Motif ID: SP1.p2

Z-value: 1.730


Transcription factors associated with SP1.p2:

Gene SymbolEntrez IDGene Name
Sp1 20683 trans-acting transcription factor 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp1chr15_+_1022367090.417.4e-09Click!


Activity profile for motif SP1.p2.

activity profile for motif SP1.p2


Sorted Z-values histogram for motif SP1.p2

Sorted Z-values for motif SP1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SP1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_24393435 20.146 NM_178665
 Lpp
LIM domain containing preferred translocation partner in lipoma
chr2_-_76486033 18.493 NM_011871
 Prkra
protein kinase, interferon inducible double stranded RNA dependent activator
chr3_+_21975544 18.102 NM_030732
 Tbl1xr1
transducin (beta)-like 1X-linked receptor 1
chr16_-_22163035 17.545 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr15_+_102236709 17.535 NM_013672
 Sp1
trans-acting transcription factor 1
chr1_-_155179844 17.290 NM_010683
 Lamc1
laminin, gamma 1
chr2_-_76486065 16.009 Prkra
protein kinase, interferon inducible double stranded RNA dependent activator
chr4_-_40800983 15.159 B4galt1
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
chr4_-_16090542 15.092 NM_138952
 Ripk2
receptor (TNFRSF)-interacting serine-threonine kinase 2
chr4_-_106925932 15.032 Lrrc42
leucine rich repeat containing 42
chr17_+_31701700 14.893 NM_016670
 Pknox1
Pbx/knotted 1 homeobox
chr4_-_106926041 14.304 NM_029985
 Lrrc42
leucine rich repeat containing 42
chr1_-_82287990 13.993 NM_010570
 Irs1
insulin receptor substrate 1
chr2_-_26788845 13.848 Surf4
surfeit gene 4
chr19_+_7049639 13.824 Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr6_+_42299820 13.789 NM_011777
 Zyx
zyxin
chr19_+_7049425 13.572 NM_008889
 Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr17_+_35196041 13.504 Ddah2
dimethylarginine dimethylaminohydrolase 2
chr17_-_71201055 13.434 NM_001164075
 Tgif1
TGFB-induced factor homeobox 1
chr4_-_134828699 13.281 Clic4
chloride intracellular channel 4 (mitochondrial)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 399 entries
Enrichment   P-value GO Accession GO Term
2.01 1.69e-02 GO:0048146 positive regulation of fibroblast proliferation
1.96 4.09e-02 GO:0045216 cell-cell junction organization
1.94 2.44e-02 GO:0042733 embryonic digit morphogenesis
1.88 1.87e-02 GO:0060349 bone morphogenesis
1.85 4.83e-05 GO:0009953 dorsal/ventral pattern formation
1.84 2.27e-02 GO:0048145 regulation of fibroblast proliferation
1.80 1.93e-04 GO:0030178 negative regulation of Wnt receptor signaling pathway
1.77 1.69e-02 GO:0009798 axis specification
1.77 2.91e-02 GO:0014020 primary neural tube formation
1.74 7.49e-04 GO:0010563 negative regulation of phosphorus metabolic process
1.74 7.49e-04 GO:0045936 negative regulation of phosphate metabolic process
1.73 5.49e-05 GO:0016331 morphogenesis of embryonic epithelium
1.73 1.88e-02 GO:0016573 histone acetylation
1.73 1.88e-02 GO:0034330 cell junction organization
1.72 1.92e-02 GO:0006475 internal protein amino acid acetylation
1.72 1.92e-02 GO:0018393 internal peptidyl-lysine acetylation
1.72 3.29e-02 GO:0009411 response to UV
1.71 1.66e-04 GO:0030326 embryonic limb morphogenesis
1.71 1.66e-04 GO:0035113 embryonic appendage morphogenesis
1.71 3.92e-03 GO:0042326 negative regulation of phosphorylation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 91 entries
Enrichment   P-value GO Accession GO Term
2.65 2.52e-03 GO:0016581 NuRD complex
2.46 2.29e-02 GO:0000932 cytoplasmic mRNA processing body
2.37 3.59e-03 GO:0031519 PcG protein complex
2.16 3.07e-05 GO:0000118 histone deacetylase complex
2.09 1.41e-03 GO:0005793 ER-Golgi intermediate compartment
2.02 1.04e-04 GO:0017053 transcriptional repressor complex
1.90 4.28e-02 GO:0005834 heterotrimeric G-protein complex
1.87 9.60e-05 GO:0000123 histone acetyltransferase complex
1.82 1.04e-07 GO:0019898 extrinsic to membrane
1.82 7.34e-05 GO:0019897 extrinsic to plasma membrane
1.80 2.13e-03 GO:0034708 methyltransferase complex
1.80 2.13e-03 GO:0035097 histone methyltransferase complex
1.79 3.42e-02 GO:0005913 cell-cell adherens junction
1.79 3.42e-02 GO:0042641 actomyosin
1.77 9.32e-05 GO:0016585 chromatin remodeling complex
1.70 1.16e-04 GO:0000790 nuclear chromatin
1.65 2.76e-03 GO:0009898 internal side of plasma membrane
1.62 9.08e-04 GO:0005769 early endosome
1.60 1.01e-04 GO:0005912 adherens junction
1.56 4.96e-02 GO:0005802 trans-Golgi network

Gene overrepresentation in function category:

Showing 1 to 20 of 77 entries
Enrichment   P-value GO Accession GO Term
1.75 4.24e-02 GO:0046332 SMAD binding
1.71 1.55e-02 GO:0016407 acetyltransferase activity
1.65 1.90e-03 GO:0003714 transcription corepressor activity
1.64 6.35e-09 GO:0010843 promoter binding
1.62 9.51e-09 GO:0000975 regulatory region DNA binding
1.62 9.51e-09 GO:0001067 regulatory region nucleic acid binding
1.62 9.51e-09 GO:0044212 transcription regulatory region DNA binding
1.61 2.47e-02 GO:0005099 Ras GTPase activator activity
1.61 4.13e-02 GO:0008017 microtubule binding
1.59 1.56e-03 GO:0017124 SH3 domain binding
1.58 6.18e-12 GO:0008134 transcription factor binding
1.54 3.85e-11 GO:0016563 transcription activator activity
1.54 3.93e-06 GO:0003682 chromatin binding
1.54 5.07e-03 GO:0051020 GTPase binding
1.54 1.60e-02 GO:0031267 small GTPase binding
1.53 4.57e-10 GO:0016564 transcription repressor activity
1.50 4.10e-06 GO:0000989 transcription factor binding transcription factor activity
1.50 6.22e-06 GO:0003712 transcription cofactor activity
1.49 1.14e-02 GO:0003690 double-stranded DNA binding
1.48 3.78e-14 GO:0019904 protein domain specific binding