Motif ID: SNAI1..3.p2

Z-value: 3.087


Transcription factors associated with SNAI1..3.p2:

Gene SymbolEntrez IDGene Name
Snai1 20613 snail homolog 1 (Drosophila)
Snai2 20583 snail homolog 2 (Drosophila)
Snai3 30927 snail homolog 3 (Drosophila)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Snai1chr2_+_167363696,
chr2_+_167363769		-0.402.6e-08Click!
Snai3chr8_-_124984513-0.153.8e-02Click!
Snai2chr16_+_14705932-0.129.9e-02Click!


Activity profile for motif SNAI1..3.p2.

activity profile for motif SNAI1..3.p2


Sorted Z-values histogram for motif SNAI1..3.p2

Sorted Z-values for motif SNAI1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SNAI1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_69778907 105.323 NM_016887
 Cldn7
claudin 7
chr11_+_69778998 94.841 Cldn7
claudin 7
chr7_-_30066867 81.075 Spint2
serine protease inhibitor, Kunitz type 2
chr7_-_30066910 80.944 NM_001082548
NM_011464
 Spint2

serine protease inhibitor, Kunitz type 2

chr7_-_30066642 79.335 Spint2
serine protease inhibitor, Kunitz type 2
chr15_+_54402914 71.308 NM_178920
 Mal2
mal, T-cell differentiation protein 2
chr15_+_54402988 57.946 Mal2
mal, T-cell differentiation protein 2
chr12_-_74647339 48.321 NM_178715
 Tmem30b
transmembrane protein 30B
chr13_-_101322672 47.759 Ocln
occludin
chr13_-_101322557 47.544 Ocln
occludin
chr13_-_101322416 45.767 NM_008756
 Ocln
occludin
chr8_+_109127326 44.275 Cdh1
cadherin 1
chr11_+_115685417 41.742 Llgl2
lethal giant larvae homolog 2 (Drosophila)
chr4_-_11313886 41.551 NM_194055
 Esrp1
epithelial splicing regulatory protein 1
chr2_+_119063194 41.061


chr11_+_115685365 39.790 NM_145438
 Llgl2
lethal giant larvae homolog 2 (Drosophila)
chr1_+_137715174 38.435 NM_133664
 Lad1
ladinin
chr1_+_137715339 37.412 Lad1
ladinin
chr9_-_30939272 36.853 St14
suppression of tumorigenicity 14 (colon carcinoma)
chr2_+_167906462 36.526 NM_021409
 Pard6b
par-6 (partitioning defective 6) homolog beta (C. elegans)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 156 entries
Enrichment   P-value GO Accession GO Term
3.94 1.82e-03 GO:0015988 energy coupled proton transport, against electrochemical gradient
3.94 1.82e-03 GO:0015991 ATP hydrolysis coupled proton transport
3.64 3.20e-03 GO:0015682 ferric iron transport
3.64 3.20e-03 GO:0033572 transferrin transport
3.51 6.50e-04 GO:0034976 response to endoplasmic reticulum stress
3.31 3.42e-02 GO:0007044 cell-substrate junction assembly
3.27 1.75e-04 GO:0034329 cell junction assembly
3.16 1.09e-04 GO:0006826 iron ion transport
2.97 2.86e-05 GO:0034330 cell junction organization
2.69 2.99e-03 GO:0048565 digestive tract development
2.66 5.76e-04 GO:0055123 digestive system development
2.64 3.11e-02 GO:0006518 peptide metabolic process
2.64 3.11e-02 GO:0006754 ATP biosynthetic process
2.63 2.97e-05 GO:0000041 transition metal ion transport
2.60 1.59e-02 GO:0006818 hydrogen transport
2.54 4.22e-02 GO:0015992 proton transport
2.51 2.13e-02 GO:0046890 regulation of lipid biosynthetic process
2.49 7.64e-03 GO:0016485 protein processing
2.36 1.69e-02 GO:0051604 protein maturation
2.31 4.06e-02 GO:0071216 cellular response to biotic stimulus

Gene overrepresentation in compartment category:

Showing 1 to 20 of 85 entries
Enrichment   P-value GO Accession GO Term
3.14 2.80e-03 GO:0016469 proton-transporting two-sector ATPase complex
3.11 1.18e-02 GO:0005793 ER-Golgi intermediate compartment
2.92 1.40e-08 GO:0016327 apicolateral plasma membrane
2.84 1.21e-07 GO:0043296 apical junction complex
2.72 1.03e-05 GO:0005923 tight junction
2.72 1.03e-05 GO:0070160 occluding junction
2.67 2.21e-02 GO:0005913 cell-cell adherens junction
2.60 2.20e-02 GO:0030176 integral to endoplasmic reticulum membrane
2.51 2.60e-11 GO:0016324 apical plasma membrane
2.43 2.76e-02 GO:0005903 brush border
2.34 1.19e-02 GO:0001726 ruffle
2.32 5.54e-12 GO:0045177 apical part of cell
2.31 3.12e-02 GO:0031227 intrinsic to endoplasmic reticulum membrane
2.22 1.14e-04 GO:0005912 adherens junction
2.22 2.28e-04 GO:0031301 integral to organelle membrane
2.21 4.91e-09 GO:0005911 cell-cell junction
2.21 2.57e-03 GO:0031253 cell projection membrane
2.14 1.63e-04 GO:0031300 intrinsic to organelle membrane
2.10 8.36e-09 GO:0005789 endoplasmic reticulum membrane
2.09 5.71e-09 GO:0042175 nuclear membrane-endoplasmic reticulum network

Gene overrepresentation in function category:

Showing 1 to 20 of 46 entries
Enrichment   P-value GO Accession GO Term
5.98 9.83e-03 GO:0050998 nitric-oxide synthase binding
4.23 8.68e-04 GO:0019829 cation-transporting ATPase activity
3.19 2.82e-02 GO:0046915 transition metal ion transmembrane transporter activity
2.65 2.80e-03 GO:0042625 ATPase activity, coupled to transmembrane movement of ions
2.55 2.64e-07 GO:0046873 metal ion transmembrane transporter activity
2.44 1.49e-10 GO:0022890 inorganic cation transmembrane transporter activity
2.37 8.30e-03 GO:0015078 hydrogen ion transmembrane transporter activity
2.18 7.63e-05 GO:0015077 monovalent inorganic cation transmembrane transporter activity
2.15 3.02e-02 GO:0030165 PDZ domain binding
2.13 3.78e-02 GO:0043492 ATPase activity, coupled to movement of substances
2.11 2.37e-05 GO:0015291 secondary active transmembrane transporter activity
2.05 1.23e-02 GO:0015293 symporter activity
2.03 5.00e-07 GO:0005083 small GTPase regulator activity
1.99 4.83e-08 GO:0022804 active transmembrane transporter activity
1.85 1.54e-05 GO:0003779 actin binding
1.85 1.59e-04 GO:0048037 cofactor binding
1.84 8.94e-08 GO:0008289 lipid binding
1.84 1.09e-02 GO:0005543 phospholipid binding
1.74 7.48e-08 GO:0008092 cytoskeletal protein binding
1.74 4.97e-02 GO:0008236 serine-type peptidase activity