Motif ID: NR5A1,2.p2

Z-value: 3.359


Transcription factors associated with NR5A1,2.p2:

Gene SymbolEntrez IDGene Name
Nr5a1 26423 nuclear receptor subfamily 5, group A, member 1
Nr5a2 26424 nuclear receptor subfamily 5, group A, member 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr5a2chr1_-_1388568660.231.4e-03Click!
Nr5a1chr2_-_385698910.064.3e-01Click!


Activity profile for motif NR5A1,2.p2.

activity profile for motif NR5A1,2.p2


Sorted Z-values histogram for motif NR5A1,2.p2

Sorted Z-values for motif NR5A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR5A1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_37631532 56.937 Dlc1
deleted in liver cancer 1
chr18_-_10706693 49.186 NM_134130
 Abhd3
abhydrolase domain containing 3
chr1_-_169323901 47.708 NM_025569
 Mgst3
microsomal glutathione S-transferase 3
chr19_-_43598949 46.454 NM_010324
 Got1
glutamate oxaloacetate transaminase 1, soluble
chr9_+_43893029 44.471 Usp2
ubiquitin specific peptidase 2
chr10_-_76175108 43.867 Col6a1
collagen, type VI, alpha 1
chr6_+_17257720 43.385 Cav1
caveolin 1, caveolae protein
chr13_+_21813912 40.978 NM_178200
 Hist1h2bm
histone cluster 1, H2bm
chr11_-_4604308 39.417 NM_197979
 Uqcr10
ubiquinol-cytochrome c reductase, complex III subunit X
chr16_+_34995000 39.405 Mylk
myosin, light polypeptide kinase
chr15_+_78860043 37.230 H1f0
H1 histone family, member 0
chr13_-_21808011 36.832 NM_178199
 Hist1h2bl
histone cluster 1, H2bl
chr7_-_116760069 36.642 St5
suppression of tumorigenicity 5
chr15_-_76881097 35.598 NM_013593
 Mb
myoglobin
chr13_+_21845991 35.001 NM_178201
 Hist1h2bn
histone cluster 1, H2bn
chr4_-_82151004 34.438 Nfib
nuclear factor I/B
chr6_+_17290478 34.205 Cav1
caveolin 1, caveolae protein
chr1_+_45401303 33.544 Col3a1
collagen, type III, alpha 1
chr13_+_22127689 32.912 NM_175665
 Hist1h2bk
histone cluster 1, H2bk
chr8_+_47619706 32.240



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 112 entries
Enrichment   P-value GO Accession GO Term
8.16 2.78e-02 GO:0010873 positive regulation of cholesterol esterification
8.06 3.49e-06 GO:0015985 energy coupled proton transport, down electrochemical gradient
8.06 3.49e-06 GO:0015986 ATP synthesis coupled proton transport
6.80 1.91e-07 GO:0046356 acetyl-CoA catabolic process
6.67 1.31e-06 GO:0006099 tricarboxylic acid cycle
5.71 1.39e-02 GO:0006103 2-oxoglutarate metabolic process
5.44 6.00e-06 GO:0009109 coenzyme catabolic process
5.33 9.03e-05 GO:0009060 aerobic respiration
4.90 5.76e-06 GO:0006096 glycolysis
4.62 1.38e-04 GO:0051187 cofactor catabolic process
4.52 1.14e-05 GO:0006084 acetyl-CoA metabolic process
4.30 1.07e-08 GO:0045333 cellular respiration
4.13 1.27e-02 GO:0022904 respiratory electron transport chain
4.00 8.77e-14 GO:0022900 electron transport chain
3.95 9.02e-04 GO:0043242 negative regulation of protein complex disassembly
3.91 2.41e-03 GO:0043648 dicarboxylic acid metabolic process
3.75 4.50e-02 GO:0046320 regulation of fatty acid oxidation
3.68 7.84e-05 GO:0006754 ATP biosynthetic process
3.67 2.78e-25 GO:0006091 generation of precursor metabolites and energy
3.57 2.42e-03 GO:0006007 glucose catabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 84 entries
Enrichment   P-value GO Accession GO Term
9.52 6.00e-03 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
8.73 8.57e-08 GO:0005753 mitochondrial proton-transporting ATP synthase complex
7.93 3.29e-02 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)
7.62 2.77e-07 GO:0045259 proton-transporting ATP synthase complex
7.14 1.46e-02 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)
6.06 1.24e-18 GO:0070469 respiratory chain
5.82 1.10e-10 GO:0005747 mitochondrial respiratory chain complex I
5.82 1.10e-10 GO:0030964 NADH dehydrogenase complex
5.82 1.10e-10 GO:0045271 respiratory chain complex I
5.71 2.00e-03 GO:0005865 striated muscle thin filament
5.67 1.49e-13 GO:0005746 mitochondrial respiratory chain
5.08 2.25e-02 GO:0031672 A band
4.90 1.33e-22 GO:0044455 mitochondrial membrane part
4.33 1.48e-02 GO:0034364 high-density lipoprotein particle
3.99 2.86e-03 GO:0044304 main axon
3.35 2.70e-02 GO:0016469 proton-transporting two-sector ATPase complex
3.31 1.88e-28 GO:0005743 mitochondrial inner membrane
3.14 3.44e-26 GO:0019866 organelle inner membrane
3.07 8.51e-31 GO:0031966 mitochondrial membrane
3.00 1.53e-05 GO:0030017 sarcomere

Gene overrepresentation in function category:

Showing 1 to 20 of 38 entries
Enrichment   P-value GO Accession GO Term
5.51 5.08e-04 GO:0003954 NADH dehydrogenase activity
5.29 2.83e-03 GO:0008137 NADH dehydrogenase (ubiquinone) activity
5.29 2.83e-03 GO:0050136 NADH dehydrogenase (quinone) activity
4.76 9.80e-03 GO:0016655 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
3.88 3.94e-02 GO:0016877 ligase activity, forming carbon-sulfur bonds
3.30 9.10e-06 GO:0015078 hydrogen ion transmembrane transporter activity
3.24 6.38e-03 GO:0051287 NAD binding
2.45 7.08e-03 GO:0019838 growth factor binding
2.28 3.97e-05 GO:0022890 inorganic cation transmembrane transporter activity
2.27 2.38e-03 GO:0015077 monovalent inorganic cation transmembrane transporter activity
2.20 8.99e-14 GO:0008092 cytoskeletal protein binding
2.13 1.45e-06 GO:0003779 actin binding
2.13 2.28e-05 GO:0048037 cofactor binding
2.10 1.34e-07 GO:0032403 protein complex binding
2.06 7.63e-03 GO:0050662 coenzyme binding
2.02 3.46e-02 GO:0061135 endopeptidase regulator activity
1.99 1.12e-02 GO:0061134 peptidase regulator activity
1.83 1.91e-04 GO:0005198 structural molecule activity
1.80 1.40e-08 GO:0016491 oxidoreductase activity
1.77 4.40e-02 GO:0004857 enzyme inhibitor activity