Motif ID: NKX2-3_NKX2-5.p2

Z-value: 0.871


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
Nkx2-3 18089 NK2 transcription factor related, locus 3 (Drosophila)
Nkx2-5 18091 NK2 transcription factor related, locus 5 (Drosophila)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-3chr19_+_43686803-0.258.2e-04Click!
Nkx2-5chr17_-_26978355-0.181.5e-02Click!


Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_44470218 11.395 Scd1
stearoyl-Coenzyme A desaturase 1
chr15_-_96861590 10.931 Slc38a4
solute carrier family 38, member 4
chr11_+_52202137 9.128 Vdac1
voltage-dependent anion channel 1
chr11_+_96212945 8.258 NM_134032
Hoxb2
homeobox B2
chr11_+_75578548 8.163 Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr2_+_35159780 8.138 Gsn
gelsolin
chr6_+_4484651 8.132 Col1a2
collagen, type I, alpha 2
chr2_+_125860377 7.895 NM_008008
Fgf7
fibroblast growth factor 7
chr19_-_44476302 7.835 Scd1
stearoyl-Coenzyme A desaturase 1
chr11_+_29607599 7.453 Rtn4
reticulon 4
chr1_+_45368443 7.288 Col3a1
collagen, type III, alpha 1
chr3_+_54165028 7.211 NM_001198765
NM_001198766
NM_015784
Postn


periostin, osteoblast specific factor


chr2_+_125860507 7.055 Fgf7
fibroblast growth factor 7
chr11_+_67013553 6.929 NM_030679
Myh1
myosin, heavy polypeptide 1, skeletal muscle, adult
chr11_+_66984528 6.799 NM_001039545
Myh2
myosin, heavy polypeptide 2, skeletal muscle, adult
chr7_-_56103389 6.509 Csrp3
cysteine and glycine-rich protein 3
chr7_-_56103405 6.470 NM_001198841
Csrp3
cysteine and glycine-rich protein 3
chr6_+_83290548 6.457 Mobkl1b
MOB1, Mps One Binder kinase activator-like 1B (yeast)
chr1_-_55135054 6.383 Hspd1
heat shock protein 1 (chaperonin)
chr6_+_4483741 6.248 Col1a2
collagen, type I, alpha 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 71 entries
Enrichment   P-value GO Accession GO Term
6.93 2.69e-02 GO:0031032 actomyosin structure organization
4.64 1.82e-02 GO:0061039 ovum-producing ovary development
4.63 3.35e-03 GO:0008585 female gonad development
4.60 1.56e-03 GO:0046545 development of primary female sexual characteristics
4.28 3.99e-03 GO:0046660 female sex differentiation
4.25 4.64e-02 GO:0022602 ovulation cycle process
3.35 4.79e-02 GO:0010038 response to metal ion
3.16 1.97e-02 GO:0042692 muscle cell differentiation
3.12 4.06e-02 GO:0045137 development of primary sexual characteristics
3.08 1.70e-02 GO:0060537 muscle tissue development
2.92 3.80e-02 GO:0048608 reproductive structure development
2.79 2.14e-03 GO:0061061 muscle structure development
2.77 1.47e-02 GO:0030036 actin cytoskeleton organization
2.60 4.20e-02 GO:0030029 actin filament-based process
2.50 2.59e-02 GO:0001501 skeletal system development
2.23 1.87e-07 GO:0009888 tissue development
2.19 3.02e-03 GO:0072358 cardiovascular system development
2.19 3.02e-03 GO:0072359 circulatory system development
2.17 2.73e-02 GO:0048598 embryonic morphogenesis
2.13 8.89e-04 GO:0007155 cell adhesion

Gene overrepresentation in compartment category:

Showing 1 to 20 of 36 entries
Enrichment   P-value GO Accession GO Term
4.64 3.70e-05 GO:0030017 sarcomere
4.31 5.20e-05 GO:0044449 contractile fiber part
4.25 1.51e-02 GO:0031674 I band
4.19 3.76e-05 GO:0030016 myofibril
3.85 1.46e-04 GO:0043292 contractile fiber
2.52 1.49e-02 GO:0005911 cell-cell junction
2.10 9.86e-07 GO:0005624 membrane fraction
2.03 2.90e-06 GO:0005626 insoluble fraction
1.92 1.08e-06 GO:0000267 cell fraction
1.91 1.73e-03 GO:0005615 extracellular space
1.90 8.61e-03 GO:0030054 cell junction
1.85 2.53e-04 GO:0044421 extracellular region part
1.78 4.07e-02 GO:0044451 nucleoplasm part
1.67 1.45e-02 GO:0005654 nucleoplasm
1.64 5.45e-04 GO:0005829 cytosol
1.51 7.82e-03 GO:0031974 membrane-enclosed lumen
1.51 8.94e-03 GO:0070013 intracellular organelle lumen
1.51 9.62e-03 GO:0043233 organelle lumen
1.44 4.39e-02 GO:0044459 plasma membrane part
1.42 6.48e-03 GO:0043228 non-membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 15 of 15 entries
Enrichment   P-value GO Accession GO Term
11.42 1.73e-02 GO:0034185 apolipoprotein binding
6.93 5.74e-03 GO:0005200 structural constituent of cytoskeleton
2.81 1.76e-05 GO:0016564 transcription repressor activity
2.72 9.61e-03 GO:0003682 chromatin binding
2.60 4.00e-03 GO:0019901 protein kinase binding
2.26 3.31e-02 GO:0019900 kinase binding
2.13 4.05e-02 GO:0032403 protein complex binding
1.99 5.05e-05 GO:0019899 enzyme binding
1.99 1.53e-03 GO:0043565 sequence-specific DNA binding
1.96 4.94e-04 GO:0001071 nucleic acid binding transcription factor activity
1.96 4.94e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.93 3.25e-02 GO:0008092 cytoskeletal protein binding
1.83 1.02e-03 GO:0030528 transcription regulator activity
1.49 1.07e-13 GO:0005515 protein binding
1.25 1.90e-11 GO:0005488 binding