Motif ID: NR6A1.p2

Z-value: 1.361


Transcription factors associated with NR6A1.p2:

Gene SymbolEntrez IDGene Name
Nr6a1 14536 nuclear receptor subfamily 6, group A, member 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr6a1chr2_-_387819390.092.1e-01Click!


Activity profile for motif NR6A1.p2.

activity profile for motif NR6A1.p2


Sorted Z-values histogram for motif NR6A1.p2

Sorted Z-values for motif NR6A1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR6A1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_113384474 29.436 Cidec
cell death-inducing DFFA-like effector c
chr17_-_57367499 25.061 C3
complement component 3
chr17_-_57367542 25.020 NM_009778
C3
complement component 3
chr11_-_5703677 24.026 Pgam2
phosphoglycerate mutase 2
chr10_+_96942181 23.008 Dcn
decorin
chr11_-_5703752 22.278 NM_018870
Pgam2
phosphoglycerate mutase 2
chr4_-_82151590 22.154 Nfib
nuclear factor I/B
chr6_-_124586102 22.010 NM_173864
Gm5077
predicted gene 5077
chrX_+_154137049 21.866 NM_025357
Smpx
small muscle protein, X-linked
chr4_-_82150687 21.538 Nfib
nuclear factor I/B
chr7_-_133606586 21.382 NM_007504
Atp2a1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr7_-_133606617 21.286 Atp2a1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr4_-_82151004 21.013 Nfib
nuclear factor I/B
chr5_-_138052555 19.830 NM_008788
Pcolce
procollagen C-endopeptidase enhancer protein
chr11_+_94811409 19.759 Col1a1
collagen, type I, alpha 1
chr3_+_90346956 19.691 S100a16
S100 calcium binding protein A16
chrX_+_154137114 19.142 Smpx
small muscle protein, X-linked
chr11_+_98245124 18.302 NM_011540
Tcap
titin-cap
chr4_-_60152702 16.772 NM_001045550
NM_008647
Mup1
Mup2

major urinary protein 1
major urinary protein 2

chr6_+_42195977 16.747 Gstk1
glutathione S-transferase kappa 1
chr2_-_62249889 16.591 Dpp4
dipeptidylpeptidase 4
chr6_+_42195911 15.746 NM_029555
Gstk1
glutathione S-transferase kappa 1
chr4_-_60594959 15.715 NM_001122647
Mup10
LOC100048884
Mup1
major urinary protein 10
novel member of the major urinary protein (Mup) gene family
major urinary protein 1
chr7_+_27904981 15.654 Cyp2f2
cytochrome P450, family 2, subfamily f, polypeptide 2
chrX_+_154137193 14.992 Smpx
small muscle protein, X-linked
chr8_+_11448095 14.870 Col4a2
collagen, type IV, alpha 2
chr19_-_4877874 14.837 NM_013456
Actn3
actinin alpha 3
chr4_-_82151180 14.243 NM_001113209
NM_001113210
NM_008687
Nfib


nuclear factor I/B


chr4_-_82151657 14.066 Nfib
nuclear factor I/B
chr7_+_27904997 13.804 Cyp2f2
cytochrome P450, family 2, subfamily f, polypeptide 2
chr9_+_78078473 13.449 NM_008181
Gsta1
glutathione S-transferase, alpha 1 (Ya)
chr3_+_98084352 12.731 NM_008256
Hmgcs2
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
chr9_+_78078492 12.636 Gsta1
glutathione S-transferase, alpha 1 (Ya)
chr7_+_134356373 12.508 Mylpf
myosin light chain, phosphorylatable, fast skeletal muscle
chr4_+_63005581 12.377 NM_008768
Orm1
orosomucoid 1
chr9_+_78104965 12.315 Gsta1
glutathione S-transferase, alpha 1 (Ya)
chr15_+_73582208 11.865 Ptp4a3
protein tyrosine phosphatase 4a3
chr2_-_62249934 10.344 NM_001159543
NM_010074
Dpp4

dipeptidylpeptidase 4

chr10_+_96942124 10.115 NM_001190451
Dcn
decorin
chr7_+_27904968 10.085 NM_007817
Cyp2f2
cytochrome P450, family 2, subfamily f, polypeptide 2
chr2_-_76511070 9.995 NM_010222
Fkbp7
FK506 binding protein 7
chr15_+_73582101 9.954 Ptp4a3
protein tyrosine phosphatase 4a3
chr1_-_79855177 9.886 Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr2_-_62249869 9.505 Dpp4
dipeptidylpeptidase 4
chr9_-_119066057 9.375 NM_146230
Acaa1b
acetyl-Coenzyme A acyltransferase 1B
chr19_+_46781921 9.044 NM_020577
As3mt
arsenic (+3 oxidation state) methyltransferase
chr2_-_163298253 8.859 NM_173397
Fitm2
fat storage-inducing transmembrane protein 2
chr4_-_60889249 8.847 NM_001134674
Mup13
Mup19
Mup1
major urinary protein 13
major urinary protein 19
major urinary protein 1
chr19_+_46781939 8.741 As3mt
arsenic (+3 oxidation state) methyltransferase
chr7_-_135349828 8.715 NM_009943
Cox6a2
cytochrome c oxidase, subunit VI a, polypeptide 2
chr7_+_51480806 8.615 NM_010639
Klk1
kallikrein 1
chr4_-_45543623 8.568 NM_001033306
Shb
src homology 2 domain-containing transforming protein B
chr11_-_60624733 8.377 NM_009171
Shmt1
serine hydroxymethyltransferase 1 (soluble)
chr4_-_61335031 8.209 Mup10
LOC100048884
Mup19
Mup1
Mup2
major urinary protein 10
novel member of the major urinary protein (Mup) gene family
major urinary protein 19
major urinary protein 1
major urinary protein 2
chr11_-_6333725 7.634 H2afv
H2A histone family, member V
chr9_+_78137734 7.612 NM_001122660
Gm10639
predicted gene 10639
chr1_+_120524521 7.478 NM_023755
Tcfcp2l1
transcription factor CP2-like 1
chrX_-_16394443 7.373 NM_172778
Maob
monoamine oxidase B
chr17_+_47605313 7.062 AI661453
expressed sequence AI661453
chr5_-_122020680 6.922 Aldh2
aldehyde dehydrogenase 2, mitochondrial
chr15_+_3230053 6.772


chr9_-_21935019 6.591 NM_007388
Acp5
acid phosphatase 5, tartrate resistant
chr4_+_123582074 6.465 NM_019660
Mycbp
c-myc binding protein
chr9_+_122714664 6.362 NM_001013405
D9Ertd402e
DNA segment, Chr 9, ERATO Doi 402, expressed
chr3_+_94928435 6.279 NM_016712
Tmod4
tropomodulin 4
chr10_-_68004607 6.165 NM_028491
1700040L02Rik
RIKEN cDNA 1700040L02 gene
chr15_-_75921924 5.816 Nrbp2
nuclear receptor binding protein 2
chr7_-_51920870 5.786 NM_028021
Myh14
myosin, heavy polypeptide 14
chr14_+_79248971 5.723 NM_027906
NM_173758
1300010F03Rik

RIKEN cDNA 1300010F03 gene

chr9_+_53109774 5.702 NM_176846
Exph5
exophilin 5
chr3_-_94276817 5.647 Riiad1
regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1
chr4_+_116924633 5.436 Tmem53
transmembrane protein 53
chr19_-_4190836 5.290 NM_178650
Tbc1d10c
TBC1 domain family, member 10c
chr1_-_79855209 5.265 Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr11_-_60624592 5.035 Shmt1
serine hydroxymethyltransferase 1 (soluble)
chr7_+_51231430 4.987 NM_010116
Klk1b9
kallikrein 1-related peptidase b9
chr1_+_162908733 4.921 NM_080844
Serpinc1
serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
chr2_-_127555628 4.856 NM_145532
Mall
mal, T-cell differentiation protein-like
chr7_-_139767997 4.707 Oat
ornithine aminotransferase
chr1_-_79855229 4.702 NM_009255
Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr7_+_109250256 4.659 NM_009710
Art1
ADP-ribosyltransferase 1
chr4_-_104782337 4.631 Prkaa2
protein kinase, AMP-activated, alpha 2 catalytic subunit
chr5_+_31224275 4.595 Khk
ketohexokinase
chr10_+_126938744 4.565 NM_177707
Stac3
SH3 and cysteine rich domain 3
chr6_-_119303490 4.518 Adipor2
adiponectin receptor 2
chr1_-_75176965 4.476 Abcb6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr7_-_139768035 4.435 NM_016978
Oat
ornithine aminotransferase
chr13_-_120197722 4.245 NM_008710
Nnt
nicotinamide nucleotide transhydrogenase
chr5_+_31224206 4.075 NM_008439
Khk
ketohexokinase
chr5_+_130231003 3.907 Gbas
glioblastoma amplified sequence
chr6_-_54921654 3.842 NM_001171007
Nod1
nucleotide-binding oligomerization domain containing 1
chr5_+_130231000 3.819 Gbas
glioblastoma amplified sequence
chr4_-_138419379 3.792 NM_001122954
Pla2g5
phospholipase A2, group V
chr1_-_75176926 3.760 Abcb6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr13_+_49063750 3.746 C030044B11Rik
RIKEN cDNA C030044B11 gene
chr9_+_98197280 3.675 Nmnat3
nicotinamide nucleotide adenylyltransferase 3
chr10_-_80134720 3.673 NM_021462
Mknk2
MAP kinase-interacting serine/threonine kinase 2
chr10_-_79379610 3.641 NM_177994
C030046I01Rik
RIKEN cDNA C030046I01 gene
chr1_-_66909822 3.637 NM_007381
Acadl
acyl-Coenzyme A dehydrogenase, long-chain
chr10_-_127807092 3.632 NM_001081040
Coq10a
coenzyme Q10 homolog A (yeast)
chr5_-_36826896 3.564 NM_001170454
Tada2b
transcriptional adaptor 2B
chr2_-_66512442 3.496 Scn7a
sodium channel, voltage-gated, type VII, alpha
chr7_+_52253028 3.482 NM_016849
Irf3
interferon regulatory factor 3
chr3_-_100914081 3.473 NM_011197
Ptgfrn
prostaglandin F2 receptor negative regulator
chr19_-_4009363 3.473 Ndufv1
NADH dehydrogenase (ubiquinone) flavoprotein 1
chr2_-_155949753 3.464 Nfs1
nitrogen fixation gene 1 (S. cerevisiae)
chr8_+_131028275 3.444 Nrp1
neuropilin 1
chr9_-_50583599 3.387 1110032A03Rik
RIKEN cDNA 1110032A03 gene
chr17_+_75404865 3.368 NM_019919
Ltbp1
latent transforming growth factor beta binding protein 1
chr4_+_116924581 3.355 NM_026837
Tmem53
transmembrane protein 53
chr13_-_92016479 3.303 NM_198415
Ckmt2
creatine kinase, mitochondrial 2
chr17_+_23990734 3.101 NM_027220
Prss32
protease, serine, 32
chr7_+_17366682 3.021 NM_009201
Slc1a5
solute carrier family 1 (neutral amino acid transporter), member 5
chr7_+_19469999 2.970 NM_009402
Pglyrp1
peptidoglycan recognition protein 1
chr19_-_41068625 2.936 Blnk
B-cell linker
chr15_-_75950624 2.924 NM_144848
Eppk1
BC024139
epiplakin 1
cDNA sequence BC024139
chr5_-_69933835 2.922 NM_023784
Yipf7
Yip1 domain family, member 7
chr1_+_21230683 2.917 Gsta3
glutathione S-transferase, alpha 3
chr17_+_34272535 2.898 NM_010386
H2-DMa
histocompatibility 2, class II, locus DMa
chr16_+_20128178 2.871 Klhl24
kelch-like 24 (Drosophila)
chr7_-_148067703 2.838 NM_001127351
NM_001177804
Sirt3

sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)

chr9_+_89949315 2.829 Ctsh
cathepsin H
chr8_-_3467624 2.828 NM_026951
Pex11c
peroxisomal biogenesis factor 11 gamma
chr12_-_29308124 2.827 NM_027866
Colec11
collectin sub-family member 11
chr9_-_103125934 2.775 Trf
transferrin
chr9_+_89949104 2.771 NM_007801
Ctsh
cathepsin H
chr19_-_41069024 2.768 NM_008528
Blnk
B-cell linker
chr9_-_21940154 2.679 NM_001102405
Acp5
acid phosphatase 5, tartrate resistant
chr7_+_51392136 2.662 NM_008454
Klk1b16
kallikrein 1-related peptidase b16
chr3_+_89032973 2.628 NM_013605
Muc1
mucin 1, transmembrane
chr1_+_173051791 2.603 NM_001081275
1700009P17Rik
RIKEN cDNA 1700009P17 gene
chr19_+_30307417 2.533 Mbl2
mannose-binding lectin (protein C) 2
chr9_-_121748578 2.499 NM_028384
Ccdc13
coiled-coil domain containing 13
chr4_-_107743887 2.382 Scp2
sterol carrier protein 2, liver
chr19_+_30307446 2.371 NM_010776
Mbl2
mannose-binding lectin (protein C) 2
chr2_+_172978566 2.360 NM_011044
Pck1
phosphoenolpyruvate carboxykinase 1, cytosolic
chr8_-_109927080 2.348 NM_008706
Nqo1
NAD(P)H dehydrogenase, quinone 1
chr10_+_79792864 2.347 NM_139292
Reep6
receptor accessory protein 6
chr6_-_57485419 2.347 NM_175523
Ppm1k
protein phosphatase 1K (PP2C domain containing)
chr13_-_55464135 2.347 NM_025828
Lman2
lectin, mannose-binding 2
chr15_+_81702875 2.282 NM_080633
LOC100504340
Aco2
hypothetical protein LOC100504340
aconitase 2, mitochondrial
chr7_+_19868009 2.265 NM_013648
Rtn2
reticulon 2 (Z-band associated protein)
chr2_+_92215395 2.252 NM_145122
Pex16
peroxisomal biogenesis factor 16
chr15_+_58720783 2.233 NM_175226
Tatdn1
Rnf139
TatD DNase domain containing 1
ring finger protein 139
chr7_+_135052004 2.223


chr9_+_98197001 2.223 NM_144533
Nmnat3
nicotinamide nucleotide adenylyltransferase 3
chr17_-_46462714 2.210 NM_145140
Abcc10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr1_+_133867185 2.208 NM_145977
Slc45a3
solute carrier family 45, member 3
chr2_-_174289569 2.206 NM_025983
Atp5e
ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
chr17_+_24563575 2.153 NM_010023
Dci
dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenyme A isomerase)
chr17_-_33053945 2.103 NM_022434
Cyp4f14
cytochrome P450, family 4, subfamily f, polypeptide 14
chr17_+_75404893 2.094 Ltbp1
latent transforming growth factor beta binding protein 1
chr8_+_116657473 2.081 NM_024437
NM_024446
Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7

chr4_-_60736086 2.053 Mup10
Mup1
major urinary protein 10
major urinary protein 1
chr4_-_42770030 2.002 NM_011888
Ccl19
chemokine (C-C motif) ligand 19
chr10_+_127705664 1.983 Apof
apolipoprotein F
chr5_-_135825744 1.983 NM_033571
Fkbp6
FK506 binding protein 6
chr11_-_106175797 1.980 NM_008339
Cd79b
CD79B antigen
chr10_+_43621580 1.972 NM_130892
Rtn4ip1
reticulon 4 interacting protein 1
chr7_+_51471844 1.961 NM_008456
Klk1b5
kallikrein 1-related peptidase b5
chr1_+_21230664 1.957 NM_001077353
NM_010356
Gsta3

glutathione S-transferase, alpha 3

chr11_-_74982551 1.935 Hic1
hypermethylated in cancer 1
chr11_+_58192533 1.932 NM_001083884
NM_027339
2210415F13Rik

RIKEN cDNA 2210415F13 gene

chr17_+_57201623 1.922 NM_177638
Crb3
crumbs homolog 3 (Drosophila)
chr12_-_104594210 1.893 NM_023049
Asb2
ankyrin repeat and SOCS box-containing 2
chr4_-_138686896 1.861 NM_001163006
2310028O11Rik
RIKEN cDNA 2310028O11 gene
chr6_+_3954225 1.851 Gng11
guanine nucleotide binding protein (G protein), gamma 11
chr17_-_35019039 1.793 NM_013484
C2
complement component 2 (within H-2S)
chr9_+_122076647 1.784


chr1_-_152840432 1.777 NM_001024720
Hmcn1
hemicentin 1
chr8_+_125589411 1.734 Spg7
spastic paraplegia 7 homolog (human)
chr2_+_121976631 1.720 B2m
beta-2 microglobulin
chr15_+_55083779 1.711 Deptor
DEP domain containing MTOR-interacting protein
chr15_-_77759356 1.703 NM_019913
Txn2
thioredoxin 2
chr9_+_54434140 1.683 NM_029573
Idh3a
isocitrate dehydrogenase 3 (NAD+) alpha
chr8_+_125589407 1.675 NM_153176
Spg7
spastic paraplegia 7 homolog (human)
chr4_-_8166157 1.671 Car8
carbonic anhydrase 8
chr4_-_115690068 1.653 Faah
fatty acid amide hydrolase
chr15_-_97597988 1.638 NM_001177810
NM_001177811
NM_144850
Rapgef3


Rap guanine nucleotide exchange factor (GEF) 3


chr9_+_72887524 1.636 2310009A05Rik
5031420N21Rik
RIKEN cDNA 2310009A05 gene
RIKEN cDNA 5031420N21 gene
chr1_-_75176703 1.633 NM_023732
Abcb6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr11_+_75813413 1.626 NM_198637
1700016K19Rik
RIKEN cDNA 1700016K19 gene
chr3_+_89070473 1.608 NM_026767
Dpm3
dolichyl-phosphate mannosyltransferase polypeptide 3
chr8_+_125589362 1.583 Spg7
spastic paraplegia 7 homolog (human)
chr17_-_31281223 1.572 NM_009363
Tff2
trefoil factor 2 (spasmolytic protein 1)
chr4_-_137882005 1.571 Pink1
PTEN induced putative kinase 1
chr4_+_42248495 1.559 NM_011888
Ccl19
chemokine (C-C motif) ligand 19
chr10_+_21698470 1.503 NM_001161847
Sgk1
serum/glucocorticoid regulated kinase 1
chr10_-_60895433 1.494 Eif4ebp2
eukaryotic translation initiation factor 4E binding protein 2
chr3_-_85691167 1.465 NM_177130
Glt28d2
glycosyltransferase 28 domain containing 2
chr2_+_121976718 1.451 B2m
beta-2 microglobulin
chr8_+_11512952 1.448 Carkd
carbohydrate kinase domain containing
chr8_-_4105727 1.428 NM_026956
Cd209f
CD209f antigen
chr1_+_184339297 1.422 NM_173378
Trp53bp2
transformation related protein 53 binding protein 2
chr5_+_138011057 1.422 Trfr2
transferrin receptor 2
chr5_+_122734363 1.411 NM_177242
Pptc7
PTC7 protein phosphatase homolog (S. cerevisiae)
chr4_+_155186568 1.398 NM_207678
Ccnl2
cyclin L2
chr15_-_75724685 1.384 Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr5_+_130230890 1.342 NM_008095
Gbas
glioblastoma amplified sequence
chr14_+_76888242 1.340 NM_001177751
Tsc22d1
TSC22 domain family, member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.30 6.36e-03 GO:0008152 metabolic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.71 6.83e-14 GO:0005739 mitochondrion
3.80 3.91e-11 GO:0044429 mitochondrial part
4.27 9.03e-11 GO:0031966 mitochondrial membrane
4.09 3.17e-10 GO:0005740 mitochondrial envelope
2.48 2.54e-08 GO:0031090 organelle membrane
1.40 2.90e-08 GO:0005737 cytoplasm
3.19 3.12e-08 GO:0031967 organelle envelope
1.54 4.23e-08 GO:0044444 cytoplasmic part
3.15 4.80e-08 GO:0031975 envelope
4.04 1.57e-07 GO:0019866 organelle inner membrane
4.10 2.36e-07 GO:0005743 mitochondrial inner membrane
4.86 9.25e-05 GO:0005759 mitochondrial matrix
5.77 2.07e-04 GO:0044455 mitochondrial membrane part
4.95 2.58e-03 GO:0031968 organelle outer membrane
1.20 3.08e-03 GO:0005622 intracellular
4.82 3.33e-03 GO:0019867 outer membrane
5.11 4.86e-03 GO:0005741 mitochondrial outer membrane
1.19 6.68e-03 GO:0044424 intracellular part
1.22 3.16e-02 GO:0043231 intracellular membrane-bounded organelle
1.22 3.58e-02 GO:0043227 membrane-bounded organelle

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.53 8.62e-07 GO:0003824 catalytic activity
3.37 6.93e-05 GO:0004175 endopeptidase activity
4.69 5.40e-04 GO:0004252 serine-type endopeptidase activity
3.50 1.34e-03 GO:0048037 cofactor binding
3.87 2.51e-03 GO:0008236 serine-type peptidase activity
3.81 3.02e-03 GO:0017171 serine hydrolase activity
11.43 3.12e-03 GO:0004364 glutathione transferase activity
2.31 1.49e-02 GO:0008233 peptidase activity
2.33 1.79e-02 GO:0070011 peptidase activity, acting on L-amino acid peptides
2.08 2.39e-02 GO:0042802 identical protein binding