Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 1.599


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
Lef1 16842 lymphoid enhancer binding factor 1
Tcf7 21414 transcription factor 7, T-cell specific
Tcf7l1 21415 transcription factor 7-like 1 (T-cell specific, HMG box)
Tcf7l2 21416 transcription factor 7-like 2, T-cell specific, HMG-box

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf7l2chr19_+_558163200.504.2e-13Click!
Tcf7l1chr6_-_727389350.422.6e-09Click!
Tcf7chr11_-_520957450.281.1e-04Click!
Lef1chr3_+_1308132140.213.8e-03Click!


Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_86578225 17.806 Asprv1
aspartic peptidase, retroviral-like 1
chr6_+_86578167 17.273 NM_026414
 Asprv1
aspartic peptidase, retroviral-like 1
chr6_+_86578269 14.454 Asprv1
aspartic peptidase, retroviral-like 1
chr6_+_86578550 13.893 Asprv1
aspartic peptidase, retroviral-like 1
chr11_-_77538789 12.471 NM_009965
 Cryba1
crystallin, beta A1
chr14_-_44579933 12.440 NM_001011876
 Ang6
angiogenin, ribonuclease A family, member 6
chr10_+_96944961 11.349 NM_007833
 Dcn
decorin
chr16_+_35002066 10.667 Mylk
myosin, light polypeptide kinase
chr1_+_45401303 10.300 Col3a1
collagen, type III, alpha 1
chrX_+_70728994 10.093 Bgn
biglycan
chrX_+_70728939 10.028 NM_007542
 Bgn
biglycan
chr2_-_125142715 9.998 Fbn1
fibrillin 1
chr10_+_43198945 9.597 NM_199028
 Bend3
BEN domain containing 3
chr10_+_96945057 9.505 Dcn
decorin
chr6_+_55286292 9.356 NM_007472
 Aqp1
aquaporin 1
chr3_-_92491103 9.200 NM_027137
 Lce1d
late cornified envelope 1D
chr3_+_101266000 9.164 Igsf3
immunoglobulin superfamily, member 3
chr5_-_135422730 8.868 Cldn4
claudin 4
chr7_-_31861665 8.846 NM_008557
 Fxyd3
FXYD domain-containing ion transport regulator 3
chr5_-_135422795 8.749 NM_009903
 Cldn4
claudin 4

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 3 of 3 entries
Enrichment   P-value GO Accession GO Term
1.34 3.49e-02 GO:0048513 organ development
1.31 5.64e-04 GO:0007275 multicellular organismal development
1.27 4.37e-03 GO:0032502 developmental process

Gene overrepresentation in compartment category:

Showing 1 to 8 of 8 entries
Enrichment   P-value GO Accession GO Term
7.97 9.23e-03 GO:0035098 ESC/E(Z) complex
3.87 2.57e-02 GO:0045178 basal part of cell
2.66 1.32e-03 GO:0044420 extracellular matrix part
2.02 8.48e-04 GO:0005578 proteinaceous extracellular matrix
1.89 3.11e-03 GO:0031012 extracellular matrix
1.73 6.63e-08 GO:0044421 extracellular region part
1.68 9.44e-05 GO:0005615 extracellular space
1.53 2.44e-08 GO:0005576 extracellular region

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
Enrichment   P-value GO Accession GO Term
4.12 4.93e-02 GO:0005201 extracellular matrix structural constituent
2.20 3.81e-03 GO:0061134 peptidase regulator activity
1.41 5.61e-04 GO:0046914 transition metal ion binding
1.19 5.09e-04 GO:0005515 protein binding
1.12 7.86e-05 GO:0005488 binding