Motif ID: KLF4.p3

Z-value: 2.797


Transcription factors associated with KLF4.p3:

Gene SymbolEntrez IDGene Name
Klf4 16600 Kruppel-like factor 4 (gut)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf4chr4_-_555452110.447.9e-10Click!


Activity profile for motif KLF4.p3.

activity profile for motif KLF4.p3


Sorted Z-values histogram for motif KLF4.p3

Sorted Z-values for motif KLF4.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF4.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_28232980 42.120 NM_144923
 Blvrb
biliverdin reductase B (flavin reductase (NADPH))
chr9_-_65427840 41.483 NM_153119
 Plekho2
pleckstrin homology domain containing, family O member 2
chr5_-_114358647 38.270 NM_011779
 Coro1c
coronin, actin binding protein 1C
chrX_-_71491851 37.553 NM_010227
 Flna
filamin, alpha
chr4_-_55545337 36.359 NM_010637
 Klf4
Kruppel-like factor 4 (gut)
chr17_+_29627697 35.882 Pim1
proviral integration site 1
chr7_+_28233013 35.253 Blvrb
biliverdin reductase B (flavin reductase (NADPH))
chrX_-_71491736 32.691 Flna
filamin, alpha
chr4_-_134828699 31.381 Clic4
chloride intracellular channel 4 (mitochondrial)
chr5_+_145875080 29.607 NM_023142
 Arpc1b
actin related protein 2/3 complex, subunit 1B
chr12_+_8778260 29.218 Sdc1
syndecan 1
chr7_+_52273317 28.947 NM_009101
 Rras
Harvey rat sarcoma oncogene, subgroup R
chrX_+_93291377 28.039 NM_010833
 Msn
moesin
chr7_+_26471968 27.452 NM_011577
 Tgfb1
transforming growth factor, beta 1
chr2_-_167174531 26.692 NM_019835
 B4galt5
UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5
chr18_+_70727897 26.613 NM_010773
 Mbd2
methyl-CpG binding domain protein 2
chr14_+_21748602 26.529 Vcl
vinculin
chr11_+_54911540 26.181 NM_010299
 Gm2a
GM2 ganglioside activator protein
chr14_+_21748646 25.544 NM_009502
 Vcl
vinculin
chr5_+_65194749 25.098 NM_008453
 Klf3
Kruppel-like factor 3 (basic)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 315 entries
Enrichment   P-value GO Accession GO Term
2.36 1.66e-02 GO:0051017 actin filament bundle assembly
1.97 1.95e-02 GO:0031333 negative regulation of protein complex assembly
1.93 7.07e-05 GO:0007015 actin filament organization
1.91 3.69e-02 GO:0001889 liver development
1.88 1.70e-02 GO:0007179 transforming growth factor beta receptor signaling pathway
1.86 1.54e-02 GO:0030833 regulation of actin filament polymerization
1.85 7.35e-03 GO:0051494 negative regulation of cytoskeleton organization
1.84 6.95e-03 GO:0034330 cell junction organization
1.83 6.54e-03 GO:0008064 regulation of actin polymerization or depolymerization
1.80 1.01e-12 GO:0030036 actin cytoskeleton organization
1.80 1.13e-02 GO:0030832 regulation of actin filament length
1.78 6.17e-13 GO:0030029 actin filament-based process
1.77 3.75e-02 GO:0002755 MyD88-dependent toll-like receptor signaling pathway
1.76 7.76e-03 GO:0032271 regulation of protein polymerization
1.73 1.06e-03 GO:0031346 positive regulation of cell projection organization
1.72 4.32e-02 GO:0009953 dorsal/ventral pattern formation
1.71 1.55e-03 GO:0032318 regulation of Ras GTPase activity
1.70 2.44e-03 GO:0032956 regulation of actin cytoskeleton organization
1.69 1.57e-06 GO:0051493 regulation of cytoskeleton organization
1.69 2.01e-03 GO:0032970 regulation of actin filament-based process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 69 entries
Enrichment   P-value GO Accession GO Term
2.05 3.20e-04 GO:0016363 nuclear matrix
1.97 1.68e-04 GO:0034399 nuclear periphery
1.69 7.94e-03 GO:0044448 cell cortex part
1.65 1.88e-06 GO:0031252 cell leading edge
1.63 2.80e-02 GO:0009898 internal side of plasma membrane
1.60 2.66e-04 GO:0005938 cell cortex
1.58 1.30e-06 GO:0016323 basolateral plasma membrane
1.56 7.19e-05 GO:0005635 nuclear envelope
1.56 1.57e-03 GO:0030136 clathrin-coated vesicle
1.56 6.20e-03 GO:0005912 adherens junction
1.53 1.09e-03 GO:0030135 coated vesicle
1.51 7.89e-09 GO:0005625 soluble fraction
1.50 4.97e-07 GO:0005667 transcription factor complex
1.49 2.99e-02 GO:0070161 anchoring junction
1.48 3.19e-05 GO:0005874 microtubule
1.45 3.31e-05 GO:0048471 perinuclear region of cytoplasm
1.44 6.69e-13 GO:0044451 nucleoplasm part
1.42 1.84e-27 GO:0005829 cytosol
1.42 2.92e-07 GO:0005768 endosome
1.42 4.33e-04 GO:0015629 actin cytoskeleton

Gene overrepresentation in function category:

Showing 1 to 20 of 81 entries
Enrichment   P-value GO Accession GO Term
2.73 3.06e-02 GO:0070412 R-SMAD binding
1.84 3.29e-02 GO:0046332 SMAD binding
1.71 1.06e-02 GO:0008017 microtubule binding
1.64 1.94e-03 GO:0015631 tubulin binding
1.64 4.44e-03 GO:0035091 phosphatidylinositol binding
1.58 6.58e-04 GO:0003924 GTPase activity
1.58 1.85e-03 GO:0003713 transcription coactivator activity
1.56 2.29e-06 GO:0000989 transcription factor binding transcription factor activity
1.56 1.98e-05 GO:0005096 GTPase activator activity
1.55 2.87e-06 GO:0000988 protein binding transcription factor activity
1.55 3.60e-06 GO:0003712 transcription cofactor activity
1.54 3.54e-06 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.54 2.46e-05 GO:0016881 acid-amino acid ligase activity
1.54 1.09e-04 GO:0010843 promoter binding
1.54 1.09e-04 GO:0019787 small conjugating protein ligase activity
1.54 3.71e-02 GO:0005516 calmodulin binding
1.53 1.99e-07 GO:0019900 kinase binding
1.53 7.63e-05 GO:0000975 regulatory region DNA binding
1.53 7.63e-05 GO:0001067 regulatory region nucleic acid binding
1.53 7.63e-05 GO:0044212 transcription regulatory region DNA binding