Motif ID: SMAD1..7,9.p2

Z-value: 1.171


Transcription factors associated with SMAD1..7,9.p2:

Gene SymbolEntrez IDGene Name
Smad1 17125 MAD homolog 1 (Drosophila)
Smad2 17126 MAD homolog 2 (Drosophila)
Smad3 17127 MAD homolog 3 (Drosophila)
Smad4 17128 MAD homolog 4 (Drosophila)
Smad5 17129 MAD homolog 5 (Drosophila)
Smad6 17130 MAD homolog 6 (Drosophila)
Smad7 17131 MAD homolog 7 (Drosophila)
Smad9 55994 MAD homolog 9 (Drosophila)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad2chr18_+_76401531-0.451.1e-10Click!
Smad1chr8_-_819232380.154.0e-02Click!
Smad7chr18_+_755270150.111.3e-01Click!
Smad3chr9_-_636057450.101.6e-01Click!
Smad4chr18_-_738633810.101.9e-01Click!
Smad9chr3_+_54559503-0.046.0e-01Click!
Smad6chr9_-_63868311-0.037.3e-01Click!
Smad5chr13_+_568043700.019.1e-01Click!


Activity profile for motif SMAD1..7,9.p2.

activity profile for motif SMAD1..7,9.p2


Sorted Z-values histogram for motif SMAD1..7,9.p2

Sorted Z-values for motif SMAD1..7,9.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD1..7,9.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_55233354 12.264 Sparc
secreted acidic cysteine rich glycoprotein
chr11_-_64976408 11.198 NM_001099288
NM_175003
Arhgap44

Rho GTPase activating protein 44

chr7_+_138122822 10.921 Htra1
HtrA serine peptidase 1
chr17_+_43526389 10.580 NM_001081178
Gpr116
G protein-coupled receptor 116
chr2_+_136539202 10.404 Snap25
synaptosomal-associated protein 25
chr11_-_55233581 10.304 NM_009242
Sparc
secreted acidic cysteine rich glycoprotein
chrX_+_10173557 10.159


chr16_+_96689206 9.825 NM_008791
Pcp4
Purkinje cell protein 4
chr1_+_75356913 9.797 NM_010043
Des
desmin
chr2_+_136539143 9.526 NM_011428
Snap25
synaptosomal-associated protein 25
chr8_-_126418628 9.332 NM_009606
Acta1
actin, alpha 1, skeletal muscle
chr1_+_75356906 8.764 Des
desmin
chr11_-_55233366 8.423 Sparc
secreted acidic cysteine rich glycoprotein
chr2_-_127481868 8.145 Mal
myelin and lymphocyte protein, T-cell differentiation protein
chr7_+_19996439 8.143 NM_007710
Ckm
creatine kinase, muscle
chr2_-_151458299 8.027 Snph
syntaphilin
chr6_-_92484838 7.679 NM_001134459
Prickle2
prickle homolog 2 (Drosophila)
chr11_-_55233339 7.496 Sparc
secreted acidic cysteine rich glycoprotein
chr12_+_80130149 7.431 NM_181073
Plekhh1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr7_-_149276174 7.232 NM_008748
Dusp8
dual specificity phosphatase 8

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 48 entries
Enrichment   P-value GO Accession GO Term
4.06 1.65e-03 GO:0007269 neurotransmitter secretion
3.38 3.07e-04 GO:0001505 regulation of neurotransmitter levels
3.04 1.75e-04 GO:0035023 regulation of Rho protein signal transduction
2.70 3.56e-02 GO:0006836 neurotransmitter transport
2.34 7.53e-06 GO:0007268 synaptic transmission
2.26 5.91e-07 GO:0019226 transmission of nerve impulse
2.26 5.91e-07 GO:0035637 multicellular organismal signaling
2.15 5.96e-03 GO:0046578 regulation of Ras protein signal transduction
2.09 4.63e-03 GO:0051056 regulation of small GTPase mediated signal transduction
2.01 2.09e-02 GO:0048514 blood vessel morphogenesis
1.96 7.31e-04 GO:0007167 enzyme linked receptor protein signaling pathway
1.95 2.03e-02 GO:0007264 small GTPase mediated signal transduction
1.90 8.56e-03 GO:0001944 vasculature development
1.88 9.97e-04 GO:0007267 cell-cell signaling
1.86 2.22e-02 GO:0031175 neuron projection development
1.85 6.81e-03 GO:0048729 tissue morphogenesis
1.83 4.47e-03 GO:0044057 regulation of system process
1.83 1.19e-02 GO:0051960 regulation of nervous system development
1.78 1.57e-02 GO:0060284 regulation of cell development
1.77 4.57e-05 GO:0007154 cell communication

Gene overrepresentation in compartment category:

Showing 1 to 20 of 44 entries
Enrichment   P-value GO Accession GO Term
4.71 2.14e-05 GO:0043198 dendritic shaft
3.63 1.11e-02 GO:0042734 presynaptic membrane
3.16 3.17e-05 GO:0030017 sarcomere
2.97 3.10e-06 GO:0043292 contractile fiber
2.94 1.94e-05 GO:0030016 myofibril
2.83 3.79e-03 GO:0042383 sarcolemma
2.77 5.33e-04 GO:0044449 contractile fiber part
2.76 2.34e-02 GO:0043197 dendritic spine
2.68 3.43e-02 GO:0044309 neuron spine
2.66 1.60e-02 GO:0030427 site of polarized growth
2.62 3.07e-02 GO:0030426 growth cone
2.51 1.52e-09 GO:0030425 dendrite
2.44 3.90e-02 GO:0016327 apicolateral plasma membrane
2.41 1.81e-07 GO:0030424 axon
2.37 5.35e-03 GO:0033267 axon part
2.36 2.96e-16 GO:0043005 neuron projection
2.08 6.47e-06 GO:0044297 cell body
2.05 3.43e-05 GO:0043025 neuronal cell body
2.02 1.58e-06 GO:0044463 cell projection part
1.99 2.12e-07 GO:0045202 synapse

Gene overrepresentation in function category:

Showing 1 to 20 of 31 entries
Enrichment   P-value GO Accession GO Term
11.17 4.52e-02 GO:0005030 neurotrophin receptor activity
6.02 3.40e-02 GO:0030675 Rac GTPase activator activity
3.09 7.31e-03 GO:0005089 Rho guanyl-nucleotide exchange factor activity
3.06 2.87e-03 GO:0019199 transmembrane receptor protein kinase activity
3.03 2.98e-02 GO:0004714 transmembrane receptor protein tyrosine kinase activity
2.97 2.82e-03 GO:0005088 Ras guanyl-nucleotide exchange factor activity
2.44 2.65e-07 GO:0005083 small GTPase regulator activity
2.30 2.25e-02 GO:0022843 voltage-gated cation channel activity
2.24 2.46e-03 GO:0005244 voltage-gated ion channel activity
2.24 2.46e-03 GO:0022832 voltage-gated channel activity
1.90 3.42e-06 GO:0008092 cytoskeletal protein binding
1.85 2.38e-02 GO:0022836 gated channel activity
1.84 6.33e-04 GO:0060589 nucleoside-triphosphatase regulator activity
1.84 9.35e-04 GO:0030695 GTPase regulator activity
1.83 1.90e-02 GO:0003779 actin binding
1.69 2.62e-03 GO:0005509 calcium ion binding
1.61 3.95e-02 GO:0008324 cation transmembrane transporter activity
1.57 1.53e-03 GO:0022891 substrate-specific transmembrane transporter activity
1.56 8.06e-03 GO:0015075 ion transmembrane transporter activity
1.51 3.49e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor