Motif ID: IRF1,2,7.p3

Z-value: 7.114


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
Irf1 16362 interferon regulatory factor 1
Irf2 16363 interferon regulatory factor 2
Irf7 54123 interferon regulatory factor 7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf7chr7_-_1484522990.886.0e-61Click!
Irf1chr11_+_535835150.825.4e-45Click!
Irf2chr8_+_478250720.707.4e-28Click!


Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_121195885 260.099 NM_011909
 Usp18
ubiquitin specific peptidase 18
chr5_-_121357467 210.385 NM_145211
 Oas1a
2'-5' oligoadenylate synthetase 1A
chr4_-_155574875 188.343 NM_015783
 Isg15
ISG15 ubiquitin-like modifier
chr1_-_175465858 180.573 BC094916
cDNA sequence BC094916
chr3_+_142283605 168.413 NM_010260
 Gbp2
guanylate binding protein 2
chr5_-_121337533 166.687 NM_011852
 Oas1g
2'-5' oligoadenylate synthetase 1G
chr1_-_175810248 161.412 NM_001170853
 Mndal
myeloid nuclear differentiation antigen like
chr11_+_48900507 156.137 NM_008330
 Ifi47
Olfr56
interferon gamma inducible protein 47
olfactory receptor 56
chr6_+_57531124 155.955 Herc6
hect domain and RLD 6
chr19_+_34658016 155.756 NM_010501
 Ifit3
interferon-induced protein with tetratricopeptide repeats 3
chr16_+_23609986 152.536 NM_023386
 Rtp4
receptor transporter protein 4
chr7_-_148452299 146.294 NM_016850
 Irf7
interferon regulatory factor 7
chr17_-_34324234 141.784 NM_013585
 Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr19_-_11124897 136.766 NM_001177351
 AW112010
expressed sequence AW112010
chr19_+_34682418 134.103 NM_001005858
 I830012O16Rik
RIKEN cDNA I830012O16 gene
chr8_-_108462291 133.754 NM_013640
 Psmb10
proteasome (prosome, macropain) subunit, beta type 10
chr11_-_48877704 133.166 NM_001145164
 Tgtp2
T-cell specific GTPase 2
chr6_+_57530968 132.062 NM_025992
 Herc6
hect domain and RLD 6
chr11_+_58013057 129.284 NM_018738
 Igtp
interferon gamma induced GTPase
chr11_-_48877544 128.528 Tgtp2
Tgtp1
T-cell specific GTPase 2
T-cell specific GTPase 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 102 entries
Enrichment   P-value GO Accession GO Term
24.67 2.16e-04 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
24.67 5.37e-03 GO:0019060 intracellular transport of viral proteins in host cell
24.67 5.37e-03 GO:0030581 symbiont intracellular protein transport in host
24.67 5.37e-03 GO:0046719 regulation of viral protein levels in host cell
24.67 5.37e-03 GO:0051708 intracellular protein transport in other organism involved in symbiotic interaction
21.77 2.86e-16 GO:0035456 response to interferon-beta
21.77 2.86e-16 GO:0035458 cellular response to interferon-beta
20.56 1.25e-03 GO:0032020 ISG15-protein conjugation
18.50 5.62e-11 GO:0001562 response to protozoan
18.50 5.62e-11 GO:0042832 defense response to protozoan
15.42 1.09e-02 GO:0002483 antigen processing and presentation of endogenous peptide antigen
15.42 1.09e-02 GO:0051825 adhesion to other organism involved in symbiotic interaction
15.42 1.09e-02 GO:0051856 adhesion to symbiont
14.80 2.25e-06 GO:0071346 cellular response to interferon-gamma
13.88 4.97e-06 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
13.71 2.38e-02 GO:0019883 antigen processing and presentation of endogenous antigen
13.71 2.38e-02 GO:0032647 regulation of interferon-alpha production
12.34 1.99e-10 GO:0034341 response to interferon-gamma
10.79 2.90e-03 GO:0050691 regulation of defense response to virus by host
9.25 4.91e-02 GO:0032816 positive regulation of natural killer cell activation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 29 entries
Enrichment   P-value GO Accession GO Term
24.67 1.19e-06 GO:0020005 symbiont-containing vacuole membrane
21.59 3.68e-07 GO:0020003 symbiont-containing vacuole
19.19 1.60e-06 GO:0030430 host cell cytoplasm
19.19 1.60e-06 GO:0033646 host intracellular part
19.19 1.60e-06 GO:0033655 host cell cytoplasm part
19.19 1.60e-06 GO:0043656 intracellular region of host
17.27 5.14e-06 GO:0018995 host
17.27 5.14e-06 GO:0033643 host cell part
17.27 5.14e-06 GO:0043245 extraorganismal space
17.27 5.14e-06 GO:0043657 host cell
17.27 5.14e-06 GO:0044215 other organism
17.27 5.14e-06 GO:0044216 other organism cell
17.27 5.14e-06 GO:0044217 other organism part
14.80 2.17e-04 GO:0042612 MHC class I protein complex
13.16 9.56e-06 GO:0043230 extracellular organelle
13.16 9.56e-06 GO:0065010 extracellular membrane-bounded organelle
9.09 1.57e-03 GO:0005839 proteasome core complex
7.85 4.77e-03 GO:0042611 MHC protein complex
4.18 3.18e-02 GO:0000502 proteasome complex
3.72 4.40e-02 GO:0044437 vacuolar part

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
Enrichment   P-value GO Accession GO Term
24.67 2.75e-02 GO:0001730 2'-5'-oligoadenylate synthetase activity
11.22 1.68e-02 GO:0042287 MHC protein binding
10.16 9.81e-04 GO:0003950 NAD+ ADP-ribosyltransferase activity
8.22 5.09e-03 GO:0004298 threonine-type endopeptidase activity
8.22 5.09e-03 GO:0070003 threonine-type peptidase activity
3.70 4.78e-03 GO:0019955 cytokine binding
2.70 3.49e-02 GO:0005126 cytokine receptor binding
1.40 3.00e-02 GO:0016787 hydrolase activity
1.13 3.93e-02 GO:0005488 binding