Motif ID: RUNX1..3.p2

Z-value: 3.019


Transcription factors associated with RUNX1..3.p2:

Gene SymbolEntrez IDGene Name
Runx1 12394 runt related transcription factor 1
Runx2 12393 runt related transcription factor 2
Runx3 12399 runt related transcription factor 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Runx1chr16_-_928263070.815.0e-44Click!
Runx3chr4_+_1346765590.722.0e-30Click!
Runx2chr17_-_44951745,
chr17_-_44873596
0.467.7e-11Click!


Activity profile for motif RUNX1..3.p2.

activity profile for motif RUNX1..3.p2


Sorted Z-values histogram for motif RUNX1..3.p2

Sorted Z-values for motif RUNX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_103664214 86.993 NM_008979
Ptpn22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
chr16_-_92826307 85.281 NM_001111021
NM_001111022
Runx1

runt related transcription factor 1

chr11_-_79337178 77.643 Evi2b
ecotropic viral integration site 2b
chr1_-_146096156 69.422 NM_015811
Rgs1
regulator of G-protein signaling 1
chr1_-_140071818 68.324 NM_001111316
NM_011210
Ptprc

protein tyrosine phosphatase, receptor type, C

chr16_-_92826239 65.739 Runx1
runt related transcription factor 1
chr4_+_134676559 65.635 NM_019732
Runx3
runt related transcription factor 3
chr19_+_12873063 62.262 NM_134152
Lpxn
leupaxin
chr19_+_12873115 61.537 Lpxn
leupaxin
chr4_-_143571878 55.480 3930401B19Rik
RIKEN cDNA 3930401B19 gene
chr11_-_79337251 54.250 NM_001077496
Evi2b
ecotropic viral integration site 2b
chr2_-_58012447 52.050 NM_139200
Cytip
cytohesin 1 interacting protein
chr11_-_83462722 48.654 NM_011337
Ccl3
chemokine (C-C motif) ligand 3
chr19_-_20465115 47.543 Anxa1
annexin A1
chr17_-_44951745 45.086 NM_001146038
NM_009820
Runx2

runt related transcription factor 2

chr7_+_51827801 44.337 NM_008437
Napsa
napsin A aspartic peptidase
chr1_-_140071630 44.221 Ptprc
protein tyrosine phosphatase, receptor type, C
chr5_-_65324796 43.712 Tlr1
toll-like receptor 1
chr3_-_135271247 43.686 Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
chr15_-_9459496 43.420 Il7r
interleukin 7 receptor

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 79 entries
Enrichment   P-value GO Accession GO Term
9.56 1.66e-02 GO:0002710 negative regulation of T cell mediated immunity
7.85 3.74e-03 GO:0002820 negative regulation of adaptive immune response
7.85 3.74e-03 GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
7.44 2.97e-02 GO:0032689 negative regulation of interferon-gamma production
6.38 2.25e-03 GO:0002704 negative regulation of leukocyte mediated immunity
6.38 2.25e-03 GO:0002707 negative regulation of lymphocyte mediated immunity
6.38 3.02e-02 GO:0071634 regulation of transforming growth factor-beta production
3.90 8.83e-03 GO:0031341 regulation of cell killing
3.85 5.10e-03 GO:0002698 negative regulation of immune effector process
3.61 2.60e-02 GO:0050777 negative regulation of immune response
3.45 2.82e-04 GO:0002706 regulation of lymphocyte mediated immunity
3.25 2.80e-04 GO:0002703 regulation of leukocyte mediated immunity
3.04 1.66e-02 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
2.93 2.93e-02 GO:0002819 regulation of adaptive immune response
2.82 3.40e-02 GO:0002699 positive regulation of immune effector process
2.58 7.31e-04 GO:0002697 regulation of immune effector process
2.51 2.06e-02 GO:0042110 T cell activation
2.48 1.84e-02 GO:0002764 immune response-regulating signaling pathway
2.44 8.51e-03 GO:0002521 leukocyte differentiation
2.39 2.77e-05 GO:0045321 leukocyte activation

Gene overrepresentation in compartment category:

Showing 1 to 13 of 13 entries
Enrichment   P-value GO Accession GO Term
2.26 5.72e-04 GO:0009897 external side of plasma membrane
1.74 4.08e-03 GO:0009986 cell surface
1.49 2.96e-05 GO:0005829 cytosol
1.32 1.83e-02 GO:0005576 extracellular region
1.23 8.41e-05 GO:0005634 nucleus
1.16 2.13e-02 GO:0044444 cytoplasmic part
1.14 2.23e-04 GO:0043229 intracellular organelle
1.14 1.18e-03 GO:0043231 intracellular membrane-bounded organelle
1.14 1.27e-03 GO:0043227 membrane-bounded organelle
1.13 9.13e-06 GO:0005622 intracellular
1.13 2.46e-05 GO:0044424 intracellular part
1.13 3.74e-04 GO:0043226 organelle
1.13 2.80e-03 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
Enrichment   P-value GO Accession GO Term
1.98 1.92e-02 GO:0019901 protein kinase binding
1.61 8.98e-03 GO:0043565 sequence-specific DNA binding
1.50 1.42e-02 GO:0030528 transcription regulator activity
1.35 1.11e-02 GO:0003677 DNA binding
1.32 8.29e-04 GO:0003676 nucleic acid binding
1.22 4.85e-05 GO:0005515 protein binding
1.15 1.08e-07 GO:0005488 binding