Motif ID: PITX1..3.p2

Z-value: 3.153


Transcription factors associated with PITX1..3.p2:

Gene SymbolEntrez IDGene Name
Pitx1 18740 paired-like homeodomain transcription factor 1
Pitx2 18741 paired-like homeodomain transcription factor 2
Pitx3 18742 paired-like homeodomain transcription factor 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pitx2chr3_+_128916849-0.198.5e-03Click!
Pitx1chr13_-_55932570-0.191.2e-02Click!
Pitx3chr19_-_462228140.162.7e-02Click!


Activity profile for motif PITX1..3.p2.

activity profile for motif PITX1..3.p2


Sorted Z-values histogram for motif PITX1..3.p2

Sorted Z-values for motif PITX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PITX1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_6420904 57.780 Myo1g
myosin IG
chr1_-_87500465 51.800 NM_175397
 Sp110
Sp110 nuclear body protein
chr11_-_6420931 51.166 NM_178440
 Myo1g
myosin IG
chr17_-_35325354 41.631 NM_010734
 Lst1
leukocyte specific transcript 1
chr7_+_29225955 38.703 NM_001039192
 Gmfg
glia maturation factor, gamma
chr6_-_87483228 37.480 NM_001037727
 Arhgap25
Rho GTPase activating protein 25
chr4_+_130469048 37.109 Laptm5
lysosomal-associated protein transmembrane 5
chr8_-_124948837 35.132


chr4_+_151424681 33.448 Nol9
nucleolar protein 9
chr6_+_72494474 31.552 Capg
capping protein (actin filament), gelsolin-like
chr7_+_109614267 31.027 Rrm1
ribonucleotide reductase M1
chr6_+_72494378 30.712 NM_007599
 Capg
capping protein (actin filament), gelsolin-like
chrX_-_7667574 30.553 NM_009515
 Was
Wiskott-Aldrich syndrome homolog (human)
chrX_-_9046362 30.303 NM_007807
 Cybb
cytochrome b-245, beta polypeptide
chr17_+_29629987 29.977 Pim1
proviral integration site 1
chr6_-_88848650 29.049 NM_008564
 Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr10_+_127675120 28.852 NM_011589
 Timeless
timeless homolog (Drosophila)
chr9_-_70269326 28.817 NM_007630
 Ccnb2
cyclin B2
chr8_+_72655224 26.219 NM_001025586
NM_001025587
 Nr2c2ap

nuclear receptor 2C2-associated protein

chr7_-_52494097 26.151 NM_007645
 Cd37
CD37 antigen

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 21 entries
Enrichment   P-value GO Accession GO Term
5.73 9.54e-03 GO:0032200 telomere organization
3.85 4.83e-02 GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
2.49 1.86e-03 GO:0034660 ncRNA metabolic process
2.48 2.64e-02 GO:0034470 ncRNA processing
2.17 2.35e-02 GO:0006412 translation
2.16 4.57e-02 GO:0045321 leukocyte activation
2.14 1.16e-03 GO:0006955 immune response
2.05 2.29e-02 GO:0000279 M phase
2.02 2.20e-04 GO:0006396 RNA processing
1.73 5.14e-04 GO:0002376 immune system process
1.47 2.95e-02 GO:0006996 organelle organization
1.38 7.45e-04 GO:0090304 nucleic acid metabolic process
1.37 3.17e-03 GO:0010467 gene expression
1.35 3.07e-07 GO:0044260 cellular macromolecule metabolic process
1.35 4.87e-02 GO:0044267 cellular protein metabolic process
1.30 3.93e-06 GO:0043170 macromolecule metabolic process
1.29 4.18e-02 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.27 4.29e-02 GO:0034641 cellular nitrogen compound metabolic process
1.20 9.48e-03 GO:0044237 cellular metabolic process
1.18 2.25e-02 GO:0044238 primary metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 23 entries
Enrichment   P-value GO Accession GO Term
7.12 3.44e-02 GO:0030684 preribosome
3.00 4.27e-02 GO:0031965 nuclear membrane
2.41 7.14e-03 GO:0005635 nuclear envelope
2.22 4.68e-05 GO:0005730 nucleolus
1.83 7.97e-03 GO:0030529 ribonucleoprotein complex
1.81 3.24e-02 GO:XXXXXXX unannotated
1.80 2.33e-02 GO:0005694 chromosome
1.58 9.13e-07 GO:0044428 nuclear part
1.50 9.72e-04 GO:0031981 nuclear lumen
1.46 9.44e-04 GO:0031974 membrane-enclosed lumen
1.46 1.15e-03 GO:0070013 intracellular organelle lumen
1.46 1.27e-03 GO:0043233 organelle lumen
1.37 1.47e-03 GO:0043228 non-membrane-bounded organelle
1.37 1.47e-03 GO:0043232 intracellular non-membrane-bounded organelle
1.34 8.29e-09 GO:0005634 nucleus
1.22 2.67e-02 GO:0044422 organelle part
1.22 3.61e-02 GO:0044446 intracellular organelle part
1.18 6.61e-05 GO:0043227 membrane-bounded organelle
1.18 9.07e-05 GO:0043231 intracellular membrane-bounded organelle
1.17 3.37e-05 GO:0043229 intracellular organelle

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
Enrichment   P-value GO Accession GO Term
3.19 2.77e-02 GO:0008026 ATP-dependent helicase activity
3.19 2.77e-02 GO:0070035 purine NTP-dependent helicase activity
2.55 4.98e-02 GO:0004386 helicase activity
1.84 1.01e-04 GO:0003723 RNA binding
1.37 7.80e-04 GO:0003676 nucleic acid binding
1.12 3.03e-03 GO:0005488 binding