Motif ID: NFATC1..3.p2

Z-value: 1.774


Transcription factors associated with NFATC1..3.p2:

Gene SymbolEntrez IDGene Name
Nfatc1 18018 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Nfatc2 18019 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
Nfatc3 18021 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc3chr8_+_1085834490.206.1e-03Click!
Nfatc2chr2_-_168427037-0.181.6e-02Click!
Nfatc1chr18_-_809048520.153.7e-02Click!


Activity profile for motif NFATC1..3.p2.

activity profile for motif NFATC1..3.p2


Sorted Z-values histogram for motif NFATC1..3.p2

Sorted Z-values for motif NFATC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFATC1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_135313010 35.599 Emp1
epithelial membrane protein 1
chr6_+_135312948 31.247 NM_010128
Emp1
epithelial membrane protein 1
chr2_+_24200925 27.462 Il1rn
interleukin 1 receptor antagonist
chr2_+_24201033 27.057 Il1rn
interleukin 1 receptor antagonist
chr2_+_24200890 25.878 NM_001039701
Il1rn
interleukin 1 receptor antagonist
chr4_-_58083082 23.533 Svep1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr17_-_14831095 22.970 Thbs2
thrombospondin 2
chr17_-_14831058 22.706 Thbs2
thrombospondin 2
chr1_+_89991575 22.097 NM_201642
Ugt1a7c
UDP glucuronosyltransferase 1 family, polypeptide A7C
chr12_-_27129497 21.993 Rsad2
radical S-adenosyl methionine domain containing 2
chr8_+_95376459 21.384 Mmp2
matrix metallopeptidase 2
chr2_+_24200807 20.870 NM_001159562
Il1rn
interleukin 1 receptor antagonist
chr17_-_14831233 20.346 Thbs2
thrombospondin 2
chr1_+_45402907 19.559 Col3a1
collagen, type III, alpha 1
chrX_+_70728994 19.419 Bgn
biglycan
chr10_+_87323855 19.338 NM_001111274
NM_001111276
NM_184052
Igf1


insulin-like growth factor 1


chr17_-_14831262 19.274 NM_011581
Thbs2
thrombospondin 2
chr1_-_45559866 18.464 Col5a2
collagen, type V, alpha 2
chrX_+_70728939 18.366 NM_007542
Bgn
biglycan
chr5_-_17394564 17.498 Cd36
CD36 antigen
chr3_+_95303177 17.207 NM_007802
Ctsk
cathepsin K
chrX_-_9046362 16.275 NM_007807
Cybb
cytochrome b-245, beta polypeptide
chr5_+_104868321 16.197 Spp1
secreted phosphoprotein 1
chr1_-_45559700 15.403 Col5a2
collagen, type V, alpha 2
chr9_+_7445821 15.143 NM_010809
Mmp3
matrix metallopeptidase 3
chr2_-_148263617 15.085 Cd93
CD93 antigen
chr9_+_88851757 15.067 NM_009742
Bcl2a1a
B-cell leukemia/lymphoma 2 related protein A1a
chr6_+_4484651 15.010 Col1a2
collagen, type I, alpha 2
chr1_-_45560001 14.917 NM_007737
Col5a2
collagen, type V, alpha 2
chr9_+_89094110 14.680 NM_007534
Bcl2a1a
Bcl2a1b
B-cell leukemia/lymphoma 2 related protein A1a
B-cell leukemia/lymphoma 2 related protein A1b
chrX_-_147241307 14.186 Maged2
melanoma antigen, family D, 2
chr9_+_89094190 14.099 Bcl2a1a
B-cell leukemia/lymphoma 2 related protein A1a
chrX_-_9014351 13.212 Cybb
cytochrome b-245, beta polypeptide
chr2_+_145648290 12.918 Rin2
Ras and Rab interactor 2
chr6_-_129422702 12.909 NM_020008
Clec7a
C-type lectin domain family 7, member a
chr11_+_94812919 12.667 Col1a1
collagen, type I, alpha 1
chr10_-_87819765 12.599 NM_027878
Dram1
DNA-damage regulated autophagy modulator 1
chr15_+_78757148 12.577 NM_008495
Lgals1
lectin, galactose binding, soluble 1
chr13_+_83643032 12.408 NM_001170537
NM_025282
Mef2c

myocyte enhancer factor 2C

chr6_+_72499398 11.919 NM_001042534
Capg
capping protein (actin filament), gelsolin-like
chr15_+_78757171 11.809 Lgals1
lectin, galactose binding, soluble 1
chr19_+_9092973 11.686 Ahnak
AHNAK nucleoprotein (desmoyokin)
chr3_+_66023808 11.516 NM_008987
Ptx3
pentraxin related gene
chr1_+_45368443 11.504 Col3a1
collagen, type III, alpha 1
chr1_+_40281924 11.365 NM_008362
Il1r1
interleukin 1 receptor, type I
chr6_-_123239765 11.268 Clec4e
C-type lectin domain family 4, member e
chr1_+_45368382 11.150 NM_009930
Col3a1
collagen, type III, alpha 1
chr1_-_71632834 11.136 Fn1
fibronectin 1
chr9_-_88626434 11.086 Bcl2a1d
B-cell leukemia/lymphoma 2 related protein A1d
chr10_+_96945057 10.946 Dcn
decorin
chr7_-_53971038 10.935 NM_011315
Saa3
serum amyloid A 3
chr14_+_124059330 10.865 NM_145467
Itgbl1
integrin, beta-like 1
chr10_-_87819740 10.808 Dram1
DNA-damage regulated autophagy modulator 1
chr3_-_115832278 10.777 Vcam1
vascular cell adhesion molecule 1
chr7_-_106494110 10.621


chr4_-_43536296 10.587 Tpm2
tropomyosin 2, beta
chrX_-_98463514 10.514 NM_013563
Il2rg
interleukin 2 receptor, gamma chain
chr6_+_56828743 10.511 Fkbp9
FK506 binding protein 9
chr1_-_173164404 10.307 NM_010185
Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr5_+_104864136 10.287 NM_009263
Spp1
secreted phosphoprotein 1
chr1_+_24184448 10.268 NM_007740
Col9a1
collagen, type IX, alpha 1
chr15_-_96886327 10.221 NM_027052
Slc38a4
solute carrier family 38, member 4
chr3_+_66023884 10.220 Ptx3
pentraxin related gene
chr15_-_58046380 10.127 Fbxo32
F-box protein 32
chr9_-_88626613 9.989 NM_007536
Bcl2a1d
B-cell leukemia/lymphoma 2 related protein A1d
chr15_-_99650502 9.906 NM_023063
Lima1
LIM domain and actin binding 1
chr14_-_103381744 9.803 NM_177715
Kctd12
potassium channel tetramerisation domain containing 12
chr4_-_43536259 9.687 NM_009416
Tpm2
tropomyosin 2, beta
chrX_-_140261831 9.635 Capn6
calpain 6
chr9_+_92502908 9.630 Plod2
procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
chr8_-_105308910 9.564 NM_009866
Cdh11
cadherin 11
chr6_+_145882641 9.314 NM_010656
Sspn
sarcospan
chr3_-_145312928 9.206 NM_010516
Cyr61
cysteine rich protein 61
chr1_+_12708582 9.163 NM_172294
Sulf1
sulfatase 1
chr1_+_43787442 9.093 NM_024283
1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr2_+_145647868 9.048 Rin2
Ras and Rab interactor 2
chr5_+_53981893 8.967 Rbpj
recombination signal binding protein for immunoglobulin kappa J region
chr3_-_115832327 8.886 Vcam1
vascular cell adhesion molecule 1
chr4_+_147433130 8.726 Mthfr
5,10-methylenetetrahydrofolate reductase
chr1_+_43787692 8.704 1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr10_+_57857120 8.591 NM_001193303
Lims1
LIM and senescent cell antigen-like domains 1
chr1_+_51346108 8.414 Sdpr
serum deprivation response
chr6_-_123239886 8.306 NM_019948
Clec4e
C-type lectin domain family 4, member e
chr6_+_124462696 8.275 C1ra
complement component 1, r subcomponent A
chr2_+_145611851 8.258 NM_028724
Rin2
Ras and Rab interactor 2
chr15_+_3230053 8.177


chr8_+_125710134 8.077 NM_007876
Dpep1
dipeptidase 1 (renal)
chr13_+_13529947 8.077 Nid1
nidogen 1
chr1_-_66991580 7.997 Myl1
myosin, light polypeptide 1
chr8_-_64381465 7.997 NM_001081390
Palld
palladin, cytoskeletal associated protein
chrX_-_140261954 7.992 NM_007603
Capn6
calpain 6
chr4_+_125825246 7.860 NM_172145
Fam176b
family with sequence similarity 176, member B
chr6_+_115372083 7.835 NM_011146
Pparg
peroxisome proliferator activated receptor gamma
chr16_+_45093816 7.833 Ccdc80
coiled-coil domain containing 80
chr9_+_5345475 7.797 NM_009808
Casp12
caspase 12
chr13_+_13529923 7.749 Nid1
nidogen 1
chr6_+_123212210 7.730 Clec4d
C-type lectin domain family 4, member d
chr13_+_13529902 7.723 Nid1
nidogen 1
chr6_-_136890189 7.679 NM_007486
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr6_-_54543121 7.635 NM_153573
Fkbp14
FK506 binding protein 14
chr10_+_87322774 7.609 Igf1
insulin-like growth factor 1
chr10_+_97028134 7.533 NM_008524
Lum
lumican
chr2_-_84614976 7.378 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr9_+_5308846 7.352 NM_007609
Casp4
caspase 4, apoptosis-related cysteine peptidase
chr3_-_115832605 7.348 NM_011693
Vcam1
vascular cell adhesion molecule 1
chr2_+_33071451 7.269 NM_011923
Angptl2
angiopoietin-like 2
chr18_-_36886375 7.241 Cd14
CD14 antigen
chr1_-_122401329 7.238 Marco
macrophage receptor with collagenous structure
chr1_-_172040621 7.175 Ddr2
discoidin domain receptor family, member 2
chr16_+_45093784 7.129 Ccdc80
coiled-coil domain containing 80
chr10_+_97028409 7.113 Lum
lumican
chr7_+_3289029 7.109 NM_001093764
Myadm
myeloid-associated differentiation marker
chrX_+_135448968 7.095 NM_013724
Nrk
Nik related kinase
chr13_+_16106279 7.071 NM_008380
Inhba
inhibin beta-A
chr15_+_66723067 7.064 Wisp1
WNT1 inducible signaling pathway protein 1
chr15_+_6249788 6.992 NM_001008702
Dab2
disabled homolog 2 (Drosophila)
chr11_-_83343962 6.864 NM_013653
Ccl5
chemokine (C-C motif) ligand 5
chr15_+_66722968 6.861 Wisp1
WNT1 inducible signaling pathway protein 1
chr4_+_41709182 6.824 NM_010549
Il11ra1
interleukin 11 receptor, alpha chain 1
chr6_+_4471231 6.786 Col1a2
collagen, type I, alpha 2
chr1_-_66981900 6.755 NM_001113387
Myl1
myosin, light polypeptide 1
chr6_+_123179860 6.682 NM_001190320
NM_001190321
NM_020001
Clec4n


C-type lectin domain family 4, member n


chr8_-_64069935 6.609 Palld
palladin, cytoskeletal associated protein
chr17_+_80526993 6.582 Galm
galactose mutarotase
chr1_-_164796660 6.552 NM_010231
Fmo1
flavin containing monooxygenase 1
chr15_+_66722913 6.551 NM_018865
Wisp1
WNT1 inducible signaling pathway protein 1
chr19_-_23522811 6.508 NM_174857
Mamdc2
MAM domain containing 2
chr16_+_91406408 6.501 NM_008349
Il10rb
interleukin 10 receptor, beta
chr5_+_91188324 6.441 NM_009141
Cxcl5
chemokine (C-X-C motif) ligand 5
chr1_+_89967340 6.439 NM_201644
Ugt1a9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr4_+_129725083 6.369 NM_028266
Col16a1
collagen, type XVI, alpha 1
chr5_-_92776027 6.364 Cxcl10
chemokine (C-X-C motif) ligand 10
chr3_+_123045975 6.292 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr15_-_103395483 6.270 NM_008134
Glycam1
glycosylation dependent cell adhesion molecule 1
chrX_-_35793335 6.260 Lamp2
lysosomal-associated membrane protein 2
chr3_+_113733457 6.245 NM_007729
Col11a1
collagen, type XI, alpha 1
chr6_+_3954259 6.225 Gng11
guanine nucleotide binding protein (G protein), gamma 11
chr11_-_76592473 6.214 Cpd
carboxypeptidase D
chr3_+_159502646 6.206 NM_026582
Wls
wntless homolog (Drosophila)
chr13_+_13529868 6.205 NM_010917
Nid1
nidogen 1
chr1_-_158604396 6.182 NM_023141
Tor3a
torsin family 3, member A
chr7_-_26573483 6.169 NM_001190974
NM_001190975
NM_009465
Axl


AXL receptor tyrosine kinase


chr6_+_3954225 6.141 Gng11
guanine nucleotide binding protein (G protein), gamma 11
chr3_+_121670737 6.097 Arhgap29
Rho GTPase activating protein 29
chr11_+_83522505 6.092 NM_007969
Expi
extracellular proteinase inhibitor
chr19_+_34682418 6.070 NM_001005858
I830012O16Rik
RIKEN cDNA I830012O16 gene
chr5_-_92776160 6.062 Cxcl10
chemokine (C-X-C motif) ligand 10
chr18_-_43552694 6.033 NM_009468
Dpysl3
dihydropyrimidinase-like 3
chr17_+_87362450 6.011 NM_145491
Rhoq
ras homolog gene family, member Q
chr10_+_38685424 5.979 Lama4
laminin, alpha 4
chr10_+_38685309 5.979 NM_010681
Lama4
laminin, alpha 4
chr5_-_101148612 5.912 NM_152803
Hpse
heparanase
chr9_+_69843263 5.885 NM_001008238
Bnip2
BCL2/adenovirus E1B interacting protein 2
chr1_-_164796609 5.883 Fmo1
flavin containing monooxygenase 1
chr11_-_78349594 5.883 NM_001159392
NM_009395
Tnfaip1

tumor necrosis factor, alpha-induced protein 1 (endothelial)

chr8_+_125710222 5.862 Dpep1
dipeptidase 1 (renal)
chr5_+_104864146 5.745 Spp1
secreted phosphoprotein 1
chr12_+_34642676 5.727 Twist1
twist homolog 1 (Drosophila)
chr3_+_87161790 5.726 NM_009690
Cd5l
CD5 antigen-like
chr11_+_48900507 5.724 NM_008330
Ifi47
Olfr56
interferon gamma inducible protein 47
olfactory receptor 56
chr1_-_122401512 5.687 NM_010766
Marco
macrophage receptor with collagenous structure
chr15_-_58046428 5.678 NM_026346
Fbxo32
F-box protein 32
chr6_+_124520447 5.644 NM_001113356
C1rb
complement component 1, r subcomponent B
chr15_-_96850752 5.618 Slc38a4
solute carrier family 38, member 4
chr3_+_131748252 5.613 NM_020265
Dkk2
dickkopf homolog 2 (Xenopus laevis)
chr5_+_43993160 5.611 NM_175425
C1qtnf7
C1q and tumor necrosis factor related protein 7
chr9_-_58006311 5.586 NM_001195431
Islr
immunoglobulin superfamily containing leucine-rich repeat
chr3_+_137880725 5.584 NM_009626
Adh7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr10_-_33927262 5.572 NM_172508
Dse
dermatan sulfate epimerase
chr10_+_97028456 5.568 Lum
lumican
chr8_+_54597026 5.544 NM_001005847
Aga
aspartylglucosaminidase
chr5_-_17394776 5.537 NM_001159558
Cd36
CD36 antigen
chr10_-_33816255 5.491 NM_178908
Fam26e
family with sequence similarity 26, member E
chr19_-_20465115 5.470 Anxa1
annexin A1
chr10_-_60846055 5.456 NM_013753
X99384
cDNA sequence X99384
chr19_-_47212695 5.452 NM_133746
Calhm2
calcium homeostasis modulator 2
chr16_-_36334417 5.452 NM_001001332
BC117090
cDNA sequence BC1179090
chrX_-_151650799 5.449 Sat1
spermidine/spermine N1-acetyl transferase 1
chrX_-_131135346 5.445 NM_013463
Gla
galactosidase, alpha
chr7_-_125635435 5.436 NM_001033380
Itpripl2
inositol 1,4,5-triphosphate receptor interacting protein-like 2
chr9_+_40590943 5.417 9030425E11Rik
RIKEN cDNA 9030425E11 gene
chr8_-_87297283 5.417 Nfix
nuclear factor I/X
chr5_-_65324796 5.398 Tlr1
toll-like receptor 1
chr6_+_3953944 5.387 NM_025331
Gng11
guanine nucleotide binding protein (G protein), gamma 11
chr5_+_31215857 5.360 Emilin1
elastin microfibril interfacer 1
chr1_+_174430359 5.352 NM_178598
Tagln2
transgelin 2
chr4_-_136448748 5.317 NM_007574
C1qc
complement component 1, q subcomponent, C chain
chr6_-_54543167 5.269 Fkbp14
FK506 binding protein 14
chr12_+_96930429 5.257 NM_201518
Flrt2
fibronectin leucine rich transmembrane protein 2
chr10_-_116719183 5.225 NM_017372
Lyz2
lysozyme 2
chr17_+_34290108 5.219 NM_010387
H2-DMb1
histocompatibility 2, class II, locus Mb1
chr5_+_20878459 5.192 NM_008013
Fgl2
fibrinogen-like protein 2
chr11_+_83517517 5.186 NM_001081957
Gm11428
predicted gene 11428
chr17_-_18020889 5.163 NM_013521
Fpr1
formyl peptide receptor 1
chr15_+_10882086 5.142 NM_030888
C1qtnf3
C1q and tumor necrosis factor related protein 3
chr19_-_41068625 5.132 Blnk
B-cell linker
chr11_-_55223449 5.117 Sparc
secreted acidic cysteine rich glycoprotein
chr11_-_70465629 5.087 Pfn1
profilin 1
chr6_+_15750966 5.085 Mdfic
MyoD family inhibitor domain containing
chr10_-_76629208 5.031 NM_009929
Col18a1
collagen, type XVIII, alpha 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.05 4.11e-14 GO:0002376 immune system process
1.76 4.50e-14 GO:0048583 regulation of response to stimulus
1.54 1.28e-13 GO:0048518 positive regulation of biological process
1.55 2.01e-12 GO:0048522 positive regulation of cellular process
2.23 3.17e-12 GO:0022610 biological adhesion
2.23 4.56e-12 GO:0007155 cell adhesion
2.72 1.48e-11 GO:0001944 vasculature development
2.75 7.25e-11 GO:0001568 blood vessel development
2.02 9.61e-11 GO:0048584 positive regulation of response to stimulus
1.86 1.86e-10 GO:0050793 regulation of developmental process
1.79 2.32e-10 GO:0009966 regulation of signal transduction
2.26 2.39e-10 GO:0072358 cardiovascular system development
2.26 2.39e-10 GO:0072359 circulatory system development
1.67 1.05e-09 GO:0051239 regulation of multicellular organismal process
2.12 3.42e-09 GO:0001932 regulation of protein phosphorylation
2.04 4.97e-09 GO:0070887 cellular response to chemical stimulus
1.88 5.90e-09 GO:2000026 regulation of multicellular organismal development
1.58 6.66e-09 GO:0048513 organ development
1.79 1.09e-08 GO:0032879 regulation of localization
1.77 1.23e-08 GO:0010646 regulation of cell communication
2.13 1.88e-08 GO:0051094 positive regulation of developmental process
2.02 2.44e-08 GO:0042325 regulation of phosphorylation
1.80 2.48e-08 GO:0042981 regulation of apoptosis
2.13 3.05e-08 GO:0006952 defense response
1.63 3.71e-08 GO:0023051 regulation of signaling
1.98 4.40e-08 GO:0019220 regulation of phosphate metabolic process
1.98 4.40e-08 GO:0051174 regulation of phosphorus metabolic process
1.77 4.86e-08 GO:0010941 regulation of cell death
2.32 5.42e-08 GO:0006955 immune response
1.78 5.83e-08 GO:0043067 regulation of programmed cell death
1.43 8.15e-08 GO:0048856 anatomical structure development
1.46 9.13e-08 GO:0048519 negative regulation of biological process
1.46 1.05e-07 GO:0048731 system development
2.89 1.77e-07 GO:0030155 regulation of cell adhesion
1.63 1.91e-07 GO:0009653 anatomical structure morphogenesis
1.79 2.00e-07 GO:0042127 regulation of cell proliferation
1.48 2.23e-07 GO:0048523 negative regulation of cellular process
1.79 4.12e-07 GO:0009888 tissue development
2.10 4.97e-07 GO:0009967 positive regulation of signal transduction
2.02 1.10e-06 GO:0008284 positive regulation of cell proliferation
1.84 1.26e-06 GO:0031399 regulation of protein modification process
2.40 1.85e-06 GO:0030334 regulation of cell migration
1.54 1.97e-06 GO:0006950 response to stress
2.17 2.07e-06 GO:0045597 positive regulation of cell differentiation
2.18 2.09e-06 GO:0009611 response to wounding
2.54 2.11e-06 GO:0048514 blood vessel morphogenesis
2.20 2.99e-06 GO:0045859 regulation of protein kinase activity
2.37 3.20e-06 GO:2000145 regulation of cell motility
2.30 3.55e-06 GO:0051270 regulation of cellular component movement
1.79 4.18e-06 GO:0045595 regulation of cell differentiation
2.03 4.27e-06 GO:0060548 negative regulation of cell death
2.06 4.33e-06 GO:0043066 negative regulation of apoptosis
1.98 4.54e-06 GO:0023056 positive regulation of signaling
2.15 5.28e-06 GO:0051240 positive regulation of multicellular organismal process
2.13 5.81e-06 GO:0043549 regulation of kinase activity
1.66 7.33e-06 GO:0051246 regulation of protein metabolic process
1.96 7.70e-06 GO:0010647 positive regulation of cell communication
2.03 8.00e-06 GO:0043069 negative regulation of programmed cell death
2.58 9.25e-06 GO:0006954 inflammatory response
1.34 1.41e-05 GO:0032502 developmental process
2.75 1.48e-05 GO:0030335 positive regulation of cell migration
2.75 1.48e-05 GO:2000147 positive regulation of cell motility
2.07 1.50e-05 GO:0051338 regulation of transferase activity
1.88 1.61e-05 GO:0002682 regulation of immune system process
2.70 1.75e-05 GO:0051272 positive regulation of cellular component movement
3.41 2.77e-05 GO:0045785 positive regulation of cell adhesion
2.08 3.09e-05 GO:0002684 positive regulation of immune system process
1.34 3.11e-05 GO:0007275 multicellular organismal development
2.20 4.04e-05 GO:0040012 regulation of locomotion
2.48 4.44e-05 GO:0071900 regulation of protein serine/threonine kinase activity
1.46 5.10e-05 GO:0065008 regulation of biological quality
2.63 5.70e-05 GO:0040017 positive regulation of locomotion
1.64 7.09e-05 GO:0032268 regulation of cellular protein metabolic process
2.92 7.88e-05 GO:0001503 ossification
2.09 1.06e-04 GO:0007167 enzyme linked receptor protein signaling pathway
1.45 1.12e-04 GO:0042221 response to chemical stimulus
2.35 1.33e-04 GO:0032101 regulation of response to external stimulus
1.91 1.37e-04 GO:0048585 negative regulation of response to stimulus
2.45 1.41e-04 GO:0016337 cell-cell adhesion
1.93 1.50e-04 GO:0071310 cellular response to organic substance
2.44 1.62e-04 GO:0043408 regulation of MAPKKK cascade
2.05 2.45e-04 GO:0051050 positive regulation of transport
2.68 2.84e-04 GO:0002252 immune effector process
4.62 2.85e-04 GO:0031214 biomineral tissue development
2.36 2.98e-04 GO:0010562 positive regulation of phosphorus metabolic process
2.36 2.98e-04 GO:0045937 positive regulation of phosphate metabolic process
2.25 3.77e-04 GO:0010740 positive regulation of intracellular protein kinase cascade
2.61 3.83e-04 GO:0006916 anti-apoptosis
2.44 4.77e-04 GO:0001934 positive regulation of protein phosphorylation
1.99 5.22e-04 GO:0010627 regulation of intracellular protein kinase cascade
2.24 5.38e-04 GO:0045860 positive regulation of protein kinase activity
2.75 5.79e-04 GO:0071902 positive regulation of protein serine/threonine kinase activity
2.98 6.19e-04 GO:0043406 positive regulation of MAP kinase activity
2.60 6.41e-04 GO:0043405 regulation of MAP kinase activity
2.84 6.77e-04 GO:0043410 positive regulation of MAPKKK cascade
1.89 8.01e-04 GO:0080134 regulation of response to stress
3.49 8.05e-04 GO:0010810 regulation of cell-substrate adhesion
2.18 9.77e-04 GO:0033674 positive regulation of kinase activity
3.72 1.00e-03 GO:0060348 bone development
2.43 1.13e-03 GO:0051223 regulation of protein transport
2.30 1.18e-03 GO:0042327 positive regulation of phosphorylation
1.47 1.26e-03 GO:0009893 positive regulation of metabolic process
1.54 1.40e-03 GO:0010033 response to organic substance
2.34 1.43e-03 GO:0070201 regulation of establishment of protein localization
1.55 1.44e-03 GO:0035556 intracellular signal transduction
3.00 1.46e-03 GO:0032103 positive regulation of response to external stimulus
1.51 1.66e-03 GO:0050790 regulation of catalytic activity
3.35 1.70e-03 GO:0048660 regulation of smooth muscle cell proliferation
2.54 1.71e-03 GO:0045087 innate immune response
2.22 1.76e-03 GO:0032880 regulation of protein localization
1.30 2.02e-03 GO:0016043 cellular component organization
1.47 2.83e-03 GO:0010604 positive regulation of macromolecule metabolic process
2.10 2.98e-03 GO:0051347 positive regulation of transferase activity
1.44 3.01e-03 GO:0065009 regulation of molecular function
2.40 3.07e-03 GO:0001525 angiogenesis
1.80 3.34e-03 GO:0043065 positive regulation of apoptosis
2.21 3.59e-03 GO:0043193 positive regulation of gene-specific transcription
1.71 4.42e-03 GO:0040011 locomotion
1.79 4.55e-03 GO:0043068 positive regulation of programmed cell death
1.90 4.73e-03 GO:0009968 negative regulation of signal transduction
2.10 4.82e-03 GO:0001817 regulation of cytokine production
1.61 5.20e-03 GO:0044093 positive regulation of molecular function
2.88 5.45e-03 GO:0050730 regulation of peptidyl-tyrosine phosphorylation
1.89 5.64e-03 GO:0051093 negative regulation of developmental process
1.94 6.00e-03 GO:0022603 regulation of anatomical structure morphogenesis
3.19 7.28e-03 GO:0050900 leukocyte migration
2.83 7.91e-03 GO:0051222 positive regulation of protein transport
3.74 8.03e-03 GO:0048145 regulation of fibroblast proliferation
1.45 8.19e-03 GO:0031325 positive regulation of cellular metabolic process
4.15 8.50e-03 GO:0002673 regulation of acute inflammatory response
1.92 8.63e-03 GO:0002520 immune system development
1.94 8.84e-03 GO:0048534 hemopoietic or lymphoid organ development
5.14 8.94e-03 GO:0032760 positive regulation of tumor necrosis factor production
2.67 9.40e-03 GO:0050727 regulation of inflammatory response
2.15 1.03e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.75 1.04e-02 GO:0010942 positive regulation of cell death
1.27 1.15e-02 GO:0071840 cellular component organization or biogenesis
5.52 1.16e-02 GO:0022409 positive regulation of cell-cell adhesion
1.92 1.16e-02 GO:0050776 regulation of immune response
4.05 1.18e-02 GO:0051781 positive regulation of cell division
1.88 1.37e-02 GO:0009725 response to hormone stimulus
2.04 1.42e-02 GO:0045321 leukocyte activation
2.01 1.67e-02 GO:0007507 heart development
1.97 1.68e-02 GO:0033043 regulation of organelle organization
2.57 2.11e-02 GO:0050670 regulation of lymphocyte proliferation
9.10 2.42e-02 GO:0034391 regulation of smooth muscle cell apoptosis
2.55 2.46e-02 GO:0032944 regulation of mononuclear cell proliferation
2.53 2.87e-02 GO:0010638 positive regulation of organelle organization
2.18 3.01e-02 GO:0032870 cellular response to hormone stimulus
4.60 3.18e-02 GO:0001837 epithelial to mesenchymal transition
1.62 3.29e-02 GO:0043085 positive regulation of catalytic activity
2.51 3.33e-02 GO:0070663 regulation of leukocyte proliferation
1.94 3.41e-02 GO:0030097 hemopoiesis
1.54 3.44e-02 GO:0051128 regulation of cellular component organization
1.97 3.45e-02 GO:0001501 skeletal system development
2.02 3.96e-02 GO:0050778 positive regulation of immune response
2.53 4.11e-02 GO:0030198 extracellular matrix organization
1.73 4.16e-02 GO:0051726 regulation of cell cycle
1.69 4.48e-02 GO:0051704 multi-organism process
2.86 4.57e-02 GO:0042129 regulation of T cell proliferation
1.61 4.76e-02 GO:0009887 organ morphogenesis

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.90 1.06e-23 GO:0005576 extracellular region
2.21 1.03e-20 GO:0044421 extracellular region part
2.26 1.51e-16 GO:0005615 extracellular space
2.69 9.72e-11 GO:0005578 proteinaceous extracellular matrix
2.48 1.43e-09 GO:0031012 extracellular matrix
1.20 4.78e-09 GO:0005737 cytoplasm
1.35 1.23e-08 GO:0071944 cell periphery
1.35 2.14e-08 GO:0005886 plasma membrane
1.51 8.84e-08 GO:0044459 plasma membrane part
2.05 3.03e-07 GO:0009986 cell surface
3.11 5.29e-06 GO:0044420 extracellular matrix part
1.11 2.61e-04 GO:0005622 intracellular
2.27 2.90e-04 GO:0009897 external side of plasma membrane
1.10 1.33e-03 GO:0044424 intracellular part
1.18 2.06e-03 GO:0044444 cytoplasmic part
1.94 4.66e-03 GO:0015629 actin cytoskeleton
4.67 8.28e-03 GO:0005581 collagen
6.54 1.06e-02 GO:0005583 fibrillar collagen
3.43 2.24e-02 GO:0042641 actomyosin
3.55 2.95e-02 GO:0001725 stress fiber
2.70 3.19e-02 GO:0005604 basement membrane
1.79 4.21e-02 GO:0048471 perinuclear region of cytoplasm

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.36 9.25e-17 GO:0005515 protein binding
1.18 4.75e-13 GO:0005488 binding
3.82 4.69e-09 GO:0019838 growth factor binding
2.21 2.69e-07 GO:0030246 carbohydrate binding
1.69 3.61e-07 GO:0005102 receptor binding
1.66 1.28e-05 GO:XXXXXXX unannotated
2.10 1.49e-04 GO:0003779 actin binding
1.64 2.65e-04 GO:0042802 identical protein binding
2.56 4.31e-04 GO:0001871 pattern binding
2.56 4.31e-04 GO:0030247 polysaccharide binding
2.59 1.08e-03 GO:0005539 glycosaminoglycan binding
2.50 2.32e-03 GO:0008083 growth factor activity
1.70 4.60e-03 GO:0008092 cytoskeletal protein binding
2.23 6.97e-03 GO:0005125 cytokine activity
7.08 9.23e-03 GO:0048407 platelet-derived growth factor binding
2.62 1.56e-02 GO:0008201 heparin binding