Motif ID: PRRX1,2.p2

Z-value: 1.504


Transcription factors associated with PRRX1,2.p2:

Gene SymbolEntrez IDGene Name
Prrx1 18933 paired related homeobox 1
Prrx2 20204 paired related homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prrx1chr1_-_165243777-0.231.6e-03Click!
Prrx2chr2_+_30700800-0.214.6e-03Click!


Activity profile for motif PRRX1,2.p2.

activity profile for motif PRRX1,2.p2


Sorted Z-values histogram for motif PRRX1,2.p2

Sorted Z-values for motif PRRX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PRRX1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_146622545 27.166 NM_022881
 Rgs18
regulator of G-protein signaling 18
chr14_+_27813547 24.268 NM_010420
 Hesx1
homeobox gene expressed in ES cells
chr1_-_140071818 24.121 NM_001111316
NM_011210
 Ptprc

protein tyrosine phosphatase, receptor type, C

chr17_-_51878720 22.006 Satb1
special AT-rich sequence binding protein 1
chr6_-_13785233 20.996 Gpr85
G protein-coupled receptor 85
chr1_+_6720153 18.318 St18
suppression of tumorigenicity 18
chr2_-_44965866 18.252 Zeb2
zinc finger E-box binding homeobox 2
chr2_-_7317824 18.032 NM_001110231
 Celf2
CUGBP, Elav-like family member 2
chr2_-_73291933 17.722 Wipf1
WAS/WASL interacting protein family, member 1
chr2_-_7317513 17.530 NM_001110232
 Celf2
CUGBP, Elav-like family member 2
chr3_+_17695743 17.415 6430547I21Rik
RIKEN cDNA 6430547I21 gene
chr6_-_16848352 17.311 NM_031198
 Tcfec
transcription factor EC
chr1_+_6720087 16.877 NM_173868
 St18
suppression of tumorigenicity 18
chr10_+_89280918 16.833 Uhrf1bp1l
UHRF1 (ICBP90) binding protein 1-like
chr15_-_66644127 16.348 NM_009192
 Sla
src-like adaptor
chr14_-_109313333 15.727 Slitrk1
SLIT and NTRK-like family, member 1
chr1_-_140071630 15.584 Ptprc
protein tyrosine phosphatase, receptor type, C
chr2_-_30952019 15.329 NM_001177650
 Fnbp1
formin binding protein 1
chr1_+_97230610 15.124 Fam174a
family with sequence similarity 174, member A
chr2_+_61642509 14.955 NM_009322
 Tbr1
T-box brain gene 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 106 entries
Enrichment   P-value GO Accession GO Term
3.29 5.72e-04 GO:0042102 positive regulation of T cell proliferation
2.85 2.64e-04 GO:0050671 positive regulation of lymphocyte proliferation
2.82 3.53e-04 GO:0032946 positive regulation of mononuclear cell proliferation
2.76 6.21e-04 GO:0070665 positive regulation of leukocyte proliferation
2.66 3.70e-03 GO:0042129 regulation of T cell proliferation
2.56 1.28e-02 GO:0030217 T cell differentiation
2.52 2.04e-04 GO:0050670 regulation of lymphocyte proliferation
2.51 3.76e-03 GO:0021953 central nervous system neuron differentiation
2.50 2.58e-04 GO:0032944 regulation of mononuclear cell proliferation
2.46 4.07e-04 GO:0070663 regulation of leukocyte proliferation
2.27 9.01e-03 GO:0010638 positive regulation of organelle organization
2.20 1.82e-05 GO:0007409 axonogenesis
2.14 2.99e-02 GO:0042110 T cell activation
2.11 3.89e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
2.09 2.19e-02 GO:0002696 positive regulation of leukocyte activation
2.09 4.97e-02 GO:0051251 positive regulation of lymphocyte activation
2.06 2.31e-02 GO:0050867 positive regulation of cell activation
2.05 1.19e-02 GO:0045165 cell fate commitment
2.02 2.27e-04 GO:0048812 neuron projection morphogenesis
1.92 2.03e-04 GO:0048858 cell projection morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 26 entries
Enrichment   P-value GO Accession GO Term
2.42 4.12e-05 GO:0005882 intermediate filament
2.28 2.93e-05 GO:0045111 intermediate filament cytoskeleton
2.03 5.02e-03 GO:0045211 postsynaptic membrane
1.95 9.67e-04 GO:0009897 external side of plasma membrane
1.80 3.54e-03 GO:0030424 axon
1.63 7.95e-05 GO:0043005 neuron projection
1.54 9.44e-03 GO:0045202 synapse
1.47 3.98e-02 GO:0031988 membrane-bounded vesicle
1.41 2.11e-02 GO:0031982 vesicle
1.36 6.36e-03 GO:0042995 cell projection
1.29 1.60e-03 GO:0044459 plasma membrane part
1.24 1.97e-09 GO:0005634 nucleus
1.23 2.15e-05 GO:0071944 cell periphery
1.23 1.12e-03 GO:0043234 protein complex
1.22 6.36e-05 GO:0005886 plasma membrane
1.19 1.20e-02 GO:0032991 macromolecular complex
1.15 2.90e-02 GO:0044422 organelle part
1.15 3.93e-02 GO:0044446 intracellular organelle part
1.14 8.94e-08 GO:0043226 organelle
1.14 1.54e-07 GO:0043229 intracellular organelle

Gene overrepresentation in function category:

Showing 1 to 20 of 20 entries
Enrichment   P-value GO Accession GO Term
4.43 3.96e-02 GO:0030291 protein serine/threonine kinase inhibitor activity
3.98 4.83e-02 GO:0001608 nucleotide receptor activity, G-protein coupled
3.98 4.83e-02 GO:0045028 purinergic nucleotide receptor activity, G-protein coupled
3.46 4.94e-02 GO:0001614 purinergic nucleotide receptor activity
3.46 4.94e-02 GO:0016502 nucleotide receptor activity
3.29 4.53e-02 GO:0035586 purinergic receptor activity
1.78 6.08e-13 GO:0030528 transcription regulator activity
1.77 8.95e-04 GO:0016563 transcription activator activity
1.76 2.22e-03 GO:0016564 transcription repressor activity
1.71 2.42e-02 GO:0046982 protein heterodimerization activity
1.65 5.87e-07 GO:0001071 nucleic acid binding transcription factor activity
1.65 5.87e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.64 1.18e-05 GO:0043565 sequence-specific DNA binding
1.38 3.49e-06 GO:0003677 DNA binding
1.32 1.01e-02 GO:0008270 zinc ion binding
1.28 3.72e-05 GO:0003676 nucleic acid binding
1.27 3.83e-02 GO:0046914 transition metal ion binding
1.24 1.55e-10 GO:0005515 protein binding
1.18 3.51e-02 GO:0046872 metal ion binding
1.15 1.99e-13 GO:0005488 binding