Motif ID: SPIB.p2

Z-value: 5.102


Transcription factors associated with SPIB.p2:

Gene SymbolEntrez IDGene Name
Spib 272382 Spi-B transcription factor (Spi-1/PU.1 related)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spibchr7_-_517874400.538.4e-15Click!


Activity profile for motif SPIB.p2.

activity profile for motif SPIB.p2


Sorted Z-values histogram for motif SPIB.p2

Sorted Z-values for motif SPIB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPIB.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_7667574 148.775 NM_009515
 Was
Wiskott-Aldrich syndrome homolog (human)
chrX_-_98463514 115.469 NM_013563
 Il2rg
interleukin 2 receptor, gamma chain
chr15_+_103284200 108.781 NM_153505
 Nckap1l
NCK associated protein 1 like
chr11_+_33946927 104.727 Lcp2
lymphocyte cytosolic protein 2
chr6_-_136889984 100.687 Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr7_-_52494453 97.591 Cd37
CD37 antigen
chr6_-_136890189 95.027 NM_007486
 Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr17_+_34727032 91.535 Gpsm3
G-protein signalling modulator 3 (AGS3-like, C. elegans)
chr12_+_99506844 88.519 NM_008152
 Gpr65
G-protein coupled receptor 65
chr19_+_10917326 83.710 Slc15a3
solute carrier family 15, member 3
chr7_-_3671918 70.563 NM_011095
 Lilrb3
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
chr19_+_10917005 70.467 NM_023044
 Slc15a3
solute carrier family 15, member 3
chr1_-_173164404 66.566 NM_010185
 Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr5_+_150076605 66.030 NM_009663
 Alox5ap
arachidonate 5-lipoxygenase activating protein
chr17_+_34726750 65.044 NM_134116
 Gpsm3
G-protein signalling modulator 3 (AGS3-like, C. elegans)
chr7_+_133728451 64.566 Apobr
apolipoprotein B receptor
chr11_+_33947115 63.862 NM_010696
 Lcp2
lymphocyte cytosolic protein 2
chr17_+_36003527 63.316 NM_175242
 2310014H01Rik
RIKEN cDNA 2310014H01 gene
chr7_+_29225955 61.885 NM_001039192
 Gmfg
glia maturation factor, gamma
chr2_+_90936845 59.993 NM_011355
 Sfpi1
SFFV proviral integration 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 275 entries
Enrichment   P-value GO Accession GO Term
3.67 1.88e-02 GO:0001562 response to protozoan
3.67 1.88e-02 GO:0042832 defense response to protozoan
3.53 1.46e-02 GO:0009620 response to fungus
3.06 3.94e-02 GO:0046632 alpha-beta T cell differentiation
3.02 8.12e-04 GO:0002260 lymphocyte homeostasis
3.01 2.62e-02 GO:0019884 antigen processing and presentation of exogenous antigen
2.99 5.41e-04 GO:0001776 leukocyte homeostasis
2.94 7.53e-07 GO:0002274 myeloid leukocyte activation
2.94 3.48e-05 GO:0002573 myeloid leukocyte differentiation
2.91 4.89e-08 GO:0002756 MyD88-independent toll-like receptor signaling pathway
2.80 9.17e-03 GO:0048002 antigen processing and presentation of peptide antigen
2.74 2.46e-03 GO:0050830 defense response to Gram-positive bacterium
2.67 2.82e-03 GO:0071222 cellular response to lipopolysaccharide
2.65 1.65e-15 GO:0002764 immune response-regulating signaling pathway
2.65 3.00e-05 GO:0002768 immune response-regulating cell surface receptor signaling pathway
2.63 1.35e-07 GO:0002224 toll-like receptor signaling pathway
2.63 1.35e-07 GO:0042113 B cell activation
2.62 1.84e-14 GO:0002757 immune response-activating signal transduction
2.61 1.49e-08 GO:0002218 activation of innate immune response
2.61 3.60e-08 GO:0002221 pattern recognition receptor signaling pathway

Gene overrepresentation in compartment category:

Showing 1 to 20 of 38 entries
Enrichment   P-value GO Accession GO Term
2.12 1.68e-04 GO:0000790 nuclear chromatin
2.06 2.70e-10 GO:0009897 external side of plasma membrane
1.94 1.81e-04 GO:0005681 spliceosomal complex
1.70 2.74e-03 GO:0044454 nuclear chromosome part
1.69 6.37e-03 GO:0031252 cell leading edge
1.63 4.72e-03 GO:0000785 chromatin
1.61 1.09e-02 GO:0000228 nuclear chromosome
1.60 1.83e-07 GO:0030529 ribonucleoprotein complex
1.56 4.01e-15 GO:0005654 nucleoplasm
1.56 1.04e-03 GO:0005667 transcription factor complex
1.55 4.51e-06 GO:0009986 cell surface
1.52 3.67e-08 GO:0044451 nucleoplasm part
1.50 8.62e-18 GO:0031981 nuclear lumen
1.49 1.08e-21 GO:0044428 nuclear part
1.49 2.01e-04 GO:0005694 chromosome
1.48 8.09e-04 GO:0044427 chromosomal part
1.48 2.46e-03 GO:0005730 nucleolus
1.40 1.14e-13 GO:0043233 organelle lumen
1.40 1.31e-13 GO:0070013 intracellular organelle lumen
1.39 4.71e-13 GO:0031974 membrane-enclosed lumen

Gene overrepresentation in function category:

Showing 1 to 20 of 53 entries
Enrichment   P-value GO Accession GO Term
4.14 1.48e-03 GO:0016493 C-C chemokine receptor activity
3.84 5.61e-03 GO:0019957 C-C chemokine binding
3.73 7.09e-05 GO:0001637 G-protein chemoattractant receptor activity
3.73 7.09e-05 GO:0004950 chemokine receptor activity
3.47 1.60e-04 GO:0019956 chemokine binding
2.67 1.77e-02 GO:0035586 purinergic receptor activity
2.30 2.49e-06 GO:0019955 cytokine binding
2.00 4.54e-02 GO:0005057 receptor signaling protein activity
1.82 1.36e-04 GO:0004842 ubiquitin-protein ligase activity
1.81 4.14e-05 GO:0003682 chromatin binding
1.79 1.27e-04 GO:0019787 small conjugating protein ligase activity
1.75 1.92e-07 GO:0016564 transcription repressor activity
1.73 8.68e-07 GO:0008134 transcription factor binding
1.71 9.20e-04 GO:0005096 GTPase activator activity
1.69 2.93e-05 GO:0046982 protein heterodimerization activity
1.69 1.18e-02 GO:0005126 cytokine receptor binding
1.67 4.51e-03 GO:0043566 structure-specific DNA binding
1.65 2.45e-12 GO:0043565 sequence-specific DNA binding
1.65 2.91e-03 GO:0016881 acid-amino acid ligase activity
1.63 2.63e-05 GO:0016563 transcription activator activity