Motif ID: NFE2L2.p2

Z-value: 1.290


Transcription factors associated with NFE2L2.p2:

Gene SymbolEntrez IDGene Name
Nfe2l2 18024 nuclear factor, erythroid derived 2, like 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfe2l2chr2_-_755425350.257.1e-04Click!


Activity profile for motif NFE2L2.p2.

activity profile for motif NFE2L2.p2


Sorted Z-values histogram for motif NFE2L2.p2

Sorted Z-values for motif NFE2L2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_98862163 17.476 Top2a
topoisomerase (DNA) II alpha
chr7_-_133942605 14.448 NM_001177307
 Aldoa
aldolase A, fructose-bisphosphate
chr2_+_151931424 13.990 Srxn1
sulfiredoxin 1 homolog (S. cerevisiae)
chr7_-_133942767 13.675 NM_007438
 Aldoa
aldolase A, fructose-bisphosphate
chr9_+_7272513 12.107 NM_008607
 Mmp13
matrix metallopeptidase 13
chr5_-_140212063 11.965 NM_174850
 Micall2
MICAL-like 2
chr2_-_25079684 11.384 Tubb2c
tubulin, beta 2C
chr15_-_100517580 11.303 Cela1
chymotrypsin-like elastase family, member 1
chr11_-_43561446 11.030 NM_133795
 Ttc1
tetratricopeptide repeat domain 1
chr8_-_110112368 10.962 NM_010817
 Psmd7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr5_+_67067497 10.957 Uchl1
ubiquitin carboxy-terminal hydrolase L1
chr5_-_136410488 10.685 NM_018871
 Ywhag
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chrX_+_71669985 10.628 Ikbkg
inhibitor of kappaB kinase gamma
chr8_+_34763918 10.310 Gsr
glutathione reductase
chr14_+_63754443 10.272 Ctsb
cathepsin B
chr3_+_121948541 10.125 Gclm
glutamate-cysteine ligase, modifier subunit
chr6_-_16848352 10.082 NM_031198
 Tcfec
transcription factor EC
chr2_+_151931465 10.001 NM_029688
 Srxn1
sulfiredoxin 1 homolog (S. cerevisiae)
chr3_+_121948693 9.805 Gclm
glutamate-cysteine ligase, modifier subunit
chr11_-_50024275 9.545 NM_011018
 Sqstm1
sequestosome 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 44 entries
Enrichment   P-value GO Accession GO Term
12.34 4.79e-02 GO:0008088 axon cargo transport
8.64 1.73e-02 GO:0010970 microtubule-based transport
8.64 1.73e-02 GO:0030705 cytoskeleton-dependent intracellular transport
7.19 1.98e-07 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
7.09 2.52e-07 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
7.07 9.16e-07 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
6.67 2.30e-06 GO:0051352 negative regulation of ligase activity
6.67 2.30e-06 GO:0051444 negative regulation of ubiquitin-protein ligase activity
6.63 7.96e-07 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
6.50 3.41e-07 GO:0051351 positive regulation of ligase activity
6.29 1.86e-06 GO:0051443 positive regulation of ubiquitin-protein ligase activity
5.73 3.00e-06 GO:0051340 regulation of ligase activity
5.53 1.49e-05 GO:0051438 regulation of ubiquitin-protein ligase activity
5.39 6.11e-05 GO:0031397 negative regulation of protein ubiquitination
5.02 1.07e-05 GO:0031398 positive regulation of protein ubiquitination
4.00 2.26e-04 GO:0031396 regulation of protein ubiquitination
3.91 6.76e-04 GO:0010498 proteasomal protein catabolic process
3.91 6.76e-04 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
3.75 3.46e-04 GO:0031400 negative regulation of protein modification process
2.99 2.00e-03 GO:0032269 negative regulation of cellular protein metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 16 of 16 entries
Enrichment   P-value GO Accession GO Term
10.04 6.58e-13 GO:0000502 proteasome complex
1.70 4.89e-04 GO:0005829 cytosol
1.70 4.92e-02 GO:0044430 cytoskeletal part
1.62 6.46e-03 GO:0005856 cytoskeleton
1.41 1.18e-07 GO:0044444 cytoplasmic part
1.38 3.07e-02 GO:0043234 protein complex
1.37 1.12e-11 GO:0005737 cytoplasm
1.35 2.26e-02 GO:0032991 macromolecular complex
1.29 2.04e-12 GO:0044424 intracellular part
1.28 1.06e-12 GO:0005622 intracellular
1.28 3.03e-08 GO:0043226 organelle
1.27 5.38e-08 GO:0043229 intracellular organelle
1.23 1.75e-04 GO:0043227 membrane-bounded organelle
1.22 4.51e-04 GO:0043231 intracellular membrane-bounded organelle
1.12 2.11e-05 GO:0005623 cell
1.12 2.11e-05 GO:0044464 cell part

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
Enrichment   P-value GO Accession GO Term
29.61 1.65e-02 GO:0015037 peptide disulfide oxidoreductase activity
2.27 3.09e-02 GO:0004175 endopeptidase activity
2.05 6.93e-03 GO:0008233 peptidase activity
1.98 2.81e-02 GO:0070011 peptidase activity, acting on L-amino acid peptides
1.57 3.27e-04 GO:0016787 hydrolase activity
1.38 1.18e-05 GO:0003824 catalytic activity
1.26 9.60e-03 GO:0005515 protein binding
1.19 6.33e-05 GO:0005488 binding