Motif ID: NFKB1_REL_RELA.p2

Z-value: 4.218


Transcription factors associated with NFKB1_REL_RELA.p2:

Gene SymbolEntrez IDGene Name
Nfkb1 18033 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
Rel 19696 reticuloendotheliosis oncogene
Rela 19697 v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfkb1chr3_-_135271220,
chr3_-_135354151,
chr3_-_135354500		0.872.5e-58Click!
Relchr11_-_236707660.807.7e-42Click!
Relachr19_+_56377120.772.8e-36Click!


Activity profile for motif NFKB1_REL_RELA.p2.

activity profile for motif NFKB1_REL_RELA.p2


Sorted Z-values histogram for motif NFKB1_REL_RELA.p2

Sorted Z-values for motif NFKB1_REL_RELA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFKB1_REL_RELA.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_35399970 119.668 H2-D1
histocompatibility 2, D region locus 1
chr17_+_56092045 103.771 NM_015766
 Ebi3
Epstein-Barr virus induced gene 3
chr17_+_35400056 103.072 H2-D1
H2-L
histocompatibility 2, D region locus 1
histocompatibility 2, D region
chr17_+_35400038 97.493 NM_010380
 H2-D1
histocompatibility 2, D region locus 1
chr17_+_35400049 94.830 H2-D1
histocompatibility 2, D region locus 1
chr17_+_56092075 94.030 Ebi3
Epstein-Barr virus induced gene 3
chr13_+_43880475 88.929 NM_009856
 Cd83
CD83 antigen
chr9_-_7872821 88.433 Birc3
baculoviral IAP repeat-containing 3
chr19_+_46380418 75.740 NM_001177370
 Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100
chr3_-_135354500 74.656 NM_008689
 Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
chr12_-_56593543 74.611 Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr19_+_46379216 74.517 NM_001177369
 Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100
chr8_-_26212203 74.215 Plekha2
pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2
chr12_-_56593566 72.004 NM_010907
 Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr3_-_135354151 71.695 Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
chr7_+_26472526 70.684 Tgfb1
transforming growth factor, beta 1
chr7_+_31206749 70.415 Nfkbid
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
chr7_-_109398578 70.128 NM_019566
 Rhog
ras homolog gene family, member G
chr6_+_29476655 69.054 NM_012057
 Irf5
interferon regulatory factor 5
chr19_+_46380107 68.485 NM_019408
 Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 195 entries
Enrichment   P-value GO Accession GO Term
6.28 4.50e-02 GO:0048535 lymph node development
4.97 4.48e-02 GO:0031056 regulation of histone modification
4.97 4.48e-02 GO:0032655 regulation of interleukin-12 production
4.76 6.50e-04 GO:0007249 I-kappaB kinase/NF-kappaB cascade
4.01 1.59e-02 GO:0090316 positive regulation of intracellular protein transport
3.94 2.03e-02 GO:0042108 positive regulation of cytokine biosynthetic process
3.86 2.57e-02 GO:0032388 positive regulation of intracellular transport
3.79 3.24e-02 GO:0002274 myeloid leukocyte activation
3.61 3.10e-02 GO:0060326 cell chemotaxis
3.45 6.67e-04 GO:0002699 positive regulation of immune effector process
3.37 6.40e-03 GO:0042306 regulation of protein import into nucleus
3.35 5.34e-06 GO:0001819 positive regulation of cytokine production
3.28 1.72e-03 GO:0033157 regulation of intracellular protein transport
3.28 1.72e-03 GO:0046822 regulation of nucleocytoplasmic transport
3.27 1.85e-02 GO:0002224 toll-like receptor signaling pathway
3.26 1.12e-02 GO:0002819 regulation of adaptive immune response
3.22 1.34e-02 GO:0002221 pattern recognition receptor signaling pathway
3.21 4.39e-02 GO:0042035 regulation of cytokine biosynthetic process
3.21 4.39e-02 GO:0045619 regulation of lymphocyte differentiation
3.19 2.64e-02 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

Gene overrepresentation in compartment category:

Showing 1 to 20 of 26 entries
Enrichment   P-value GO Accession GO Term
7.06 4.88e-04 GO:0031519 PcG protein complex
2.44 1.31e-06 GO:0005667 transcription factor complex
2.24 9.65e-12 GO:0044451 nucleoplasm part
2.09 3.66e-02 GO:0009897 external side of plasma membrane
2.01 3.66e-12 GO:0005654 nucleoplasm
1.77 8.33e-11 GO:0031981 nuclear lumen
1.73 2.85e-12 GO:0044428 nuclear part
1.71 3.35e-02 GO:0009986 cell surface
1.65 2.87e-09 GO:0070013 intracellular organelle lumen
1.65 3.36e-09 GO:0043233 organelle lumen
1.63 1.01e-08 GO:0031974 membrane-enclosed lumen
1.55 5.20e-26 GO:0005634 nucleus
1.42 8.50e-07 GO:0043234 protein complex
1.40 1.77e-02 GO:0005829 cytosol
1.38 4.71e-07 GO:0032991 macromolecular complex
1.30 7.48e-17 GO:0043231 intracellular membrane-bounded organelle
1.30 1.32e-16 GO:0043227 membrane-bounded organelle
1.29 2.90e-05 GO:0044422 organelle part
1.29 3.34e-05 GO:0044446 intracellular organelle part
1.26 7.38e-16 GO:0043229 intracellular organelle

Gene overrepresentation in function category:

Showing 1 to 20 of 33 entries
Enrichment   P-value GO Accession GO Term
6.06 3.43e-05 GO:0008009 chemokine activity
5.35 6.71e-05 GO:0042379 chemokine receptor binding
3.89 2.72e-04 GO:0003704 specific RNA polymerase II transcription factor activity
3.28 3.74e-04 GO:0019955 cytokine binding
3.23 8.86e-04 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
3.13 1.35e-02 GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
3.03 1.43e-07 GO:0010843 promoter binding
3.00 2.44e-06 GO:0005126 cytokine receptor binding
2.92 1.28e-02 GO:0016566 specific transcriptional repressor activity
2.91 3.00e-07 GO:0000975 regulatory region DNA binding
2.91 3.00e-07 GO:0001067 regulatory region nucleic acid binding
2.91 3.00e-07 GO:0044212 transcription regulatory region DNA binding
2.90 6.16e-06 GO:0005125 cytokine activity
2.80 6.22e-04 GO:0003702 RNA polymerase II transcription factor activity
2.64 4.38e-03 GO:0003690 double-stranded DNA binding
2.57 1.41e-04 GO:0003682 chromatin binding
2.41 3.53e-06 GO:0008134 transcription factor binding
2.32 1.63e-02 GO:0001664 G-protein-coupled receptor binding
2.25 1.59e-02 GO:0043566 structure-specific DNA binding
2.24 5.07e-11 GO:0043565 sequence-specific DNA binding