• All motifs sorted by activity significance
• All samples sorted alphabetically

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)

Motif ID: PITX1..3.p2

Z-value: 3.153

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr11_-_6420904	57.780		Myo1g	myosin IG
chr1_-_87500465	51.800	NM_175397	Sp110	Sp110 nuclear body protein
chr11_-_6420931	51.166	NM_178440	Myo1g	myosin IG
chr17_-_35325354	41.631	NM_010734	Lst1	leukocyte specific transcript 1
chr7_+_29225955	38.703	NM_001039192	Gmfg	glia maturation factor, gamma
chr6_-_87483228	37.480	NM_001037727	Arhgap25	Rho GTPase activating protein 25
chr4_+_130469048	37.109		Laptm5	lysosomal-associated protein transmembrane 5
chr8_-_124948837	35.132
chr4_+_151424681	33.448		Nol9	nucleolar protein 9
chr6_+_72494474	31.552		Capg	capping protein (actin filament), gelsolin-like
chr7_+_109614267	31.027		Rrm1	ribonucleotide reductase M1
chr6_+_72494378	30.712	NM_007599	Capg	capping protein (actin filament), gelsolin-like
chrX_-_7667574	30.553	NM_009515	Was	Wiskott-Aldrich syndrome homolog (human)
chrX_-_9046362	30.303	NM_007807	Cybb	cytochrome b-245, beta polypeptide
chr17_+_29629987	29.977		Pim1	proviral integration site 1
chr6_-_88848650	29.049	NM_008564	Mcm2	minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr10_+_127675120	28.852	NM_011589	Timeless	timeless homolog (Drosophila)
chr9_-_70269326	28.817	NM_007630	Ccnb2	cyclin B2
chr8_+_72655224	26.219	NM_001025586 NM_001025587	Nr2c2ap	nuclear receptor 2C2-associated protein
chr7_-_52494097	26.151	NM_007645	Cd37	CD37 antigen
chr10_-_88875526	25.738		Gas2l3	growth arrest-specific 2 like 3
chr1_-_177909236	24.451	NM_001039518	B020018G12Rik	RIKEN cDNA B020018G12 gene
chr9_-_62644026	24.199		Fem1b	feminization 1 homolog b (C. elegans)
chr7_-_97103461	24.108
chr2_+_122573644	23.904
chr2_+_165818203	23.749		Ncoa3	nuclear receptor coactivator 3
chr2_+_165818161	23.334		Ncoa3	nuclear receptor coactivator 3
chr5_-_101001191	23.113		Plac8	placenta-specific 8
chr1_-_133141708	22.734	NM_018750	Rassf5	Ras association (RalGDS/AF-6) domain family member 5
chr5_-_101001209	22.655	NM_139198	Plac8	placenta-specific 8
chr2_-_126959605	22.478	NM_144818	Ncaph	non-SMC condensin I complex, subunit H
chr9_-_78290953	22.234	NM_173386	E330016A19Rik	RIKEN cDNA E330016A19 gene
chr9_-_70269246	22.214		Ccnb2	cyclin B2
chr10_-_90612412	22.104		Tmpo	thymopoietin
chr17_+_87762817	22.083		Ttc7	tetratricopeptide repeat domain 7
chr5_+_90919739	22.017	NM_007423	Afp	alpha fetoprotein
chr1_+_58042183	21.675	NM_001177867	Sgol2	shugoshin-like 2 (S. pombe)
chr11_+_32105414	21.479	NM_030093	Snrnp25	small nuclear ribonucleoprotein 25 (U11/U12)
chr17_+_71965554	21.450	NM_175639	Wdr43	WD repeat domain 43
chr5_+_90919758	21.332		Afp	alpha fetoprotein
chr5_+_90919768	21.247		Afp	alpha fetoprotein
chr1_+_58859345	21.189	NM_001080126	Casp8	caspase 8
chr11_+_101309725	20.875	NM_027320	Ifi35	interferon-induced protein 35
chr5_+_34868420	20.382	NM_011893	Sh3bp2	SH3-domain binding protein 2
chr4_-_116855158	20.301	NM_134471	Kif2c	kinesin family member 2C
chr4_-_86257921	20.265	NM_173400	Haus6	HAUS augmin-like complex, subunit 6
chr3_+_89876566	20.233	NM_022314	Tpm3	tropomyosin 3, gamma
chr17_+_88382830	20.092		Msh6	mutS homolog 6 (E. coli)
chr8_-_122333171	20.004
chr16_+_93832365	19.165	NM_001045529	Morc3	microrchidia 3
chr18_-_74367362	18.343		Ska1	spindle and kinetochore associated complex subunit 1
chr17_+_35998262	18.145	NM_134122	Nrm	nurim (nuclear envelope membrane protein)
chr19_+_4154645	17.883	NM_016933	Ptprcap	protein tyrosine phosphatase, receptor type, C polypeptide-associated protein
chr16_+_35938555	17.747	NM_030253	Parp9	poly (ADP-ribose) polymerase family, member 9
chr10_+_126760748	17.736	NM_146011	Arhgap9	Rho GTPase activating protein 9
chr5_+_145888588	17.718		Arpc1b	actin related protein 2/3 complex, subunit 1B
chr1_+_52065087	17.460	NM_011487	Stat4	signal transducer and activator of transcription 4
chr7_-_31204764	17.447	NM_011827	Hcst	hematopoietic cell signal transducer
chr6_+_128837604	17.355	NM_020257	Clec2i	C-type lectin domain family 2, member i
chr5_-_139936486	17.314	NM_028469	3110082I17Rik	RIKEN cDNA 3110082I17 gene
chr11_-_106860803	16.870	NM_010655	Kpna2	karyopherin (importin) alpha 2
chr5_-_92738981	16.824		Sdad1	SDA1 domain containing 1
chr19_-_17414057	16.709	NM_001136484	Gcnt1	glucosaminyl (N-acetyl) transferase 1, core 2
chr15_-_82074765	16.697	NM_001080158	Cenpm	centromere protein M
chr11_-_106860750	16.592		Kpna2	karyopherin (importin) alpha 2
chr5_+_135058559	16.377	NM_020022	Rfc2	replication factor C (activator 1) 2
chr15_+_99800504	16.295	NM_001080948	Larp4	La ribonucleoprotein domain family, member 4
chrX_+_83115611	16.182	NM_001163539	5430427O19Rik	RIKEN cDNA 5430427O19 gene
chr7_-_16870007	16.164	NM_172297	Ccdc9	coiled-coil domain containing 9
chr10_+_57857120	16.077	NM_001193303	Lims1	LIM and senescent cell antigen-like domains 1
chr11_-_54769601	16.029		Tnip1	TNFAIP3 interacting protein 1
chr12_+_85291629	16.026		2410016O06Rik	RIKEN cDNA 2410016O06 gene
chr2_+_172294281	15.935		2410001C21Rik	RIKEN cDNA 2410001C21 gene
chr5_-_139936448	15.927		3110082I17Rik	RIKEN cDNA 3110082I17 gene
chr11_-_83388330	15.720		Ccl9	chemokine (C-C motif) ligand 9
chr7_-_87857062	15.677
chr19_+_3935169	15.658	NM_001161428 NM_019449	Unc93b1	unc-93 homolog B1 (C. elegans)
chr17_-_32557807	15.304		Pglyrp2	peptidoglycan recognition protein 2
chr11_+_62413710	15.287
chr3_+_135148555	15.202	NM_027288	Manba	mannosidase, beta A, lysosomal
chr9_+_110322311	15.137	NM_008694	Ngp	neutrophilic granule protein
chr2_+_79547936	15.068	NM_172420	Ppp1r1c	protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr2_+_157563136	14.952	NM_025680	Ctnnbl1	catenin, beta like 1
chr6_-_99385338	14.767	NM_053202	Foxp1	forkhead box P1
chr5_-_92738919	14.756		Sdad1	SDA1 domain containing 1
chr17_+_29178865	14.698
chr11_+_115337029	14.476		Armc7	armadillo repeat containing 7
chr17_+_27693518	14.465	NM_001166476 NM_001166477 NM_001025427 NM_001039356 NM_001166535 NM_001166536 NM_001166539 NM_001166540 NM_001166541 NM_001166542 NM_001166543 NM_001166544 NM_001166545 NM_001166546 NM_001166537 NM_016660	Hmga1-rs1 Hmga1	high mobility group AT-hook I, related sequence 1 high mobility group AT-hook 1
chr7_-_52409783	14.453	NM_145954	Aldh16a1	aldehyde dehydrogenase 16 family, member A1
chr10_+_79457716	14.399		Cnn2	calponin 2
chr9_-_7872896	14.340	NM_007464	Birc3	baculoviral IAP repeat-containing 3
chr8_-_86265035	14.280	NM_001163029 NM_001163030 NM_001163031 NM_011925	Cd97	CD97 antigen
chr15_+_80778910	14.251	NM_009634	Adsl	adenylosuccinate lyase
chr11_-_114995194	14.198	NM_001169153 NM_145634	Cd300lf	CD300 antigen like family member F
chr11_-_115992196	14.190	NM_178802	Trim65	tripartite motif-containing 65
chr5_+_138220097	14.181	NM_027242	2010007H12Rik	RIKEN cDNA 2010007H12 gene
chr10_+_20067606	14.108	NM_027930	Fam54a	family with sequence similarity 54, member A
chr4_+_88783273	14.034	NM_024433	Mtap	methylthioadenosine phosphorylase
chr14_-_64147067	14.021		Mtmr9	myotubularin related protein 9
chr6_+_83065466	13.952	NM_020619	Mogs	mannosyl-oligosaccharide glucosidase
chr14_-_31832165	13.741		Gnl3	guanine nucleotide binding protein-like 3 (nucleolar)
chr1_+_52065469	13.523		Stat4	signal transducer and activator of transcription 4
chr5_-_128097687	13.521	NM_133895	Slc15a4	solute carrier family 15, member 4
chr17_+_29178771	13.431
chr2_+_24831667	13.407		Pnpla7	patatin-like phospholipase domain containing 7
chr5_-_136450345	13.295	NM_001160366	Srcrb4d	scavenger receptor cysteine rich domain containing, group B (4 domains)
chr12_+_85291605	13.230		2410016O06Rik	RIKEN cDNA 2410016O06 gene
chr8_+_126547293	13.223	NM_001029876	Urb2	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
chr4_-_148511650	13.188	NM_027263	Apitd1	apoptosis-inducing, TAF9-like domain 1
chr17_+_32185229	13.186	NM_001163734	Rrp1b	ribosomal RNA processing 1 homolog B (S. cerevisiae)
chr12_+_85291557	13.101	NM_023633	2410016O06Rik	RIKEN cDNA 2410016O06 gene
chr9_+_69843263	13.089	NM_001008238	Bnip2	BCL2/adenovirus E1B interacting protein 2
chr7_-_148286422	13.014	NM_023059	Sigirr	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr16_+_59471600	12.961	NM_025910	Mina	myc induced nuclear antigen
chr19_+_9022763	12.950		Mta2	metastasis-associated gene family, member 2
chr4_-_116300533	12.833	NM_016777	Nasp	nuclear autoantigenic sperm protein (histone-binding)
chr12_+_88959817	12.827	NM_001177564 NM_001177573	Gm4027 BB287469	predicted gene 4027 expressed sequence BB287469
chr3_+_89904553	12.711		Tpm3	tropomyosin 3, gamma
chr17_-_32557916	12.678	NM_021319	Pglyrp2	peptidoglycan recognition protein 2
chr11_+_115336968	12.668	NM_177778	Armc7	armadillo repeat containing 7
chr17_-_28759356	12.650	NM_016795	Srpk1	serine/arginine-rich protein specific kinase 1
chr5_-_73143979	12.638	NM_001122754	Txk	TXK tyrosine kinase
chr19_-_41970627	12.626	NM_199447	Rrp12	ribosomal RNA processing 12 homolog (S. cerevisiae)
chr16_+_32179885	12.533	NM_001033539	Bex6	brain expressed gene 6
chr4_+_146125090	12.360	NM_001177545	Zfp600	zinc finger protein 600
chr2_+_165818136	12.290	NM_008679	Ncoa3	nuclear receptor coactivator 3
chr10_-_62064925	12.283		Ddx21	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
chr10_+_7387285	12.191	NM_145706	Nup43	nucleoporin 43
chr7_+_130337876	12.182		Tnrc6a	trinucleotide repeat containing 6a
chr14_-_79790474	12.058	NM_025832	Naa16	N(alpha)-acetyltransferase 16, NatA auxiliary subunit
chr3_-_153575890	12.002	NM_001163478	Rabggtb	RAB geranylgeranyl transferase, b subunit
chr13_-_101086551	11.969	NM_010871	Naip6	NLR family, apoptosis inhibitory protein 6
chr4_+_116692006	11.959	NM_001111277 NM_175135	Eif2b3	eukaryotic translation initiation factor 2B, subunit 3
chr12_+_52449216	11.910	NM_001015099 NM_001167963 NM_001167964	G2e3	G2/M-phase specific E3 ubiquitin ligase
chr13_-_38750866	11.869	NM_025380	Eef1e1	eukaryotic translation elongation factor 1 epsilon 1
chr4_-_142718290	11.862		Prdm2	PR domain containing 2, with ZNF domain
chr3_+_20008792	11.839		Hltf	helicase-like transcription factor
chr16_+_36081360	11.809	NM_001159422	Ccdc58	coiled-coil domain containing 58
chr3_-_153575944	11.605		Rabggtb	RAB geranylgeranyl transferase, b subunit
chrX_-_137491205	11.582	NM_001164177 NM_016883	Psmd10	proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
chr1_+_140864297	11.547	NM_181347	Dennd1b	DENN/MADD domain containing 1B
chr12_-_80081732	11.527		Tmem229b	transmembrane protein 229B
chr6_+_64992584	11.499	NM_007958	Smarcad1	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr8_+_18595130	11.498	NM_173189	Mcph1	microcephaly, primary autosomal recessive 1
chr5_-_92739036	11.471	NM_172713	Sdad1	SDA1 domain containing 1
chr13_+_55471165	11.463		Rgs14	regulator of G-protein signaling 14
chr3_+_88420105	11.406	NM_001198911	Arhgef2	rho/rac guanine nucleotide exchange factor (GEF) 2
chr9_+_15110657	11.376	NM_027261 NM_029248	Taf1d	TATA box binding protein (Tbp)-associated factor, RNA polymerase I, D
chr12_+_89055024	11.345	NM_001177573	Gm4027 BB287469	predicted gene 4027 expressed sequence BB287469
chr16_+_48310386	11.330	NM_028615	Dppa2	developmental pluripotency associated 2
chr8_-_44226818	11.293	NM_177742	Triml1	tripartite motif family-like 1
chr16_+_36935029	11.239	NM_008225	Hcls1	hematopoietic cell specific Lyn substrate 1
chr11_-_69635657	11.233	NM_028855	Spem1	sperm maturation 1
chr6_-_120307360	11.220	NM_026028	Ccdc77	coiled-coil domain containing 77
chr7_-_34981664	11.200	NM_026549	Pdcd2l	programmed cell death 2-like
chr4_-_35792385	11.185	NM_001166001 NM_175516	Lingo2	leucine rich repeat and Ig domain containing 2
chr4_-_144836658	11.093	NM_011610	Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b
chr15_-_102181072	11.041	NM_153416	Aaas	achalasia, adrenocortical insufficiency, alacrimia
chr9_+_103207488	11.025	NM_176979	Topbp1	topoisomerase (DNA) II binding protein 1
chr8_+_87823530	11.018	NM_001163791 NM_019716	Orc6	origin recognition complex, subunit 6
chr3_-_103613069	10.977		Dclre1b	DNA cross-link repair 1B, PSO2 homolog (S. cerevisiae)
chr10_+_110601745	10.975	NM_001003717 NM_175489	Osbpl8	oxysterol binding protein-like 8
chr2_+_29925959	10.966		Set	SET nuclear oncogene
chr15_-_99200868	10.881	NM_011711	Fmnl3	formin-like 3
chr15_-_82075137	10.873	NM_025639 NM_178269	Cenpm	centromere protein M
chr12_-_119474010	10.858		Sp4	trans-acting transcription factor 4
chr19_+_6298813	10.840		Ehd1	EH-domain containing 1
chr9_-_15162159	10.788	NM_176976	5830418K08Rik	RIKEN cDNA 5830418K08 gene
chr14_+_56364564	10.737		2610027L16Rik	RIKEN cDNA 2610027L16 gene
chr4_+_154936480	10.718	NM_138671	Nadk	NAD kinase
chr16_-_32165509	10.716	NM_146069	Lrrc33	leucine rich repeat containing 33
chr1_+_58852303	10.665		Casp8	caspase 8
chr7_+_147433182	10.619	NM_175533 NM_001128146 NM_001128145	5830411N06Rik	RIKEN cDNA 5830411N06 gene
chr5_+_130505237	10.582		Crcp	calcitonin gene-related peptide-receptor component protein
chr15_+_81494375	10.582		L3mbtl2	l(3)mbt-like 2 (Drosophila)
chr18_+_9957913	10.544	NM_153552	Thoc1	THO complex 1
chr16_+_48283847	10.532	NM_001018002 NM_028610	Dppa4	developmental pluripotency associated 4
chr13_-_67710581	10.512		AA987161	expressed sequence AA987161
chr11_+_3863948	10.483	NM_022889	Pes1	pescadillo homolog 1, containing BRCT domain (zebrafish)
chr13_-_119175893	10.463	NM_021556	Mrps30	mitochondrial ribosomal protein S30
chr18_-_74367400	10.423	NM_001164355 NM_025581	Ska1	spindle and kinetochore associated complex subunit 1
chr4_-_116944199	10.403
chr9_-_58097569	10.384	NM_008884 NM_178087	Pml	promyelocytic leukemia
chr8_+_74134884	10.357	NM_146211	Glt25d1	glycosyltransferase 25 domain containing 1
chr8_-_123112974	10.305	NM_178856	Gins2	GINS complex subunit 2 (Psf2 homolog)
chr2_+_128926721	10.301	NM_009086	Polr1b	polymerase (RNA) I polypeptide B
chr7_-_4397194	10.266	NM_175372	Rdh13	retinol dehydrogenase 13 (all-trans and 9-cis)
chr9_+_99476204	10.245	NM_031403	Dbr1	debranching enzyme homolog 1 (S. cerevisiae)
chr4_-_34754469	10.221		Zfp292	zinc finger protein 292
chr11_-_121090513	10.178	NM_144832	BC017643	cDNA sequence BC017643
chr11_-_54891581	10.151	NM_177471	Ccdc69	coiled-coil domain containing 69
chr11_+_4136787	10.099	NM_001013365	Osm	oncostatin M
chr11_-_68821930	10.034	NM_001159519	Pfas	phosphoribosylformylglycinamidine synthase (FGAR amidotransferase)
chr15_+_81494399	10.003		L3mbtl2	l(3)mbt-like 2 (Drosophila)
chr15_+_81494368	9.891		L3mbtl2	l(3)mbt-like 2 (Drosophila)
chr6_-_72382855	9.877
chr17_-_35971652	9.813		Tubb5	tubulin, beta 5
chr13_+_55471092	9.736	NM_016758	Rgs14	regulator of G-protein signaling 14
chr11_-_78564918	9.732	NM_197989	Fam58b	family with sequence similarity 58, member B
chr8_+_13785611	9.648	NM_025924	Upf3a	UPF3 regulator of nonsense transcripts homolog A (yeast)

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
1.35	3.07e-07	GO:0044260	cellular macromolecule metabolic process
1.30	3.93e-06	GO:0043170	macromolecule metabolic process
2.02	2.20e-04	GO:0006396	RNA processing
1.73	5.14e-04	GO:0002376	immune system process
1.38	7.45e-04	GO:0090304	nucleic acid metabolic process
2.14	1.16e-03	GO:0006955	immune response
2.49	1.86e-03	GO:0034660	ncRNA metabolic process
1.37	3.17e-03	GO:0010467	gene expression
1.20	9.48e-03	GO:0044237	cellular metabolic process
5.73	9.54e-03	GO:0032200	telomere organization
1.18	2.25e-02	GO:0044238	primary metabolic process
2.05	2.29e-02	GO:0000279	M phase
2.17	2.35e-02	GO:0006412	translation
2.48	2.64e-02	GO:0034470	ncRNA processing
1.47	2.95e-02	GO:0006996	organelle organization
1.16	2.97e-02	GO:0008152	metabolic process
1.29	4.18e-02	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.27	4.29e-02	GO:0034641	cellular nitrogen compound metabolic process
2.16	4.57e-02	GO:0045321	leukocyte activation
3.85	4.83e-02	GO:0002824	positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
1.35	4.87e-02	GO:0044267	cellular protein metabolic process

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
1.34	8.29e-09	GO:0005634	nucleus
1.16	4.44e-07	GO:0044424	intracellular part
1.58	9.13e-07	GO:0044428	nuclear part
1.16	1.16e-06	GO:0005622	intracellular
1.17	3.37e-05	GO:0043229	intracellular organelle
2.22	4.68e-05	GO:0005730	nucleolus
1.16	5.45e-05	GO:0043226	organelle
1.18	6.61e-05	GO:0043227	membrane-bounded organelle
1.18	9.07e-05	GO:0043231	intracellular membrane-bounded organelle
1.46	9.44e-04	GO:0031974	membrane-enclosed lumen
1.50	9.72e-04	GO:0031981	nuclear lumen
1.46	1.15e-03	GO:0070013	intracellular organelle lumen
1.46	1.27e-03	GO:0043233	organelle lumen
1.37	1.47e-03	GO:0043228	non-membrane-bounded organelle
1.37	1.47e-03	GO:0043232	intracellular non-membrane-bounded organelle
2.41	7.14e-03	GO:0005635	nuclear envelope
1.83	7.97e-03	GO:0030529	ribonucleoprotein complex
1.80	2.33e-02	GO:0005694	chromosome
1.22	2.67e-02	GO:0044422	organelle part
1.81	3.24e-02	GO:XXXXXXX	unannotated
7.12	3.44e-02	GO:0030684	preribosome
1.22	3.61e-02	GO:0044446	intracellular organelle part
3.00	4.27e-02	GO:0031965	nuclear membrane

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
1.84	1.01e-04	GO:0003723	RNA binding
1.37	7.80e-04	GO:0003676	nucleic acid binding
1.12	3.03e-03	GO:0005488	binding
3.19	2.77e-02	GO:0008026	ATP-dependent helicase activity
3.19	2.77e-02	GO:0070035	purine NTP-dependent helicase activity
2.55	4.98e-02	GO:0004386	helicase activity