Motif ID: KLF12.p2

Z-value: 2.777


Transcription factors associated with KLF12.p2:

Gene SymbolEntrez IDGene Name
Klf12 16597 Kruppel-like factor 12

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf12chr14_-_1005489820.621.2e-20Click!


Activity profile for motif KLF12.p2.

activity profile for motif KLF12.p2


Sorted Z-values histogram for motif KLF12.p2

Sorted Z-values for motif KLF12.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF12.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_117881591 45.210 Ptprf
protein tyrosine phosphatase, receptor type, F
chr6_-_124718354 42.089 Eno2
enolase 2, gamma neuronal
chr11_+_68505616 38.155 Myh10
myosin, heavy polypeptide 10, non-muscle
chr11_+_68505416 37.002 NM_175260
 Myh10
myosin, heavy polypeptide 10, non-muscle
chr11_+_68505612 34.365 Myh10
myosin, heavy polypeptide 10, non-muscle
chr10_-_108447996 34.248 Syt1
synaptotagmin I
chr10_-_108447894 33.678 Syt1
synaptotagmin I
chr8_+_56040445 33.224 Gpm6a
glycoprotein m6a
chr10_-_108448003 32.325 Syt1
synaptotagmin I
chr8_+_56040193 32.261 Gpm6a
glycoprotein m6a
chr8_+_56040553 29.068 Gpm6a
glycoprotein m6a
chr16_+_91270319 28.384 Olig1
oligodendrocyte transcription factor 1
chr3_+_90341208 27.952 S100a16
S100 calcium binding protein A16
chr16_+_41533317 27.876 NM_175548
 Lsamp
limbic system-associated membrane protein
chr12_+_76409299 27.588 NM_023275
 Rhoj
ras homolog gene family, member J
chr2_-_25325196 27.532 Ptgds
prostaglandin D2 synthase (brain)
chr8_+_56040211 26.398 Gpm6a
glycoprotein m6a
chr2_+_25264823 25.945


chr4_+_41707315 25.610 NM_001163401
NM_001172054
 Il11ra1

interleukin 11 receptor, alpha chain 1

chr12_+_110784600 25.046 Meg3
maternally expressed 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 172 entries
Enrichment   P-value GO Accession GO Term
3.88 1.88e-04 GO:0030199 collagen fibril organization
3.47 8.23e-06 GO:0007266 Rho protein signal transduction
3.13 3.63e-03 GO:0048286 lung alveolus development
2.96 3.56e-02 GO:0033762 response to glucagon stimulus
2.96 3.56e-02 GO:0090263 positive regulation of canonical Wnt receptor signaling pathway
2.77 7.22e-03 GO:0030177 positive regulation of Wnt receptor signaling pathway
2.70 1.27e-04 GO:0045667 regulation of osteoblast differentiation
2.69 3.70e-02 GO:0007269 neurotransmitter secretion
2.69 3.70e-02 GO:0051149 positive regulation of muscle cell differentiation
2.42 1.25e-03 GO:0030178 negative regulation of Wnt receptor signaling pathway
2.41 2.32e-02 GO:0050680 negative regulation of epithelial cell proliferation
2.30 1.27e-04 GO:0030278 regulation of ossification
2.25 3.05e-05 GO:0030111 regulation of Wnt receptor signaling pathway
2.18 8.07e-07 GO:0043062 extracellular structure organization
2.17 5.78e-04 GO:0030198 extracellular matrix organization
2.16 4.38e-02 GO:0090257 regulation of muscle system process
2.15 2.65e-02 GO:0060828 regulation of canonical Wnt receptor signaling pathway
2.13 4.47e-02 GO:0010721 negative regulation of cell development
2.12 1.01e-03 GO:0030324 lung development
2.12 1.30e-03 GO:0003012 muscle system process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 81 entries
Enrichment   P-value GO Accession GO Term
4.10 2.24e-02 GO:0005583 fibrillar collagen
2.54 3.69e-02 GO:0016529 sarcoplasmic reticulum
2.45 4.29e-02 GO:0016528 sarcoplasm
2.42 1.70e-04 GO:0030426 growth cone
2.40 1.36e-04 GO:0030427 site of polarized growth
2.35 1.72e-02 GO:0005901 caveola
2.32 1.66e-04 GO:0030017 sarcomere
2.21 9.48e-03 GO:0044309 neuron spine
2.20 2.69e-04 GO:0044449 contractile fiber part
2.19 1.62e-02 GO:0043197 dendritic spine
2.16 4.91e-13 GO:0030425 dendrite
2.15 8.10e-05 GO:0043292 contractile fiber
2.14 2.82e-03 GO:0043296 apical junction complex
2.10 4.79e-03 GO:0016327 apicolateral plasma membrane
2.07 2.32e-04 GO:0033267 axon part
2.05 4.58e-22 GO:0043005 neuron projection
2.05 4.78e-03 GO:0034703 cation channel complex
2.01 9.43e-09 GO:0030424 axon
2.01 6.10e-04 GO:0019717 synaptosome
1.96 4.31e-02 GO:0005741 mitochondrial outer membrane

Gene overrepresentation in function category:

Showing 1 to 20 of 46 entries
Enrichment   P-value GO Accession GO Term
3.27 3.15e-03 GO:0005201 extracellular matrix structural constituent
2.60 1.87e-09 GO:0005516 calmodulin binding
2.26 9.93e-04 GO:0030165 PDZ domain binding
2.19 3.03e-02 GO:0019199 transmembrane receptor protein kinase activity
2.15 1.48e-03 GO:0019838 growth factor binding
2.12 2.46e-02 GO:0005099 Ras GTPase activator activity
2.09 1.58e-04 GO:0005539 glycosaminoglycan binding
2.03 1.47e-02 GO:0008201 heparin binding
1.95 1.03e-03 GO:0001871 pattern binding
1.95 1.03e-03 GO:0030247 polysaccharide binding
1.86 1.02e-05 GO:0005083 small GTPase regulator activity
1.86 3.53e-02 GO:0022843 voltage-gated cation channel activity
1.86 4.79e-02 GO:0051020 GTPase binding
1.84 1.78e-03 GO:0005244 voltage-gated ion channel activity
1.84 1.78e-03 GO:0022832 voltage-gated channel activity
1.81 7.22e-12 GO:0019904 protein domain specific binding
1.78 2.75e-02 GO:0016829 lyase activity
1.73 8.21e-03 GO:0005096 GTPase activator activity
1.71 2.57e-06 GO:0030695 GTPase regulator activity
1.67 8.27e-06 GO:0060589 nucleoside-triphosphatase regulator activity