Motif ID: NFATC1..3.p2

Z-value: 1.774


Transcription factors associated with NFATC1..3.p2:

Gene SymbolEntrez IDGene Name
Nfatc1 18018 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Nfatc2 18019 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
Nfatc3 18021 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc3chr8_+_1085834490.206.1e-03Click!
Nfatc2chr2_-_168427037-0.181.6e-02Click!
Nfatc1chr18_-_809048520.153.7e-02Click!


Activity profile for motif NFATC1..3.p2.

activity profile for motif NFATC1..3.p2


Sorted Z-values histogram for motif NFATC1..3.p2

Sorted Z-values for motif NFATC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFATC1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_135313010 35.599 Emp1
epithelial membrane protein 1
chr6_+_135312948 31.247 NM_010128
 Emp1
epithelial membrane protein 1
chr2_+_24200925 27.462 Il1rn
interleukin 1 receptor antagonist
chr2_+_24201033 27.057 Il1rn
interleukin 1 receptor antagonist
chr2_+_24200890 25.878 NM_001039701
 Il1rn
interleukin 1 receptor antagonist
chr4_-_58083082 23.533 Svep1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr17_-_14831095 22.970 Thbs2
thrombospondin 2
chr17_-_14831058 22.706 Thbs2
thrombospondin 2
chr1_+_89991575 22.097 NM_201642
 Ugt1a7c
UDP glucuronosyltransferase 1 family, polypeptide A7C
chr12_-_27129497 21.993 Rsad2
radical S-adenosyl methionine domain containing 2
chr8_+_95376459 21.384 Mmp2
matrix metallopeptidase 2
chr2_+_24200807 20.870 NM_001159562
 Il1rn
interleukin 1 receptor antagonist
chr17_-_14831233 20.346 Thbs2
thrombospondin 2
chr1_+_45402907 19.559 Col3a1
collagen, type III, alpha 1
chrX_+_70728994 19.419 Bgn
biglycan
chr10_+_87323855 19.338 NM_001111274
NM_001111276
NM_184052
 Igf1


insulin-like growth factor 1


chr17_-_14831262 19.274 NM_011581
 Thbs2
thrombospondin 2
chr1_-_45559866 18.464 Col5a2
collagen, type V, alpha 2
chrX_+_70728939 18.366 NM_007542
 Bgn
biglycan
chr5_-_17394564 17.498 Cd36
CD36 antigen

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 161 entries
Enrichment   P-value GO Accession GO Term
9.10 2.42e-02 GO:0034391 regulation of smooth muscle cell apoptosis
5.52 1.16e-02 GO:0022409 positive regulation of cell-cell adhesion
5.14 8.94e-03 GO:0032760 positive regulation of tumor necrosis factor production
4.62 2.85e-04 GO:0031214 biomineral tissue development
4.60 3.18e-02 GO:0001837 epithelial to mesenchymal transition
4.15 8.50e-03 GO:0002673 regulation of acute inflammatory response
4.05 1.18e-02 GO:0051781 positive regulation of cell division
3.74 8.03e-03 GO:0048145 regulation of fibroblast proliferation
3.72 1.00e-03 GO:0060348 bone development
3.49 8.05e-04 GO:0010810 regulation of cell-substrate adhesion
3.41 2.77e-05 GO:0045785 positive regulation of cell adhesion
3.35 1.70e-03 GO:0048660 regulation of smooth muscle cell proliferation
3.19 7.28e-03 GO:0050900 leukocyte migration
3.00 1.46e-03 GO:0032103 positive regulation of response to external stimulus
2.98 6.19e-04 GO:0043406 positive regulation of MAP kinase activity
2.92 7.88e-05 GO:0001503 ossification
2.89 1.77e-07 GO:0030155 regulation of cell adhesion
2.88 5.45e-03 GO:0050730 regulation of peptidyl-tyrosine phosphorylation
2.86 4.57e-02 GO:0042129 regulation of T cell proliferation
2.84 6.77e-04 GO:0043410 positive regulation of MAPKKK cascade

Gene overrepresentation in compartment category:

Showing 1 to 20 of 22 entries
Enrichment   P-value GO Accession GO Term
6.54 1.06e-02 GO:0005583 fibrillar collagen
4.67 8.28e-03 GO:0005581 collagen
3.55 2.95e-02 GO:0001725 stress fiber
3.43 2.24e-02 GO:0042641 actomyosin
3.11 5.29e-06 GO:0044420 extracellular matrix part
2.70 3.19e-02 GO:0005604 basement membrane
2.69 9.72e-11 GO:0005578 proteinaceous extracellular matrix
2.48 1.43e-09 GO:0031012 extracellular matrix
2.27 2.90e-04 GO:0009897 external side of plasma membrane
2.26 1.51e-16 GO:0005615 extracellular space
2.21 1.03e-20 GO:0044421 extracellular region part
2.05 3.03e-07 GO:0009986 cell surface
1.94 4.66e-03 GO:0015629 actin cytoskeleton
1.90 1.06e-23 GO:0005576 extracellular region
1.79 4.21e-02 GO:0048471 perinuclear region of cytoplasm
1.51 8.84e-08 GO:0044459 plasma membrane part
1.35 1.23e-08 GO:0071944 cell periphery
1.35 2.14e-08 GO:0005886 plasma membrane
1.20 4.78e-09 GO:0005737 cytoplasm
1.18 2.06e-03 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

Showing 1 to 16 of 16 entries
Enrichment   P-value GO Accession GO Term
7.08 9.23e-03 GO:0048407 platelet-derived growth factor binding
3.82 4.69e-09 GO:0019838 growth factor binding
2.62 1.56e-02 GO:0008201 heparin binding
2.59 1.08e-03 GO:0005539 glycosaminoglycan binding
2.56 4.31e-04 GO:0001871 pattern binding
2.56 4.31e-04 GO:0030247 polysaccharide binding
2.50 2.32e-03 GO:0008083 growth factor activity
2.23 6.97e-03 GO:0005125 cytokine activity
2.21 2.69e-07 GO:0030246 carbohydrate binding
2.10 1.49e-04 GO:0003779 actin binding
1.70 4.60e-03 GO:0008092 cytoskeletal protein binding
1.69 3.61e-07 GO:0005102 receptor binding
1.66 1.28e-05 GO:XXXXXXX unannotated
1.64 2.65e-04 GO:0042802 identical protein binding
1.36 9.25e-17 GO:0005515 protein binding
1.18 4.75e-13 GO:0005488 binding