Motif ID: RXR{A,B,G}.p2

Z-value: 1.785


Transcription factors associated with RXR{A,B,G}.p2:

Gene SymbolEntrez IDGene Name
Rxra 20181 retinoid X receptor alpha
Rxrb 20182 retinoid X receptor beta
Rxrg 20183 retinoid X receptor gamma

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rxrgchr1_+_169528492,
chr1_+_169548381		0.402.8e-08Click!
Rxrbchr17_+_34168703-0.241.3e-03Click!
Rxrachr2_+_275326920.036.9e-01Click!


Activity profile for motif RXR{A,B,G}.p2.

activity profile for motif RXR{A,B,G}.p2


Sorted Z-values histogram for motif RXR{A,B,G}.p2

Sorted Z-values for motif RXR{A,B,G}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RXR{A,B,G}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_112910475 24.320 NM_021273
 Ckb
creatine kinase, brain
chr17_+_43938789 23.304 NM_207649
 Rcan2
regulator of calcineurin 2
chr11_+_101329457 22.434 Rnd2
Rho family GTPase 2
chr10_+_59569052 20.095 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr16_-_85173764 19.837 App
amyloid beta (A4) precursor protein
chr9_+_110148568 19.276 Cspg5
chondroitin sulfate proteoglycan 5
chr13_-_25029458 18.788 NM_172532
 Aldh5a1
aldhehyde dehydrogenase family 5, subfamily A1
chr16_-_85173930 18.750 App
amyloid beta (A4) precursor protein
chr16_-_85173851 18.743 App
amyloid beta (A4) precursor protein
chr16_-_85173918 18.587 App
amyloid beta (A4) precursor protein
chr16_-_85173978 17.790 App
amyloid beta (A4) precursor protein
chr8_+_86496844 17.381 NM_008854
 Prkaca
protein kinase, cAMP dependent, catalytic, alpha
chr11_+_78139476 16.962 Aldoc
aldolase C, fructose-bisphosphate
chr2_-_25325248 16.828 NM_008963
 Ptgds
prostaglandin D2 synthase (brain)
chr9_-_31019412 16.425 Aplp2
amyloid beta (A4) precursor-like protein 2
chr10_+_59569206 16.354 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr16_-_18629938 15.648 NM_213614
 Sept5
septin 5
chr2_-_25325196 15.512 Ptgds
prostaglandin D2 synthase (brain)
chr16_-_84955488 15.177 App
amyloid beta (A4) precursor protein
chr7_-_52124950 13.938 Ptov1
prostate tumor over expressed gene 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 59 entries
Enrichment   P-value GO Accession GO Term
6.42 2.56e-02 GO:0007416 synapse assembly
5.78 2.07e-02 GO:0042133 neurotransmitter metabolic process
5.44 4.19e-03 GO:0035249 synaptic transmission, glutamatergic
5.14 2.31e-02 GO:0007215 glutamate signaling pathway
4.71 2.21e-02 GO:0022904 respiratory electron transport chain
3.44 4.42e-02 GO:0050808 synapse organization
3.21 1.06e-02 GO:0001505 regulation of neurotransmitter levels
3.12 3.47e-04 GO:0022900 electron transport chain
2.69 4.17e-02 GO:0071375 cellular response to peptide hormone stimulus
2.48 6.00e-04 GO:0050804 regulation of synaptic transmission
2.42 5.30e-04 GO:0051969 regulation of transmission of nerve impulse
2.34 6.69e-04 GO:0031644 regulation of neurological system process
2.29 2.49e-04 GO:0007268 synaptic transmission
2.25 1.57e-05 GO:0019226 transmission of nerve impulse
2.25 1.57e-05 GO:0035637 multicellular organismal signaling
2.24 3.81e-04 GO:0007264 small GTPase mediated signal transduction
2.24 7.37e-03 GO:0071495 cellular response to endogenous stimulus
2.10 2.73e-05 GO:0044057 regulation of system process
2.10 3.35e-02 GO:0006091 generation of precursor metabolites and energy
2.01 8.30e-05 GO:0055082 cellular chemical homeostasis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 62 entries
Enrichment   P-value GO Accession GO Term
5.00 9.06e-05 GO:0005747 mitochondrial respiratory chain complex I
5.00 9.06e-05 GO:0030964 NADH dehydrogenase complex
5.00 9.06e-05 GO:0045271 respiratory chain complex I
4.65 1.61e-05 GO:0005746 mitochondrial respiratory chain
4.44 6.16e-06 GO:0070469 respiratory chain
3.12 1.79e-04 GO:0008021 synaptic vesicle
2.99 3.89e-04 GO:0044455 mitochondrial membrane part
2.64 3.27e-04 GO:0030136 clathrin-coated vesicle
2.59 1.74e-10 GO:0044456 synapse part
2.55 2.28e-03 GO:0019717 synaptosome
2.53 3.93e-03 GO:0033267 axon part
2.48 1.10e-13 GO:0045202 synapse
2.40 1.82e-03 GO:0030135 coated vesicle
2.39 2.70e-03 GO:0045211 postsynaptic membrane
2.36 1.79e-03 GO:0031252 cell leading edge
2.22 1.35e-04 GO:0030424 axon
2.16 2.75e-05 GO:0043025 neuronal cell body
2.13 7.26e-05 GO:0005743 mitochondrial inner membrane
2.09 1.53e-06 GO:0005740 mitochondrial envelope
2.08 7.50e-09 GO:0043005 neuron projection

Gene overrepresentation in function category:

Showing 1 to 20 of 23 entries
Enrichment   P-value GO Accession GO Term
9.18 3.65e-02 GO:0001640 adenylate cyclase inhibiting metabotropic glutamate receptor activity
5.14 4.97e-02 GO:0035255 ionotropic glutamate receptor binding
4.04 3.10e-02 GO:0019905 syntaxin binding
3.67 4.04e-02 GO:0000149 SNARE binding
2.51 1.62e-02 GO:0005516 calmodulin binding
2.35 3.16e-05 GO:0005083 small GTPase regulator activity
1.92 5.06e-04 GO:0060589 nucleoside-triphosphatase regulator activity
1.92 8.67e-04 GO:0030695 GTPase regulator activity
1.73 4.11e-03 GO:0019904 protein domain specific binding
1.66 3.85e-02 GO:0008324 cation transmembrane transporter activity
1.65 3.23e-02 GO:0008092 cytoskeletal protein binding
1.64 2.00e-02 GO:0004672 protein kinase activity
1.63 3.52e-04 GO:0030234 enzyme regulator activity
1.59 7.29e-05 GO:0005215 transporter activity
1.58 4.22e-03 GO:0016301 kinase activity
1.58 1.66e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.57 1.47e-03 GO:0022892 substrate-specific transporter activity
1.56 3.40e-02 GO:0015075 ion transmembrane transporter activity
1.51 8.88e-03 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.51 2.15e-02 GO:0022857 transmembrane transporter activity