Motif ID: REST.p3

Z-value: 5.393


Transcription factors associated with REST.p3:

Gene SymbolEntrez IDGene Name
Rest 19712 RE1-silencing transcription factor

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Restchr5_+_77694506-0.712.5e-29Click!


Activity profile for motif REST.p3.

activity profile for motif REST.p3


Sorted Z-values histogram for motif REST.p3

Sorted Z-values for motif REST.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of REST.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 135 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_132607432 274.238 Chgb
chromogranin B
chr2_+_132607013 274.060 NM_007694
 Chgb
chromogranin B
chr2_+_132607398 269.078 Chgb
chromogranin B
chr2_+_132607408 267.647 Chgb
chromogranin B
chr2_-_181049204 260.292 NM_009133
 Stmn3
stathmin-like 3
chr2_-_181048957 254.386 Stmn3
stathmin-like 3
chr16_-_23890909 243.530 NM_009215
 Sst
somatostatin
chr6_-_121423633 223.441 Iqsec3
IQ motif and Sec7 domain 3
chrX_+_7215705 214.562 NM_009305
 Syp
synaptophysin
chr18_-_31606908 203.883 NM_009308
 Syt4
synaptotagmin IV
chr3_-_80606500 201.906 Gria2
glutamate receptor, ionotropic, AMPA2 (alpha 2)
chr2_+_164793698 198.509 Slc12a5
solute carrier family 12, member 5
chr1_-_84692750 191.074 NM_152915
 Dner
delta/notch-like EGF-related receptor
chr6_-_121423682 190.570 NM_001033354
 Iqsec3
IQ motif and Sec7 domain 3
chr12_+_103793130 188.428 NM_007693
 Chga
chromogranin A
chr4_-_128798481 187.735 NM_010471
 Hpca
hippocalcin
chr1_-_84692352 185.430 Dner
delta/notch-like EGF-related receptor
chrX_-_20498021 174.139 NM_001110780
NM_013680
 Syn1

synapsin I

chr11_-_35612385 165.999 NM_001004147
 Fbll1
fibrillarin-like 1
chr5_+_137506122 157.171 NM_001039385
 Vgf
VGF nerve growth factor inducible

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 28 entries
Enrichment   P-value GO Accession GO Term
46.03 1.65e-02 GO:0046329 negative regulation of JNK cascade
37.91 3.04e-02 GO:0070303 negative regulation of stress-activated protein kinase signaling cascade
29.30 2.47e-05 GO:0007269 neurotransmitter secretion
22.62 1.08e-06 GO:0001505 regulation of neurotransmitter levels
20.46 2.05e-02 GO:0048489 synaptic vesicle transport
17.74 9.17e-07 GO:0003001 generation of a signal involved in cell-cell signaling
17.74 9.17e-07 GO:0023061 signal release
16.53 1.03e-04 GO:0006836 neurotransmitter transport
14.14 1.32e-02 GO:0007631 feeding behavior
12.50 4.27e-10 GO:0007268 synaptic transmission
10.55 9.26e-10 GO:0019226 transmission of nerve impulse
10.55 9.26e-10 GO:0035637 multicellular organismal signaling
10.46 3.70e-06 GO:0032940 secretion by cell
9.16 1.69e-09 GO:0007267 cell-cell signaling
8.96 9.61e-07 GO:0046903 secretion
8.72 3.14e-02 GO:0048511 rhythmic process
7.27 2.41e-02 GO:0051969 regulation of transmission of nerve impulse
6.69 4.07e-02 GO:0031644 regulation of neurological system process
6.26 1.94e-07 GO:0007154 cell communication
5.86 3.68e-03 GO:0007610 behavior

Gene overrepresentation in compartment category:

Showing 1 to 20 of 28 entries
Enrichment   P-value GO Accession GO Term
107.39 1.38e-02 GO:0032588 trans-Golgi network membrane
29.63 1.01e-03 GO:0030672 synaptic vesicle membrane
19.53 8.59e-08 GO:0008021 synaptic vesicle
15.92 1.23e-02 GO:0030665 clathrin coated vesicle membrane
13.27 3.99e-03 GO:0030426 growth cone
13.25 2.69e-06 GO:0030136 clathrin-coated vesicle
12.79 4.76e-03 GO:0030427 site of polarized growth
12.28 3.38e-02 GO:0030662 coated vesicle membrane
11.65 8.16e-06 GO:0030135 coated vesicle
9.04 4.30e-08 GO:0044456 synapse part
8.15 4.01e-02 GO:0033267 axon part
8.11 6.14e-10 GO:0045202 synapse
7.91 4.59e-02 GO:0019717 synaptosome
6.62 2.98e-03 GO:0030424 axon
6.36 3.96e-04 GO:0044297 cell body
6.20 5.18e-07 GO:0043005 neuron projection
6.04 5.70e-03 GO:0030425 dendrite
6.01 1.96e-03 GO:0043025 neuronal cell body
5.57 5.61e-05 GO:0016023 cytoplasmic membrane-bounded vesicle
5.28 1.03e-04 GO:0031988 membrane-bounded vesicle

Gene overrepresentation in function category:

Showing 1 to 1 of 1 entries
Enrichment   P-value GO Accession GO Term
4.72 2.30e-03 GO:0005509 calcium ion binding