Motif ID: KLF12.p2

Z-value: 2.777


Transcription factors associated with KLF12.p2:

Gene SymbolEntrez IDGene Name
Klf12 16597 Kruppel-like factor 12

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf12chr14_-_1005489820.621.2e-20Click!


Activity profile for motif KLF12.p2.

activity profile for motif KLF12.p2


Sorted Z-values histogram for motif KLF12.p2

Sorted Z-values for motif KLF12.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF12.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_117881591 45.210 Ptprf
protein tyrosine phosphatase, receptor type, F
chr6_-_124718354 42.089 Eno2
enolase 2, gamma neuronal
chr11_+_68505616 38.155 Myh10
myosin, heavy polypeptide 10, non-muscle
chr11_+_68505416 37.002 NM_175260
Myh10
myosin, heavy polypeptide 10, non-muscle
chr11_+_68505612 34.365 Myh10
myosin, heavy polypeptide 10, non-muscle
chr10_-_108447996 34.248 Syt1
synaptotagmin I
chr10_-_108447894 33.678 Syt1
synaptotagmin I
chr8_+_56040445 33.224 Gpm6a
glycoprotein m6a
chr10_-_108448003 32.325 Syt1
synaptotagmin I
chr8_+_56040193 32.261 Gpm6a
glycoprotein m6a
chr8_+_56040553 29.068 Gpm6a
glycoprotein m6a
chr16_+_91270319 28.384 Olig1
oligodendrocyte transcription factor 1
chr3_+_90341208 27.952 S100a16
S100 calcium binding protein A16
chr16_+_41533317 27.876 NM_175548
Lsamp
limbic system-associated membrane protein
chr12_+_76409299 27.588 NM_023275
Rhoj
ras homolog gene family, member J
chr2_-_25325196 27.532 Ptgds
prostaglandin D2 synthase (brain)
chr8_+_56040211 26.398 Gpm6a
glycoprotein m6a
chr2_+_25264823 25.945


chr4_+_41707315 25.610 NM_001163401
NM_001172054
Il11ra1

interleukin 11 receptor, alpha chain 1

chr12_+_110784600 25.046 Meg3
maternally expressed 3
chr10_+_75398588 24.893 Chchd10
coiled-coil-helix-coiled-coil-helix domain containing 10
chr12_+_91570569 24.877 Nrxn3
neurexin III
chr8_+_56040080 24.503 NM_153581
Gpm6a
glycoprotein m6a
chr4_-_151235861 24.227 NM_001081557
NM_001195565
Camta1

calmodulin binding transcription activator 1

chr4_+_115894231 23.834 Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr12_+_110783786 23.073 Meg3
maternally expressed 3
chr11_-_64976408 22.702 NM_001099288
NM_175003
Arhgap44

Rho GTPase activating protein 44

chr10_+_75716647 22.443 S100b
S100 protein, beta polypeptide, neural
chr7_-_20283542 22.294 Apoe
apolipoprotein E
chr2_+_152512797 21.937 NM_025543
Mcts2
malignant T cell amplified sequence 2
chr10_+_106708886 21.907 NM_001033223
NM_001039354
Lin7a

lin-7 homolog A (C. elegans)

chr9_-_107134182 21.523 NM_153413
Dock3
dedicator of cyto-kinesis 3
chr7_-_149838254 21.471 Igf2
insulin-like growth factor 2
chr10_+_75716580 21.119 NM_009115
S100b
S100 protein, beta polypeptide, neural
chr19_-_8913619 20.977 NM_010316
Gng3
guanine nucleotide binding protein (G protein), gamma 3
chr4_+_115894518 20.954 NM_181585
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr15_+_54402988 20.954 Mal2
mal, T-cell differentiation protein 2
chr9_-_45743950 20.870 Tagln
transgelin
chr4_+_41707341 20.814 Il11ra1
interleukin 11 receptor, alpha chain 1
chr11_-_32109606 20.472


chr16_-_17842060 20.351 Dgcr2
DiGeorge syndrome critical region gene 2
chr5_-_38550627 20.142 NM_010942
Nsg1
neuron specific gene family member 1
chrX_-_49033640 20.006 NM_015819
Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr11_-_69419330 19.868 Atp1b2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr9_-_103125934 19.795 Trf
transferrin
chr6_+_4471231 19.777 Col1a2
collagen, type I, alpha 2
chr7_+_4873852 19.747 NM_201355
Nat14
N-acetyltransferase 14
chr11_+_94808758 19.662 Col1a1
collagen, type I, alpha 1
chr10_-_108447674 19.554 NM_009306
Syt1
synaptotagmin I
chr2_+_16277963 19.366 Plxdc2
plexin domain containing 2
chr3_+_8509479 19.242 NM_025285
Stmn2
stathmin-like 2
chr14_+_68701838 19.221 NM_010910
Nefl
neurofilament, light polypeptide
chr2_-_25325248 19.199 NM_008963
Ptgds
prostaglandin D2 synthase (brain)
chr12_+_30687597 19.159 Pxdn
peroxidasin homolog (Drosophila)
chr4_+_147534729 19.145 Fbxo2
F-box protein 2
chr4_+_147534776 18.428 NM_176848
Fbxo2
F-box protein 2
chr11_+_3414884 18.112 Selm
selenoprotein M
chr7_+_138079669 17.952 NM_019564
Htra1
HtrA serine peptidase 1
chr2_+_32484995 17.695 NM_021515
Ak1
adenylate kinase 1
chr7_+_89319681 17.639 Sh3gl3
SH3-domain GRB2-like 3
chr15_+_54402914 17.197 NM_178920
Mal2
mal, T-cell differentiation protein 2
chr4_-_104782444 17.120 NM_178143
Prkaa2
protein kinase, AMP-activated, alpha 2 catalytic subunit
chr7_-_89079168 17.038 Hdgfrp3
hepatoma-derived growth factor, related protein 3
chr2_+_26447647 16.910


chr11_+_70461024 16.260 NM_027445
Rnf167
ring finger protein 167
chr11_+_31901708 16.140 Nsg2
neuron specific gene family member 2
chr1_-_83404659 16.125 NM_172430
Sphkap
SPHK1 interactor, AKAP domain containing
chr7_+_19868009 15.944 NM_013648
Rtn2
reticulon 2 (Z-band associated protein)
chr18_+_37925619 15.742 Pcdhga12
protocadherin gamma subfamily A, 12
chr7_+_89319717 15.699 NM_017400
Sh3gl3
SH3-domain GRB2-like 3
chr16_+_7069971 15.651 Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chrX_+_7496899 15.623 NM_013892
Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
chr11_-_75236018 15.414 Serpinf1
serine (or cysteine) peptidase inhibitor, clade F, member 1
chr18_+_37828606 15.296 NM_033585
Pcdhga2
protocadherin gamma subfamily A, 2
chr18_-_42900793 15.287 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr11_-_75236085 15.286 NM_011340
Serpinf1
serine (or cysteine) peptidase inhibitor, clade F, member 1
chr18_-_12978106 15.093 Osbpl1a
oxysterol binding protein-like 1A
chr11_-_55209320 15.032 Sparc
secreted acidic cysteine rich glycoprotein
chr6_+_90416405 14.881 Klf15
Kruppel-like factor 15
chr11_+_98629709 14.863


chr1_+_42752608 14.774


chr6_+_17231172 14.593 Cav2
caveolin 2
chr9_+_27598853 14.438 NM_177906
Opcml
opioid binding protein/cell adhesion molecule-like
chrX_-_100381703 14.327 Nap1l2
nucleosome assembly protein 1-like 2
chr1_+_66515003 14.295 NM_175510
Unc80
unc-80 homolog (C. elegans)
chr16_+_43619057 14.270 Zbtb20
zinc finger and BTB domain containing 20
chr19_+_44368557 14.248 Scd2
stearoyl-Coenzyme A desaturase 2
chr9_-_117161234 14.216 Rbms3
RNA binding motif, single stranded interacting protein
chr7_-_52230179 14.030 Cpt1c
carnitine palmitoyltransferase 1c
chr18_-_46887869 14.026 NM_033037
Cdo1
cysteine dioxygenase 1, cytosolic
chr10_+_40603330 13.946 NM_031877
Wasf1
WASP family 1
chr7_-_35437859 13.804 NM_146188
Kctd15
potassium channel tetramerisation domain containing 15
chr4_+_57867433 13.787 NM_001035533
Akap2
A kinase (PRKA) anchor protein 2
chr7_+_19876447 13.687 NM_001025364
Rtn2
reticulon 2 (Z-band associated protein)
chr14_-_46149660 13.648 NM_146054
Fermt2
fermitin family homolog 2 (Drosophila)
chr12_+_37968225 13.639 NM_178767
Tmem195
transmembrane protein 195
chr4_-_60235470 13.578 NM_001134676
Mup8
major urinary protein 8
chrX_-_100381973 13.545 NM_008671
Nap1l2
nucleosome assembly protein 1-like 2
chr9_-_45744036 13.540 NM_011526
Tagln
transgelin
chr9_-_29219306 13.459 Ntm
neurotrimin
chr19_+_44368578 13.451 Scd2
stearoyl-Coenzyme A desaturase 2
chr11_+_94811409 13.434 Col1a1
collagen, type I, alpha 1
chr3_+_67696141 13.393 NM_001113419
NM_177585
Iqcj-schip1
Iqcj
IQ motif containing J-schwannomin interacting protein 1 read-through transcript
IQ motif containing J
chr7_-_89079335 13.354 NM_013886
Hdgfrp3
hepatoma-derived growth factor, related protein 3
chr2_+_84890611 13.228 NM_001081260
Tnks1bp1
tankyrase 1 binding protein 1
chr11_+_3414792 13.016 Selm
selenoprotein M
chr15_-_78236262 12.785 NM_009437
Tst
thiosulfate sulfurtransferase, mitochondrial
chr10_-_94877824 12.753 NM_001168657
Socs2
suppressor of cytokine signaling 2
chr1_-_194681914 12.735 NM_198247
Sertad4
SERTA domain containing 4
chr15_+_34236408 12.635 NM_016762
Matn2
matrilin 2
chr6_+_21166108 12.554 NM_019697
Kcnd2
potassium voltage-gated channel, Shal-related family, member 2
chr9_-_29219382 12.501 Ntm
neurotrimin
chrX_+_53985133 12.391 NM_001077361
Fhl1
four and a half LIM domains 1
chr3_+_107698740 12.388 NM_010360
Gstm5
glutathione S-transferase, mu 5
chr19_+_44368588 12.348 Scd2
stearoyl-Coenzyme A desaturase 2
chr4_-_68615283 12.314 Dbc1
deleted in bladder cancer 1 (human)
chr13_-_60278723 12.305 Gas1
growth arrest specific 1
chr19_+_44368576 12.302 Scd2
stearoyl-Coenzyme A desaturase 2
chr15_-_98780503 12.248 Tuba1a
tubulin, alpha 1A
chr7_+_25266986 12.235 NM_153112
Cadm4
cell adhesion molecule 4
chr14_-_119498586 12.226 NM_001081252
Uggt2
UDP-glucose glycoprotein glucosyltransferase 2
chr1_+_34347244 12.151 Dst
dystonin
chr10_-_79600131 12.134 NM_001195268
Dos
downstream of Stk11
chr8_-_67171481 12.119 Cpe
carboxypeptidase E
chr18_+_82723854 12.063 NM_001025251
NM_001025255
NM_001025256
NM_001025258
NM_001025259
NM_001025254
Mbp





myelin basic protein





chr19_-_10944196 12.020 NM_133804
Tmem132a
transmembrane protein 132A
chrX_+_96331496 11.900 Efnb1
ephrin B1
chr1_-_77511577 11.881 Epha4
Eph receptor A4
chr11_-_69419419 11.869 NM_013415
Atp1b2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr7_-_26460180 11.862 NM_177102
Tmem91
transmembrane protein 91
chr18_-_13100228 11.826 NM_207530
Osbpl1a
oxysterol binding protein-like 1A
chr10_-_94878117 11.801 NM_001168656
Socs2
suppressor of cytokine signaling 2
chrX_+_162782484 11.788 NM_001177955
NM_001177956
NM_001177957
NM_001177958
NM_001177959
NM_001177960
Gpm6b





glycoprotein m6b





chr1_+_45401659 11.780 Col3a1
collagen, type III, alpha 1
chr2_-_73498303 11.738 NM_001166604
NM_175752
Chn1

chimerin (chimaerin) 1

chr18_+_82723907 11.709 Mbp
myelin basic protein
chr17_+_81343933 11.666 NM_026516
Tmem178
transmembrane protein 178
chr7_-_20281956 11.659


chr11_+_94812919 11.622 Col1a1
collagen, type I, alpha 1
chr10_-_76175108 11.592 Col6a1
collagen, type VI, alpha 1
chr12_-_8505780 11.552 Rhob
ras homolog gene family, member B
chr19_-_44470218 11.529 Scd1
stearoyl-Coenzyme A desaturase 1
chr3_-_108218411 11.463 NM_001004177
NM_017392
Celsr2

cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)

chr1_-_166368439 11.454 Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr16_+_41532938 11.444 Lsamp
limbic system-associated membrane protein
chr15_-_33617572 11.438 NM_001085421
Tspyl5
testis-specific protein, Y-encoded-like 5
chr1_-_137063881 11.433 Gpr37l1
G protein-coupled receptor 37-like 1
chr14_-_55531726 11.339 NM_021551
Slc22a17
solute carrier family 22 (organic cation transporter), member 17
chrX_+_54032858 11.265 NM_001077362
Fhl1
four and a half LIM domains 1
chrX_+_20265093 11.239 Cdk16
cyclin-dependent kinase 16
chr1_+_87804443 11.224 Itm2c
integral membrane protein 2C
chr7_-_149763600 11.217 H19
H19 fetal liver mRNA
chr1_+_87804349 11.206 Itm2c
integral membrane protein 2C
chr1_+_166726827 11.191 NM_019759
Dpt
dermatopontin
chr18_-_43058544 11.183 NM_027531
Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr8_-_67171805 11.107 NM_013494
Cpe
carboxypeptidase E
chr4_+_149022081 11.049 Clstn1
calsyntenin 1
chr11_+_68901989 10.989 Vamp2
vesicle-associated membrane protein 2
chr16_+_6349108 10.921 Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr11_+_105451296 10.918 NM_181071
Tanc2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr1_-_137064124 10.747 NM_134438
Gpr37l1
G protein-coupled receptor 37-like 1
chr5_-_51848420 10.730 Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr7_-_137409683 10.664 Fgfr2
fibroblast growth factor receptor 2
chr15_+_12047555 10.618 NM_011767
Zfr
zinc finger RNA binding protein
chr11_+_3414983 10.616 Selm
selenoprotein M
chr2_+_16277924 10.521 NM_026162
Plxdc2
plexin domain containing 2
chr3_-_83967952 10.502 Trim2
tripartite motif-containing 2
chr1_-_77511653 10.475 NM_007936
Epha4
Eph receptor A4
chr17_+_27822162 10.469 NM_178365
Pacsin1
protein kinase C and casein kinase substrate in neurons 1
chr2_+_156246644 10.464 NM_001003815
NM_013510
Epb4.1l1

erythrocyte protein band 4.1-like 1

chr13_+_22127689 10.352 NM_175665
Hist1h2bk
histone cluster 1, H2bk
chr7_+_31092787 10.315 Clip3
CAP-GLY domain containing linker protein 3
chr11_-_96691198 10.261 Nfe2l1
nuclear factor, erythroid derived 2,-like 1
chrX_+_96331434 10.255 NM_010110
Efnb1
ephrin B1
chr19_-_4009363 10.239 Ndufv1
NADH dehydrogenase (ubiquinone) flavoprotein 1
chrX_-_132738383 10.229 NM_177919
Tceal5
transcription elongation factor A (SII)-like 5
chr6_-_4697009 10.225 NM_001130188
NM_001130189
NM_001130190
NM_001130191
NM_011360
Sgce




sarcoglycan, epsilon




chr7_+_97497207 10.180 NM_001040085
NM_031394
Sytl2

synaptotagmin-like 2

chrX_+_54032914 10.140 Fhl1
four and a half LIM domains 1
chr15_+_101933364 10.130 NM_153533
Tenc1
tensin like C1 domain-containing phosphatase
chr9_+_107948476 10.100 Ip6k1
inositol hexaphosphate kinase 1
chrX_+_20276404 10.096 Cdk16
cyclin-dependent kinase 16
chrX_+_97963061 10.088 NM_001177778
NM_016747
Dlg3

discs, large homolog 3 (Drosophila)

chr8_+_88016492 10.046 NM_173866
Gpt2
glutamic pyruvate transaminase (alanine aminotransferase) 2
chr2_-_173053287 10.024 Pmepa1
prostate transmembrane protein, androgen induced 1
chr2_+_74543545 10.014 NM_008276
Hoxd8
homeobox D8
chr17_+_46787285 10.012 NM_025611
Cul7
cullin 7
chr11_-_94902584 10.006 NM_133667
Pdk2
pyruvate dehydrogenase kinase, isoenzyme 2
chr11_-_60166321 9.958 Tom1l2
target of myb1-like 2 (chicken)
chr1_-_174128558 9.931 Pea15a
phosphoprotein enriched in astrocytes 15A
chr3_+_75878452 9.923 NM_178673
Fstl5
follistatin-like 5
chr7_+_52104591 9.916 NM_026270
Akt1s1
AKT1 substrate 1 (proline-rich)
chr18_+_61204953 9.886 Pdgfrb
platelet derived growth factor receptor, beta polypeptide
chr19_+_20676453 9.877 NM_013467
Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr18_+_82723920 9.871 Mbp
myelin basic protein
chr6_+_17231334 9.791 NM_016900
Cav2
caveolin 2
chr8_-_11212651 9.696 Col4a1
collagen, type IV, alpha 1
chr17_+_24731733 9.639 Pkd1
polycystic kidney disease 1 homolog
chr15_+_78258993 9.635 NM_001081367
Kctd17
potassium channel tetramerisation domain containing 17
chr8_+_72853663 9.634 NM_008107
Gdf1
growth differentiation factor 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.46 4.54e-20 GO:0048731 system development
1.38 9.07e-20 GO:0032502 developmental process
1.67 1.28e-18 GO:0007399 nervous system development
1.37 2.21e-18 GO:0051179 localization
1.38 7.88e-18 GO:0007275 multicellular organismal development
1.41 9.10e-18 GO:0048856 anatomical structure development
1.38 3.37e-15 GO:0006810 transport
1.38 3.63e-15 GO:0051234 establishment of localization
1.48 9.85e-12 GO:0023051 regulation of signaling
1.56 4.47e-11 GO:0035556 intracellular signal transduction
1.37 5.18e-11 GO:0048523 negative regulation of cellular process
1.63 1.65e-10 GO:0022008 neurogenesis
1.34 4.45e-10 GO:0048519 negative regulation of biological process
1.40 6.03e-10 GO:0065008 regulation of biological quality
1.61 6.36e-10 GO:0051128 regulation of cellular component organization
1.63 8.13e-10 GO:0048699 generation of neurons
1.49 1.15e-09 GO:0009966 regulation of signal transduction
1.36 1.42e-09 GO:0048869 cellular developmental process
1.37 2.30e-09 GO:0030154 cell differentiation
1.66 2.02e-08 GO:0007155 cell adhesion
1.39 3.02e-08 GO:0048583 regulation of response to stimulus
1.28 3.61e-08 GO:0016043 cellular component organization
1.65 4.23e-08 GO:0022610 biological adhesion
1.70 8.50e-08 GO:0072358 cardiovascular system development
1.70 8.50e-08 GO:0072359 circulatory system development
1.49 8.90e-08 GO:0032879 regulation of localization
1.89 1.31e-07 GO:0001944 vasculature development
1.53 1.57e-07 GO:0048468 cell development
1.41 2.37e-07 GO:0009653 anatomical structure morphogenesis
1.36 6.32e-07 GO:0044281 small molecule metabolic process
1.25 7.02e-07 GO:0071840 cellular component organization or biogenesis
2.18 8.07e-07 GO:0043062 extracellular structure organization
1.45 1.05e-06 GO:0010646 regulation of cell communication
1.37 1.38e-06 GO:0051239 regulation of multicellular organismal process
1.45 2.21e-06 GO:0051641 cellular localization
1.74 2.33e-06 GO:0060284 regulation of cell development
1.57 2.60e-06 GO:0019220 regulation of phosphate metabolic process
1.57 2.60e-06 GO:0051174 regulation of phosphorus metabolic process
1.85 3.59e-06 GO:0001568 blood vessel development
1.89 3.79e-06 GO:0007264 small GTPase mediated signal transduction
1.13 4.42e-06 GO:0008152 metabolic process
3.47 8.23e-06 GO:0007266 Rho protein signal transduction
1.78 8.63e-06 GO:0019226 transmission of nerve impulse
1.78 8.63e-06 GO:0035637 multicellular organismal signaling
1.24 1.12e-05 GO:0048518 positive regulation of biological process
1.61 1.19e-05 GO:0030182 neuron differentiation
1.69 1.27e-05 GO:0048666 neuron development
1.28 1.37e-05 GO:0071842 cellular component organization at cellular level
1.42 2.11e-05 GO:0050793 regulation of developmental process
1.50 2.28e-05 GO:0051049 regulation of transport
1.79 2.82e-05 GO:0000904 cell morphogenesis involved in differentiation
1.54 3.04e-05 GO:0042325 regulation of phosphorylation
2.25 3.05e-05 GO:0030111 regulation of Wnt receptor signaling pathway
1.25 3.07e-05 GO:0048522 positive regulation of cellular process
1.72 3.84e-05 GO:0007167 enzyme linked receptor protein signaling pathway
1.91 4.55e-05 GO:0051129 negative regulation of cellular component organization
1.61 4.77e-05 GO:0030030 cell projection organization
1.38 5.20e-05 GO:0033036 macromolecule localization
1.67 5.62e-05 GO:0044057 regulation of system process
1.47 6.46e-05 GO:0045595 regulation of cell differentiation
1.69 7.31e-05 GO:0051960 regulation of nervous system development
2.05 1.07e-04 GO:0043434 response to peptide hormone stimulus
1.29 1.13e-04 GO:0048513 organ development
1.40 1.13e-04 GO:0008104 protein localization
1.60 1.17e-04 GO:0032989 cellular component morphogenesis
1.43 1.22e-04 GO:2000026 regulation of multicellular organismal development
2.30 1.27e-04 GO:0030278 regulation of ossification
2.70 1.27e-04 GO:0045667 regulation of osteoblast differentiation
1.63 1.83e-04 GO:0007267 cell-cell signaling
3.88 1.88e-04 GO:0030199 collagen fibril organization
1.25 2.09e-04 GO:0071841 cellular component organization or biogenesis at cellular level
2.01 2.19e-04 GO:0016055 Wnt receptor signaling pathway
1.61 2.27e-04 GO:0000902 cell morphogenesis
1.50 2.39e-04 GO:0042180 cellular ketone metabolic process
1.71 2.39e-04 GO:0031175 neuron projection development
1.49 2.48e-04 GO:0007154 cell communication
1.44 2.53e-04 GO:0006629 lipid metabolic process
1.92 2.77e-04 GO:0031344 regulation of cell projection organization
1.79 2.81e-04 GO:0007268 synaptic transmission
1.52 3.19e-04 GO:0001932 regulation of protein phosphorylation
1.77 3.50e-04 GO:0045664 regulation of neuron differentiation
1.58 4.09e-04 GO:0070727 cellular macromolecule localization
1.69 4.52e-04 GO:0050767 regulation of neurogenesis
1.61 4.64e-04 GO:0009719 response to endogenous stimulus
1.58 5.10e-04 GO:0034613 cellular protein localization
1.50 5.43e-04 GO:0044255 cellular lipid metabolic process
1.67 5.61e-04 GO:0022603 regulation of anatomical structure morphogenesis
2.17 5.78e-04 GO:0030198 extracellular matrix organization
1.43 7.86e-04 GO:0055114 oxidation-reduction process
1.48 1.01e-03 GO:0019752 carboxylic acid metabolic process
1.48 1.01e-03 GO:0043436 oxoacid metabolic process
2.12 1.01e-03 GO:0030324 lung development
1.79 1.03e-03 GO:0048514 blood vessel morphogenesis
1.54 1.08e-03 GO:0048585 negative regulation of response to stimulus
2.42 1.25e-03 GO:0030178 negative regulation of Wnt receptor signaling pathway
2.12 1.30e-03 GO:0003012 muscle system process
1.77 1.46e-03 GO:0051056 regulation of small GTPase mediated signal transduction
1.40 1.54e-03 GO:0051649 establishment of localization in cell
1.47 1.59e-03 GO:0006082 organic acid metabolic process
1.47 1.66e-03 GO:0048878 chemical homeostasis
1.66 1.68e-03 GO:0009894 regulation of catabolic process
2.08 1.70e-03 GO:0030323 respiratory tube development
1.92 2.17e-03 GO:0010975 regulation of neuron projection development
2.05 2.18e-03 GO:0001503 ossification
1.12 2.28e-03 GO:0044237 cellular metabolic process
1.61 2.53e-03 GO:0008285 negative regulation of cell proliferation
1.64 2.62e-03 GO:0035295 tube development
1.57 2.74e-03 GO:0010648 negative regulation of cell communication
1.55 2.87e-03 GO:0055082 cellular chemical homeostasis
1.50 3.08e-03 GO:0019725 cellular homeostasis
1.55 3.15e-03 GO:0007417 central nervous system development
3.13 3.63e-03 GO:0048286 lung alveolus development
1.26 3.65e-03 GO:0042221 response to chemical stimulus
1.38 3.65e-03 GO:0009888 tissue development
1.60 3.81e-03 GO:0009725 response to hormone stimulus
1.68 4.12e-03 GO:0030334 regulation of cell migration
1.35 4.30e-03 GO:0006796 phosphate metabolic process
1.58 4.76e-03 GO:0007610 behavior
1.35 5.04e-03 GO:0006793 phosphorus metabolic process
1.88 5.21e-03 GO:0042391 regulation of membrane potential
1.60 5.21e-03 GO:0008610 lipid biosynthetic process
1.34 5.34e-03 GO:0010941 regulation of cell death
1.96 5.35e-03 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.96 5.35e-03 GO:0022604 regulation of cell morphogenesis
1.64 6.20e-03 GO:0032787 monocarboxylic acid metabolic process
2.77 7.22e-03 GO:0030177 positive regulation of Wnt receptor signaling pathway
1.65 7.52e-03 GO:2000145 regulation of cell motility
1.53 7.63e-03 GO:0006873 cellular ion homeostasis
1.54 7.89e-03 GO:0023057 negative regulation of signaling
1.50 8.24e-03 GO:0050801 ion homeostasis
1.91 9.89e-03 GO:0019216 regulation of lipid metabolic process
1.27 1.03e-02 GO:0065009 regulation of molecular function
1.36 1.04e-02 GO:0022607 cellular component assembly
1.69 1.16e-02 GO:0048812 neuron projection morphogenesis
1.34 1.25e-02 GO:0043067 regulation of programmed cell death
1.55 1.28e-02 GO:0009968 negative regulation of signal transduction
1.60 1.52e-02 GO:0040012 regulation of locomotion
1.85 1.65e-02 GO:0060537 muscle tissue development
1.60 1.66e-02 GO:0051270 regulation of cellular component movement
1.58 1.73e-02 GO:0007420 brain development
1.33 1.75e-02 GO:0042981 regulation of apoptosis
1.60 1.81e-02 GO:0032990 cell part morphogenesis
1.91 2.11e-02 GO:0060541 respiratory system development
1.38 2.14e-02 GO:0031399 regulation of protein modification process
1.42 2.20e-02 GO:0016192 vesicle-mediated transport
1.86 2.24e-02 GO:0050678 regulation of epithelial cell proliferation
1.64 2.25e-02 GO:0031329 regulation of cellular catabolic process
2.41 2.32e-02 GO:0050680 negative regulation of epithelial cell proliferation
1.73 2.34e-02 GO:0046578 regulation of Ras protein signal transduction
1.57 2.56e-02 GO:0051130 positive regulation of cellular component organization
2.15 2.65e-02 GO:0060828 regulation of canonical Wnt receptor signaling pathway
1.29 2.66e-02 GO:0050790 regulation of catalytic activity
2.05 2.72e-02 GO:0006936 muscle contraction
1.60 2.84e-02 GO:0048858 cell projection morphogenesis
1.53 2.93e-02 GO:0051093 negative regulation of developmental process
1.52 3.17e-02 GO:0043549 regulation of kinase activity
1.36 3.18e-02 GO:0015031 protein transport
1.73 3.22e-02 GO:0044087 regulation of cellular component biogenesis
1.78 3.51e-02 GO:0040017 positive regulation of locomotion
1.41 3.54e-02 GO:0009887 organ morphogenesis
2.96 3.56e-02 GO:0033762 response to glucagon stimulus
2.96 3.56e-02 GO:0090263 positive regulation of canonical Wnt receptor signaling pathway
2.69 3.70e-02 GO:0007269 neurotransmitter secretion
2.69 3.70e-02 GO:0051149 positive regulation of muscle cell differentiation
1.06 3.88e-02 GO:0009987 cellular process
2.16 4.38e-02 GO:0090257 regulation of muscle system process
1.44 4.45e-02 GO:0010647 positive regulation of cell communication
1.68 4.46e-02 GO:0006091 generation of precursor metabolites and energy
1.68 4.46e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
2.13 4.47e-02 GO:0010721 negative regulation of cell development
1.49 4.49e-02 GO:0060341 regulation of cellular localization
1.10 4.93e-02 GO:0044238 primary metabolic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.31 1.18e-51 GO:0005737 cytoplasm
1.35 4.85e-36 GO:0044444 cytoplasmic part
1.19 1.95e-32 GO:0005622 intracellular
1.18 6.17e-30 GO:0044424 intracellular part
2.05 4.58e-22 GO:0043005 neuron projection
1.09 6.31e-20 GO:0005623 cell
1.09 6.31e-20 GO:0044464 cell part
1.69 3.03e-19 GO:0042995 cell projection
1.16 1.33e-17 GO:0043226 organelle
1.16 1.71e-17 GO:0043229 intracellular organelle
1.62 3.50e-17 GO:0000267 cell fraction
1.30 1.09e-15 GO:0071944 cell periphery
1.30 4.56e-15 GO:0005886 plasma membrane
1.66 6.33e-15 GO:0005626 insoluble fraction
1.68 7.57e-15 GO:0005624 membrane fraction
2.16 4.91e-13 GO:0030425 dendrite
1.15 7.08e-12 GO:0043227 membrane-bounded organelle
1.15 7.59e-12 GO:0043231 intracellular membrane-bounded organelle
1.83 1.27e-11 GO:0045202 synapse
1.14 1.17e-10 GO:0016020 membrane
1.42 2.82e-10 GO:0005739 mitochondrion
1.46 1.45e-09 GO:0031090 organelle membrane
1.93 1.50e-09 GO:0043025 neuronal cell body
1.37 1.97e-09 GO:0044459 plasma membrane part
1.89 3.06e-09 GO:0044297 cell body
1.80 6.09e-09 GO:0031966 mitochondrial membrane
1.78 6.65e-09 GO:0005740 mitochondrial envelope
1.63 7.93e-09 GO:0030054 cell junction
2.01 9.43e-09 GO:0030424 axon
1.89 1.08e-08 GO:0031012 extracellular matrix
1.67 2.08e-08 GO:0044429 mitochondrial part
1.47 2.49e-08 GO:0005783 endoplasmic reticulum
1.48 9.87e-08 GO:0005794 Golgi apparatus
1.82 1.76e-07 GO:0044456 synapse part
1.72 2.56e-07 GO:0044463 cell projection part
1.86 6.63e-07 GO:0005578 proteinaceous extracellular matrix
1.45 7.10e-07 GO:0044421 extracellular region part
1.81 1.85e-06 GO:0048471 perinuclear region of cytoplasm
1.54 3.78e-06 GO:0031967 organelle envelope
1.74 5.99e-06 GO:0019866 organelle inner membrane
1.53 6.27e-06 GO:0031975 envelope
1.33 8.88e-06 GO:0005829 cytosol
1.74 1.43e-05 GO:0005743 mitochondrial inner membrane
2.15 8.10e-05 GO:0043292 contractile fiber
1.44 1.03e-04 GO:0005615 extracellular space
2.40 1.36e-04 GO:0030427 site of polarized growth
2.32 1.66e-04 GO:0030017 sarcomere
2.42 1.70e-04 GO:0030426 growth cone
2.07 2.32e-04 GO:0033267 axon part
2.20 2.69e-04 GO:0044449 contractile fiber part
1.91 2.84e-04 GO:0031252 cell leading edge
2.01 6.10e-04 GO:0019717 synaptosome
1.15 8.93e-04 GO:0044422 organelle part
1.39 9.98e-04 GO:0031982 vesicle
1.27 1.83e-03 GO:0005856 cytoskeleton
2.14 2.82e-03 GO:0043296 apical junction complex
1.23 2.90e-03 GO:0005576 extracellular region
1.55 3.12e-03 GO:0005625 soluble fraction
1.62 3.16e-03 GO:0015629 actin cytoskeleton
1.38 4.21e-03 GO:0031410 cytoplasmic vesicle
2.05 4.78e-03 GO:0034703 cation channel complex
2.10 4.79e-03 GO:0016327 apicolateral plasma membrane
1.14 5.58e-03 GO:0044446 intracellular organelle part
1.57 7.48e-03 GO:0005792 microsome
2.21 9.48e-03 GO:0044309 neuron spine
1.66 9.59e-03 GO:0005911 cell-cell junction
1.55 1.13e-02 GO:0042598 vesicular fraction
1.17 1.34e-02 GO:0043234 protein complex
1.93 1.44e-02 GO:0044420 extracellular matrix part
2.19 1.62e-02 GO:0043197 dendritic spine
2.35 1.72e-02 GO:0005901 caveola
1.56 1.73e-02 GO:0044431 Golgi apparatus part
1.92 1.86e-02 GO:0030016 myofibril
4.10 2.24e-02 GO:0005583 fibrillar collagen
1.32 3.02e-02 GO:0012505 endomembrane system
1.29 3.50e-02 GO:0044430 cytoskeletal part
2.54 3.69e-02 GO:0016529 sarcoplasmic reticulum
1.69 4.13e-02 GO:0034702 ion channel complex
2.45 4.29e-02 GO:0016528 sarcoplasm
1.96 4.31e-02 GO:0005741 mitochondrial outer membrane
1.89 4.71e-02 GO:0031968 organelle outer membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.33 1.16e-31 GO:0005515 protein binding
1.18 1.89e-30 GO:0005488 binding
1.81 7.22e-12 GO:0019904 protein domain specific binding
2.60 1.87e-09 GO:0005516 calmodulin binding
1.54 9.94e-09 GO:0019899 enzyme binding
1.64 6.24e-07 GO:0008092 cytoskeletal protein binding
1.17 1.78e-06 GO:0003824 catalytic activity
1.71 2.57e-06 GO:0030695 GTPase regulator activity
1.67 8.27e-06 GO:0060589 nucleoside-triphosphatase regulator activity
1.86 1.02e-05 GO:0005083 small GTPase regulator activity
1.45 1.70e-05 GO:0030234 enzyme regulator activity
1.46 1.15e-04 GO:0016491 oxidoreductase activity
1.54 1.58e-04 GO:0005509 calcium ion binding
2.09 1.58e-04 GO:0005539 glycosaminoglycan binding
1.34 8.79e-04 GO:0005215 transporter activity
2.26 9.93e-04 GO:0030165 PDZ domain binding
1.95 1.03e-03 GO:0001871 pattern binding
1.95 1.03e-03 GO:0030247 polysaccharide binding
2.15 1.48e-03 GO:0019838 growth factor binding
1.42 1.56e-03 GO:0015075 ion transmembrane transporter activity
1.63 1.68e-03 GO:0008047 enzyme activator activity
1.84 1.78e-03 GO:0005244 voltage-gated ion channel activity
1.84 1.78e-03 GO:0022832 voltage-gated channel activity
1.49 1.85e-03 GO:0008324 cation transmembrane transporter activity
1.17 1.89e-03 GO:0043169 cation binding
1.17 1.96e-03 GO:0043167 ion binding
1.17 1.97e-03 GO:0046872 metal ion binding
1.36 2.84e-03 GO:0022857 transmembrane transporter activity
3.27 3.15e-03 GO:0005201 extracellular matrix structural constituent
1.60 6.32e-03 GO:0003779 actin binding
1.60 6.32e-03 GO:0019900 kinase binding
1.52 7.19e-03 GO:0005198 structural molecule activity
1.36 7.38e-03 GO:0022891 substrate-specific transmembrane transporter activity
1.73 8.21e-03 GO:0005096 GTPase activator activity
1.33 9.02e-03 GO:0022892 substrate-specific transporter activity
1.31 1.03e-02 GO:0005102 receptor binding
1.38 1.15e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.35 1.25e-02 GO:0016301 kinase activity
1.60 1.41e-02 GO:0022836 gated channel activity
2.03 1.47e-02 GO:0008201 heparin binding
1.20 1.83e-02 GO:0000166 nucleotide binding
2.12 2.46e-02 GO:0005099 Ras GTPase activator activity
1.78 2.75e-02 GO:0016829 lyase activity
2.19 3.03e-02 GO:0019199 transmembrane receptor protein kinase activity
1.86 3.53e-02 GO:0022843 voltage-gated cation channel activity
1.86 4.79e-02 GO:0051020 GTPase binding