Motif ID: NR1H4.p2

Z-value: 1.603


Transcription factors associated with NR1H4.p2:

Gene SymbolEntrez IDGene Name
Nr1h4 20186 nuclear receptor subfamily 1, group H, member 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr1h4chr10_-_889693710.281.7e-04Click!


Activity profile for motif NR1H4.p2.

activity profile for motif NR1H4.p2


Sorted Z-values histogram for motif NR1H4.p2

Sorted Z-values for motif NR1H4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR1H4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_94407548 35.279 Bhmt
betaine-homocysteine methyltransferase
chr19_-_38199737 32.702 NM_001159487
Rbp4
retinol binding protein 4, plasma
chr19_-_38199291 32.471 NM_011255
Rbp4
retinol binding protein 4, plasma
chr19_-_38199036 32.458 Rbp4
retinol binding protein 4, plasma
chr16_+_23146608 32.175 NM_009605
Adipoq
adiponectin, C1Q and collagen domain containing
chr16_+_23146631 31.186 Adipoq
adiponectin, C1Q and collagen domain containing
chr6_-_124492297 31.027 NM_144938
NM_001097617
C1s

complement component 1, s subcomponent

chr19_-_38199267 30.971 Rbp4
retinol binding protein 4, plasma
chr7_-_31839825 30.504 NM_052991
NM_194321
Fxyd1

FXYD domain-containing ion transport regulator 1

chr19_-_38199112 29.614 Rbp4
retinol binding protein 4, plasma
chr7_-_31840647 25.282 NM_019503
NM_052992
Fxyd1

FXYD domain-containing ion transport regulator 1

chr10_-_76175108 20.920 Col6a1
collagen, type VI, alpha 1
chr17_+_75404893 20.770 Ltbp1
latent transforming growth factor beta binding protein 1
chr11_-_75236018 20.734 Serpinf1
serine (or cysteine) peptidase inhibitor, clade F, member 1
chr11_-_75236012 20.491 Serpinf1
serine (or cysteine) peptidase inhibitor, clade F, member 1
chr4_-_129851941 20.150 Tinagl1
tubulointerstitial nephritis antigen-like 1
chr17_+_75404865 20.125 NM_019919
Ltbp1
latent transforming growth factor beta binding protein 1
chr10_-_76188683 20.000 NM_009933
Col6a1
collagen, type VI, alpha 1
chr4_-_129852030 19.297 NM_001168333
Tinagl1
tubulointerstitial nephritis antigen-like 1
chr11_-_75236085 19.229 NM_011340
Serpinf1
serine (or cysteine) peptidase inhibitor, clade F, member 1
chr4_-_129851289 17.514 Tinagl1
tubulointerstitial nephritis antigen-like 1
chr4_-_60594496 17.297 Mup1
major urinary protein 1
chr1_-_164796660 17.112 NM_010231
Fmo1
flavin containing monooxygenase 1
chr7_-_133819870 16.466 NM_133670
Sult1a1
sulfotransferase family 1A, phenol-preferring, member 1
chr13_-_94407590 16.195 NM_016668
Bhmt
betaine-homocysteine methyltransferase
chr9_-_48413181 15.108 NM_010924
Nnmt
nicotinamide N-methyltransferase
chrX_+_154137193 14.823 Smpx
small muscle protein, X-linked
chr10_+_115738429 14.708 NM_029928
Ptprb
protein tyrosine phosphatase, receptor type, B
chr9_+_46076689 14.692 NM_080434
Apoa5
apolipoprotein A-V
chrX_+_154137049 14.240 NM_025357
Smpx
small muscle protein, X-linked
chr1_-_164796609 13.795 Fmo1
flavin containing monooxygenase 1
chr4_-_60235470 13.503 NM_001134676
Mup8
major urinary protein 8
chrX_+_154137114 13.473 Smpx
small muscle protein, X-linked
chr13_-_94407455 13.418 Bhmt
betaine-homocysteine methyltransferase
chr7_-_91733736 13.413 Fah
fumarylacetoacetate hydrolase
chr10_-_5734448 13.043 NM_007956
Esr1
estrogen receptor 1 (alpha)
chr8_-_112102961 12.825 Hp
haptoglobin
chrX_-_49518428 11.738 Gpc4
glypican 4
chr7_-_74879894 11.643 Synm
synemin, intermediate filament protein
chr9_-_48413097 11.627 Nnmt
nicotinamide N-methyltransferase
chr8_-_112103065 11.590 NM_017370
Hp
haptoglobin
chr9_+_46076832 10.972 Apoa5
apolipoprotein A-V
chr13_-_93564652 10.906 NM_011582
Thbs4
thrombospondin 4
chr10_+_79353597 10.881 NM_013459
Cfd
complement factor D (adipsin)
chrX_-_49518099 10.207 NM_008150
Gpc4
glypican 4
chr7_+_94395160 9.958 NM_015760
Nox4
NADPH oxidase 4
chr9_-_21936207 9.638 NM_001102404
Acp5
acid phosphatase 5, tartrate resistant
chr3_+_59885811 9.362 Sucnr1
succinate receptor 1
chr7_-_91754314 9.219 Fah
fumarylacetoacetate hydrolase
chr17_+_87153083 8.747 NM_010137
Epas1
endothelial PAS domain protein 1
chr9_-_44611033 8.653 NM_138951
Ttc36
tetratricopeptide repeat domain 36
chr9_+_37209481 8.448 Robo4
roundabout homolog 4 (Drosophila)
chr11_-_116060358 8.372 NM_015729
Acox1
acyl-Coenzyme A oxidase 1, palmitoyl
chr5_-_138052555 8.321 NM_008788
Pcolce
procollagen C-endopeptidase enhancer protein
chr9_-_44610921 8.110 Ttc36
tetratricopeptide repeat domain 36
chr6_-_48522660 8.090 NM_027852
Rarres2
retinoic acid receptor responder (tazarotene induced) 2
chr11_+_3230733 7.964 NM_178149
Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr4_-_60594469 7.642 Mup1
major urinary protein 1
chr9_+_5345475 7.488 NM_009808
Casp12
caspase 12
chr11_-_116060026 7.365 Acox1
acyl-Coenzyme A oxidase 1, palmitoyl
chr3_+_137286635 7.315 NM_030143
Ddit4l
DNA-damage-inducible transcript 4-like
chr1_+_162917640 7.267 Serpinc1
serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
chr7_-_91754236 7.250 Fah
fumarylacetoacetate hydrolase
chr9_+_43915391 6.973 NM_001190319
C1qtnf5
C1q and tumor necrosis factor related protein 5
chr7_-_123138599 6.968 NM_011445
Sox6
SRY-box containing gene 6
chr3_+_90341208 6.932 S100a16
S100 calcium binding protein A16
chr5_-_148537561 6.913 NM_010228
Flt1
FMS-like tyrosine kinase 1
chr9_+_43915327 6.778 NM_001040631
NM_001040632
C1qtnf5

C1q and tumor necrosis factor related protein 5

chr4_-_63681749 6.709 NM_011607
Tnc
tenascin C
chr14_-_66743271 6.677 NM_007940
Ephx2
epoxide hydrolase 2, cytoplasmic
chr17_-_84246141 6.598 Haao
3-hydroxyanthranilate 3,4-dioxygenase
chr7_+_27620354 6.498 NM_007812
Cyp2a5
cytochrome P450, family 2, subfamily a, polypeptide 5
chr2_-_69180643 6.117 NM_021022
Abcb11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr4_-_62815137 6.112 NM_007443
Ambp
alpha 1 microglobulin/bikunin
chr5_+_89316245 6.061 NM_001136260
NM_001197147
NM_018760
Slc4a4


solute carrier family 4 (anion exchanger), member 4


chr9_+_37209586 5.975 NM_028783
Robo4
roundabout homolog 4 (Drosophila)
chr17_-_84246073 5.952 NM_025325
Haao
3-hydroxyanthranilate 3,4-dioxygenase
chr11_+_75323840 5.948 Rilp
Rab interacting lysosomal protein
chrX_+_130442964 5.869 NM_001083895
NM_026838
Srpx2

sushi-repeat-containing protein, X-linked 2

chr9_-_103119803 5.736 Trf
transferrin
chr8_+_11312828 5.720 NM_009932
Col4a2
collagen, type IV, alpha 2
chr3_+_134944184 5.699 NM_001172055
NM_027208
Bdh2

3-hydroxybutyrate dehydrogenase, type 2

chr14_+_13073221 5.652 Ptprg
protein tyrosine phosphatase, receptor type, G
chr7_-_112630662 5.633 NM_028444
Prkcdbp
protein kinase C, delta binding protein
chr3_+_134944239 5.576 Bdh2
3-hydroxybutyrate dehydrogenase, type 2
chr7_-_112748624 5.572 NM_017371
Hpx
hemopexin
chr2_-_181194085 5.545 NM_028125
Zbtb46
zinc finger and BTB domain containing 46
chr1_+_162917586 5.516 Serpinc1
serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
chr15_-_82624638 5.506 Cyp2d26
cytochrome P450, family 2, subfamily d, polypeptide 26
chr5_-_123632567 5.461 NM_008277
Hpd
4-hydroxyphenylpyruvic acid dioxygenase
chr9_-_44611055 5.339 Ttc36
tetratricopeptide repeat domain 36
chr1_-_51535232 5.275 NM_028696
Obfc2a
oligonucleotide/oligosaccharide-binding fold containing 2A
chr11_-_120685860 5.261 NM_007988
Fasn
fatty acid synthase
chr17_+_43526389 5.232 NM_001081178
Gpr116
G protein-coupled receptor 116
chr11_+_69867893 5.086 Asgr1
asialoglycoprotein receptor 1
chr1_+_167391489 4.775 Brp44
brain protein 44
chr16_-_23029154 4.744 NM_001102409
NM_001102410
NM_201375
Kng2


kininogen 2


chr17_-_46865894 4.716 Gnmt
glycine N-methyltransferase
chr7_-_112936063 4.707 NM_001162943
Dchs1
dachsous 1 (Drosophila)
chr17_-_46169322 4.692 NM_001025250
NM_001025257
NM_009505
Vegfa


vascular endothelial growth factor A


chr8_+_11313002 4.671 Col4a2
collagen, type IV, alpha 2
chr7_-_110962416 4.652 NM_008220
NM_016956
Hbb-b1
Hbb-b2
hemoglobin, beta adult major chain
hemoglobin, beta adult minor chain
chr11_-_98636538 4.578 NM_145434
Nr1d1
nuclear receptor subfamily 1, group D, member 1
chr14_-_66539632 4.574 Scara3
scavenger receptor class A, member 3
chr7_+_27620380 4.497 Cyp2a4
Cyp2a5
cytochrome P450, family 2, subfamily a, polypeptide 4
cytochrome P450, family 2, subfamily a, polypeptide 5
chr17_+_87153425 4.447 Epas1
endothelial PAS domain protein 1
chr12_-_71328622 4.370 NM_133198
Pygl
liver glycogen phosphorylase
chr8_-_73905790 4.321 NM_010150
Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr11_-_98636689 4.291 Nr1d1
nuclear receptor subfamily 1, group D, member 1
chr6_-_31513817 4.282 NM_013723
Podxl
podocalyxin-like
chr17_+_35607497 4.254 H2-Q10
histocompatibility 2, Q region locus 10
chr10_-_39745065 4.252 NM_144821
AI317395
expressed sequence AI317395
chr3_-_108029499 4.161 NM_008596
Sypl2
synaptophysin-like 2
chr12_+_82127791 4.127 NM_001146217
NM_022316
Smoc1

SPARC related modular calcium binding 1

chr16_-_85901362 4.101 NM_011782
Adamts5
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
chr8_-_11312686 4.072 Col4a1
collagen, type IV, alpha 1
chr4_+_133109291 4.053 NM_011850
Nr0b2
nuclear receptor subfamily 0, group B, member 2
chr8_-_11312729 3.998 NM_009931
Col4a1
collagen, type IV, alpha 1
chr3_-_89084872 3.969 NM_001162425
Efna1
ephrin A1
chr11_+_54716439 3.967 Gpx3
glutathione peroxidase 3
chr18_+_32091098 3.960 NM_144862
Lims2
LIM and senescent cell antigen like domains 2
chr10_+_126432666 3.935 NM_146012
Ctdsp2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr1_+_167391318 3.861 NM_027430
Brp44
brain protein 44
chr6_+_83299439 3.859 NM_175277
Bola3
bolA-like 3 (E. coli)
chr6_+_90500855 3.835 Aldh1l1
aldehyde dehydrogenase 1 family, member L1
chr1_+_72871060 3.813 NM_008342
Igfbp2
insulin-like growth factor binding protein 2
chr10_+_79451332 3.787 NM_007725
Cnn2
calponin 2
chr6_+_90500848 3.767 Aldh1l1
aldehyde dehydrogenase 1 family, member L1
chr6_+_90500776 3.739 NM_027406
Aldh1l1
aldehyde dehydrogenase 1 family, member L1
chr1_+_173155414 3.726 Apoa2
apolipoprotein A-II
chr10_-_39744964 3.701 AI317395
expressed sequence AI317395
chr2_+_158157639 3.691 Lbp
lipopolysaccharide binding protein
chr2_-_3339919 3.675 NM_008579
Meig1
meiosis expressed gene 1
chr4_-_4065585 3.663 NM_001002927
Penk
preproenkephalin
chr7_-_110976439 3.634 Hbb-b1
hemoglobin, beta adult major chain
chr4_+_43888373 3.630 NM_016678
Reck
reversion-inducing-cysteine-rich protein with kazal motifs
chr7_+_31548774 3.599 NM_001166173
NM_001166174
NM_172899
Dmkn


dermokine


chr15_-_82624668 3.579 NM_029562
Cyp2d26
cytochrome P450, family 2, subfamily d, polypeptide 26
chr9_-_70782614 3.512 NM_008280
Lipc
lipase, hepatic
chr16_-_23029075 3.497 Kng2
kininogen 2
chr10_+_79240035 3.482 Fstl3
follistatin-like 3
chr11_-_120685418 3.477 Fasn
fatty acid synthase
chr11_+_69906145 3.476 NM_007493
Asgr2
asialoglycoprotein receptor 2
chr10_+_17516024 3.463 NM_138628
Txlnb
taxilin beta
chr4_+_125825246 3.454 NM_172145
Fam176b
family with sequence similarity 176, member B
chr3_+_94176747 3.430 NM_011281
Rorc
RAR-related orphan receptor gamma
chr4_-_61443185 3.421 NM_001135127
Mup10
LOC100048884
Mup19
Mup1
major urinary protein 10
novel member of the major urinary protein (Mup) gene family
major urinary protein 19
major urinary protein 1
chr7_-_110976438 3.360 Hbb-b1
hemoglobin, beta adult major chain
chr7_-_138465593 3.323 NM_008411
Cuzd1
CUB and zona pellucida-like domains 1
chr10_-_127325668 3.310 Rdh7
retinol dehydrogenase 7
chr16_+_30599808 3.295 NM_177632
Fam43a
family with sequence similarity 43, member A
chr11_-_3831963 3.291 NM_001130459
NM_015749
NM_001130458
Tcn2


transcobalamin 2


chr11_+_54716354 3.210 NM_001083929
NM_008161
Gpx3

glutathione peroxidase 3

chr4_-_61100653 3.200 NM_001045550
NM_008647
Mup2

major urinary protein 2

chr7_-_133618335 3.184 NM_001081459
NM_011363
Sh2b1

SH2B adaptor protein 1

chr10_-_127325725 3.154 NM_017473
NM_001150749
Rdh7

retinol dehydrogenase 7

chr7_-_28122615 3.132 NM_175641
Ltbp4
latent transforming growth factor beta binding protein 4
chr1_+_133737686 3.118 Slc41a1
solute carrier family 41, member 1
chr8_+_122516369 3.104 NM_030209
Crispld2
cysteine-rich secretory protein LCCL domain containing 2
chr6_+_129130632 3.082 NM_053109
Clec2d
C-type lectin domain family 2, member d
chr17_+_35610430 3.070 H2-Q10
histocompatibility 2, Q region locus 10
chr3_+_121670737 3.010 Arhgap29
Rho GTPase activating protein 29
chr13_-_93346126 2.996 NM_030237
Spz1
spermatogenic leucine zipper 1
chr10_-_127325698 2.990 Rdh7
retinol dehydrogenase 7
chr13_-_23802696 2.961 Hfe
hemochromatosis
chr1_-_157626552 2.958 Qsox1
quiescin Q6 sulfhydryl oxidase 1
chr6_+_72364256 2.948 NM_019802
Ggcx
gamma-glutamyl carboxylase
chr7_-_28122694 2.934 Ltbp4
latent transforming growth factor beta binding protein 4
chr15_+_10106992 2.932 NM_011169
Prlr
prolactin receptor
chr16_-_14201162 2.921 Myh11
myosin, heavy polypeptide 11, smooth muscle
chr7_+_108599740 2.918 NM_001143849
Pde2a
phosphodiesterase 2A, cGMP-stimulated
chr19_+_6401701 2.908 Rasgrp2
RAS, guanyl releasing protein 2
chr16_-_23029138 2.859 Kng2
kininogen 2
chr3_+_54165028 2.855 NM_001198765
NM_001198766
NM_015784
Postn


periostin, osteoblast specific factor


chr19_+_6241665 2.842 NM_194348
Atg2a
ATG2 autophagy related 2 homolog A (S. cerevisiae)
chr5_-_115569276 2.830 NM_007383
Acads
acyl-Coenzyme A dehydrogenase, short chain
chr7_+_108599819 2.821 Pde2a
phosphodiesterase 2A, cGMP-stimulated
chr19_-_9003845 2.803 NM_009073
Rom1
rod outer segment membrane protein 1
chr1_+_90031368 2.789 NM_145079
Ugt1a6a
UDP glucuronosyltransferase 1 family, polypeptide A6A
chr2_+_32477264 2.755 NM_001198790
Ak1
adenylate kinase 1
chr10_+_79239973 2.751 NM_031380
Fstl3
follistatin-like 3
chr17_-_46168654 2.720 Vegfa
vascular endothelial growth factor A
chr9_+_108393006 2.693 NM_001168371
NM_001168372
NM_001168373
NM_027804
NM_145407
Usp19




ubiquitin specific peptidase 19




chr6_+_72364353 2.689 Ggcx
gamma-glutamyl carboxylase
chr7_-_112748585 2.662 Hpx
hemopexin
chr15_+_82282806 2.656 NM_010006
Cyp2d9
cytochrome P450, family 2, subfamily d, polypeptide 9
chr9_-_70782366 2.631 Lipc
lipase, hepatic
chr2_+_121973414 2.618 NM_009735
B2m
beta-2 microglobulin
chr15_-_78633301 2.610 NM_130859
Card10
caspase recruitment domain family, member 10
chr6_+_116600624 2.605 NM_001166580
NM_145980
8430408G22Rik

RIKEN cDNA 8430408G22 gene

chr7_-_110976314 2.603 Hbb-b1
Hbb-b2
hemoglobin, beta adult major chain
hemoglobin, beta adult minor chain
chr7_-_110962324 2.603 Hbb-b1
Hbb-b2
hemoglobin, beta adult major chain
hemoglobin, beta adult minor chain
chr8_-_73919683 2.588 NM_181418
Ushbp1
Usher syndrome 1C binding protein 1
chr11_+_80623859 2.580 NM_029537
Tmem98
transmembrane protein 98
chr9_-_21793855 2.575 Rgl3
ral guanine nucleotide dissociation stimulator-like 3
chr18_-_33623668 2.573 NM_001109988
D0H4S114
DNA segment, human D4S114
chr17_-_57367542 2.573 NM_009778
C3
complement component 3
chr4_-_125879832 2.556 NM_146153
Thrap3
thyroid hormone receptor associated protein 3
chr9_+_108393149 2.552 Usp19
ubiquitin specific peptidase 19
chr3_-_142058569 2.544 Pdlim5
PDZ and LIM domain 5

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.27 2.71e-05 GO:0006082 organic acid metabolic process
2.19 1.95e-04 GO:0019752 carboxylic acid metabolic process
2.19 1.95e-04 GO:0043436 oxoacid metabolic process
2.14 4.51e-04 GO:0042180 cellular ketone metabolic process
1.98 1.16e-03 GO:0055114 oxidation-reduction process
1.63 1.34e-03 GO:0044281 small molecule metabolic process
10.94 2.57e-03 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
1.22 6.96e-03 GO:0008152 metabolic process
7.69 1.01e-02 GO:0019439 aromatic compound catabolic process
2.08 1.71e-02 GO:0072358 cardiovascular system development
2.08 1.71e-02 GO:0072359 circulatory system development
4.41 2.76e-02 GO:0071383 cellular response to steroid hormone stimulus
2.39 2.81e-02 GO:0032787 monocarboxylic acid metabolic process
5.10 3.81e-02 GO:0043401 steroid hormone mediated signaling pathway
12.50 4.18e-02 GO:0009698 phenylpropanoid metabolic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
17.50 4.83e-06 GO:0042612 MHC class I protein complex
1.33 5.80e-06 GO:0044444 cytoplasmic part
1.66 1.13e-05 GO:0005576 extracellular region
2.34 3.18e-04 GO:0031966 mitochondrial membrane
2.24 9.01e-04 GO:0005740 mitochondrial envelope
1.61 9.75e-04 GO:0005739 mitochondrion
2.01 3.18e-03 GO:0044429 mitochondrial part
1.73 3.87e-03 GO:0044421 extracellular region part
7.96 4.50e-03 GO:0042611 MHC protein complex
2.31 7.45e-03 GO:0005743 mitochondrial inner membrane
2.25 1.25e-02 GO:0031012 extracellular matrix
1.59 1.33e-02 GO:0031090 organelle membrane
3.40 1.69e-02 GO:0044455 mitochondrial membrane part
2.19 1.94e-02 GO:0019866 organelle inner membrane
2.29 2.21e-02 GO:0005578 proteinaceous extracellular matrix
2.21 3.03e-02 GO:0005792 microsome
2.15 4.64e-02 GO:0042598 vesicular fraction
1.16 4.96e-02 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.39 2.93e-04 GO:0008289 lipid binding
1.38 9.56e-04 GO:0043167 ion binding
1.38 1.16e-03 GO:0043169 cation binding
5.50 1.57e-03 GO:0003707 steroid hormone receptor activity
5.39 1.93e-03 GO:0004879 ligand-dependent nuclear receptor activity
1.37 1.99e-03 GO:0046872 metal ion binding
3.01 4.97e-03 GO:0031406 carboxylic acid binding
2.55 5.60e-03 GO:0048037 cofactor binding
1.26 9.07e-03 GO:0003824 catalytic activity
1.14 1.58e-02 GO:0005488 binding
2.68 1.82e-02 GO:0005506 iron ion binding
1.50 1.87e-02 GO:0046914 transition metal ion binding
6.25 4.06e-02 GO:0070330 aromatase activity