Motif ID: SPI1.p2

Z-value: 4.314


Transcription factors associated with SPI1.p2:

Gene SymbolEntrez IDGene Name
Sfpi1 20375 SFFV proviral integration 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sfpi1chr2_+_909368450.831.5e-47Click!


Activity profile for motif SPI1.p2.

activity profile for motif SPI1.p2


Sorted Z-values histogram for motif SPI1.p2

Sorted Z-values for motif SPI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPI1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_78075220 100.253 NM_008677
 Ncf4
neutrophil cytosolic factor 4
chr17_+_34726750 76.746 NM_134116
 Gpsm3
G-protein signalling modulator 3 (AGS3-like, C. elegans)
chr17_+_34727032 69.542 Gpsm3
G-protein signalling modulator 3 (AGS3-like, C. elegans)
chr11_-_16908631 63.096 NM_019549
 Plek
pleckstrin
chr15_-_102062309 59.277 Itgb7
integrin beta 7
chr11_-_69479553 54.821 NM_009853
 Cd68
CD68 antigen
chr3_-_106592919 53.996 NM_007651
 Cd53
CD53 antigen
chr19_-_6932673 53.462 NM_001081291
 Ccdc88b
coiled-coil domain containing 88B
chr15_+_103284200 53.001 NM_153505
 Nckap1l
NCK associated protein 1 like
chrX_-_20508314 52.823 Cfp
complement factor properdin
chr1_-_173164404 52.173 NM_010185
 Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr7_-_52494453 51.119 Cd37
CD37 antigen
chr6_+_145070255 50.793 NM_008511
 Lrmp
lymphoid-restricted membrane protein
chrX_-_7667574 50.291 NM_009515
 Was
Wiskott-Aldrich syndrome homolog (human)
chr9_-_57492978 48.465 NM_007783
 Csk
c-src tyrosine kinase
chrX_-_98463514 48.264 NM_013563
 Il2rg
interleukin 2 receptor, gamma chain
chr7_+_133728483 46.882 NM_138310
 Apobr
apolipoprotein B receptor
chr15_-_102062331 46.853 NM_013566
 Itgb7
integrin beta 7
chr11_-_79337178 46.154 Evi2b
ecotropic viral integration site 2b
chr2_+_92024338 44.800 NM_138755
 Phf21a
PHD finger protein 21A

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 295 entries
Enrichment   P-value GO Accession GO Term
3.41 4.27e-02 GO:0002286 T cell activation involved in immune response
3.41 4.27e-02 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
3.15 1.57e-03 GO:0019884 antigen processing and presentation of exogenous antigen
3.08 6.99e-05 GO:0002285 lymphocyte activation involved in immune response
3.08 2.89e-04 GO:0046631 alpha-beta T cell activation
3.03 1.56e-02 GO:0046632 alpha-beta T cell differentiation
2.87 2.46e-02 GO:0002200 somatic diversification of immune receptors
2.86 1.04e-03 GO:0048002 antigen processing and presentation of peptide antigen
2.71 2.23e-05 GO:0019882 antigen processing and presentation
2.68 1.65e-02 GO:0002260 lymphocyte homeostasis
2.65 1.13e-02 GO:0001776 leukocyte homeostasis
2.60 3.05e-02 GO:0050764 regulation of phagocytosis
2.59 2.50e-03 GO:0030183 B cell differentiation
2.51 2.05e-03 GO:0050851 antigen receptor-mediated signaling pathway
2.49 9.46e-04 GO:0000082 G1/S transition of mitotic cell cycle
2.47 4.36e-04 GO:0002263 cell activation involved in immune response
2.47 4.36e-04 GO:0002366 leukocyte activation involved in immune response
2.43 1.93e-02 GO:0002573 myeloid leukocyte differentiation
2.37 2.15e-02 GO:0030595 leukocyte chemotaxis
2.37 3.20e-02 GO:0032943 mononuclear cell proliferation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 51 entries
Enrichment   P-value GO Accession GO Term
4.07 4.24e-07 GO:0031519 PcG protein complex
4.04 2.44e-02 GO:0035098 ESC/E(Z) complex
2.40 2.12e-02 GO:0000118 histone deacetylase complex
2.18 2.62e-02 GO:0005884 actin filament
1.97 1.32e-03 GO:0000790 nuclear chromatin
1.91 2.62e-02 GO:0016585 chromatin remodeling complex
1.78 9.13e-06 GO:0000785 chromatin
1.76 2.31e-05 GO:0000228 nuclear chromosome
1.75 2.26e-03 GO:0005938 cell cortex
1.74 6.83e-03 GO:0016604 nuclear body
1.73 3.54e-04 GO:0044454 nuclear chromosome part
1.72 5.51e-05 GO:0009897 external side of plasma membrane
1.69 1.12e-03 GO:0005635 nuclear envelope
1.66 6.80e-15 GO:0044451 nucleoplasm part
1.65 1.72e-22 GO:0005654 nucleoplasm
1.62 1.55e-08 GO:0005694 chromosome
1.60 3.34e-07 GO:0044427 chromosomal part
1.58 2.01e-33 GO:0044428 nuclear part
1.57 1.44e-25 GO:0031981 nuclear lumen
1.57 3.18e-03 GO:0000323 lytic vacuole

Gene overrepresentation in function category:

Showing 1 to 20 of 62 entries
Enrichment   P-value GO Accession GO Term
2.45 1.60e-02 GO:0042379 chemokine receptor binding
2.40 3.97e-02 GO:0004715 non-membrane spanning protein tyrosine kinase activity
2.05 3.01e-03 GO:0035257 nuclear hormone receptor binding
1.97 1.80e-02 GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
1.90 4.58e-02 GO:0005099 Ras GTPase activator activity
1.89 1.03e-11 GO:0008134 transcription factor binding
1.88 4.24e-07 GO:0003682 chromatin binding
1.87 2.57e-02 GO:0051427 hormone receptor binding
1.84 1.23e-06 GO:0000975 regulatory region DNA binding
1.84 1.23e-06 GO:0001067 regulatory region nucleic acid binding
1.84 1.23e-06 GO:0044212 transcription regulatory region DNA binding
1.83 2.02e-10 GO:0016564 transcription repressor activity
1.82 7.74e-06 GO:0010843 promoter binding
1.78 3.96e-03 GO:0003690 double-stranded DNA binding
1.77 3.00e-09 GO:0016563 transcription activator activity
1.75 7.76e-05 GO:0005096 GTPase activator activity
1.71 1.09e-16 GO:0043565 sequence-specific DNA binding
1.69 8.13e-04 GO:0043566 structure-specific DNA binding
1.68 3.01e-22 GO:0030528 transcription regulator activity
1.65 1.42e-02 GO:0005126 cytokine receptor binding