 NM_001145960
NM_020258
Slc37a2

solute carrier family 37 (glycerol-3-phosphate transporter), member 2

chr8_-_113861802 64.390 NM_029005
Mlkl
mixed lineage kinase domain-like
chr17_+_34056555 64.077 Tapbp
TAP binding protein
chr9_-_110959702 63.662 NM_017466
Ccrl2
chemokine (C-C motif) receptor-like 2
chrX_+_106392094 63.285 NM_001037917
Gm6377
predicted gene 6377
chr17_+_34056585 62.846 Tapbp
TAP binding protein
chr15_-_76073854 62.812 Parp10
poly (ADP-ribose) polymerase family, member 10
chr1_+_58859345 62.778 NM_001080126
Casp8
caspase 8
chr19_-_3905229 62.385 NM_016921
Tcirg1
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3
chr8_-_125075222 62.248 NM_001037298
Fam38a
family with sequence similarity 38, member A
chr1_-_175961813 60.981 NM_172648
Ifi205
Ifi202b
interferon activated gene 205
interferon activated gene 202B
chr15_+_83393975 60.949 NM_009775
Tspo
translocator protein
chr5_-_121199781 60.834 NM_145227
Oas2
2'-5' oligoadenylate synthetase 2
chr9_+_107877887 60.479 NM_023738
Uba7
ubiquitin-like modifier activating enzyme 7
chr10_-_94407211 59.951 NM_018797
Plxnc1
plexin C1
chr12_-_27129497 59.173 Rsad2
radical S-adenosyl methionine domain containing 2
chr5_-_105539282 57.797 NM_172777
Gbp9
guanylate-binding protein 9
chr6_+_122902532 57.111 NM_153197
Clec4a3
C-type lectin domain family 4, member a3
chr13_-_113891176 56.975 NM_010370
Gzma
granzyme A
chr5_-_105482574 56.922 NM_029509
Gbp8
guanylate-binding protein 8
chr8_-_46418352 56.442 NM_133969
Cyp4v3
cytochrome P450, family 4, subfamily v, polypeptide 3
chr17_-_34999068 56.271 Cfb
complement factor B
chr7_+_86058817 55.889 Isg20
interferon-stimulated protein
chr17_-_36258349 55.816 NM_010395
H2-T10
H2-T9
histocompatibility 2, T region locus 10
histocompatibility 2, T region locus 9
chr5_+_115346942 55.355 NM_011854
Oasl2
2'-5' oligoadenylate synthetase-like 2
chr2_-_51790163 55.215 NM_001141982
Rbm43
RNA binding motif protein 43
chr11_+_82988687 55.050 NM_011410
Slfn4
schlafen 4
chr17_-_34999458 54.777 NM_001142706
NM_008198
Cfb

complement factor B

chr6_+_122902755 54.540 Clec4a3
C-type lectin domain family 4, member a3
chr17_-_36179615 52.961 NM_010397
NM_010399
H2-T22
H2-T9
histocompatibility 2, T region locus 22
histocompatibility 2, T region locus 9
chr7_-_111613624 52.520 NM_009099
Trim30a
tripartite motif-containing 30A
chr7_-_134158053 52.404 NM_080638
Mvp
major vault protein
chr1_-_175529396 52.280 NM_001177349
NM_001177350
Pydc4

pyrin domain containing 4

chr3_+_127494295 52.203 Tifa
TRAF-interacting protein with forkhead-associated domain
chr1_-_172906094 50.910 NM_001077189
NM_010187
Fcgr2b

Fc receptor, IgG, low affinity IIb

chr13_-_101087625 50.684 NM_021545
Naip6
Naip7
NLR family, apoptosis inhibitory protein 6
NLR family, apoptosis inhibitory protein 7
chr1_-_186556046 50.638 Hlx
H2.0-like homeobox
chr11_+_81928683 50.105 NM_021443
Ccl8
chemokine (C-C motif) ligand 8
chr10_+_127707555 49.971 NM_019963
Stat2
signal transducer and activator of transcription 2
chr13_-_23802635 49.892 NM_010424
Hfe
hemochromatosis
chr17_-_35137278 49.390 D17H6S56E-5
DNA segment, Chr 17, human D6S56E 5
chr6_+_70676428 48.726


chr3_+_142223490 47.963 Gbp3
guanylate binding protein 3
chr8_+_70018744 47.768 NM_001168577
NM_010874
Nat2

N-acetyltransferase 2 (arylamine N-acetyltransferase)

chr11_+_58028478 46.311 NM_019440
Irgm2
immunity-related GTPase family M member 2
chr2_-_51828671 46.293 NM_001141948
NM_001141949
NM_019401
Nmi


N-myc (and STAT) interactor


chr7_-_152469796 46.233 NM_146206
Tpcn2
two pore segment channel 2
chr6_-_54922563 45.640 NM_172729
Nod1
nucleotide-binding oligomerization domain containing 1
chr1_-_186556329 45.227 NM_008250
Hlx
H2.0-like homeobox
chr19_+_12535536 44.775 Mpeg1
macrophage expressed gene 1
chr18_+_60535680 44.567 NM_001146275
NM_021792
Iigp1

interferon inducible GTPase 1

chr6_-_3349470 44.484 NM_010156
Samd9l
sterile alpha motif domain containing 9-like
chr12_+_33063902 44.389 2010109K11Rik
RIKEN cDNA 2010109K11 gene
chr7_-_111501738 43.620 NM_175677
NM_001146007
9230105E10Rik

RIKEN cDNA 9230105E10 gene

chr17_-_35137291 43.615 D17H6S56E-5
DNA segment, Chr 17, human D6S56E 5
chr13_+_74777303 43.578 NM_030711
Erap1
endoplasmic reticulum aminopeptidase 1
chr7_+_31206749 43.549 Nfkbid
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
chr15_-_77363703 42.852 NM_175391
Apol7c
apolipoprotein L 7c
chr5_-_101148612 42.778 NM_152803
Hpse
heparanase
chr1_-_158604396 42.424 NM_023141
Tor3a
torsin family 3, member A
chr14_+_56197282 41.024 NM_011189
Psme1
proteasome (prosome, macropain) 28 subunit, alpha
chr17_+_18024787 40.909 NM_008039
Fpr2
Fpr3
formyl peptide receptor 2
formyl peptide receptor 3
chr7_-_148196606 40.723 Ifitm3
interferon induced transmembrane protein 3
chr7_-_148196526 40.576 Ifitm3
interferon induced transmembrane protein 3
chr7_-_148196635 40.559 NM_025378
Ifitm3
interferon induced transmembrane protein 3
chr4_-_86314560 40.419 Plin2
perilipin 2
chr13_+_33096472 40.412 Serpinb9
serine (or cysteine) peptidase inhibitor, clade B, member 9
chr9_-_119248925 39.872 NM_010851
Myd88
myeloid differentiation primary response gene 88
chr5_-_121262512 39.621 NM_033541
Oas1c
2'-5' oligoadenylate synthetase 1C
chr3_-_135271220 39.551 Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
chr2_-_126758750 39.230 2010106G01Rik
RIKEN cDNA 2010106G01 gene
chr6_+_127396847 39.041 Parp11
poly (ADP-ribose) polymerase family, member 11
chr1_+_177562307 39.023 Kmo
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr7_+_111392998 39.015 Trim34a
tripartite motif-containing 34A
chr18_-_67405109 38.917 NM_172630
Mppe1
metallophosphoesterase 1
chr14_-_59960166 38.798 NM_001164327
Gm4902
predicted gene 4902
chr9_-_106378901 38.473 NM_145619
Parp3
poly (ADP-ribose) polymerase family, member 3
chr2_+_164881126 38.322 NM_011611
NM_170702
NM_170703
NM_170704
Cd40



CD40 antigen



chr6_+_123212124 37.978 NM_001163161
NM_010819
Clec4d

C-type lectin domain family 4, member d


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
5.11 6.73e-30 GO:0006955 immune response
3.35 6.17e-29 GO:0002376 immune system process
4.84 1.18e-22 GO:0051707 response to other organism
4.33 4.92e-22 GO:0009607 response to biotic stimulus
3.86 6.92e-21 GO:0051704 multi-organism process
3.74 4.80e-20 GO:0006952 defense response
6.56 1.02e-19 GO:0045087 innate immune response
21.77 2.86e-16 GO:0035456 response to interferon-beta
21.77 2.86e-16 GO:0035458 cellular response to interferon-beta
5.18 6.34e-16 GO:0034097 response to cytokine stimulus
6.26 2.24e-15 GO:0071345 cellular response to cytokine stimulus
2.12 2.50e-13 GO:0006950 response to stress
6.52 2.10e-12 GO:0009615 response to virus
2.83 4.31e-11 GO:0002682 regulation of immune system process
18.50 5.62e-11 GO:0001562 response to protozoan
18.50 5.62e-11 GO:0042832 defense response to protozoan
12.34 1.99e-10 GO:0034341 response to interferon-gamma
4.81 1.27e-09 GO:0002252 immune effector process
4.04 1.57e-09 GO:0009617 response to bacterium
3.01 3.29e-08 GO:0002684 positive regulation of immune system process
2.11 7.77e-08 GO:0010033 response to organic substance
3.42 1.20e-07 GO:0031347 regulation of defense response
2.72 2.62e-07 GO:0071310 cellular response to organic substance
4.85 1.30e-06 GO:0002237 response to molecule of bacterial origin
14.80 2.25e-06 GO:0071346 cellular response to interferon-gamma
7.12 2.50e-06 GO:0019882 antigen processing and presentation
13.88 4.97e-06 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
2.86 1.19e-05 GO:0050776 regulation of immune response
3.20 1.29e-05 GO:0050778 positive regulation of immune response
2.27 1.31e-05 GO:0070887 cellular response to chemical stimulus
4.94 1.39e-05 GO:0032496 response to lipopolysaccharide
4.11 1.51e-05 GO:0001819 positive regulation of cytokine production
4.24 1.78e-05 GO:0042742 defense response to bacterium
5.31 2.70e-05 GO:0044419 interspecies interaction between organisms
1.69 3.32e-05 GO:0042221 response to chemical stimulus
5.88 4.50e-05 GO:0044403 symbiosis, encompassing mutualism through parasitism
3.75 4.68e-05 GO:0050867 positive regulation of cell activation
2.49 5.60e-05 GO:0080134 regulation of response to stress
5.05 5.91e-05 GO:0071216 cellular response to biotic stimulus
7.22 9.57e-05 GO:0050830 defense response to Gram-positive bacterium
3.88 9.59e-05 GO:0051251 positive regulation of lymphocyte activation
3.73 9.85e-05 GO:0002696 positive regulation of leukocyte activation
3.06 1.05e-04 GO:0050865 regulation of cell activation
3.09 1.46e-04 GO:0002694 regulation of leukocyte activation
7.75 1.53e-04 GO:0048002 antigen processing and presentation of peptide antigen
7.75 1.53e-04 GO:0051607 defense response to virus
3.53 1.56e-04 GO:0002697 regulation of immune effector process
3.22 1.70e-04 GO:0051249 regulation of lymphocyte activation
6.17 2.10e-04 GO:0071219 cellular response to molecule of bacterial origin
24.67 2.16e-04 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
6.73 2.29e-04 GO:0071222 cellular response to lipopolysaccharide
2.85 5.18e-04 GO:0001817 regulation of cytokine production
1.65 6.31e-04 GO:0048583 regulation of response to stimulus
4.33 6.45e-04 GO:0050870 positive regulation of T cell activation
3.03 9.97e-04 GO:0006954 inflammatory response
3.37 1.18e-03 GO:0031349 positive regulation of defense response
20.56 1.25e-03 GO:0032020 ISG15-protein conjugation
1.96 1.70e-03 GO:0048584 positive regulation of response to stimulus
3.50 2.10e-03 GO:0045088 regulation of innate immune response
1.44 2.45e-03 GO:0048518 positive regulation of biological process
4.35 2.89e-03 GO:0050671 positive regulation of lymphocyte proliferation
10.79 2.90e-03 GO:0050691 regulation of defense response to virus by host
4.30 3.37e-03 GO:0032946 positive regulation of mononuclear cell proliferation
1.48 4.25e-03 GO:0048519 negative regulation of biological process
3.34 4.55e-03 GO:0050863 regulation of T cell activation
4.21 4.55e-03 GO:0070665 positive regulation of leukocyte proliferation
3.61 4.56e-03 GO:0050670 regulation of lymphocyte proliferation
3.58 5.14e-03 GO:0032944 regulation of mononuclear cell proliferation
24.67 5.37e-03 GO:0019060 intracellular transport of viral proteins in host cell
24.67 5.37e-03 GO:0030581 symbiont intracellular protein transport in host
24.67 5.37e-03 GO:0046719 regulation of viral protein levels in host cell
24.67 5.37e-03 GO:0051708 intracellular protein transport in other organism involved in symbiotic interaction
3.53 6.49e-03 GO:0070663 regulation of leukocyte proliferation
15.42 1.09e-02 GO:0002483 antigen processing and presentation of endogenous peptide antigen
15.42 1.09e-02 GO:0051825 adhesion to other organism involved in symbiotic interaction
15.42 1.09e-02 GO:0051856 adhesion to symbiont
7.59 1.14e-02 GO:0019884 antigen processing and presentation of exogenous antigen
2.24 1.17e-02 GO:0032270 positive regulation of cellular protein metabolic process
3.90 1.22e-02 GO:0002699 positive regulation of immune effector process
6.35 1.53e-02 GO:0001912 positive regulation of leukocyte mediated cytotoxicity
5.61 1.59e-02 GO:0001910 regulation of leukocyte mediated cytotoxicity
1.73 1.59e-02 GO:0044248 cellular catabolic process
2.06 1.60e-02 GO:0044092 negative regulation of molecular function
2.26 1.79e-02 GO:0000278 mitotic cell cycle
3.93 2.26e-02 GO:0031397 negative regulation of protein ubiquitination
13.71 2.38e-02 GO:0019883 antigen processing and presentation of endogenous antigen
13.71 2.38e-02 GO:0032647 regulation of interferon-alpha production
2.33 2.43e-02 GO:0031401 positive regulation of protein modification process
8.22 2.47e-02 GO:0001916 positive regulation of T cell mediated cytotoxicity
4.85 2.52e-02 GO:0042102 positive regulation of T cell proliferation
4.42 2.76e-02 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
1.80 2.91e-02 GO:0007049 cell cycle
3.63 2.96e-02 GO:0019221 cytokine-mediated signaling pathway
2.14 3.12e-02 GO:0051247 positive regulation of protein metabolic process
6.58 3.70e-02 GO:0032755 positive regulation of interleukin-6 production
3.76 3.81e-02 GO:0045637 regulation of myeloid cell differentiation
4.23 4.39e-02 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
5.04 4.39e-02 GO:0031341 regulation of cell killing
3.35 4.41e-02 GO:0045089 positive regulation of innate immune response
3.35 4.41e-02 GO:0050727 regulation of inflammatory response
9.25 4.91e-02 GO:0032816 positive regulation of natural killer cell activation
5.55 4.95e-02 GO:0031343 positive regulation of cell killing

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
21.59 3.68e-07 GO:0020003 symbiont-containing vacuole
24.67 1.19e-06 GO:0020005 symbiont-containing vacuole membrane
19.19 1.60e-06 GO:0030430 host cell cytoplasm
19.19 1.60e-06 GO:0033646 host intracellular part
19.19 1.60e-06 GO:0033655 host cell cytoplasm part
19.19 1.60e-06 GO:0043656 intracellular region of host
17.27 5.14e-06 GO:0018995 host
17.27 5.14e-06 GO:0033643 host cell part
17.27 5.14e-06 GO:0043245 extraorganismal space
17.27 5.14e-06 GO:0043657 host cell
17.27 5.14e-06 GO:0044215 other organism
17.27 5.14e-06 GO:0044216 other organism cell
17.27 5.14e-06 GO:0044217 other organism part
13.16 9.56e-06 GO:0043230 extracellular organelle
13.16 9.56e-06 GO:0065010 extracellular membrane-bounded organelle
3.11 4.62e-05 GO:0009897 external side of plasma membrane
14.80 2.17e-04 GO:0042612 MHC class I protein complex
1.15 5.27e-04 GO:0005622 intracellular
9.09 1.57e-03 GO:0005839 proteasome core complex
2.46 3.10e-03 GO:0005773 vacuole
7.85 4.77e-03 GO:0042611 MHC protein complex
1.18 8.69e-03 GO:0005737 cytoplasm
1.13 1.49e-02 GO:0044424 intracellular part
1.98 1.82e-02 GO:0009986 cell surface
1.17 1.89e-02 GO:0043227 membrane-bounded organelle
1.16 2.77e-02 GO:0043231 intracellular membrane-bounded organelle
4.18 3.18e-02 GO:0000502 proteasome complex
1.63 3.37e-02 GO:0044421 extracellular region part
3.72 4.40e-02 GO:0044437 vacuolar part

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
10.16 9.81e-04 GO:0003950 NAD+ ADP-ribosyltransferase activity
3.70 4.78e-03 GO:0019955 cytokine binding
8.22 5.09e-03 GO:0004298 threonine-type endopeptidase activity
8.22 5.09e-03 GO:0070003 threonine-type peptidase activity
11.22 1.68e-02 GO:0042287 MHC protein binding
24.67 2.75e-02 GO:0001730 2'-5'-oligoadenylate synthetase activity
1.40 3.00e-02 GO:0016787 hydrolase activity
2.70 3.49e-02 GO:0005126 cytokine receptor binding
1.13 3.93e-02 GO:0005488 binding