Motif ID: MAZ.p2

Z-value: 1.740


Transcription factors associated with MAZ.p2:

Gene SymbolEntrez IDGene Name
Maz 17188 MYC-associated zinc finger protein (purine-binding transcription factor)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mazchr7_-_134169581-0.263.1e-04Click!


Activity profile for motif MAZ.p2.

activity profile for motif MAZ.p2


Sorted Z-values histogram for motif MAZ.p2

Sorted Z-values for motif MAZ.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MAZ.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_156224757 28.090 NM_001039094
NM_177274
Negr1

neuronal growth regulator 1

chrX_+_53985133 25.499 NM_001077361
Fhl1
four and a half LIM domains 1
chr13_-_78337844 23.555 Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr14_-_46149660 23.329 NM_146054
Fermt2
fermitin family homolog 2 (Drosophila)
chr1_-_82287990 23.171 NM_010570
Irs1
insulin receptor substrate 1
chrX_+_53984926 22.920 NM_010211
Fhl1
four and a half LIM domains 1
chr4_-_82151590 21.417 Nfib
nuclear factor I/B
chr15_+_98465328 20.054 Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
chr4_+_138011061 19.593 NM_025451
Camk2n1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr19_-_44482138 19.589 NM_009127
Scd1
stearoyl-Coenzyme A desaturase 1
chr9_+_98325217 19.213 Rbp1
retinol binding protein 1, cellular
chr19_-_44482033 18.936 Scd1
stearoyl-Coenzyme A desaturase 1
chr9_+_43893029 18.850 Usp2
ubiquitin specific peptidase 2
chrX_+_70728939 18.178 NM_007542
Bgn
biglycan
chr4_+_137283714 18.176 Rap1gap
Rap1 GTPase-activating protein
chr9_+_106356125 17.883 NM_021567
Pcbp4
poly(rC) binding protein 4
chr9_+_43892984 17.735 NM_198091
Usp2
ubiquitin specific peptidase 2
chr19_+_27292039 17.529 Vldlr
very low density lipoprotein receptor
chr6_+_4455686 17.296 NM_007743
Col1a2
collagen, type I, alpha 2
chr7_-_17200285 16.482 NM_172739
Grlf1
glucocorticoid receptor DNA binding factor 1
chr4_-_82151657 16.365 Nfib
nuclear factor I/B
chr1_+_66515003 15.899 NM_175510
Unc80
unc-80 homolog (C. elegans)
chr8_+_96334879 15.637 Gnao1
guanine nucleotide binding protein, alpha O
chr8_-_87323896 15.575 Nfix
nuclear factor I/X
chr19_+_27291897 15.352 Vldlr
very low density lipoprotein receptor
chr15_+_98465193 15.278 NM_007581
Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
chr2_+_136539143 14.658 NM_011428
Snap25
synaptosomal-associated protein 25
chr7_-_134164487 14.620 Prrt2
proline-rich transmembrane protein 2
chr2_+_136539202 14.398 Snap25
synaptosomal-associated protein 25
chr4_-_151235861 14.260 NM_001081557
NM_001195565
Camta1

calmodulin binding transcription activator 1

chrX_+_7215705 13.991 NM_009305
Syp
synaptophysin
chr9_-_86775282 13.813 Snap91
synaptosomal-associated protein 91
chr9_+_80012837 13.786 NM_001039546
Myo6
myosin VI
chr16_+_35154935 13.560 Adcy5
adenylate cyclase 5
chr10_-_127058163 13.461 Lrp1
low density lipoprotein receptor-related protein 1
chr15_+_89330287 13.365 NM_021423
Shank3
SH3/ankyrin domain gene 3
chr14_-_35315715 13.338 NM_009758
Bmpr1a
bone morphogenetic protein receptor, type 1A
chr5_+_109123455 13.248 Fgfrl1
fibroblast growth factor receptor-like 1
chr8_-_87298118 13.033 NM_001081981
Nfix
nuclear factor I/X
chr15_-_32174172 12.931 Snord123
small nucleolar RNA, C/D box 123
chr16_-_24393527 12.900 1110054M08Rik
RIKEN cDNA 1110054M08 gene
chr19_-_44481898 12.584 Scd1
stearoyl-Coenzyme A desaturase 1
chr9_-_107612238 12.554 Sema3f
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr17_+_44215851 12.550 Enpp5
ectonucleotide pyrophosphatase/phosphodiesterase 5
chr4_-_11313886 12.539 NM_194055
Esrp1
epithelial splicing regulatory protein 1
chrX_-_147248183 12.428 Maged2
melanoma antigen, family D, 2
chrX_-_91787372 12.179 NM_019791
Maged1
melanoma antigen, family D, 1
chrX_-_91787353 12.099 Maged1
melanoma antigen, family D, 1
chr5_-_24107718 12.071 NM_025891
Smarcd3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr15_+_98462650 12.044 NM_001044741
Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
chrX_-_91787338 12.041 Maged1
melanoma antigen, family D, 1
chrX_-_91787317 12.040 Maged1
melanoma antigen, family D, 1
chr15_-_3533122 11.980 NM_001048178
NM_010284
Ghr

growth hormone receptor

chr11_-_100007218 11.909 NM_008471
Krt19
keratin 19
chr11_-_48630854 11.691 NM_145377
Trim41
tripartite motif-containing 41
chrX_-_91787351 11.678 Maged1
melanoma antigen, family D, 1
chr4_-_82151004 11.589 Nfib
nuclear factor I/B
chr1_-_191167582 11.504 NM_010607
Kcnk2
potassium channel, subfamily K, member 2
chr7_-_25857275 11.492 NM_008168
Grik5
glutamate receptor, ionotropic, kainate 5 (gamma 2)
chrX_+_97972559 11.362 NM_001177780
Dlg3
discs, large homolog 3 (Drosophila)
chr14_+_121434765 11.346 NM_134082
Farp1
FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)
chr7_-_28118628 11.324 NM_001113549
Ltbp4
latent transforming growth factor beta binding protein 4
chr15_-_32174404 11.285 Snord123
small nucleolar RNA, C/D box 123
chr9_-_86775154 11.276 NM_013669
Snap91
synaptosomal-associated protein 91
chr2_-_130468507 11.267 NM_197945
Prosapip1
ProSAPiP1 protein
chr5_-_21850490 11.239 NM_011261
Reln
reelin
chr14_-_52532988 11.219 Ndrg2
N-myc downstream regulated gene 2
chr14_-_52533039 11.087 Ndrg2
N-myc downstream regulated gene 2
chr7_+_19868009 11.075 NM_013648
Rtn2
reticulon 2 (Z-band associated protein)
chr11_+_56825258 11.063 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr7_+_25266986 10.990 NM_153112
Cadm4
cell adhesion molecule 4
chr7_+_108469819 10.986 NM_019990
Stard10
START domain containing 10
chr3_-_57651409 10.904 Pfn2
profilin 2
chr14_-_52533114 10.829 NM_001145959
NM_013864
Ndrg2

N-myc downstream regulated gene 2

chr17_+_87153083 10.795 NM_010137
Epas1
endothelial PAS domain protein 1
chrX_+_70728994 10.770 Bgn
biglycan
chr6_+_43215604 10.765 NM_133674
Arhgef5
Rho guanine nucleotide exchange factor (GEF) 5
chr10_-_80893737 10.727 Nfic
nuclear factor I/C
chr12_+_113960530 10.708 AW555464
expressed sequence AW555464
chr18_-_16967557 10.690 NM_007664
Cdh2
cadherin 2
chr8_-_4259126 10.686 NM_183315
Ctxn1
cortexin 1
chr4_+_43644806 10.570 NM_173788
Npr2
natriuretic peptide receptor 2
chr7_-_134164627 10.542 NM_001102563
Prrt2
proline-rich transmembrane protein 2
chr4_+_137220675 10.537 Rap1gap
Rap1 GTPase-activating protein
chr7_-_106501620 10.494 Serpinh1
serine (or cysteine) peptidase inhibitor, clade H, member 1
chr7_-_30066642 10.470 Spint2
serine protease inhibitor, Kunitz type 2
chr5_+_109123159 10.469 NM_001164259
NM_054071
Fgfrl1

fibroblast growth factor receptor-like 1

chr10_-_70062025 10.426 NM_178621
Phyhipl
phytanoyl-CoA hydroxylase interacting protein-like
chr5_+_37637027 10.388 NM_007765
Crmp1
collapsin response mediator protein 1
chr5_-_134932407 10.384 NM_001081462
NM_001081463
NM_001081464
NM_001081466
NM_001081467
NM_001081468
NM_001081469
NM_001081470
NM_020331
Gtf2ird1








general transcription factor II I repeat domain-containing 1








chr10_-_70061996 10.310 Phyhipl
phytanoyl-CoA hydroxylase interacting protein-like
chr8_-_92872139 10.224 NM_172913
Tox3
TOX high mobility group box family member 3
chr8_+_47556503 10.207 Acsl1
acyl-CoA synthetase long-chain family member 1
chr10_-_80119815 10.192 NM_145361
Btbd2
BTB (POZ) domain containing 2
chr3_+_68298129 10.158 Schip1
schwannomin interacting protein 1
chr16_+_93608058 10.085 NM_007620
Cbr1
carbonyl reductase 1
chr14_-_66743271 9.851 NM_007940
Ephx2
epoxide hydrolase 2, cytoplasmic
chr2_+_58998938 9.849 Pkp4
plakophilin 4
chr16_-_18629938 9.824 NM_213614
Sept5
septin 5
chr11_-_90252208 9.762 Hlf
hepatic leukemia factor
chr4_-_82150687 9.738 Nfib
nuclear factor I/B
chr13_-_49243351 9.615 NM_029361
Wnk2
WNK lysine deficient protein kinase 2
chr7_+_36119255 9.603 NM_027897
Rhpn2
rhophilin, Rho GTPase binding protein 2
chrX_-_73119876 9.601 Pls3
plastin 3 (T-isoform)
chr11_-_120051109 9.599 2810410L24Rik
RIKEN cDNA 2810410L24 gene
chr19_-_59150558 9.568 NM_001114312
NM_175172
4930506M07Rik

RIKEN cDNA 4930506M07 gene

chr14_-_122196929 9.527 NM_134074
Dock9
dedicator of cytokinesis 9
chr12_+_113960424 9.432 AW555464
expressed sequence AW555464
chr14_+_76814750 9.412 Tsc22d1
TSC22 domain family, member 1
chr13_+_42804911 9.411 NM_001005740
Phactr1
phosphatase and actin regulator 1
chr16_+_16213397 9.351 Pkp2
plakophilin 2
chr7_+_133966816 9.316 NM_029978
Fam57b
family with sequence similarity 57, member B
chr10_+_79792864 9.240 NM_139292
Reep6
receptor accessory protein 6
chr4_-_129851941 9.178 Tinagl1
tubulointerstitial nephritis antigen-like 1
chr6_+_17256383 9.030 Cav1
caveolin 1, caveolae protein
chr6_+_83085799 9.029 NM_001136227
Rtkn
rhotekin
chr18_-_75857207 9.027 NM_201354
Ctif
CBP80/20-dependent translation initiation factor
chr17_+_44215761 8.927 NM_032003
NM_001168620
Enpp5

ectonucleotide pyrophosphatase/phosphodiesterase 5

chr15_-_77137015 8.892 Rbfox2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr7_-_30066910 8.884 NM_001082548
NM_011464
Spint2

serine protease inhibitor, Kunitz type 2

chr15_+_78258993 8.819 NM_001081367
Kctd17
potassium channel tetramerisation domain containing 17
chr9_+_108686107 8.725 Ip6k2
inositol hexaphosphate kinase 2
chr17_-_25570566 8.723 Cacna1h
calcium channel, voltage-dependent, T type, alpha 1H subunit
chr7_-_30066867 8.695 Spint2
serine protease inhibitor, Kunitz type 2
chr4_+_129662284 8.633 NM_173071
Bai2
brain-specific angiogenesis inhibitor 2
chr4_-_43536296 8.619 Tpm2
tropomyosin 2, beta
chr17_+_78599556 8.611 NM_015800
Crim1
cysteine rich transmembrane BMP regulator 1 (chordin like)
chr11_-_116515361 8.609 Cygb
cytoglobin
chr17_+_31523178 8.574 NM_001163748
NM_008804
Pde9a

phosphodiesterase 9A

chr9_-_86589782 8.561 NM_008615
Me1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr10_-_76086045 8.517 Col6a2
collagen, type VI, alpha 2
chr17_-_57199207 8.445 NM_025877
Slc25a23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr8_-_83404377 8.420 NM_021356
Gab1
growth factor receptor bound protein 2-associated protein 1
chr4_+_148960536 8.401 Clstn1
calsyntenin 1
chr6_+_55286292 8.390 NM_007472
Aqp1
aquaporin 1
chr18_-_16967100 8.373 Cdh2
cadherin 2
chr13_-_78338131 8.365 NM_010151
Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr4_+_126290825 8.338


chr8_-_87323958 8.319 Nfix
nuclear factor I/X
chr10_+_13685882 8.303 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr4_+_132567420 8.260 NM_146155
Ahdc1
AT hook, DNA binding motif, containing 1
chr16_+_8513513 8.235 NM_001170978
NM_172961
Abat

4-aminobutyrate aminotransferase

chr12_+_114378688 8.229 Crip2
cysteine rich protein 2
chr10_+_110943341 8.156 NM_009344
Phlda1
pleckstrin homology-like domain, family A, member 1
chr9_-_31019392 8.132 NM_001102455
NM_001102456
NM_009691
Aplp2


amyloid beta (A4) precursor-like protein 2


chr7_+_108469591 8.131 Stard10
START domain containing 10
chr1_-_167564449 8.130 NM_001001880
NM_001083897
Mpzl1

myelin protein zero-like 1

chr2_+_91096960 8.127 NM_030880
Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr2_-_167014273 8.041 NM_008420
Kcnb1
potassium voltage gated channel, Shab-related subfamily, member 1
chr6_-_92656148 8.032 NM_001081146
Prickle2
prickle homolog 2 (Drosophila)
chr18_-_6135887 8.021 Arhgap12
Rho GTPase activating protein 12
chr7_-_150646883 8.017 NM_001161624
NM_009876
Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr1_-_170362298 8.011 Pbx1
pre B-cell leukemia transcription factor 1
chr2_+_91096984 8.010 Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr10_-_87966607 7.979 NM_001146690
NM_144807
Chpt1

choline phosphotransferase 1

chr2_-_91772424 7.960 NM_010784
Mdk
midkine
chr2_+_58999028 7.948 Pkp4
plakophilin 4
chr4_-_129852325 7.922 NM_023476
Tinagl1
tubulointerstitial nephritis antigen-like 1
chr1_-_170361985 7.903 Pbx1
pre B-cell leukemia transcription factor 1
chr8_-_94325138 7.870 NM_008393
Irx3
Iroquois related homeobox 3 (Drosophila)
chr4_-_117963950 7.805 NM_011213
Ptprf
protein tyrosine phosphatase, receptor type, F
chr15_-_12479631 7.802 Pdzd2
PDZ domain containing 2
chr6_-_124718354 7.797 Eno2
enolase 2, gamma neuronal
chr19_-_5424751 7.763 Drap1
Dr1 associated protein 1 (negative cofactor 2 alpha)
chrX_-_47988434 7.748 6720401G13Rik
RIKEN cDNA 6720401G13 gene
chr12_+_53604952 7.725 Arhgap5
Rho GTPase activating protein 5
chr17_+_37182910 7.677 NM_019439
Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr12_-_87419813 7.673 NM_009368
Tgfb3
transforming growth factor, beta 3
chr11_-_116515602 7.590 NM_030206
Cygb
cytoglobin
chr17_-_87657365 7.560 Mcfd2
multiple coagulation factor deficiency 2
chr2_-_91771882 7.512 Mdk
midkine
chr14_-_21613162 7.502 NM_001039138
NM_001039139
NM_178597
Camk2g


calcium/calmodulin-dependent protein kinase II gamma


chr16_-_20621287 7.468 NM_028420
Camk2n2
calcium/calmodulin-dependent protein kinase II inhibitor 2
chr7_-_107806887 7.466 NM_001163183
NM_001163184
NM_001163185
Plekhb1


pleckstrin homology domain containing, family B (evectins) member 1


chr7_-_91754314 7.368 Fah
fumarylacetoacetate hydrolase
chr9_+_69137659 7.359 Rora
RAR-related orphan receptor alpha
chr9_-_31019412 7.332 Aplp2
amyloid beta (A4) precursor-like protein 2
chr11_-_69648350 7.324 NM_198862
Nlgn2
neuroligin 2
chr18_+_58038278 7.311 NM_009194
Slc12a2
solute carrier family 12, member 2
chr7_+_108469700 7.304 Stard10
START domain containing 10
chr11_+_94072732 7.294 NM_009427
Tob1
transducer of ErbB-2.1
chrX_-_98615096 7.281 NM_001177985
NM_001177986
Zmym3

zinc finger, MYM-type 3

chr14_-_19726121 7.274 NM_144839
Ube2e2
ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)
chr2_-_168559743 7.266 Atp9a
ATPase, class II, type 9A
chr7_-_31319977 7.243 NM_178252
Arhgap33
Rho GTPase activating protein 33
chr11_+_56825192 7.228 NM_001113325
NM_008165
Gria1

glutamate receptor, ionotropic, AMPA1 (alpha 1)

chr17_+_25945986 7.199 NM_001164225
Fbxl16
F-box and leucine-rich repeat protein 16
chr4_+_148960604 7.197 NM_023051
Clstn1
calsyntenin 1
chr2_-_64860728 7.194 NM_016719
Grb14
growth factor receptor bound protein 14
chr6_-_124867872 7.158 Ptms
parathymosin
chr12_+_113960379 7.151 NM_001024602
AW555464
expressed sequence AW555464
chr15_+_81641869 7.142 Tef
thyrotroph embryonic factor
chr5_+_67137054 7.122 NM_001001980
Limch1
LIM and calponin homology domains 1
chr15_+_81641832 7.121 NM_017376
Tef
thyrotroph embryonic factor
chr8_-_35040277 7.115 NM_001042674
NM_001042675
NM_019733
Rbpms


RNA binding protein gene with multiple splicing


chr7_-_112729716 7.098 Apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1
chr3_-_57651621 7.051 NM_019410
Pfn2
profilin 2
chr5_+_73882264 7.023 NM_001190733
NM_178896
Dcun1d4

DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae)

chr11_-_87800799 7.015 NM_026556
Dynll2
dynein light chain LC8-type 2
chr5_+_143734622 7.003



Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.20 1.32e-35 GO:0044237 cellular metabolic process
1.17 3.25e-31 GO:0008152 metabolic process
1.29 1.36e-29 GO:0051179 localization
1.18 1.62e-29 GO:0044238 primary metabolic process
1.24 1.12e-26 GO:0019222 regulation of metabolic process
1.26 1.48e-26 GO:0031323 regulation of cellular metabolic process
1.26 2.49e-26 GO:0080090 regulation of primary metabolic process
1.29 2.21e-25 GO:0016043 cellular component organization
1.29 4.15e-24 GO:0051234 establishment of localization
1.21 4.66e-24 GO:0044260 cellular macromolecule metabolic process
1.26 1.86e-23 GO:0032502 developmental process
1.27 2.49e-23 GO:0071840 cellular component organization or biogenesis
1.19 3.49e-23 GO:0043170 macromolecule metabolic process
1.28 5.60e-23 GO:0048856 anatomical structure development
1.29 7.99e-23 GO:0006810 transport
1.27 5.16e-22 GO:0051171 regulation of nitrogen compound metabolic process
1.27 5.32e-22 GO:0048518 positive regulation of biological process
1.28 7.85e-22 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.23 2.42e-21 GO:0006807 nitrogen compound metabolic process
1.23 6.69e-21 GO:0034641 cellular nitrogen compound metabolic process
1.29 6.95e-21 GO:0048731 system development
1.28 7.12e-21 GO:0048522 positive regulation of cellular process
1.38 1.13e-20 GO:0023051 regulation of signaling
1.31 1.41e-20 GO:0071842 cellular component organization at cellular level
1.25 1.69e-20 GO:0007275 multicellular organismal development
1.29 2.19e-20 GO:0048519 negative regulation of biological process
1.23 3.71e-20 GO:0060255 regulation of macromolecule metabolic process
1.34 4.05e-20 GO:0065008 regulation of biological quality
1.29 6.21e-19 GO:0048523 negative regulation of cellular process
1.29 8.00e-19 GO:0071841 cellular component organization or biogenesis at cellular level
1.25 8.44e-18 GO:0031326 regulation of cellular biosynthetic process
1.25 8.65e-18 GO:0010468 regulation of gene expression
1.40 1.26e-17 GO:0009966 regulation of signal transduction
1.39 3.22e-17 GO:0033036 macromolecule localization
1.24 4.70e-17 GO:0009889 regulation of biosynthetic process
1.26 5.65e-17 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.22 9.09e-17 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.42 1.41e-16 GO:0032879 regulation of localization
1.24 7.34e-16 GO:0010556 regulation of macromolecule biosynthetic process
1.41 1.47e-15 GO:0008104 protein localization
1.45 2.31e-15 GO:0051128 regulation of cellular component organization
1.25 5.40e-15 GO:0051252 regulation of RNA metabolic process
1.21 6.76e-15 GO:0044249 cellular biosynthetic process
1.40 1.25e-14 GO:0051641 cellular localization
1.21 1.76e-14 GO:0009058 biosynthetic process
1.25 2.43e-14 GO:0006355 regulation of transcription, DNA-dependent
1.36 5.99e-14 GO:0007399 nervous system development
1.36 8.83e-13 GO:0010646 regulation of cell communication
1.22 9.08e-13 GO:0090304 nucleic acid metabolic process
1.30 1.09e-12 GO:0051239 regulation of multicellular organismal process
1.44 1.11e-12 GO:0051049 regulation of transport
1.31 1.14e-12 GO:0006996 organelle organization
1.26 1.85e-12 GO:0030154 cell differentiation
1.23 2.56e-12 GO:0016070 RNA metabolic process
1.25 2.62e-12 GO:0048869 cellular developmental process
1.41 3.57e-12 GO:0045184 establishment of protein localization
1.07 1.21e-11 GO:0009987 cellular process
1.21 1.65e-11 GO:0010467 gene expression
1.39 2.82e-11 GO:0051649 establishment of localization in cell
1.27 4.23e-11 GO:0048583 regulation of response to stimulus
1.40 4.54e-11 GO:0015031 protein transport
1.28 7.80e-11 GO:0065009 regulation of molecular function
1.26 7.82e-11 GO:0006351 transcription, DNA-dependent
1.26 8.21e-11 GO:0032774 RNA biosynthetic process
1.21 9.55e-11 GO:0009059 macromolecule biosynthetic process
1.21 3.96e-10 GO:0034645 cellular macromolecule biosynthetic process
1.28 3.45e-09 GO:0009653 anatomical structure morphogenesis
1.37 3.67e-09 GO:0048699 generation of neurons
1.35 2.04e-08 GO:0022008 neurogenesis
1.31 2.53e-08 GO:0010941 regulation of cell death
1.31 3.33e-08 GO:0050793 regulation of developmental process
1.34 4.04e-08 GO:0048468 cell development
1.43 6.47e-08 GO:0030182 neuron differentiation
1.23 7.69e-08 GO:0006464 protein modification process
1.30 9.76e-08 GO:0035556 intracellular signal transduction
1.30 1.98e-07 GO:0043067 regulation of programmed cell death
1.45 2.19e-07 GO:0070727 cellular macromolecule localization
1.22 2.21e-07 GO:0048513 organ development
1.27 3.02e-07 GO:0050790 regulation of catalytic activity
1.38 3.63e-07 GO:0016192 vesicle-mediated transport
1.52 4.28e-07 GO:0009894 regulation of catabolic process
1.30 4.48e-07 GO:0042981 regulation of apoptosis
1.19 5.39e-07 GO:0044267 cellular protein metabolic process
1.31 5.72e-07 GO:2000026 regulation of multicellular organismal development
1.44 6.88e-07 GO:0034613 cellular protein localization
1.31 9.42e-07 GO:0042592 homeostatic process
1.25 1.41e-06 GO:0010604 positive regulation of macromolecule metabolic process
1.37 1.54e-06 GO:0046907 intracellular transport
1.27 1.72e-06 GO:0009892 negative regulation of metabolic process
1.32 1.78e-06 GO:0045595 regulation of cell differentiation
1.49 2.16e-06 GO:0051130 positive regulation of cellular component organization
1.23 2.63e-06 GO:0009893 positive regulation of metabolic process
1.33 2.64e-06 GO:0031327 negative regulation of cellular biosynthetic process
1.16 3.20e-06 GO:0019538 protein metabolic process
1.21 3.29e-06 GO:0043412 macromolecule modification
1.24 3.74e-06 GO:0031325 positive regulation of cellular metabolic process
1.31 4.13e-06 GO:0007049 cell cycle
1.28 4.74e-06 GO:0031324 negative regulation of cellular metabolic process
1.32 5.58e-06 GO:0009890 negative regulation of biosynthetic process
1.46 5.81e-06 GO:0051050 positive regulation of transport
1.43 7.83e-06 GO:0048666 neuron development
1.21 7.88e-06 GO:0006950 response to stress
1.42 1.85e-05 GO:0010648 negative regulation of cell communication
1.37 2.62e-05 GO:0010942 positive regulation of cell death
1.51 2.92e-05 GO:0031329 regulation of cellular catabolic process
1.26 3.08e-05 GO:0010605 negative regulation of macromolecule metabolic process
1.54 3.18e-05 GO:0051056 regulation of small GTPase mediated signal transduction
1.38 3.46e-05 GO:0030030 cell projection organization
1.34 3.48e-05 GO:0048878 chemical homeostasis
1.31 3.72e-05 GO:0051172 negative regulation of nitrogen compound metabolic process
1.46 3.98e-05 GO:0031175 neuron projection development
1.26 4.18e-05 GO:0006796 phosphate metabolic process
1.36 4.18e-05 GO:0051094 positive regulation of developmental process
1.50 4.72e-05 GO:0001501 skeletal system development
1.40 4.78e-05 GO:0060341 regulation of cellular localization
1.40 4.83e-05 GO:0023057 negative regulation of signaling
1.40 5.43e-05 GO:0040008 regulation of growth
1.32 5.51e-05 GO:0007154 cell communication
1.26 5.62e-05 GO:0006793 phosphorus metabolic process
1.26 7.95e-05 GO:0032268 regulation of cellular protein metabolic process
1.40 8.78e-05 GO:0060284 regulation of cell development
2.10 8.91e-05 GO:0007163 establishment or maintenance of cell polarity
1.45 9.82e-05 GO:0003006 developmental process involved in reproduction
1.31 1.02e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.78 1.05e-04 GO:0003001 generation of a signal involved in cell-cell signaling
1.78 1.05e-04 GO:0023061 signal release
1.36 1.12e-04 GO:0043068 positive regulation of programmed cell death
1.27 1.15e-04 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.47 1.27e-04 GO:0033043 regulation of organelle organization
1.29 1.32e-04 GO:0044093 positive regulation of molecular function
1.35 2.38e-04 GO:0043065 positive regulation of apoptosis
1.26 2.47e-04 GO:0051173 positive regulation of nitrogen compound metabolic process
1.30 2.60e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.28 2.75e-04 GO:0051254 positive regulation of RNA metabolic process
1.35 2.85e-04 GO:0048585 negative regulation of response to stimulus
1.29 2.95e-04 GO:0010558 negative regulation of macromolecule biosynthetic process
1.44 3.09e-04 GO:0046903 secretion
1.37 3.15e-04 GO:0007010 cytoskeleton organization
1.26 3.17e-04 GO:0010557 positive regulation of macromolecule biosynthetic process
1.24 3.46e-04 GO:0051246 regulation of protein metabolic process
1.40 3.64e-04 GO:0009968 negative regulation of signal transduction
1.42 4.07e-04 GO:0006886 intracellular protein transport
1.41 4.14e-04 GO:0022603 regulation of anatomical structure morphogenesis
1.35 4.32e-04 GO:0050801 ion homeostasis
1.29 4.89e-04 GO:0010629 negative regulation of gene expression
1.24 5.79e-04 GO:0031328 positive regulation of cellular biosynthetic process
1.33 7.13e-04 GO:0019725 cellular homeostasis
1.45 7.41e-04 GO:0006140 regulation of nucleotide metabolic process
1.36 7.46e-04 GO:0055082 cellular chemical homeostasis
1.24 7.53e-04 GO:0009891 positive regulation of biosynthetic process
1.51 7.91e-04 GO:0046578 regulation of Ras protein signal transduction
1.63 8.33e-04 GO:0030811 regulation of nucleotide catabolic process
1.63 8.33e-04 GO:0033121 regulation of purine nucleotide catabolic process
1.26 8.86e-04 GO:0016310 phosphorylation
1.27 9.02e-04 GO:0045893 positive regulation of transcription, DNA-dependent
1.32 9.61e-04 GO:0023056 positive regulation of signaling
1.36 1.07e-03 GO:0006873 cellular ion homeostasis
1.24 1.10e-03 GO:0042127 regulation of cell proliferation
1.32 1.43e-03 GO:0072358 cardiovascular system development
1.32 1.43e-03 GO:0072359 circulatory system development
1.34 1.51e-03 GO:0071310 cellular response to organic substance
1.40 1.54e-03 GO:0019226 transmission of nerve impulse
1.40 1.54e-03 GO:0035637 multicellular organismal signaling
1.29 1.65e-03 GO:0043085 positive regulation of catalytic activity
1.23 1.71e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.37 1.76e-03 GO:0010627 regulation of intracellular protein kinase cascade
1.72 1.87e-03 GO:0031346 positive regulation of cell projection organization
1.25 2.14e-03 GO:0009790 embryo development
1.39 2.17e-03 GO:0007420 brain development
1.29 2.21e-03 GO:0006915 apoptosis
1.31 2.31e-03 GO:0010647 positive regulation of cell communication
1.29 2.40e-03 GO:0012501 programmed cell death
1.35 2.45e-03 GO:0007267 cell-cell signaling
1.40 2.46e-03 GO:0050767 regulation of neurogenesis
1.30 2.77e-03 GO:0022402 cell cycle process
2.10 3.23e-03 GO:0007269 neurotransmitter secretion
1.45 3.26e-03 GO:0061061 muscle structure development
1.28 3.78e-03 GO:0046483 heterocycle metabolic process
1.32 3.80e-03 GO:0009967 positive regulation of signal transduction
1.35 3.86e-03 GO:0044057 regulation of system process
1.35 3.95e-03 GO:0045597 positive regulation of cell differentiation
1.37 4.10e-03 GO:0007167 enzyme linked receptor protein signaling pathway
1.44 4.30e-03 GO:0007268 synaptic transmission
1.27 4.37e-03 GO:0008219 cell death
1.32 4.38e-03 GO:0032989 cellular component morphogenesis
1.28 4.45e-03 GO:0051253 negative regulation of RNA metabolic process
1.27 4.83e-03 GO:0006468 protein phosphorylation
1.62 5.70e-03 GO:0043087 regulation of GTPase activity
1.28 5.71e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.33 6.11e-03 GO:0000902 cell morphogenesis
1.36 6.52e-03 GO:0090066 regulation of anatomical structure size
1.81 6.73e-03 GO:0001505 regulation of neurotransmitter levels
1.24 7.20e-03 GO:0010628 positive regulation of gene expression
1.61 8.34e-03 GO:0033124 regulation of GTP catabolic process
1.26 8.40e-03 GO:0016265 death
1.19 9.21e-03 GO:0009056 catabolic process
1.27 9.31e-03 GO:0022610 biological adhesion
1.38 9.68e-03 GO:0032535 regulation of cellular component size
1.27 9.75e-03 GO:0007155 cell adhesion
1.35 1.18e-02 GO:0008285 negative regulation of cell proliferation
1.34 1.46e-02 GO:0051093 negative regulation of developmental process
1.40 1.49e-02 GO:0045664 regulation of neuron differentiation
1.31 1.51e-02 GO:0051726 regulation of cell cycle
1.16 1.57e-02 GO:0044281 small molecule metabolic process
1.44 1.58e-02 GO:0032940 secretion by cell
1.33 1.65e-02 GO:0009719 response to endogenous stimulus
1.40 1.67e-02 GO:0008380 RNA splicing
1.31 1.87e-02 GO:0007417 central nervous system development
1.42 1.88e-02 GO:0048812 neuron projection morphogenesis
1.22 1.93e-02 GO:0009888 tissue development
1.37 1.98e-02 GO:0000904 cell morphogenesis involved in differentiation
1.32 2.01e-02 GO:0022403 cell cycle phase
1.34 2.10e-02 GO:0051960 regulation of nervous system development
1.39 2.11e-02 GO:0051347 positive regulation of transferase activity
1.25 2.34e-02 GO:0019220 regulation of phosphate metabolic process
1.25 2.34e-02 GO:0051174 regulation of phosphorus metabolic process
1.20 2.46e-02 GO:0044248 cellular catabolic process
1.32 2.50e-02 GO:0061024 membrane organization
2.17 2.55e-02 GO:0030010 establishment of cell polarity
1.47 2.57e-02 GO:0043269 regulation of ion transport
1.26 2.70e-02 GO:0042325 regulation of phosphorylation
1.31 2.79e-02 GO:0016044 cellular membrane organization
1.57 2.79e-02 GO:0030111 regulation of Wnt receptor signaling pathway
1.38 2.84e-02 GO:0001568 blood vessel development
1.53 2.89e-02 GO:0048511 rhythmic process
1.80 2.90e-02 GO:0045667 regulation of osteoblast differentiation
1.43 2.95e-02 GO:0006897 endocytosis
1.43 2.95e-02 GO:0010324 membrane invagination
1.49 3.29e-02 GO:0042391 regulation of membrane potential
1.61 3.49e-02 GO:0001822 kidney development
1.52 3.52e-02 GO:0042692 muscle cell differentiation
1.39 3.80e-02 GO:0033674 positive regulation of kinase activity
1.23 4.19e-02 GO:0031399 regulation of protein modification process
1.60 4.51e-02 GO:0072001 renal system development
1.45 4.56e-02 GO:0031344 regulation of cell projection organization
1.31 4.61e-02 GO:0051338 regulation of transferase activity
2.24 4.61e-02 GO:0072006 nephron development
1.29 4.76e-02 GO:0060548 negative regulation of cell death
1.42 4.84e-02 GO:0030036 actin cytoskeleton organization

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.21 7.54e-105 GO:0005622 intracellular
1.21 3.95e-102 GO:0044424 intracellular part
1.24 1.78e-76 GO:0005737 cytoplasm
1.21 1.14e-72 GO:0043226 organelle
1.21 1.32e-71 GO:0043229 intracellular organelle
1.21 1.45e-59 GO:0043227 membrane-bounded organelle
1.21 8.27e-59 GO:0043231 intracellular membrane-bounded organelle
1.09 2.62e-44 GO:0005623 cell
1.09 2.62e-44 GO:0044464 cell part
1.23 1.55e-38 GO:0044444 cytoplasmic part
1.24 1.92e-36 GO:0005634 nucleus
1.23 9.02e-28 GO:0044422 organelle part
1.23 5.67e-27 GO:0044446 intracellular organelle part
1.26 2.21e-25 GO:0032991 macromolecular complex
1.28 5.25e-24 GO:0043234 protein complex
1.33 5.72e-16 GO:0005829 cytosol
1.37 8.90e-15 GO:0042995 cell projection
1.52 9.11e-15 GO:0043005 neuron projection
1.28 1.42e-14 GO:0044459 plasma membrane part
1.24 2.03e-14 GO:0043228 non-membrane-bounded organelle
1.24 2.03e-14 GO:0043232 intracellular non-membrane-bounded organelle
1.28 2.04e-14 GO:0044428 nuclear part
1.18 3.06e-14 GO:0071944 cell periphery
1.47 1.32e-13 GO:0030054 cell junction
1.18 1.64e-13 GO:0005886 plasma membrane
1.30 2.44e-13 GO:0005856 cytoskeleton
1.32 1.08e-11 GO:0000267 cell fraction
1.66 1.25e-11 GO:0030425 dendrite
1.34 2.05e-11 GO:0005654 nucleoplasm
1.28 2.45e-11 GO:0031981 nuclear lumen
1.38 3.45e-11 GO:0012505 endomembrane system
1.35 6.57e-11 GO:0005626 insoluble fraction
1.48 8.78e-11 GO:0045202 synapse
1.25 3.59e-10 GO:0043233 organelle lumen
1.24 3.97e-10 GO:0031974 membrane-enclosed lumen
1.25 5.06e-10 GO:0070013 intracellular organelle lumen
1.34 6.59e-10 GO:0005624 membrane fraction
1.51 3.69e-08 GO:0044297 cell body
1.62 6.62e-08 GO:0005911 cell-cell junction
1.30 6.82e-08 GO:0005794 Golgi apparatus
1.51 9.82e-08 GO:0043025 neuronal cell body
1.29 3.23e-07 GO:0044430 cytoskeletal part
1.78 6.95e-07 GO:0005912 adherens junction
1.43 7.62e-07 GO:0044463 cell projection part
1.74 1.17e-06 GO:0070161 anchoring junction
1.47 1.21e-06 GO:0044456 synapse part
1.90 1.22e-06 GO:0016327 apicolateral plasma membrane
1.58 1.36e-06 GO:0016323 basolateral plasma membrane
1.33 2.13e-06 GO:0044451 nucleoplasm part
1.30 3.47e-06 GO:0031982 vesicle
1.87 4.45e-06 GO:0043296 apical junction complex
1.63 5.83e-06 GO:0031252 cell leading edge
1.22 1.72e-05 GO:0031090 organelle membrane
1.57 3.32e-05 GO:0045121 membrane raft
1.44 5.32e-05 GO:0048471 perinuclear region of cytoplasm
1.45 6.66e-05 GO:0044431 Golgi apparatus part
2.14 9.75e-05 GO:0005913 cell-cell adherens junction
1.45 1.08e-04 GO:0015629 actin cytoskeleton
1.31 1.88e-04 GO:0031988 membrane-bounded vesicle
1.27 1.94e-04 GO:0031410 cytoplasmic vesicle
1.46 2.67e-04 GO:0045177 apical part of cell
1.80 4.02e-04 GO:0005923 tight junction
1.80 4.02e-04 GO:0070160 occluding junction
1.30 4.31e-04 GO:0015630 microtubule cytoskeleton
1.44 5.33e-04 GO:0030424 axon
1.60 7.28e-04 GO:0019717 synaptosome
1.52 1.28e-03 GO:0012506 vesicle membrane
1.54 1.59e-03 GO:0000139 Golgi membrane
1.20 1.87e-03 GO:0005783 endoplasmic reticulum
1.29 2.07e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
1.73 3.46e-03 GO:0014069 postsynaptic density
1.49 7.51e-03 GO:0044433 cytoplasmic vesicle part
1.33 8.44e-03 GO:0005625 soluble fraction
1.69 8.47e-03 GO:0030027 lamellipodium
1.70 1.17e-02 GO:0005925 focal adhesion
1.45 1.17e-02 GO:0016324 apical plasma membrane
1.71 1.44e-02 GO:0044309 neuron spine
1.15 1.56e-02 GO:0005739 mitochondrion
1.64 1.75e-02 GO:0030055 cell-substrate junction
1.54 1.76e-02 GO:0043292 contractile fiber
1.46 2.34e-02 GO:0030135 coated vesicle
1.66 2.46e-02 GO:0005924 cell-substrate adherens junction
1.36 2.49e-02 GO:0005874 microtubule
1.43 2.51e-02 GO:0005635 nuclear envelope
1.46 2.90e-02 GO:0030659 cytoplasmic vesicle membrane
1.58 3.01e-02 GO:0031253 cell projection membrane
1.55 3.25e-02 GO:0030016 myofibril
1.96 3.58e-02 GO:0000118 histone deacetylase complex
1.56 3.79e-02 GO:0044449 contractile fiber part
1.68 4.31e-02 GO:0043197 dendritic spine

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.18 5.49e-76 GO:0005488 binding
1.30 3.43e-68 GO:0005515 protein binding
1.46 8.89e-18 GO:0019899 enzyme binding
1.52 3.26e-13 GO:0019904 protein domain specific binding
1.51 1.52e-12 GO:0008092 cytoskeletal protein binding
1.24 3.21e-12 GO:0000166 nucleotide binding
1.17 4.81e-11 GO:0043169 cation binding
1.17 5.25e-11 GO:0043167 ion binding
1.17 9.94e-11 GO:0046872 metal ion binding
1.13 2.74e-10 GO:0003824 catalytic activity
1.51 1.04e-09 GO:0060589 nucleoside-triphosphatase regulator activity
1.51 2.18e-09 GO:0030695 GTPase regulator activity
1.56 1.56e-08 GO:0019900 kinase binding
1.59 1.21e-07 GO:0005083 small GTPase regulator activity
1.17 1.83e-07 GO:0003676 nucleic acid binding
1.32 3.01e-07 GO:0042802 identical protein binding
1.21 4.05e-07 GO:0032553 ribonucleotide binding
1.24 4.22e-07 GO:0008270 zinc ion binding
1.57 4.41e-07 GO:0019901 protein kinase binding
1.21 5.00e-07 GO:0032555 purine ribonucleotide binding
1.33 5.55e-07 GO:0003723 RNA binding
1.20 8.41e-07 GO:0035639 purine ribonucleoside triphosphate binding
1.47 9.10e-07 GO:0032403 protein complex binding
1.29 9.45e-07 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.20 1.15e-06 GO:0017076 purine nucleotide binding
1.30 1.47e-06 GO:0030234 enzyme regulator activity
1.49 3.10e-06 GO:0003779 actin binding
1.22 3.90e-06 GO:0032559 adenyl ribonucleotide binding
1.31 6.03e-06 GO:0046983 protein dimerization activity
1.29 8.38e-06 GO:0016301 kinase activity
1.21 9.32e-06 GO:0030554 adenyl nucleotide binding
1.20 1.42e-05 GO:0046914 transition metal ion binding
1.21 1.42e-05 GO:0005524 ATP binding
1.71 6.72e-05 GO:0051020 GTPase binding
1.30 7.83e-05 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.25 9.42e-05 GO:0030528 transcription regulator activity
1.17 3.30e-04 GO:0016740 transferase activity
1.33 7.65e-04 GO:0042803 protein homodimerization activity
1.21 8.06e-04 GO:0005215 transporter activity
1.29 1.03e-03 GO:0004672 protein kinase activity
1.23 1.55e-03 GO:0022892 substrate-specific transporter activity
1.68 2.12e-03 GO:0019838 growth factor binding
1.66 2.58e-03 GO:0031267 small GTPase binding
1.20 3.55e-03 GO:0005102 receptor binding
1.54 6.39e-03 GO:0005085 guanyl-nucleotide exchange factor activity
1.66 6.81e-03 GO:0017016 Ras GTPase binding
1.23 6.93e-03 GO:0022891 substrate-specific transmembrane transporter activity
2.63 7.07e-03 GO:0004407 histone deacetylase activity
2.63 7.07e-03 GO:0033558 protein deacetylase activity
1.22 8.48e-03 GO:0022857 transmembrane transporter activity
1.28 9.52e-03 GO:0005509 calcium ion binding
1.79 1.56e-02 GO:0019902 phosphatase binding
1.34 2.31e-02 GO:0008047 enzyme activator activity
1.33 2.51e-02 GO:0016563 transcription activator activity
1.14 2.51e-02 GO:0003677 DNA binding
1.12 3.28e-02 GO:0016787 hydrolase activity
1.29 4.07e-02 GO:0004674 protein serine/threonine kinase activity
2.31 4.90e-02 GO:0005520 insulin-like growth factor binding
2.59 4.93e-02 GO:0017136 NAD-dependent histone deacetylase activity
2.59 4.93e-02 GO:0034979 NAD-dependent protein deacetylase activity