Motif ID: SPZ1.p2

Z-value: 1.285


Transcription factors associated with SPZ1.p2:

Gene SymbolEntrez IDGene Name
Spz1 79401 spermatogenic leucine zipper 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spz1chr13_-_933461260.121.2e-01Click!


Activity profile for motif SPZ1.p2.

activity profile for motif SPZ1.p2


Sorted Z-values histogram for motif SPZ1.p2

Sorted Z-values for motif SPZ1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPZ1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_73509668 13.015 Rtn1
reticulon 1
chr12_-_73509537 11.675 Rtn1
reticulon 1
chr14_+_66587319 10.656 NM_013492
Clu
clusterin
chr15_+_91881593 10.069 NM_001159648
Cntn1
contactin 1
chr4_+_129662284 9.334 NM_173071
Bai2
brain-specific angiogenesis inhibitor 2
chr4_+_104040160 8.583 NM_010014
NM_177259
Dab1

disabled homolog 1 (Drosophila)

chr9_-_29219382 8.122 Ntm
neurotrimin
chr9_-_86775282 8.032 Snap91
synaptosomal-associated protein 91
chr10_-_108447894 7.911 Syt1
synaptotagmin I
chr9_-_86775154 7.819 NM_013669
Snap91
synaptosomal-associated protein 91
chr11_+_98629709 7.657


chr2_+_28048779 7.515 Olfm1
olfactomedin 1
chr10_-_108448003 6.976 Syt1
synaptotagmin I
chr4_+_129662110 6.972 Bai2
brain-specific angiogenesis inhibitor 2
chr6_-_119280616 6.865 NM_172492
Lrtm2
leucine-rich repeats and transmembrane domains 2
chr14_-_55734213 6.654 NM_001003829
Jph4
junctophilin 4
chr4_-_41587115 6.640 Enho
energy homeostasis associated
chr6_-_113841295 6.534 Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chr7_+_53651811 6.517 NM_008421
NM_001112739
Kcnc1

potassium voltage gated channel, Shaw-related subfamily, member 1

chr9_-_44688946 6.319 Mll1
myeloid/lymphoid or mixed-lineage leukemia 1
chr5_+_74591336 6.225 NM_026878
Rasl11b
RAS-like, family 11, member B
chr7_-_88851823 6.126 Homer2
homer homolog 2 (Drosophila)
chr9_+_27598853 6.081 NM_177906
Opcml
opioid binding protein/cell adhesion molecule-like
chr1_-_84692352 6.057 Dner
delta/notch-like EGF-related receptor
chr13_-_49243351 6.052 NM_029361
Wnk2
WNK lysine deficient protein kinase 2
chr9_+_103014374 5.899 NM_173781
Rab6b
RAB6B, member RAS oncogene family
chr12_-_73509925 5.807 NM_153457
Rtn1
reticulon 1
chr6_-_113841356 5.772 NM_001036684
Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chr15_-_98637560 5.682 Ddn
dendrin
chr5_-_21850490 5.680 NM_011261
Reln
reelin
chr2_+_38206759 5.659 NM_010710
Lhx2
LIM homeobox protein 2
chr7_+_108469700 5.614 Stard10
START domain containing 10
chr11_-_69419330 5.534 Atp1b2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr2_-_115890247 5.493 NM_001159569
NM_001159570
Meis2

Meis homeobox 2

chr10_+_59569206 5.476 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr13_+_19040215 5.439 NM_175007
Amph
amphiphysin
chr5_+_34339258 5.433 Nat8l
N-acetyltransferase 8-like
chr6_+_77193078 5.402 Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr14_-_55531726 5.374 NM_021551
Slc22a17
solute carrier family 22 (organic cation transporter), member 17
chr1_+_155500166 5.357 NM_026380
Rgs8
regulator of G-protein signaling 8
chr17_+_27792487 5.337 Pacsin1
protein kinase C and casein kinase substrate in neurons 1
chr12_+_101447480 5.302 Calm1
calmodulin 1
chrX_+_5624624 5.261 NM_021431
Nudt11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr16_-_20621287 5.139 NM_028420
Camk2n2
calcium/calmodulin-dependent protein kinase II inhibitor 2
chr16_+_35154935 5.126 Adcy5
adenylate cyclase 5
chr6_-_77929685 5.099 Ctnna2
catenin (cadherin associated protein), alpha 2
chr2_+_38194775 5.098 Lhx2
LIM homeobox protein 2
chr18_+_36446680 5.025 Pura
purine rich element binding protein A
chr1_+_184695026 4.969 NM_144796
Susd4
sushi domain containing 4
chr7_-_147268150 4.916 NM_001190386
Caly
calcyon neuron-specific vesicular protein
chr7_-_134164627 4.914 NM_001102563
Prrt2
proline-rich transmembrane protein 2
chr12_+_91050912 4.877 Nrxn3
neurexin III
chr9_-_41932371 4.821 NM_011436
Sorl1
sortilin-related receptor, LDLR class A repeats-containing
chr17_-_57226987 4.765 NM_009451
Tubb4
tubulin, beta 4
chr4_-_25727109 4.750 NM_010243
Fut9
fucosyltransferase 9
chr12_-_46175433 4.739 NM_144552
Stxbp6
syntaxin binding protein 6 (amisyn)
chr9_-_41932195 4.699 Sorl1
sortilin-related receptor, LDLR class A repeats-containing
chr5_+_34339351 4.680 Nat8l
N-acetyltransferase 8-like
chr11_+_54117703 4.600 NM_001033597
NM_144823
Acsl6

acyl-CoA synthetase long-chain family member 6

chr14_-_55400722 4.599 NM_016972
Slc7a8
solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
chr1_+_129999868 4.542 NM_181750
R3hdm1
R3H domain 1 (binds single-stranded nucleic acids)
chr8_-_92872139 4.540 NM_172913
Tox3
TOX high mobility group box family member 3
chr19_+_3851772 4.391 NM_001025566
NM_013490
Chka

choline kinase alpha

chr13_+_43218207 4.333 NM_001005748
Phactr1
phosphatase and actin regulator 1
chr11_+_78136681 4.324 Aldoc
aldolase C, fructose-bisphosphate
chr2_+_28048592 4.306 NM_001038613
NM_001038614
Olfm1

olfactomedin 1

chr11_+_54128404 4.258 NM_001033599
Acsl6
acyl-CoA synthetase long-chain family member 6
chr7_+_137789668 4.253 Tacc2
transforming, acidic coiled-coil containing protein 2
chr2_-_127482430 4.252 NM_001171187
NM_010762
Mal

myelin and lymphocyte protein, T-cell differentiation protein

chr4_-_57002965 4.230 6430704M03Rik
RIKEN cDNA 6430704M03 gene
chr5_-_73729789 4.204 NM_026950
Ociad2
OCIA domain containing 2
chr16_-_23890909 4.184 NM_009215
Sst
somatostatin
chr2_-_165060352 4.175 Cdh22
cadherin 22
chr17_+_43938789 4.142 NM_207649
Rcan2
regulator of calcineurin 2
chrX_+_5624820 4.140 Nudt11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr8_-_108467294 4.112 NM_008490
Lcat
lecithin cholesterol acyltransferase
chr6_+_124959207 4.093 Zfp384
zinc finger protein 384
chr7_+_30088984 4.084 NM_013874
Dpf1
D4, zinc and double PHD fingers family 1
chr4_+_128820458 4.023 Fndc5
fibronectin type III domain containing 5
chr4_+_102432879 4.018 Sgip1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr16_+_41533317 4.018 NM_175548
Lsamp
limbic system-associated membrane protein
chr11_+_97258202 4.007 Socs7
suppressor of cytokine signaling 7
chr12_+_70342818 3.908 NM_178253
Klhdc1
kelch domain containing 1
chr11_+_97223739 3.905 Socs7
suppressor of cytokine signaling 7
chr4_-_133054355 3.875 NM_001081156
Trnp1
TMF1-regulated nuclear protein 1
chr7_+_52960585 3.836 NM_016974
Dbp
D site albumin promoter binding protein
chrX_-_7151340 3.828 Ppp1r3f
protein phosphatase 1, regulatory (inhibitor) subunit 3F
chr16_+_31428887 3.823 Bdh1
3-hydroxybutyrate dehydrogenase, type 1
chr4_+_137220675 3.793 Rap1gap
Rap1 GTPase-activating protein
chr10_+_34017221 3.769 NM_030203
Tspyl4
TSPY-like 4
chr8_-_108467275 3.725 Lcat
lecithin cholesterol acyltransferase
chr11_+_32183671 3.723 NM_001083955
NM_008218
Hba-a2
Hba-a1
hemoglobin alpha, adult chain 2
hemoglobin alpha, adult chain 1
chr6_+_4853319 3.718 NM_181595
Ppp1r9a
protein phosphatase 1, regulatory (inhibitor) subunit 9A
chr2_+_164312023 3.713 Dbndd2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr13_+_94074449 3.707 NM_011982
NM_147176
Homer1

homer homolog 1 (Drosophila)

chr9_-_83699706 3.681 NM_001145974
NM_148941
Elovl4

elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4

chr17_+_25707771 3.674 2810468N07Rik
RIKEN cDNA 2810468N07 gene
chr7_-_88851798 3.670 NM_001164086
NM_011983
Homer2

homer homolog 2 (Drosophila)

chr1_+_171585621 3.656 NM_009063
Rgs5
regulator of G-protein signaling 5
chr15_-_101834746 3.652 NM_031170
Krt8
keratin 8
chr9_+_103014279 3.641 Rab6b
RAB6B, member RAS oncogene family
chr1_+_75233276 3.627 NM_001159885
Dnajb2
DnaJ (Hsp40) homolog, subfamily B, member 2
chr6_-_77929543 3.623 Ctnna2
catenin (cadherin associated protein), alpha 2
chr1_-_84692750 3.614 NM_152915
Dner
delta/notch-like EGF-related receptor
chr1_-_134638361 3.609 NM_001160317
NM_182716
Nfasc

neurofascin

chr13_+_42775991 3.602 NM_198419
Phactr1
phosphatase and actin regulator 1
chr4_-_150503464 3.602 Camta1
calmodulin binding transcription activator 1
chr2_-_148558110 3.588 NM_019632
Napb
N-ethylmaleimide sensitive fusion protein attachment protein beta
chr11_+_68901989 3.584 Vamp2
vesicle-associated membrane protein 2
chr9_+_44947045 3.577 NM_001013390
Scn4b
sodium channel, type IV, beta
chr1_+_109258889 3.574 NM_025867
Serpinb11
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 11
chr3_-_89577134 3.567 4632404H12Rik
RIKEN cDNA 4632404H12 gene
chr7_+_134094045 3.565 NM_144926
Sez6l2
seizure related 6 homolog like 2
chr5_+_37633353 3.536 Crmp1
collapsin response mediator protein 1
chr17_-_57199207 3.534 NM_025877
Slc25a23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr4_-_122638401 3.526 NM_029662
Mfsd2a
major facilitator superfamily domain containing 2A
chr19_+_5689759 3.521 Map3k11
mitogen-activated protein kinase kinase kinase 11
chr2_+_155343804 3.515 Acss2
acyl-CoA synthetase short-chain family member 2
chr1_-_75274936 3.506 NM_009049
Resp18
regulated endocrine-specific protein 18
chr1_-_75274890 3.498 Resp18
regulated endocrine-specific protein 18
chr8_+_32200076 3.493 NM_025869
Dusp26
dual specificity phosphatase 26 (putative)
chr2_+_29658139 3.485 NM_011989
Slc27a4
solute carrier family 27 (fatty acid transporter), member 4
chr4_+_102432943 3.465 NM_144906
Sgip1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr10_+_122115755 3.450 NM_001110218
NM_176919
Ppm1h

protein phosphatase 1H (PP2C domain containing)

chr15_-_83936038 3.440 Sult4a1
sulfotransferase family 4A, member 1
chr5_-_31395853 3.438 NM_011773
Slc30a3
solute carrier family 30 (zinc transporter), member 3
chr2_-_180891448 3.426 Eef1a2
eukaryotic translation elongation factor 1 alpha 2
chr1_+_50984361 3.390 NM_019790
Tmeff2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr7_-_135073617 3.371 NM_133351
Prss8
protease, serine, 8 (prostasin)
chr11_+_102622885 3.368 Adam11
a disintegrin and metallopeptidase domain 11
chr18_-_31476527 3.362 Rit2
Ras-like without CAAX 2
chr15_-_98638230 3.359 Ddn
dendrin
chr8_+_65430028 3.349 NM_023689
Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr5_-_121161653 3.336 Dtx1
deltex 1 homolog (Drosophila)
chr9_+_108998083 3.335 Plxnb1
plexin B1
chr16_+_7069927 3.332 NM_183188
Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr19_+_47089168 3.323 NM_146100
Ina
internexin neuronal intermediate filament protein, alpha
chr4_-_124539414 3.319 NM_001007573
Maneal
mannosidase, endo-alpha-like
chr7_+_48154647 3.318 NM_021387
Vstm2b
V-set and transmembrane domain containing 2B
chr19_+_48280514 3.309 NM_025696
Sorcs3
sortilin-related VPS10 domain containing receptor 3
chr4_-_68615283 3.281 Dbc1
deleted in bladder cancer 1 (human)
chr5_+_34339551 3.277 Nat8l
N-acetyltransferase 8-like
chr6_+_53989925 3.272 NM_001163640
Chn2
chimerin (chimaerin) 2
chr7_-_104886507 3.270 Aqp11
aquaporin 11
chr15_-_101834744 3.256 Krt8
keratin 8
chr18_+_64425037 3.241 St8sia3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr12_+_81619976 3.201 NM_001081421
Galntl1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1
chr7_+_52960702 3.183 Dbp
D site albumin promoter binding protein
chr2_-_168567422 3.182 Atp9a
ATPase, class II, type 9A
chr7_-_25772525 3.181 Atp1a3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chr14_-_76956445 3.167 NM_001160326
Serp2
stress-associated endoplasmic reticulum protein family member 2
chr9_+_103014445 3.166 Rab6b
RAB6B, member RAS oncogene family
chr4_-_68615382 3.138 NM_019967
Dbc1
deleted in bladder cancer 1 (human)
chr9_-_35365985 3.136 NM_013932
Ddx25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr1_+_66515003 3.119 NM_175510
Unc80
unc-80 homolog (C. elegans)
chr7_-_135073600 3.113 Prss8
protease, serine, 8 (prostasin)
chr2_-_165060188 3.112 NM_174988
Cdh22
cadherin 22
chr7_-_30066867 3.104 Spint2
serine protease inhibitor, Kunitz type 2
chr2_+_149656518 3.084 NM_001085521
Tmem90b
transmembrane protein 90B
chr11_-_64976408 3.061 NM_001099288
NM_175003
Arhgap44

Rho GTPase activating protein 44

chr5_-_118694869 3.049 NM_172998
NM_001109902
Rnft2

ring finger protein, transmembrane 2

chr2_+_102498839 3.047 NM_001077514
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr7_-_31319977 3.021 NM_178252
Arhgap33
Rho GTPase activating protein 33
chr1_+_74379182 3.012 NM_019999
Pnkd
paroxysmal nonkinesiogenic dyskinesia
chr7_+_134716853 3.011 NM_026888
Phkg2
phosphorylase kinase, gamma 2 (testis)
chr4_+_122860705 3.009 NM_174998
Hpcal4
hippocalcin-like 4
chr12_+_3365295 3.001 Kif3c
kinesin family member 3C
chr18_-_31476721 3.001 NM_009065
Rit2
Ras-like without CAAX 2
chr1_+_194014650 3.000 Kcnh1
potassium voltage-gated channel, subfamily H (eag-related), member 1
chr5_-_123582394 2.998 Rhof
ras homolog gene family, member f
chr11_-_116442760 2.996 NM_173755
Ube2o
ubiquitin-conjugating enzyme E2O
chr7_-_31758185 2.994 Lsr
lipolysis stimulated lipoprotein receptor
chr1_+_34858612 2.992 Arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr7_-_26460133 2.992 Tmem91
transmembrane protein 91
chr14_-_46277816 2.992 NM_001039106
NM_001042719
NM_176845
Ddhd1


DDHD domain containing 1


chr11_-_98190774 2.990 NM_010895
Neurod2
neurogenic differentiation 2
chr5_-_53604673 2.986 NM_172710
Sel1l3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr3_-_108218411 2.982 NM_001004177
NM_017392
Celsr2

cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)

chr1_-_166388431 2.970 NM_009721
Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr17_-_46865894 2.970 Gnmt
glycine N-methyltransferase
chr11_-_70501586 2.968 NM_001190376
NM_001190378
NM_001190379
NM_178116
Camta2



calmodulin binding transcription activator 2



chr14_-_13655592 2.958 NM_001042617
NM_012061
Cadps

Ca2+-dependent secretion activator

chr4_-_25726753 2.945 Fut9
fucosyltransferase 9
chr16_+_96689373 2.943 Pcp4
Purkinje cell protein 4
chrX_-_149471740 2.942 NM_023788
Mageh1
melanoma antigen, family H, 1
chr5_-_44485951 2.938 NM_001163578
NM_001163581
NM_001163582
NM_001163583
NM_001163584
NM_001163585
Prom1





prominin 1





chr2_+_25251393 2.938 NM_009849
Entpd2
ectonucleoside triphosphate diphosphohydrolase 2
chr11_-_94902584 2.932 NM_133667
Pdk2
pyruvate dehydrogenase kinase, isoenzyme 2
chr9_+_103014463 2.930 Rab6b
RAB6B, member RAS oncogene family
chr18_-_39078304 2.928 NM_010197
Fgf1
fibroblast growth factor 1
chr7_-_135073577 2.927 Prss8
protease, serine, 8 (prostasin)
chr18_+_56591785 2.923 NM_026240
Gramd3
GRAM domain containing 3
chrX_-_103414967 2.913 Taf9b
TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr7_-_107806887 2.902 NM_001163183
NM_001163184
NM_001163185
Plekhb1


pleckstrin homology domain containing, family B (evectins) member 1


chr1_-_193220140 2.893


chr11_-_4847968 2.881 NM_010904
Nefh
neurofilament, heavy polypeptide
chr14_-_13655558 2.870 Cadps
Ca2+-dependent secretion activator
chr11_-_72303447 2.870 Spns2
spinster homolog 2 (Drosophila)
chr12_-_112910475 2.864 NM_021273
Ckb
creatine kinase, brain
chr11_+_87394543 2.864 Sept4
septin 4

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.59 3.54e-12 GO:0007399 nervous system development
1.38 1.53e-11 GO:0048731 system development
1.30 2.88e-10 GO:0051179 localization
1.34 2.90e-10 GO:0048856 anatomical structure development
1.33 1.41e-09 GO:0006810 transport
1.30 5.80e-09 GO:0007275 multicellular organismal development
1.32 7.58e-09 GO:0051234 establishment of localization
1.28 1.13e-08 GO:0032502 developmental process
1.58 1.86e-07 GO:0022008 neurogenesis
1.81 4.33e-07 GO:0048666 neuron development
1.71 5.64e-07 GO:0030182 neuron differentiation
1.90 7.22e-07 GO:0019226 transmission of nerve impulse
1.90 7.22e-07 GO:0035637 multicellular organismal signaling
1.34 8.06e-07 GO:0030154 cell differentiation
1.24 1.07e-06 GO:0080090 regulation of primary metabolic process
1.90 1.11e-06 GO:0031175 neuron projection development
1.33 1.60e-06 GO:0048869 cellular developmental process
1.88 2.16e-06 GO:0009894 regulation of catabolic process
1.27 2.18e-06 GO:0051171 regulation of nitrogen compound metabolic process
1.23 2.73e-06 GO:0031323 regulation of cellular metabolic process
1.55 2.95e-06 GO:0048699 generation of neurons
1.27 3.59e-06 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.96 1.44e-05 GO:0048812 neuron projection morphogenesis
1.15 3.11e-05 GO:0044237 cellular metabolic process
1.20 3.56e-05 GO:0019222 regulation of metabolic process
1.49 3.92e-05 GO:0048468 cell development
1.36 4.38e-05 GO:0023051 regulation of signaling
1.89 7.66e-05 GO:0007268 synaptic transmission
1.54 1.14e-04 GO:0007154 cell communication
1.63 1.15e-04 GO:0030030 cell projection organization
1.24 1.25e-04 GO:0016043 cellular component organization
1.85 1.61e-04 GO:0031329 regulation of cellular catabolic process
1.94 2.18e-04 GO:0007409 axonogenesis
1.55 2.53e-04 GO:0006812 cation transport
1.13 2.61e-04 GO:0044238 primary metabolic process
1.88 3.33e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.33 3.78e-04 GO:0065009 regulation of molecular function
1.46 5.53e-04 GO:0006811 ion transport
1.80 6.88e-04 GO:0006140 regulation of nucleotide metabolic process
1.23 7.71e-04 GO:0031326 regulation of cellular biosynthetic process
1.12 8.69e-04 GO:0008152 metabolic process
1.22 8.86e-04 GO:0009889 regulation of biosynthetic process
1.57 1.01e-03 GO:0030001 metal ion transport
1.26 1.04e-03 GO:0071842 cellular component organization at cellular level
1.63 1.10e-03 GO:0007267 cell-cell signaling
1.63 1.46e-03 GO:0044057 regulation of system process
1.24 2.57e-03 GO:0006355 regulation of transcription, DNA-dependent
1.65 2.71e-03 GO:0006163 purine nucleotide metabolic process
1.76 3.07e-03 GO:0009205 purine ribonucleoside triphosphate metabolic process
1.85 3.14e-03 GO:0046578 regulation of Ras protein signal transduction
1.29 3.18e-03 GO:0044281 small molecule metabolic process
1.27 3.58e-03 GO:0048513 organ development
1.61 3.58e-03 GO:0072521 purine-containing compound metabolic process
1.74 3.61e-03 GO:0009144 purine nucleoside triphosphate metabolic process
1.23 3.84e-03 GO:0051252 regulation of RNA metabolic process
1.37 3.85e-03 GO:0035556 intracellular signal transduction
2.12 3.95e-03 GO:0043087 regulation of GTPase activity
1.34 4.00e-03 GO:0033036 macromolecule localization
1.74 4.14e-03 GO:0009199 ribonucleoside triphosphate metabolic process
2.04 4.16e-03 GO:0030811 regulation of nucleotide catabolic process
2.04 4.16e-03 GO:0033121 regulation of purine nucleotide catabolic process
1.81 4.72e-03 GO:0031644 regulation of neurological system process
2.11 4.96e-03 GO:0033124 regulation of GTP catabolic process
1.89 5.00e-03 GO:0050804 regulation of synaptic transmission
1.45 5.12e-03 GO:0055085 transmembrane transport
1.72 5.63e-03 GO:0009141 nucleoside triphosphate metabolic process
1.68 6.48e-03 GO:0048858 cell projection morphogenesis
1.36 7.03e-03 GO:0006793 phosphorus metabolic process
1.28 7.24e-03 GO:0006464 protein modification process
1.67 7.39e-03 GO:0032990 cell part morphogenesis
1.68 7.43e-03 GO:0000904 cell morphogenesis involved in differentiation
1.54 8.01e-03 GO:0006753 nucleoside phosphate metabolic process
1.54 8.01e-03 GO:0009117 nucleotide metabolic process
1.18 8.10e-03 GO:0060255 regulation of macromolecule metabolic process
2.55 8.18e-03 GO:0009755 hormone-mediated signaling pathway
1.68 8.54e-03 GO:0009259 ribonucleotide metabolic process
1.19 8.74e-03 GO:0071840 cellular component organization or biogenesis
1.21 9.23e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.51 9.61e-03 GO:0055086 nucleobase, nucleoside and nucleotide metabolic process
2.82 1.19e-02 GO:0043401 steroid hormone mediated signaling pathway
1.75 1.26e-02 GO:0051056 regulation of small GTPase mediated signal transduction
1.81 1.27e-02 GO:0051969 regulation of transmission of nerve impulse
1.20 1.29e-02 GO:0048518 positive regulation of biological process
1.29 1.36e-02 GO:0051239 regulation of multicellular organismal process
1.35 1.38e-02 GO:0006796 phosphate metabolic process
2.66 1.43e-02 GO:0006754 ATP biosynthetic process
1.54 1.52e-02 GO:0044283 small molecule biosynthetic process
1.25 1.92e-02 GO:0065008 regulation of biological quality
1.66 1.94e-02 GO:0009150 purine ribonucleotide metabolic process
1.20 2.03e-02 GO:0010468 regulation of gene expression
2.44 2.12e-02 GO:0009142 nucleoside triphosphate biosynthetic process
1.20 2.64e-02 GO:0048522 positive regulation of cellular process
1.63 2.80e-02 GO:0015672 monovalent inorganic cation transport
1.44 3.29e-02 GO:0046483 heterocycle metabolic process
1.20 3.43e-02 GO:0010556 regulation of macromolecule biosynthetic process
1.86 3.52e-02 GO:0042391 regulation of membrane potential
1.36 3.59e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
1.33 3.72e-02 GO:0008104 protein localization
1.56 3.94e-02 GO:0007610 behavior
2.42 3.94e-02 GO:0009145 purine nucleoside triphosphate biosynthetic process
1.49 3.96e-02 GO:0044282 small molecule catabolic process
1.36 4.04e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.36 4.14e-02 GO:0022607 cellular component assembly
1.43 4.26e-02 GO:0048878 chemical homeostasis
1.51 4.30e-02 GO:0070271 protein complex biogenesis
1.39 4.35e-02 GO:0045893 positive regulation of transcription, DNA-dependent
1.33 4.63e-02 GO:0051641 cellular localization
2.09 4.67e-02 GO:0032318 regulation of Ras GTPase activity

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.31 3.64e-14 GO:0071944 cell periphery
1.30 1.71e-13 GO:0005886 plasma membrane
1.13 1.96e-13 GO:0005622 intracellular
1.85 1.15e-12 GO:0043005 neuron projection
1.12 7.94e-12 GO:0044424 intracellular part
1.89 9.72e-12 GO:0045202 synapse
1.16 2.15e-11 GO:0005737 cytoplasm
2.20 6.69e-11 GO:0030424 axon
1.53 7.57e-10 GO:0042995 cell projection
1.99 8.42e-10 GO:0044297 cell body
2.00 1.32e-09 GO:0043025 neuronal cell body
1.67 1.03e-08 GO:0030054 cell junction
1.92 2.72e-08 GO:0044456 synapse part
1.36 3.98e-08 GO:0044459 plasma membrane part
1.06 4.66e-07 GO:0005623 cell
1.06 4.66e-07 GO:0044464 cell part
1.11 2.96e-06 GO:0043226 organelle
1.11 6.08e-06 GO:0043229 intracellular organelle
2.29 8.94e-06 GO:0033267 axon part
1.15 1.55e-05 GO:0044444 cytoplasmic part
1.42 5.36e-05 GO:0005626 insoluble fraction
1.42 6.26e-05 GO:0005794 Golgi apparatus
1.43 7.66e-05 GO:0005624 membrane fraction
1.64 8.69e-05 GO:0044463 cell projection part
1.36 8.73e-05 GO:0000267 cell fraction
2.04 1.44e-04 GO:0045211 postsynaptic membrane
1.10 2.05e-04 GO:0043227 membrane-bounded organelle
1.44 3.37e-04 GO:0031982 vesicle
1.10 3.40e-04 GO:0043231 intracellular membrane-bounded organelle
1.73 3.77e-04 GO:0030425 dendrite
2.96 3.55e-03 GO:0042734 presynaptic membrane
1.09 4.00e-03 GO:0016020 membrane
2.74 4.66e-03 GO:0043204 perikaryon
1.39 8.46e-03 GO:0031410 cytoplasmic vesicle
1.17 3.05e-02 GO:0043234 protein complex
3.66 4.49e-02 GO:0080008 CUL4 RING ubiquitin ligase complex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.17 3.69e-22 GO:0005488 binding
1.27 8.48e-19 GO:0005515 protein binding
2.04 1.73e-07 GO:0005083 small GTPase regulator activity
1.22 4.47e-06 GO:0046872 metal ion binding
1.22 4.81e-06 GO:0043167 ion binding
1.22 4.84e-06 GO:0043169 cation binding
1.72 6.29e-06 GO:0060589 nucleoside-triphosphatase regulator activity
1.71 1.94e-05 GO:0030695 GTPase regulator activity
1.34 1.62e-04 GO:0008270 zinc ion binding
1.38 2.09e-04 GO:0005215 transporter activity
1.58 2.32e-04 GO:0008324 cation transmembrane transporter activity
1.43 3.30e-04 GO:0030234 enzyme regulator activity
2.19 3.92e-04 GO:0005516 calmodulin binding
1.48 3.96e-04 GO:0015075 ion transmembrane transporter activity
1.41 5.00e-04 GO:0022857 transmembrane transporter activity
1.75 5.24e-04 GO:0022836 gated channel activity
1.40 6.00e-04 GO:0022892 substrate-specific transporter activity
1.43 6.07e-04 GO:0016301 kinase activity
1.40 1.29e-03 GO:0019899 enzyme binding
1.42 1.62e-03 GO:0022891 substrate-specific transmembrane transporter activity
1.51 2.39e-03 GO:0008092 cytoskeletal protein binding
1.26 4.77e-03 GO:0046914 transition metal ion binding
2.55 5.41e-03 GO:0042625 ATPase activity, coupled to transmembrane movement of ions
1.70 6.75e-03 GO:0005261 cation channel activity
1.57 8.10e-03 GO:0005216 ion channel activity
1.21 1.30e-02 GO:0000166 nucleotide binding
1.53 1.44e-02 GO:0022803 passive transmembrane transporter activity
2.63 1.82e-02 GO:0003707 steroid hormone receptor activity
1.53 1.95e-02 GO:0022838 substrate-specific channel activity
1.39 2.04e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.79 2.15e-02 GO:0005244 voltage-gated ion channel activity
1.79 2.15e-02 GO:0022832 voltage-gated channel activity
1.52 2.26e-02 GO:0015267 channel activity
2.58 2.57e-02 GO:0004879 ligand-dependent nuclear receptor activity
1.58 3.13e-02 GO:0008047 enzyme activator activity
1.43 3.50e-02 GO:0019904 protein domain specific binding
3.87 4.37e-02 GO:0015079 potassium ion transmembrane transporter activity