Motif ID: RFX1..5_RFXANK_RFXAP.p2

Z-value: 5.544


Transcription factors associated with RFX1..5_RFXANK_RFXAP.p2:

Gene SymbolEntrez IDGene Name
Rfx1 19724 regulatory factor X, 1 (influences HLA class II expression)
Rfx2 19725 regulatory factor X, 2 (influences HLA class II expression)
Rfx3 19726 regulatory factor X, 3 (influences HLA class II expression)
Rfx4 71137 regulatory factor X, 4 (influences HLA class II expression)
Rfx5 53970 regulatory factor X, 5 (influences HLA class II expression)
Rfxank 19727 regulatory factor X-associated ankyrin-containing protein
Rfxap 170767 regulatory factor X-associated protein

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rfx4chr10_+_842187920.754.0e-34Click!
Rfx3chr19_-_280855340.643.1e-22Click!
Rfxankchr8_-_72662994-0.365.1e-07Click!
Rfxapchr3_-_546116630.296.6e-05Click!
Rfx1chr8_+_865907180.241.3e-03Click!
Rfx2chr17_-_569703320.191.1e-02Click!
Rfx5chr3_+_94758056,
chr3_+_94758936
-0.018.6e-01Click!


Activity profile for motif RFX1..5_RFXANK_RFXAP.p2.

activity profile for motif RFX1..5_RFXANK_RFXAP.p2


Sorted Z-values histogram for motif RFX1..5_RFXANK_RFXAP.p2

Sorted Z-values for motif RFX1..5_RFXANK_RFXAP.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RFX1..5_RFXANK_RFXAP.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_7496899 182.767 NM_013892
Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
chr9_-_60535699 150.267 Lrrc49
leucine rich repeat containing 49
chr10_+_34017221 99.331 NM_030203
Tspyl4
TSPY-like 4
chr12_-_73509668 87.579 Rtn1
reticulon 1
chr12_-_73509537 87.042 Rtn1
reticulon 1
chr14_-_9142289 86.656 NM_183187
Fam107a
family with sequence similarity 107, member A
chr11_-_70846926 78.512 6330403K07Rik
RIKEN cDNA 6330403K07 gene
chr4_+_122860705 73.543 NM_174998
Hpcal4
hippocalcin-like 4
chr11_-_70847078 71.999 NM_134022
6330403K07Rik
RIKEN cDNA 6330403K07 gene
chr9_-_60535841 70.860 NM_001146046
NM_145616
Lrrc49

leucine rich repeat containing 49

chrX_+_133527693 70.541 NM_001035509
NM_001035510
NM_025893
Zcchc18


zinc finger, CCHC domain containing 18


chr5_+_31117077 68.075 NM_133350
Mapre3
microtubule-associated protein, RP/EB family, member 3
chr17_+_27822162 68.048 NM_178365
Pacsin1
protein kinase C and casein kinase substrate in neurons 1
chr10_+_74500008 67.746 Rab36
RAB36, member RAS oncogene family
chr17_+_46390828 66.941 NM_001111142
Gm88
predicted gene 88
chr7_+_17530050 61.493 Pnmal2
PNMA-like 2
chr3_+_82162091 60.630 Mtap9
microtubule-associated protein 9
chr7_+_17529961 60.338 NM_001099636
Pnmal2
PNMA-like 2
chrX_+_33735898 58.016 NM_028325
Zcchc12
zinc finger, CCHC domain containing 12
chr18_-_43847367 57.453 NM_001163637
Jakmip2
janus kinase and microtubule interacting protein 2
chr7_-_147268395 57.335 NM_001190385
NM_026769
Caly

calcyon neuron-specific vesicular protein

chr7_+_106416854 56.660 NM_001043355
Mtap6
microtubule-associated protein 6
chr11_+_87574041 56.424 NM_172449
Bzrap1
benzodiazepine receptor associated protein 1
chr10_+_20672352 56.154 NM_026203
Ahi1
Abelson helper integration site 1
chr7_-_147268150 54.694 NM_001190386
Caly
calcyon neuron-specific vesicular protein
chr3_+_82162037 54.199 Mtap9
microtubule-associated protein 9
chr4_+_43681807 53.910 NM_001085508
Tmem8b
transmembrane protein 8B
chr3_+_124023954 53.864 NM_146140
Tram1l1
translocation associated membrane protein 1-like 1
chr3_+_82161952 53.575 NM_001081230
Mtap9
microtubule-associated protein 9
chr2_-_73613381 53.109 NM_001113246
NM_001166603
Chn1

chimerin (chimaerin) 1

chr19_-_4906607 51.886 NM_001033128
Bbs1
Bardet-Biedl syndrome 1 (human)
chr2_+_121115337 51.540 NM_032393
Mtap1a
microtubule-associated protein 1 A
chr15_-_33617572 51.324 NM_001085421
Tspyl5
testis-specific protein, Y-encoded-like 5
chr5_-_115263896 50.398 1500011B03Rik
RIKEN cDNA 1500011B03 gene
chr9_-_7176964 49.363 NM_029851
Dync2h1
dynein cytoplasmic 2 heavy chain 1
chr3_-_126701367 49.139 NM_178655
Ank2
ankyrin 2, brain
chr16_-_59639164 48.809 NM_019665
Arl6
ADP-ribosylation factor-like 6
chr17_-_31414288 48.682 NM_025290
Rsph1
radial spoke head 1 homolog (Chlamydomonas)
chr17_-_31414199 48.413 Rsph1
radial spoke head 1 homolog (Chlamydomonas)
chr2_-_91284778 46.857 NM_175123
1110051M20Rik
RIKEN cDNA 1110051M20 gene
chr5_+_125048757 46.630 NM_026486
Tctn2
tectonic family member 2
chr16_-_59638878 46.515 Arl6
ADP-ribosylation factor-like 6
chr16_-_59638990 46.017 Arl6
ADP-ribosylation factor-like 6
chr10_+_74499810 45.731 NM_029781
Rab36
RAB36, member RAS oncogene family
chr3_+_13946371 45.575 NM_001163329
NM_001163330
Ralyl

RALY RNA binding protein-like

chr7_-_4498168 45.391 NM_016908
Syt5
synaptotagmin V
chr14_-_71028756 45.047 Epb4.9
erythrocyte protein band 4.9
chr1_-_89406861 44.911 NM_019867
Ngef
neuronal guanine nucleotide exchange factor
chr7_-_112717810 44.299 Apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1
chr2_-_91284827 43.912 1110051M20Rik
RIKEN cDNA 1110051M20 gene
chr10_-_38853662 43.552 NM_183254
1700025K23Rik
RIKEN cDNA 1700025K23 gene
chr11_-_4060222 43.104 NM_001164620
NM_177616
Ccdc157

coiled-coil domain containing 157

chr15_+_97998282 43.074 AI836003
expressed sequence AI836003
chr1_-_38851746 42.231 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr9_+_82723787 42.066 Irak1bp1
interleukin-1 receptor-associated kinase 1 binding protein 1
chrX_+_45976916 41.696 Slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr17_-_36116411 41.675 NM_001165892
NM_145487
Prr3

proline-rich polypeptide 3

chr15_-_78971563 41.568 NM_138581
1700088E04Rik
RIKEN cDNA 1700088E04 gene
chr14_+_60997104 41.352 NM_001164705
NM_028113
Fam123a

family with sequence similarity 123, member A

chr2_+_69485227 40.971 NM_028284
Bbs5
Bardet-Biedl syndrome 5 (human)
chr11_+_78139476 40.130 Aldoc
aldolase C, fructose-bisphosphate
chr4_+_151712739 40.031 NM_001081376
NM_029216
Chd5

chromodomain helicase DNA binding protein 5

chr9_+_20836560 39.948 Icam5
intercellular adhesion molecule 5, telencephalin
chr4_+_125735850 39.516 Oscp1
organic solute carrier partner 1
chr4_+_137237557 39.447 NM_001081155
Rap1gap
Rap1 GTPase-activating protein
chr6_+_38331516 39.444 NM_153600
Ttc26
tetratricopeptide repeat domain 26
chrX_+_45976650 39.101 NM_011398
Slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr9_-_26962964 39.033 NM_023277
Jam3
junction adhesion molecule 3
chr5_-_103640272 38.925 NM_001081567
NM_009158
Mapk10

mitogen-activated protein kinase 10

chr7_-_6683113 38.759 NM_008817
Peg3
paternally expressed 3
chr4_-_119088052 38.559 NM_029286
Ccdc30
coiled-coil domain containing 30
chr8_-_73987384 38.406 NM_022419
Abhd8
abhydrolase domain containing 8
chr3_-_89049088 38.286 NM_001039466
Trim46
tripartite motif-containing 46
chr10_+_41210244 38.169 NM_028430
Ppil6
peptidylprolyl isomerase (cyclophilin)-like 6
chr4_+_125735808 38.163 NM_172701
Oscp1
organic solute carrier partner 1
chr11_-_87172419 37.812 NM_177167
Ppm1e
protein phosphatase 1E (PP2C domain containing)
chr14_+_60997156 37.769 Fam123a
family with sequence similarity 123, member A
chr13_+_24936973 37.664 NM_001081051
D130043K22Rik
RIKEN cDNA D130043K22 gene
chrX_+_45976982 37.277 NM_001166450
Slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr5_-_149740213 37.066 NM_153572
Katnal1
katanin p60 subunit A-like 1
chr11_-_61267383 36.819 NM_009548
Rnf112
ring finger protein 112
chr15_-_84387921 36.748 Ldoc1l
leucine zipper, down-regulated in cancer 1-like
chr15_+_97998090 36.653 NM_177716
AI836003
expressed sequence AI836003
chr11_+_53380870 36.538 NM_008443
Kif3a
kinesin family member 3A
chr15_-_84388113 36.334 Ldoc1l
leucine zipper, down-regulated in cancer 1-like
chr8_+_14777772 36.086 Dlgap2
discs, large (Drosophila) homolog-associated protein 2
chr17_+_80689536 35.923 NM_194269
Morn2
MORN repeat containing 2
chr7_+_3303657 35.693 NM_011102
Prkcc
protein kinase C, gamma
chr7_+_3303770 35.476 Prkcc
protein kinase C, gamma
chr18_+_23656024 35.233 Dtna
dystrobrevin alpha
chrX_-_7709452 35.061 Wdr13
WD repeat domain 13
chr6_-_124813720 35.049 Gpr162
G protein-coupled receptor 162
chr15_-_84388245 34.715 NM_177630
Ldoc1l
leucine zipper, down-regulated in cancer 1-like
chr12_+_30213224 34.599 NM_001093775
NM_001093778
NM_008666
Myt1l


myelin transcription factor 1-like


chr3_-_57651621 34.512 NM_019410
Pfn2
profilin 2
chr9_+_47338255 33.613 Cadm1
cell adhesion molecule 1
chr8_+_41393330 33.449 NM_030110
Efha2
EF-hand domain family, member A2
chr6_-_122289630 33.424 Phc1
polyhomeotic-like 1 (Drosophila)
chr19_-_46401618 33.306 NM_028627
Psd
pleckstrin and Sec7 domain containing
chr13_+_24937049 33.097 D130043K22Rik
RIKEN cDNA D130043K22 gene
chr7_-_31836457 33.072 NM_022007
Fxyd7
FXYD domain-containing ion transport regulator 7
chr7_-_99785544 32.837 NM_028665
Ankrd42
ankyrin repeat domain 42
chr8_+_125736728 32.830 NM_177279
4732415M23Rik
RIKEN cDNA 4732415M23 gene
chr10_+_74429876 32.772 NM_010311
Gnaz
guanine nucleotide binding protein, alpha z subunit
chr16_+_14906698 32.650 NM_025769
Efcab1
EF hand calcium binding domain 1
chr6_+_115803545 32.539 NM_001167763
NM_031177
Ift122

intraflagellar transport 122 homolog (Chlamydomonas)

chr1_+_166205728 32.465 NM_029115
4930455F23Rik
RIKEN cDNA 4930455F23 gene
chr3_-_108339375 32.355 NM_001033304
5330417C22Rik
RIKEN cDNA 5330417C22 gene
chr9_+_47338431 32.145 NM_001025600
NM_018770
NM_207675
NM_207676
Cadm1



cell adhesion molecule 1



chr14_-_78936606 31.904 NM_001164503
Akap11
A kinase (PRKA) anchor protein 11
chr19_+_5050805 31.805 NM_145495
Rin1
Ras and Rab interactor 1
chr9_-_60535274 31.775 NM_001146047
Lrrc49
leucine rich repeat containing 49
chr6_+_83106397 31.770 NM_027948
1700003E16Rik
RIKEN cDNA 1700003E16 gene
chr9_+_110379461 30.967 NM_010628
Kif9
kinesin family member 9
chr6_+_83106466 30.459 1700003E16Rik
RIKEN cDNA 1700003E16 gene
chr15_+_78258993 30.387 NM_001081367
Kctd17
potassium channel tetramerisation domain containing 17
chr9_+_110379481 30.359 NM_001163569
Kif9
kinesin family member 9
chr3_-_94276817 30.232 Riiad1
regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1
chr16_+_49699314 30.228 NM_028680
Ift57
intraflagellar transport 57 homolog (Chlamydomonas)
chr11_-_29147217 30.070 NM_025740
Ccdc104
coiled-coil domain containing 104
chr2_+_71819264 30.007 NM_019688
Rapgef4
Rap guanine nucleotide exchange factor (GEF) 4
chr3_-_36512237 29.959 NM_027810
Bbs7
Bardet-Biedl syndrome 7 (human)
chr9_+_82723591 29.843 Irak1bp1
interleukin-1 receptor-associated kinase 1 binding protein 1
chr18_-_32109233 29.754 NM_001025381
Gpr17
G protein-coupled receptor 17
chr7_+_17545027 29.722 NM_001007569
Pnmal1
PNMA-like 1
chr4_-_151851574 29.657 NM_010598
Kcnab2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr9_-_50535949 29.579 NM_178118
Dixdc1
DIX domain containing 1
chr1_-_60099916 29.329 NM_027407
Ica1l
islet cell autoantigen 1-like
chr4_-_151851624 29.305 Kcnab2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr9_-_121186287 29.227 NM_177589
Ulk4
unc-51-like kinase 4 (C. elegans)
chr8_+_125736919 28.692 4732415M23Rik
RIKEN cDNA 4732415M23 gene
chr10_+_105907394 28.524 NM_177373
Ppfia2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr9_-_54349409 28.291 NM_172771
Dmxl2
Dmx-like 2
chr12_-_85489188 28.160 NM_027438
Pnma1
paraneoplastic antigen MA1
chr17_+_28314083 28.141 Zfp523
zinc finger protein 523
chr11_+_61318701 28.135 B9d1
B9 protein domain 1
chr12_+_53800369 28.073 NM_198111
Akap6
A kinase (PRKA) anchor protein 6
chr12_-_112079127 27.899 NM_011973
Stk30
serine/threonine kinase 30
chr5_+_137384005 27.890 NM_026073
Rabl5
RAB, member of RAS oncogene family-like 5
chr19_-_42160732 27.704 NM_198108
Morn4
MORN repeat containing 4
chr18_-_77285981 27.611 Katnal2
katanin p60 subunit A-like 2
chr15_+_36109284 27.291 NM_012031
Spag1
sperm associated antigen 1
chr17_-_46281016 26.966 NM_029338
Rsph9
radial spoke head 9 homolog (Chlamydomonas)
chr17_+_36116923 26.902 Gnl1
guanine nucleotide binding protein-like 1
chr12_-_73171976 26.890 NM_181752
Gpr135
G protein-coupled receptor 135
chr10_-_80464109 26.624 NM_001038655
Gng7
guanine nucleotide binding protein (G protein), gamma 7
chr10_-_79600131 26.531 NM_001195268
Dos
downstream of Stk11
chr1_+_163072784 26.516 NM_028664
Ankrd45
ankyrin repeat domain 45
chr11_+_61318645 26.356 NM_013717
B9d1
B9 protein domain 1
chr11_+_51817722 26.343 NM_001166653
NM_001166654
NM_001166655
NM_001166656
NM_001166657
NM_153785
Cdkl3





cyclin-dependent kinase-like 3





chr2_-_134469754 26.332 Tmx4
thioredoxin-related transmembrane protein 4
chr8_-_47060486 26.115 NM_001033148
1700029J07Rik
RIKEN cDNA 1700029J07 gene
chr4_-_61869579 26.114 NM_009554
Zfp37
zinc finger protein 37
chr1_+_174451174 26.069 Ccdc19
coiled-coil domain containing 19
chr19_+_45635070 25.932 NM_172639
Dpcd
deleted in primary ciliary dyskinesia
chr2_+_180954720 25.804 NM_199312
BC051628
cDNA sequence BC051628
chr1_-_59176902 25.757 NM_001033449
Als2cr4
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4
chr17_+_36116889 25.727 NM_008136
Gnl1
guanine nucleotide binding protein-like 1
chr7_+_19661548 25.290 NM_010058
Dmwd
dystrophia myotonica-containing WD repeat motif
chr9_+_50425460 25.277 Pih1d2
PIH1 domain containing 2
chr2_-_110790259 24.872 NM_001128103
NM_001081556
Ano3

anoctamin 3

chr9_+_82723410 24.867 NM_001168240
NM_022986
Irak1bp1

interleukin-1 receptor-associated kinase 1 binding protein 1

chr11_-_105805442 24.772 NM_007805
Cyb561
cytochrome b-561
chr11_-_5965555 24.714 Camk2b
calcium/calmodulin-dependent protein kinase II, beta
chr8_+_55686133 24.636 NM_133711
Spata4
spermatogenesis associated 4
chr11_-_5965544 24.373 Camk2b
calcium/calmodulin-dependent protein kinase II, beta
chr4_-_118293009 24.073 NM_026789
Wdr65
WD repeat domain 65
chr2_-_29904342 23.846 NM_001008498
Wdr34
WD repeat domain 34
chr16_+_38902431 23.746 NM_170599
Igsf11
immunoglobulin superfamily, member 11
chr18_-_77286034 23.608 NM_027721
Katnal2
katanin p60 subunit A-like 2
chrX_+_6644644 23.533 NM_009651
Akap4
A kinase (PRKA) anchor protein 4
chr5_-_150438750 23.470 Hsph1
heat shock 105kDa/110kDa protein 1
chr7_+_147080594 23.433 NM_177261
Kndc1
kinase non-catalytic C-lobe domain (KIND) containing 1
chr15_+_54577256 23.391 NM_010930
Nov
nephroblastoma overexpressed gene
chr7_-_116582511 23.310 NM_054103
Stk33
serine/threonine kinase 33
chr5_-_150438704 23.238 Hsph1
heat shock 105kDa/110kDa protein 1
chr5_-_150438856 23.236 NM_013559
Hsph1
heat shock 105kDa/110kDa protein 1
chr4_-_149148173 23.111 NM_027460
Slc25a33
solute carrier family 25, member 33
chr11_-_72175341 23.034 NM_011569
Tekt1
tektin 1
chr9_+_50425425 22.967 NM_028300
Pih1d2
PIH1 domain containing 2
chr17_-_85489544 22.844 NM_001163622
NM_001163623
NM_145984
NM_001163624
Prepl



prolyl endopeptidase-like



chr12_+_112127468 22.821 NM_001081057
Tecpr2
tectonin beta-propeller repeat containing 2
chr3_-_105804304 22.747 NM_029604
1700027A23Rik
RIKEN cDNA 1700027A23 gene
chr17_+_85025803 22.743 Dync2li1
dynein cytoplasmic 2 light intermediate chain 1
chr5_-_143026961 22.521 NM_178702
Radil
Ras association and DIL domains
chr14_+_77556622 22.416 NM_172813
Enox1
ecto-NOX disulfide-thiol exchanger 1
chr14_-_119322244 22.257 NM_025943
Dzip1
DAZ interacting protein 1
chr8_+_112017926 22.155 NM_019938
Pmfbp1
polyamine modulated factor 1 binding protein 1
chr4_-_12098948 22.105 Fam92a
family with sequence similarity 92, member A
chr2_-_118082593 22.089 NM_027759
Fsip1
fibrous sheath-interacting protein 1
chr18_+_63868337 21.902 NM_001014981
Wdr7
WD repeat domain 7
chr2_+_28555680 21.898 NM_001033874
Ak8
adenylate kinase 8
chr2_-_5816381 21.819 NM_021305
Sec61a2
Sec61, alpha subunit 2 (S. cerevisiae)
chr4_-_12098960 21.692 Fam92a
family with sequence similarity 92, member A
chr4_-_102786828 21.604 NM_146254
Wdr78
E030030F06Rik
WD repeat domain 78
RIKEN cDNA E030030F06 gene
chr6_+_29867012 21.526 NM_001037740
NM_177204
Fam40b

family with sequence similarity 40, member B

chr8_-_23916037 21.491 NM_001122820
NM_029505
Ap3m2

adaptor-related protein complex 3, mu 2 subunit

chr2_+_21127350 21.468 NM_001001297
NM_177588
Thnsl1

threonine synthase-like 1 (bacterial)

chr18_+_52853332 21.412 NM_010293
Gykl1
glycerol kinase-like 1
chr17_+_85025830 21.340 NM_172256
Dync2li1
dynein cytoplasmic 2 light intermediate chain 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.35 5.12e-13 GO:0008150 biological_process
8.26 8.66e-09 GO:0060271 cilium morphogenesis
9.54 1.38e-08 GO:0042384 cilium assembly
5.40 1.32e-05 GO:0010927 cellular component assembly involved in morphogenesis
4.51 9.76e-05 GO:0030031 cell projection assembly
2.44 3.38e-02 GO:0007283 spermatogenesis
2.44 3.38e-02 GO:0048232 male gamete generation

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
5.99 6.37e-19 GO:0005929 cilium
7.97 8.34e-10 GO:0019861 flagellum
2.15 1.01e-09 GO:0042995 cell projection
1.32 1.87e-09 GO:0005575 cellular_component
2.60 7.18e-09 GO:0015630 microtubule cytoskeleton
3.29 1.54e-07 GO:0005874 microtubule
8.00 5.58e-05 GO:0005930 axoneme
1.69 7.22e-05 GO:0005856 cytoskeleton
2.30 4.45e-04 GO:0044463 cell projection part
7.44 4.55e-04 GO:0044441 cilium part
9.92 3.91e-03 GO:0035085 cilium axoneme
1.73 5.19e-03 GO:0044430 cytoskeletal part
6.43 1.87e-02 GO:0005932 microtubule basal body
6.43 1.87e-02 GO:0009434 microtubule-based flagellum
12.40 4.09e-02 GO:0034464 BBSome

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.28 1.50e-09 GO:0003674 molecular_function
8.26 1.68e-02 GO:0051018 protein kinase A binding