Motif ID: RXRA_VDR{dimer}.p2

Z-value: 1.042


Transcription factors associated with RXRA_VDR{dimer}.p2:

Gene SymbolEntrez IDGene Name
Vdr 22337 vitamin D receptor

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Vdrchr15_-_97738692-0.208.1e-03Click!


Activity profile for motif RXRA_VDR{dimer}.p2.

activity profile for motif RXRA_VDR{dimer}.p2


Sorted Z-values histogram for motif RXRA_VDR{dimer}.p2

Sorted Z-values for motif RXRA_VDR{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RXRA_VDR{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_87391881 17.927 Sept4
septin 4
chr9_-_37360141 16.715 NM_022029
Nrgn
neurogranin
chr2_+_30219837 14.216 NM_175392
Fam73b
family with sequence similarity 73, member B
chr12_+_4082739 13.634 Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr6_-_11857434 13.119 NM_010886
Ndufa4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4
chr1_+_78306890 12.951 NM_001004173
Sgpp2
sphingosine-1-phosphate phosphotase 2
chr15_+_82105322 12.329 NM_011889
Sept3
septin 3
chr2_+_30219752 11.341 Fam73b
family with sequence similarity 73, member B
chr3_-_107499129 11.326 Ahcyl1
S-adenosylhomocysteine hydrolase-like 1
chr2_+_144425688 10.836 NM_025314
Dtd1
D-tyrosyl-tRNA deacylase 1 homolog (S. cerevisiae)
chr7_-_148615247 10.505 NM_021316
Cend1
cell cycle exit and neuronal differentiation 1
chr12_+_4082573 10.276 NM_153082
Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr7_+_30074296 10.032 NM_026731
Ppp1r14a
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr2_+_144425632 9.999 Dtd1
D-tyrosyl-tRNA deacylase 1 homolog (S. cerevisiae)
chr9_+_121206613 9.919 Trak1
trafficking protein, kinesin binding 1
chr14_-_31736727 9.904 NM_008407
Itih3
inter-alpha trypsin inhibitor, heavy chain 3
chr7_+_5031809 9.888 NM_010147
Epn1
epsin 1
chr1_-_25886551 9.563 NM_175642
Bai3
brain-specific angiogenesis inhibitor 3
chr4_+_122860705 9.524 NM_174998
Hpcal4
hippocalcin-like 4
chr7_-_125676808 9.061 Coq7
demethyl-Q 7
chr11_-_116274124 8.802 Rnf157
ring finger protein 157
chr2_+_144425704 8.757 Dtd1
D-tyrosyl-tRNA deacylase 1 homolog (S. cerevisiae)
chr9_+_108838660 8.100 NM_025407
Uqcrc1
ubiquinol-cytochrome c reductase core protein 1
chr7_-_125676823 7.856 NM_009940
Coq7
demethyl-Q 7
chr11_-_69418965 7.845 Atp1b2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chrX_-_47141382 7.838 NM_183336
Igsf1
immunoglobulin superfamily, member 1
chr17_-_57184507 7.815 Slc25a23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr6_+_125165597 7.733 NM_001080557
NM_009496
Vamp1

vesicle-associated membrane protein 1

chr1_+_93076578 7.419 Ramp1
receptor (calcitonin) activity modifying protein 1
chr7_-_125676764 7.366 Coq7
demethyl-Q 7
chr11_+_6295127 7.362 NM_001005867
Zmiz2
zinc finger, MIZ-type containing 2
chr5_-_23948000 7.233


chr7_-_52184801 6.820 Ap2a1
adaptor protein complex AP-2, alpha 1 subunit
chr8_-_124102548 6.796 NM_133765
Fbxo31
F-box protein 31
chr2_-_174289569 6.442 NM_025983
Atp5e
ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
chr18_-_74224541 6.439 NM_172632
Mapk4
mitogen-activated protein kinase 4
chr7_+_148247172 6.196 NM_177897
B4galnt4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr4_-_11893500 5.980 NM_001033453
NM_001098230
Pdp1

pyruvate dehyrogenase phosphatase catalytic subunit 1

chr7_-_52184840 5.903 NM_001077264
NM_007458
Ap2a1

adaptor protein complex AP-2, alpha 1 subunit

chr7_-_52184789 5.889 Ap2a1
adaptor protein complex AP-2, alpha 1 subunit
chr7_+_19661811 5.841 Dmwd
dystrophia myotonica-containing WD repeat motif
chr1_-_195196423 5.789 NM_144817
Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr17_-_45823086 5.755 Tmem63b
transmembrane protein 63b
chr2_-_174289526 5.552 Atp5e
ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
chr3_-_40650624 5.443 NM_028140
Mfsd8
major facilitator superfamily domain containing 8
chr5_-_45841351 5.402 Qdpr
quinoid dihydropteridine reductase
chr1_-_95531961 5.308 Stk25
serine/threonine kinase 25 (yeast)
chr5_-_45841382 5.297 NM_024236
Qdpr
quinoid dihydropteridine reductase
chr13_+_13876667 5.266 NM_010317
Gng4
guanine nucleotide binding protein (G protein), gamma 4
chr14_-_52533114 5.210 NM_001145959
NM_013864
Ndrg2

N-myc downstream regulated gene 2

chr3_-_116671573 5.019 Palmd
palmdelphin
chr2_+_28048779 4.963 Olfm1
olfactomedin 1
chr10_+_127795461 4.925 Cs
citrate synthase
chr3_-_115417847 4.859 S1pr1
sphingosine-1-phosphate receptor 1
chr9_-_29219382 4.856 Ntm
neurotrimin
chr14_-_52533039 4.823 Ndrg2
N-myc downstream regulated gene 2
chr3_-_144695718 4.817 NM_017474
Clca3
chloride channel calcium activated 3
chr10_+_79167102 4.663 NM_001077184
NM_009768
Bsg

basigin

chr2_+_71819264 4.659 NM_019688
Rapgef4
Rap guanine nucleotide exchange factor (GEF) 4
chr11_-_120673433 4.645 Fasn
fatty acid synthase
chr7_-_31230564 4.629 Aplp1
amyloid beta (A4) precursor-like protein 1
chr7_-_52184752 4.619 Ap2a1
adaptor protein complex AP-2, alpha 1 subunit
chr3_-_115417685 4.485 S1pr1
sphingosine-1-phosphate receptor 1
chr15_+_57817333 4.483 NM_173862
Fam83a
family with sequence similarity 83, member A
chr15_+_82105647 4.459 Sept3
septin 3
chr3_+_117278144 4.403 NM_029425
4833424O15Rik
RIKEN cDNA 4833424O15 gene
chr9_+_57369014 4.400 NM_007747
Cox5a
cytochrome c oxidase, subunit Va
chr14_-_52532988 4.338 Ndrg2
N-myc downstream regulated gene 2
chr19_-_36811137 4.284 Ppp1r3c
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr19_-_36811090 4.082 NM_016854
Ppp1r3c
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr5_+_37633317 4.036 NM_001136058
Crmp1
collapsin response mediator protein 1
chr9_-_29219306 3.992 Ntm
neurotrimin
chr3_-_152331083 3.904 NM_001081277
Ak5
adenylate kinase 5
chr7_-_31230577 3.891 NM_007467
Aplp1
amyloid beta (A4) precursor-like protein 1
chr4_+_147534729 3.767 Fbxo2
F-box protein 2
chr4_+_13670425 3.736 NM_001111026
Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr7_+_133415982 3.664 NM_145587
Sbk1
SH3-binding kinase 1
chr7_-_91754236 3.590 Fah
fumarylacetoacetate hydrolase
chr2_+_28048511 3.579 Olfm1
olfactomedin 1
chr7_-_91754314 3.541 Fah
fumarylacetoacetate hydrolase
chr17_+_35068258 3.529 Neu1
neuraminidase 1
chr5_-_8622882 3.517 NM_198620
Rundc3b
RUN domain containing 3B
chr5_-_31504348 3.479 NM_001177901
Zfp513
zinc finger protein 513
chr11_-_120442448 3.384 Arhgdia
Rho GDP dissociation inhibitor (GDI) alpha
chr5_+_37633353 3.375 Crmp1
collapsin response mediator protein 1
chr17_+_57129686 3.341 NM_017393
Clpp
caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli)
chr18_-_75857207 3.328 NM_201354
Ctif
CBP80/20-dependent translation initiation factor
chr11_+_68902025 3.255 NM_009497
Vamp2
vesicle-associated membrane protein 2
chr11_+_68901989 3.244 Vamp2
vesicle-associated membrane protein 2
chr4_+_42930076 3.037 NM_172690
N28178
expressed sequence N28178
chr1_-_16509276 3.024 NM_001111272
NM_025303
Stau2

staufen (RNA binding protein) homolog 2 (Drosophila)

chr10_+_127472725 3.005 Naca
nascent polypeptide-associated complex alpha polypeptide
chr7_-_88599560 3.003 NM_007755
Cpeb1
cytoplasmic polyadenylation element binding protein 1
chr11_+_55017825 3.002 NM_153139
Slc36a1
solute carrier family 36 (proton/amino acid symporter), member 1
chr7_+_80885175 2.978 NM_001162532
Fam174b
family with sequence similarity 174, member B
chr11_+_4886860 2.928 NM_007454
Ap1b1
adaptor protein complex AP-1, beta 1 subunit
chr4_-_140221801 2.927 NM_001112722
Arhgef10l
Rho guanine nucleotide exchange factor (GEF) 10-like
chr2_-_80287218 2.901 Frzb
frizzled-related protein
chr10_+_127472624 2.887 Naca
nascent polypeptide-associated complex alpha polypeptide
chr8_-_105308910 2.865 NM_009866
Cdh11
cadherin 11
chr9_+_57369044 2.833 Cox5a
cytochrome c oxidase, subunit Va
chr4_+_42929523 2.806 N28178
expressed sequence N28178
chr7_+_19868009 2.784 NM_013648
Rtn2
reticulon 2 (Z-band associated protein)
chr2_-_117168706 2.729 Rasgrp1
RAS guanyl releasing protein 1
chr10_+_80085486 2.686 NM_134002
Csnk1g2
casein kinase 1, gamma 2
chr19_-_7016916 2.683 NM_001177361
Gpr137
G protein-coupled receptor 137
chr3_-_108339375 2.656 NM_001033304
5330417C22Rik
RIKEN cDNA 5330417C22 gene
chr8_+_4253079 2.654 NM_133968
Snapc2
small nuclear RNA activating complex, polypeptide 2
chr5_+_116295259 2.652 Cit
citron
chr19_-_6077175 2.598 NM_001081041
1110014N23Rik
RIKEN cDNA 1110014N23 gene
chrX_+_7455387 2.573 NM_138606
Pim2
proviral integration site 2
chr13_-_14155631 2.520 NM_010282
Ggps1
geranylgeranyl diphosphate synthase 1
chr17_-_45686604 2.435 NM_001013749
Tmem151b
transmembrane protein 151B
chr2_-_73224394 2.426 NM_001080707
NM_001190297
Gpr155

G protein-coupled receptor 155

chr8_-_28340059 2.422 NM_013462
Adrb3
adrenergic receptor, beta 3
chr6_-_85452851 2.286 NM_001001160
Fbxo41
F-box protein 41
chr4_-_117587421 2.267 NM_146152
Ipo13
importin 13
chr11_+_75300278 2.188 NM_138659
Prpf8
pre-mRNA processing factor 8
chr16_+_18066571 2.180 Dgcr6
DiGeorge syndrome critical region gene 6
chr16_+_18066494 2.149 Dgcr6
DiGeorge syndrome critical region gene 6
chr11_+_3414983 2.125 Selm
selenoprotein M
chrX_-_61530035 2.114 Slitrk4
SLIT and NTRK-like family, member 4
chr8_+_96676506 2.084 NM_013603
Mt3
metallothionein 3
chr13_-_14155541 2.079 Ggps1
geranylgeranyl diphosphate synthase 1
chr18_+_37098858 2.050 NM_198117
Pcdha2
protocadherin alpha 2
chr5_-_124666426 2.025 NM_011256
Pitpnm2
phosphatidylinositol transfer protein, membrane-associated 2
chr2_+_164312087 1.988 Dbndd2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr1_-_186823350 1.976 NM_145515
Mark1
MAP/microtubule affinity-regulating kinase 1
chr3_+_88987108 1.967 NM_001014995
Fam189b
family with sequence similarity 189, member B
chr2_+_128524597 1.952 NM_008587
Mertk
c-mer proto-oncogene tyrosine kinase
chr2_+_28048592 1.946 NM_001038613
NM_001038614
Olfm1

olfactomedin 1

chr7_+_133968166 1.936 NM_001146347
Fam57b
family with sequence similarity 57, member B
chr7_+_133416177 1.901 Sbk1
SH3-binding kinase 1
chr15_+_12251184 1.875 Golph3
golgi phosphoprotein 3
chr2_+_181255209 1.875 NM_016775
Dnajc5
DnaJ (Hsp40) homolog, subfamily C, member 5
chr19_-_4906607 1.861 NM_001033128
Bbs1
Bardet-Biedl syndrome 1 (human)
chr4_-_147533696 1.859 NM_001161851
Fbxo44
F-box protein 44
chr5_-_31456576 1.857 NM_008622
Mpv17
MpV17 mitochondrial inner membrane protein
chr4_+_13670582 1.840 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr11_+_3414884 1.818 Selm
selenoprotein M
chr8_-_73132125 1.794 NM_133772
Ssbp4
single stranded DNA binding protein 4
chr17_-_24826873 1.770 NM_011522
Syngr3
synaptogyrin 3
chr10_-_77707385 1.745 NM_001081055
Trappc10
trafficking protein particle complex 10
chr11_+_75323840 1.711 Rilp
Rab interacting lysosomal protein
chr7_-_129245303 1.703 NM_028177
Ndufab1
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1
chr1_-_24012436 1.682 NM_026503
1110058L19Rik
RIKEN cDNA 1110058L19 gene
chr12_+_77866520 1.663 NM_206534
Churc1
churchill domain containing 1
chr9_+_57351848 1.637 NM_133982
Rpp25
ribonuclease P 25 subunit (human)
chr13_+_19040215 1.634 NM_175007
Amph
amphiphysin
chr5_+_107926763 1.608 NM_001007574
NM_001168557
A830010M20Rik

RIKEN cDNA A830010M20 gene

chr19_+_8911956 1.599 NM_001136064
Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr5_-_114881393 1.558


chr9_+_57351830 1.533 Rpp25
ribonuclease P 25 subunit (human)
chr8_-_86671651 1.525 NM_145970
Cc2d1a
coiled-coil and C2 domain containing 1A
chr2_+_26483976 1.520 NM_019833
Fam69b
family with sequence similarity 69, member B
chr10_+_19868725 1.495 NM_001198635
NM_008635
Mtap7

microtubule-associated protein 7

chr7_+_13507659 1.491 NM_009095
Rps5
ribosomal protein S5
chr1_-_173177243 1.479 Ndufs2
NADH dehydrogenase (ubiquinone) Fe-S protein 2
chr1_-_173177242 1.467 NM_153064
Ndufs2
NADH dehydrogenase (ubiquinone) Fe-S protein 2
chr7_-_3629631 1.440 Mboat7
membrane bound O-acyltransferase domain containing 7
chr18_-_13100228 1.438 NM_207530
Osbpl1a
oxysterol binding protein-like 1A
chr8_-_73030643 1.437 2810428I15Rik
RIKEN cDNA 2810428I15 gene
chr1_-_173177236 1.433 Ndufs2
NADH dehydrogenase (ubiquinone) Fe-S protein 2
chr5_-_44492908 1.431 NM_001163577
NM_008935
Prom1

prominin 1

chr5_-_101103051 1.428 NM_027978
Coq2
coenzyme Q2 homolog, prenyltransferase (yeast)
chr1_+_39251056 1.421 NM_008719
Npas2
neuronal PAS domain protein 2
chr19_-_6984433 1.414 Prdx5
peroxiredoxin 5
chr16_-_84835812 1.410 NM_016755
Atp5j
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
chr15_+_99556127 1.404 2310016M24Rik
RIKEN cDNA 2310016M24 gene
chr10_+_79179326 1.393 NM_008226
Hcn2
hyperpolarization-activated, cyclic nucleotide-gated K+ 2
chr3_+_88425073 1.377 Arhgef2
rho/rac guanine nucleotide exchange factor (GEF) 2
chr2_+_174167172 1.375 Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr10_-_53470714 1.375 NM_001081428
Fam184a
family with sequence similarity 184, member A
chr15_+_99556048 1.355 NM_183256
2310016M24Rik
RIKEN cDNA 2310016M24 gene
chr4_-_124527811 1.351 NM_001142727
1110065P20Rik
RIKEN cDNA 1110065P20 gene
chr16_+_32271553 1.316 NM_183283
2310010M20Rik
RIKEN cDNA 2310010M20 gene
chr3_-_129763586 1.294 Sec24b
Sec24 related gene family, member B (S. cerevisiae)
chr5_+_136363914 1.275 Hspb1
heat shock protein 1
chr5_+_116295664 1.272 NM_007708
Cit
citron
chr11_-_96805259 1.269 Pnpo
pyridoxine 5'-phosphate oxidase
chr8_-_73030573 1.268 NM_025577
2810428I15Rik
RIKEN cDNA 2810428I15 gene
chr1_-_127808790 1.247 NM_145100
Lypd1
Ly6/Plaur domain containing 1
chr1_-_173177232 1.242 Ndufs2
NADH dehydrogenase (ubiquinone) Fe-S protein 2
chr2_+_3035692 1.235 Fam171a1
family with sequence similarity 171, member A1
chr15_-_101966611 1.190 NM_001033277
Spryd3
SPRY domain containing 3
chr10_+_98377759 1.184 NM_026482
Atp2b1
ATPase, Ca++ transporting, plasma membrane 1
chr19_-_29101759 1.165


chr8_+_97501008 1.164 NM_001198894
Gpr56
G protein-coupled receptor 56
chr1_-_173177227 1.157 Ndufs2
NADH dehydrogenase (ubiquinone) Fe-S protein 2
chr5_-_124545776 1.137 NM_019875
Abcb9
ATP-binding cassette, sub-family B (MDR/TAP), member 9
chr9_-_117539030 1.135 NM_001172121
Rbms3
RNA binding motif, single stranded interacting protein
chr8_-_47296201 1.119 NM_007450
Slc25a4
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
chr7_-_52271450 1.118 NM_001008422
Scaf1
SR-related CTD-associated factor 1
chr11_-_96805294 1.114 NM_134021
Pnpo
pyridoxine 5'-phosphate oxidase
chr5_+_121847967 1.097 NM_172722
Naa25
N(alpha)-acetyltransferase 25, NatB auxiliary subunit
chr5_-_36928872 1.091 NM_001113362
Tbc1d14
TBC1 domain family, member 14
chr5_+_74591336 1.060 NM_026878
Rasl11b
RAS-like, family 11, member B
chr10_-_13272820 1.054 Pex3
peroxisomal biogenesis factor 3
chr12_+_112812710 1.051 NM_021516
NM_022801
Mark3

MAP/microtubule affinity-regulating kinase 3

chr5_+_74591290 1.047 Rasl11b
RAS-like, family 11, member B

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
37.63 1.68e-03 GO:0006743 ubiquinone metabolic process
37.63 1.68e-03 GO:0006744 ubiquinone biosynthetic process
30.79 4.32e-03 GO:0045426 quinone cofactor biosynthetic process
1.80 7.35e-03 GO:0051234 establishment of localization
1.80 9.64e-03 GO:0006810 transport
24.19 1.28e-02 GO:0042375 quinone cofactor metabolic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.44 7.52e-11 GO:0005622 intracellular
1.59 1.89e-10 GO:0005737 cytoplasm
1.41 6.70e-09 GO:0044424 intracellular part
1.73 2.94e-08 GO:0044444 cytoplasmic part
1.22 8.55e-07 GO:0005623 cell
1.22 8.55e-07 GO:0044464 cell part
1.35 2.26e-04 GO:0043229 intracellular organelle
1.35 2.74e-04 GO:0043226 organelle
2.14 2.33e-03 GO:0005739 mitochondrion
1.34 5.09e-03 GO:0043227 membrane-bounded organelle
1.33 7.92e-03 GO:0043231 intracellular membrane-bounded organelle
3.58 7.93e-03 GO:0019866 organelle inner membrane
3.51 1.85e-02 GO:0005743 mitochondrial inner membrane
2.84 3.49e-02 GO:0045202 synapse

Nothing significant found in function category.