Motif ID: NKX3-2.p2

Z-value: 1.217


Transcription factors associated with NKX3-2.p2:

Gene SymbolEntrez IDGene Name
Nkx3-2 12020 NK3 homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx3-2chr5_-_42155453-0.257.6e-04Click!


Activity profile for motif NKX3-2.p2.

activity profile for motif NKX3-2.p2


Sorted Z-values histogram for motif NKX3-2.p2

Sorted Z-values for motif NKX3-2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_45401303 18.343 Col3a1
collagen, type III, alpha 1
chr1_+_45401659 17.612 Col3a1
collagen, type III, alpha 1
chr6_+_4484651 16.835 Col1a2
collagen, type I, alpha 2
chr15_+_54402988 10.493 Mal2
mal, T-cell differentiation protein 2
chr1_-_45559866 9.969 Col5a2
collagen, type V, alpha 2
chr1_-_45559904 9.677 Col5a2
collagen, type V, alpha 2
chr9_-_45743950 9.647 Tagln
transgelin
chrX_+_10062237 9.162 NM_019634
 Tspan7
tetraspanin 7
chr1_-_170362298 8.959 Pbx1
pre B-cell leukemia transcription factor 1
chr9_-_45744036 8.828 NM_011526
 Tagln
transgelin
chr19_-_34329804 8.354 NM_007392
 Acta2
actin, alpha 2, smooth muscle, aorta
chr19_+_27291897 8.340 Vldlr
very low density lipoprotein receptor
chr8_+_11443165 7.969 Col4a2
collagen, type IV, alpha 2
chr3_+_121426422 7.869 NM_010171
 F3
coagulation factor III
chr9_-_66880619 7.814 Tpm1
tropomyosin 1, alpha
chr8_-_64381465 7.805 NM_001081390
 Palld
palladin, cytoskeletal associated protein
chr19_+_27292039 7.796 Vldlr
very low density lipoprotein receptor
chr15_-_78236262 7.429 NM_009437
 Tst
thiosulfate sulfurtransferase, mitochondrial
chr18_-_46887869 7.285 NM_033037
 Cdo1
cysteine dioxygenase 1, cytosolic
chr15_+_75427044 7.276 NM_026730
 Gpihbp1
GPI-anchored HDL-binding protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 142 entries
Enrichment   P-value GO Accession GO Term
3.60 4.04e-02 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
3.05 6.65e-03 GO:0034330 cell junction organization
2.59 3.66e-03 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
2.43 4.46e-02 GO:0006936 muscle contraction
2.38 3.43e-02 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
2.36 2.75e-02 GO:0003012 muscle system process
2.25 1.05e-04 GO:0051129 negative regulation of cellular component organization
2.24 4.18e-04 GO:0044087 regulation of cellular component biogenesis
2.16 3.96e-04 GO:0030029 actin filament-based process
2.14 8.49e-03 GO:0008015 blood circulation
2.13 9.76e-03 GO:0003013 circulatory system process
2.11 2.35e-03 GO:0030036 actin cytoskeleton organization
2.10 5.08e-05 GO:0001568 blood vessel development
2.02 1.03e-04 GO:0001944 vasculature development
2.02 3.04e-04 GO:0001701 in utero embryonic development
2.01 3.76e-03 GO:0048812 neuron projection morphogenesis
2.01 6.07e-03 GO:0048514 blood vessel morphogenesis
1.99 6.79e-08 GO:0072358 cardiovascular system development
1.99 6.79e-08 GO:0072359 circulatory system development
1.99 5.42e-03 GO:0061061 muscle structure development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 76 entries
Enrichment   P-value GO Accession GO Term
6.37 1.02e-02 GO:0060076 excitatory synapse
2.95 2.14e-04 GO:0030027 lamellipodium
2.78 1.88e-03 GO:0014069 postsynaptic density
2.67 1.45e-02 GO:0044309 neuron spine
2.61 3.25e-02 GO:0043197 dendritic spine
2.50 8.04e-03 GO:0016327 apicolateral plasma membrane
2.50 1.19e-02 GO:0030017 sarcomere
2.45 1.73e-02 GO:0043296 apical junction complex
2.39 1.33e-02 GO:0044449 contractile fiber part
2.33 4.09e-02 GO:0008021 synaptic vesicle
2.30 1.71e-04 GO:0031252 cell leading edge
2.29 5.46e-04 GO:0044433 cytoplasmic vesicle part
2.28 9.38e-08 GO:0015629 actin cytoskeleton
2.25 1.03e-02 GO:0005912 adherens junction
2.25 2.81e-02 GO:0044445 cytosolic part
2.23 1.88e-03 GO:0030659 cytoplasmic vesicle membrane
2.23 3.28e-02 GO:0044420 extracellular matrix part
2.18 3.49e-02 GO:0043292 contractile fiber
2.14 2.88e-02 GO:0019717 synaptosome
2.09 4.99e-04 GO:0016323 basolateral plasma membrane

Gene overrepresentation in function category:

Showing 1 to 15 of 15 entries
Enrichment   P-value GO Accession GO Term
2.64 2.79e-13 GO:0003779 actin binding
2.23 9.89e-14 GO:0008092 cytoskeletal protein binding
2.04 1.64e-02 GO:0005543 phospholipid binding
1.88 1.36e-02 GO:0019901 protein kinase binding
1.82 1.01e-05 GO:0005509 calcium ion binding
1.82 3.22e-04 GO:0008289 lipid binding
1.80 1.09e-02 GO:0019900 kinase binding
1.75 6.42e-05 GO:0019904 protein domain specific binding
1.75 6.43e-03 GO:0032403 protein complex binding
1.69 1.91e-02 GO:0030246 carbohydrate binding
1.65 5.57e-08 GO:0005102 receptor binding
1.60 7.88e-05 GO:0042802 identical protein binding
1.56 1.73e-04 GO:0019899 enzyme binding
1.49 6.77e-38 GO:0005515 protein binding
1.24 5.38e-28 GO:0005488 binding