Motif ID: SREBF1,2.p2

Z-value: 1.537


Transcription factors associated with SREBF1,2.p2:

Gene SymbolEntrez IDGene Name
Srebf1 20787 sterol regulatory element binding transcription factor 1
Srebf2 20788 sterol regulatory element binding factor 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Srebf2chr15_+_82000246-0.334.1e-06Click!
Srebf1chr11_-_600131410.222.5e-03Click!


Activity profile for motif SREBF1,2.p2.

activity profile for motif SREBF1,2.p2


Sorted Z-values histogram for motif SREBF1,2.p2

Sorted Z-values for motif SREBF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SREBF1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_131135346 47.394 NM_013463
Gla
galactosidase, alpha
chr8_+_77617514 44.046 NM_010442
Hmox1
heme oxygenase (decycling) 1
chr8_+_77617542 40.594 Hmox1
heme oxygenase (decycling) 1
chr2_+_164659268 32.690 Ctsa
cathepsin A
chr10_-_18735154 32.067 NM_009397
Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr8_+_120022149 32.045 NM_172285
Plcg2
phospholipase C, gamma 2
chr10_+_122116066 31.152 Ppm1h
protein phosphatase 1H (PP2C domain containing)
chr10_+_122115755 31.068 NM_001110218
NM_176919
Ppm1h

protein phosphatase 1H (PP2C domain containing)

chr7_-_149573693 29.523 NM_009983
Ctsd
cathepsin D
chr17_-_24300592 29.233 NM_172935
Amdhd2
amidohydrolase domain containing 2
chr17_+_25270317 29.126 NM_011930
Clcn7
chloride channel 7
chr10_+_120802099 28.769 NM_029364
Gns
glucosamine (N-acetyl)-6-sulfatase
chr1_-_75138905 25.928 NM_026977
1810031K17Rik
RIKEN cDNA 1810031K17 gene
chr7_-_133726668 25.357 NM_009907
Cln3
ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)
chr17_+_29629987 25.148 Pim1
proviral integration site 1
chr16_-_5204078 24.985 NM_013796
Nagpa
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr11_+_102291635 24.831 NM_008175
Grn
granulin
chr13_-_12742377 24.711 Gpr137b-ps
Gpr137b
G protein-coupled receptor 137B, pseudogene
G protein-coupled receptor 137B
chr16_-_5204069 24.570 Nagpa
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr2_-_25211822 24.456 NM_031843
Dpp7
dipeptidylpeptidase 7
chr4_+_61947463 24.287 NM_025286
Slc31a2
solute carrier family 31, member 2
chr7_+_108496574 23.571 NM_001040111
Arap1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr14_+_63741286 23.508 NM_007798
Ctsb
cathepsin B
chr11_+_100931369 22.999 NM_013792
Naglu
alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)
chr8_-_124956759 22.466 NM_007806
Cyba
cytochrome b-245, alpha polypeptide
chr14_+_75576599 22.068 Lcp1
lymphocyte cytosolic protein 1
chrX_+_45499599 21.539 NM_028773
Sash3
SAM and SH3 domain containing 3
chr6_-_108135548 21.346 NM_145937
Sumf1
sulfatase modifying factor 1
chr10_-_62801726 21.257 NM_001159590
NM_019812
NM_001159589
Sirt1


sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)


chr7_+_117365214 21.055 NM_009302
Swap70
SWA-70 protein
chr7_+_109054350 21.044 NM_025605
2400001E08Rik
RIKEN cDNA 2400001E08 gene
chr5_-_140865121 20.441 NM_172277
Snx8
sorting nexin 8
chr10_+_110601745 20.170 NM_001003717
NM_175489
Osbpl8

oxysterol binding protein-like 8

chr3_+_67386633 20.135 NM_025813
Mfsd1
major facilitator superfamily domain containing 1
chr10_+_79479416 19.955 NM_001142701
Hmha1
histocompatibility (minor) HA-1
chr1_-_75139207 19.719 1810031K17Rik
RIKEN cDNA 1810031K17 gene
chr8_+_13159279 19.259 Lamp1
lysosomal-associated membrane protein 1
chr6_+_116287992 18.731 March8
membrane-associated ring finger (C3HC4) 8
chr3_+_89006824 18.651 NM_001077411
NM_008094
Gba

glucosidase, beta, acid

chr1_+_16678513 18.265 Ly96
lymphocyte antigen 96
chr4_+_123594654 18.262 NM_017475
Rragc
Ras-related GTP binding C
chr4_+_123594712 17.815 Rragc
Ras-related GTP binding C
chr14_+_63741339 17.606 Ctsb
cathepsin B
chr1_+_16678536 17.524 NM_001159711
NM_016923
Ly96

lymphocyte antigen 96

chr2_-_164658954 17.480 NM_001082974
Neurl2
neuralized-like 2 (Drosophila)
chr13_-_13485585 17.224 NM_031999
Gpr137b
G protein-coupled receptor 137B
chr19_-_41068625 17.041 Blnk
B-cell linker
chr5_-_114280434 16.960 NM_009151
Selplg
selectin, platelet (p-selectin) ligand
chr11_-_34597324 16.855 NM_033374
Dock2
dedicator of cyto-kinesis 2
chr4_-_147462051 16.555 NM_009642
Agtrap
angiotensin II, type I receptor-associated protein
chr11_+_102291759 16.530 Grn
granulin
chr15_+_59205752 16.470 NM_001164604
NM_026746
Nsmce2

non-SMC element 2 homolog (MMS21, S. cerevisiae)

chrX_+_33868347 16.402 NM_028894
Lonrf3
LON peptidase N-terminal domain and ring finger 3
chr19_-_11893431 16.159 Stx3
syntaxin 3
chr19_+_10092665 16.138 NM_144538
Rab3il1
RAB3A interacting protein (rabin3)-like 1
chr8_+_13159112 16.134 NM_010684
Lamp1
lysosomal-associated membrane protein 1
chr6_+_116288073 15.994 March8
membrane-associated ring finger (C3HC4) 8
chr6_+_108610606 15.955 NM_011498
Bhlhe40
basic helix-loop-helix family, member e40
chr19_-_4201541 15.855 NM_011237
Rad9
RAD9 homolog (S. pombe)
chr11_-_73012493 15.808 NM_031251
Ctns
cystinosis, nephropathic
chr3_+_89006938 15.440 Gba
glucosidase, beta, acid
chrX_+_103222548 15.412 NM_001109757
NM_009726
Atp7a

ATPase, Cu++ transporting, alpha polypeptide

chr1_+_154613622 15.328 NM_026369
Arpc5
actin related protein 2/3 complex, subunit 5
chr6_+_48986625 15.184 Gpnmb
glycoprotein (transmembrane) nmb
chr10_+_67000613 15.134 NM_010118
Egr2
early growth response 2
chr12_-_103196366 15.112 NM_001167914
NM_029705
Atxn3

ataxin 3

chr11_+_102291828 15.035 Grn
granulin
chr3_-_20054974 14.891 NM_013755
Gyg
glycogenin
chr6_+_48986501 14.852 NM_053110
Gpnmb
glycoprotein (transmembrane) nmb
chr3_-_79371600 14.747 NM_001162999
Fnip2
folliculin interacting protein 2
chr13_+_5860749 14.692 Klf6
Kruppel-like factor 6
chr13_+_5860701 14.598 NM_011803
Klf6
Kruppel-like factor 6
chr11_-_50244605 14.556 NM_172557
Rufy1
RUN and FYVE domain containing 1
chr4_-_117559857 14.485 NM_033617
Atp6v0b
ATPase, H+ transporting, lysosomal V0 subunit B
chr17_-_12962478 14.378 NM_010515
Igf2r
insulin-like growth factor 2 receptor
chr3_+_89577436 14.193 NM_027315
Ube2q1
ubiquitin-conjugating enzyme E2Q (putative) 1
chr13_+_64533703 14.047 NM_053180
Cdk20
cyclin-dependent kinase 20
chr17_-_46782935 13.972 Klc4
kinesin light chain 4
chr9_-_107192203 13.937 NM_178907
Mapkapk3
mitogen-activated protein kinase-activated protein kinase 3
chr10_+_57514349 13.729 NM_020561
Smpdl3a
sphingomyelin phosphodiesterase, acid-like 3A
chr8_+_77557582 13.726 NM_001136259
NM_011622
Tom1

target of myb1 homolog (chicken)

chr11_+_102294276 13.654 Grn
granulin
chr3_-_20054899 13.550 Gyg
glycogenin
chr7_+_114738722 13.433 Ppfibp2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr16_+_17406078 13.396 NM_023348
Snap29
synaptosomal-associated protein 29
chr5_+_28492235 13.236 NM_010134
En2
engrailed 2
chr11_+_54251680 13.235 NM_173753
Fnip1
folliculin interacting protein 1
chr17_+_6106858 13.135 Tulp4
tubby like protein 4
chr14_+_79880952 13.126 NM_007920
Elf1
E74-like factor 1
chr4_-_86315874 13.111 NM_007408
Plin2
perilipin 2
chr8_+_3500470 12.848 NM_053177
Mcoln1
mucolipin 1
chr12_-_80397239 12.830 NM_001008550
Zfyve26
zinc finger, FYVE domain containing 26
chr7_+_97278722 12.756 NM_146194
Picalm
phosphatidylinositol binding clathrin assembly protein
chr6_+_116288075 12.595 NM_027920
March8
membrane-associated ring finger (C3HC4) 8
chr1_+_154613692 12.468 Arpc5
actin related protein 2/3 complex, subunit 5
chr10_-_119638448 12.442 NM_028679
Irak3
interleukin-1 receptor-associated kinase 3
chr9_+_59387443 12.373 NM_010421
Hexa
hexosaminidase A
chr12_-_92828896 12.345 NM_175335
Gtf2a1
general transcription factor II A, 1
chr8_-_86222963 12.335 NM_177262
Pkn1
protein kinase N1
chrX_+_68468175 12.334 NM_001164191
NM_001164192
NM_001164193
NM_019926
Mtm1



X-linked myotubular myopathy gene 1



chr9_-_107191674 12.275 Mapkapk3
mitogen-activated protein kinase-activated protein kinase 3
chr10_+_13220952 12.249 Fuca2
fucosidase, alpha-L- 2, plasma
chr19_-_11893333 12.055 NM_011502
Stx3
syntaxin 3
chr6_+_116288396 12.046 March8
membrane-associated ring finger (C3HC4) 8
chr15_+_102751533 12.019 NM_010464
Hoxc13
homeobox C13
chr15_-_10644312 11.981 NM_001166408
Rai14
retinoic acid induced 14
chr7_-_20214596 11.921 NM_009046
Relb
avian reticuloendotheliosis viral (v-rel) oncogene related B
chr9_+_59387346 11.857 Hexa
hexosaminidase A
chr7_-_112900699 11.782 NM_009906
Tpp1
tripeptidyl peptidase I
chr4_+_135502353 11.720 NM_008254
Hmgcl
3-hydroxy-3-methylglutaryl-Coenzyme A lyase
chr2_+_122060526 11.670 NM_146126
Sord
sorbitol dehydrogenase
chr17_-_35325354 11.588 NM_010734
Lst1
leukocyte specific transcript 1
chr11_+_120494714 11.515


chr11_-_117641895 11.426 NM_181321
Tmc6
transmembrane channel-like gene family 6
chr4_+_147413185 11.398 NM_010840
Mthfr
5,10-methylenetetrahydrofolate reductase
chr11_-_3831963 11.335 NM_001130459
NM_015749
NM_001130458
Tcn2


transcobalamin 2


chr1_+_134212642 11.316 NM_001195025
NM_028778
Nuak2

NUAK family, SNF1-like kinase, 2

chr1_+_154613763 11.247 Arpc5
actin related protein 2/3 complex, subunit 5
chr11_-_117641951 11.069 NM_145439
Tmc6
transmembrane channel-like gene family 6
chr7_+_134985164 10.976 NM_009294
Stx4a
syntaxin 4A (placental)
chr1_+_174430081 10.768 Tagln2
transgelin 2
chr14_-_67627598 10.682 NM_009761
Bnip3l
BCL2/adenovirus E1B interacting protein 3-like
chr8_-_42459932 10.616 NM_019734
Asah1
N-acylsphingosine amidohydrolase 1
chr11_+_109224104 10.595 NM_010303
Gna13
guanine nucleotide binding protein, alpha 13
chr18_+_65960170 10.586 NM_025468
Sec11c
SEC11 homolog C (S. cerevisiae)
chr9_-_21935019 10.543 NM_007388
Acp5
acid phosphatase 5, tartrate resistant
chr19_+_37624879 10.539 NM_175353
Exoc6
exocyst complex component 6
chr1_+_192922288 10.501 NM_030060
Batf3
basic leucine zipper transcription factor, ATF-like 3
chr19_-_60656627 10.416 NM_001172096
NM_001172097
NM_030197
2700078E11Rik


RIKEN cDNA 2700078E11 gene


chr3_+_152059620 10.411 NM_198416
Zzz3
zinc finger, ZZ domain containing 3
chr11_-_70273190 10.388 Cxcl16
chemokine (C-X-C motif) ligand 16
chr12_+_35731853 10.378 NM_001014973
Snx13
sorting nexin 13
chr8_-_125135240 10.208 NM_001193645
NM_016722
Galns

galactosamine (N-acetyl)-6-sulfate sulfatase

chr12_-_99497498 10.200 NM_008079
Galc
galactosylceramidase
chr2_+_24831548 10.173 NM_146251
Pnpla7
patatin-like phospholipase domain containing 7
chr7_+_90780446 10.169 NM_023377
Stard5
StAR-related lipid transfer (START) domain containing 5
chr2_+_29989278 10.159 NM_146252
Tbc1d13
TBC1 domain family, member 13
chr18_+_12327237 9.948 NM_029623
3110002H16Rik
RIKEN cDNA 3110002H16 gene
chr15_+_80502276 9.887 NM_145986
Fam83f
family with sequence similarity 83, member F
chr3_+_88128944 9.755 NM_020003
0610031J06Rik
RIKEN cDNA 0610031J06 gene
chr7_+_114738564 9.747 NM_008905
Ppfibp2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr1_+_90108533 9.687 NM_201645
Ugt1a1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr11_-_103265172 9.585 Plekhm1
pleckstrin homology domain containing, family M (with RUN domain) member 1
chr9_-_87150115 9.578 4922501C03Rik
RIKEN cDNA 4922501C03 gene
chr7_+_134985435 9.573 Stx4a
syntaxin 4A (placental)
chr18_-_38498564 9.551 NM_011937
Gnpda1
glucosamine-6-phosphate deaminase 1
chr11_-_8564514 9.507 NM_001083587
Tns3
tensin 3
chr11_+_55017825 9.436 NM_153139
Slc36a1
solute carrier family 36 (proton/amino acid symporter), member 1
chr10_-_77927652 9.411 NM_172134
Pdxk
pyridoxal (pyridoxine, vitamin B6) kinase
chr8_+_109960256 9.379 NM_025830
Wwp2
WW domain containing E3 ubiquitin protein ligase 2
chr3_-_19935292 9.321 NM_001146323
NM_001146324
NM_080634
Hps3


Hermansky-Pudlak syndrome 3 homolog (human)


chr9_+_35075447 9.316 NM_028040
Rpusd4
RNA pseudouridylate synthase domain containing 4
chr1_+_60803231 9.236 NM_007642
Cd28
CD28 antigen
chr9_-_104165221 9.209 NM_001163026
Dnajc13
DnaJ (Hsp40) homolog, subfamily C, member 13
chr6_-_82724366 9.169 NM_013820
Hk2
hexokinase 2
chr15_-_77787128 9.106 NM_001017983
NM_001168260
Foxred2

FAD-dependent oxidoreductase domain containing 2

chr12_+_3891743 9.102 NM_153743
Dnmt3a
DNA methyltransferase 3A
chr17_+_26813327 9.084 NM_025272
Atp6v0e
ATPase, H+ transporting, lysosomal V0 subunit E
chr10_+_13220833 9.077 NM_025799
Fuca2
fucosidase, alpha-L- 2, plasma
chr11_-_86621074 9.071 Dhx40
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr17_-_26645284 9.044 Dusp1
dual specificity phosphatase 1
chr15_-_77787081 9.019 Foxred2
FAD-dependent oxidoreductase domain containing 2
chr17_-_26645403 8.995 NM_013642
Dusp1
dual specificity phosphatase 1
chr18_+_66618186 8.900 NM_021451
Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
chr2_-_28555168 8.838 NM_027283
1700026L06Rik
RIKEN cDNA 1700026L06 gene
chr11_+_88860710 8.710 NM_009546
Trim25
tripartite motif-containing 25
chr11_+_53164267 8.694 NM_033565
Aff4
AF4/FMR2 family, member 4
chr2_+_160557441 8.594 Plcg1
phospholipase C, gamma 1
chr7_-_147174332 8.567 Adam8
a disintegrin and metallopeptidase domain 8
chr11_-_70273434 8.498 Cxcl16
chemokine (C-X-C motif) ligand 16
chr3_+_90416815 8.434 NM_011313
S100a6
S100 calcium binding protein A6 (calcyclin)
chr5_-_121902350 8.429 NM_026129
Erp29
endoplasmic reticulum protein 29
chr3_-_107135939 8.419 NM_001045807
Rbm15
RNA binding motif protein 15
chr15_+_102109859 8.400 NM_134100
Mfsd5
major facilitator superfamily domain containing 5
chr11_-_70273333 8.392 Cxcl16
chemokine (C-X-C motif) ligand 16
chr11_-_86621130 8.367 NM_026191
Dhx40
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr17_-_66426165 8.353 Ankrd12
ankyrin repeat domain 12
chr5_+_145016060 8.333 NM_018772
Bri3
brain protein I3
chr9_-_103267697 8.250 Cdv3
carnitine deficiency-associated gene expressed in ventricle 3
chr12_-_78063011 8.244 NM_001146176
NM_008558
Max

Max protein

chr4_+_122513481 8.197 NM_008917
Ppt1
palmitoyl-protein thioesterase 1
chr17_-_66426361 8.185 NM_001025572
Ankrd12
ankyrin repeat domain 12
chr17_+_6270474 8.170 NM_001033178
Tmem181a
transmembrane protein 181A
chr9_-_70504934 8.141 NM_172772
Fam63b
family with sequence similarity 63, member B
chr12_-_99497634 8.131 Galc
galactosylceramidase
chr11_+_69804871 8.124 NM_019749
Gabarap
gamma-aminobutyric acid receptor associated protein
chr6_+_52195241 7.939 Hoxa11as
HOXA11 antisense RNA (non-protein coding)
chr18_-_6490682 7.890 Epc1
enhancer of polycomb homolog 1 (Drosophila)
chr15_+_102844438 7.885 NM_175730
Hoxc5
homeobox C5
chr7_-_106289639 7.865 Uvrag
UV radiation resistance associated gene
chr15_+_34012415 7.828 NM_026002
Mtdh
metadherin
chr2_+_112124767 7.825 NM_133648
Slc12a6
solute carrier family 12, member 6
chr3_-_89856250 7.808 NM_001165983
NM_001165985
NM_001165987
NM_028475
NM_153489
NM_001165984
NM_001165986
NM_001165988
Ubap2l







ubiquitin associated protein 2-like







chr14_+_31528352 7.762 NM_001166531
Sfmbt1
Scm-like with four mbt domains 1
chr11_+_31770920 7.762 Cpeb4
cytoplasmic polyadenylation element binding protein 4
chr1_+_75139300 7.689 NM_170755
Fam134a
family with sequence similarity 134, member A
chr7_+_54305973 7.666 NM_026436
Tmem86a
transmembrane protein 86A
chr2_+_90875783 7.638 NM_009023
Rapsn
receptor-associated protein of the synapse
chr2_-_104582953 7.627 NM_144804
Depdc7
DEP domain containing 7
chr7_-_28338185 7.599 Pld3
phospholipase D family, member 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.31 1.86e-09 GO:0044238 primary metabolic process
1.28 4.62e-09 GO:0008152 metabolic process
1.70 1.95e-08 GO:0006351 transcription, DNA-dependent
1.48 2.19e-08 GO:0009058 biosynthetic process
1.70 2.25e-08 GO:0032774 RNA biosynthetic process
1.57 3.23e-08 GO:0034645 cellular macromolecule biosynthetic process
1.56 3.93e-08 GO:0009059 macromolecule biosynthetic process
1.57 4.02e-08 GO:0051252 regulation of RNA metabolic process
1.30 4.18e-08 GO:0044237 cellular metabolic process
1.48 6.43e-08 GO:0044249 cellular biosynthetic process
1.57 6.66e-08 GO:0006355 regulation of transcription, DNA-dependent
1.84 9.39e-08 GO:0033036 macromolecule localization
1.51 1.46e-07 GO:0051171 regulation of nitrogen compound metabolic process
1.51 1.57e-07 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.51 2.51e-07 GO:0010468 regulation of gene expression
1.42 4.59e-07 GO:0031323 regulation of cellular metabolic process
1.44 5.60e-07 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.41 6.06e-07 GO:0006807 nitrogen compound metabolic process
1.38 8.20e-07 GO:0019222 regulation of metabolic process
1.51 8.78e-07 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.01 9.96e-07 GO:0015031 protein transport
1.41 1.01e-06 GO:0034641 cellular nitrogen compound metabolic process
1.32 1.22e-06 GO:0043170 macromolecule metabolic process
1.99 1.38e-06 GO:0045184 establishment of protein localization
1.52 1.56e-06 GO:0016070 RNA metabolic process
1.48 1.80e-06 GO:0090304 nucleic acid metabolic process
1.34 1.90e-06 GO:0044260 cellular macromolecule metabolic process
1.48 4.45e-06 GO:0010556 regulation of macromolecule biosynthetic process
1.83 4.92e-06 GO:0008104 protein localization
1.39 5.59e-06 GO:0080090 regulation of primary metabolic process
1.46 6.15e-06 GO:0031326 regulation of cellular biosynthetic process
4.14 9.36e-06 GO:0000041 transition metal ion transport
1.47 1.07e-05 GO:0010467 gene expression
1.45 1.12e-05 GO:0009889 regulation of biosynthetic process
1.46 1.26e-05 GO:0006810 transport
2.06 1.98e-05 GO:0046907 intracellular transport
1.40 2.32e-05 GO:0051179 localization
1.44 3.08e-05 GO:0051234 establishment of localization
1.38 4.13e-05 GO:0060255 regulation of macromolecule metabolic process
1.84 5.95e-05 GO:0051649 establishment of localization in cell
1.76 6.40e-05 GO:0051641 cellular localization
6.91 9.95e-05 GO:0015682 ferric iron transport
6.91 9.95e-05 GO:0033572 transferrin transport
7.30 1.83e-04 GO:0015988 energy coupled proton transport, against electrochemical gradient
7.30 1.83e-04 GO:0015991 ATP hydrolysis coupled proton transport
1.75 2.11e-04 GO:0006357 regulation of transcription from RNA polymerase II promoter
2.88 2.21e-04 GO:0009952 anterior/posterior pattern formation
7.03 2.93e-04 GO:0007040 lysosome organization
5.25 4.18e-04 GO:0007033 vacuole organization
2.24 4.51e-04 GO:0007389 pattern specification process
4.80 5.84e-04 GO:0006826 iron ion transport
2.05 1.73e-03 GO:0034613 cellular protein localization
2.90 2.06e-03 GO:0048705 skeletal system morphogenesis
2.03 2.13e-03 GO:0070727 cellular macromolecule localization
2.36 2.45e-03 GO:0001501 skeletal system development
2.06 2.77e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
3.42 4.81e-03 GO:0048706 embryonic skeletal system development
2.34 5.51e-03 GO:0003002 regionalization
1.79 6.30e-03 GO:0010629 negative regulation of gene expression
3.73 9.09e-03 GO:0048704 embryonic skeletal system morphogenesis
2.14 1.09e-02 GO:0006886 intracellular protein transport
12.33 2.79e-02 GO:0021546 rhombomere development
2.17 3.18e-02 GO:0048568 embryonic organ development
1.67 3.63e-02 GO:0045893 positive regulation of transcription, DNA-dependent
1.32 3.86e-02 GO:0048518 positive regulation of biological process
1.41 4.78e-02 GO:0048513 organ development
1.75 4.89e-02 GO:0045892 negative regulation of transcription, DNA-dependent

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
4.30 1.66e-23 GO:0005773 vacuole
1.38 5.07e-23 GO:0043227 membrane-bounded organelle
1.37 9.72e-23 GO:0043231 intracellular membrane-bounded organelle
1.27 2.22e-21 GO:0005622 intracellular
1.32 1.86e-20 GO:0043226 organelle
1.27 2.63e-20 GO:0044424 intracellular part
1.32 4.61e-20 GO:0043229 intracellular organelle
4.30 1.39e-19 GO:0000323 lytic vacuole
4.30 1.39e-19 GO:0005764 lysosome
1.27 1.45e-11 GO:0005737 cytoplasm
1.35 1.87e-10 GO:0044444 cytoplasmic part
2.54 2.93e-09 GO:0005768 endosome
9.99 3.95e-07 GO:0033176 proton-transporting V-type ATPase complex
1.32 4.36e-07 GO:0005634 nucleus
4.73 1.19e-06 GO:0044437 vacuolar part
4.82 2.04e-06 GO:0005774 vacuolar membrane
11.51 1.70e-05 GO:0016471 vacuolar proton-transporting V-type ATPase complex
5.60 2.21e-04 GO:0016469 proton-transporting two-sector ATPase complex
1.28 3.67e-04 GO:0044422 organelle part
1.29 3.89e-04 GO:0044446 intracellular organelle part
1.73 9.05e-04 GO:0031982 vesicle
1.74 1.37e-03 GO:0031410 cytoplasmic vesicle
1.08 1.43e-03 GO:0005623 cell
1.08 1.43e-03 GO:0044464 cell part
1.82 6.08e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
1.58 6.47e-03 GO:0005794 Golgi apparatus
1.76 1.36e-02 GO:0031988 membrane-bounded vesicle
1.52 2.52e-02 GO:0005654 nucleoplasm
1.29 2.74e-02 GO:0043234 protein complex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.19 6.61e-09 GO:0005488 binding
2.01 3.48e-07 GO:0001071 nucleic acid binding transcription factor activity
2.01 3.48e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.48 1.10e-06 GO:0003676 nucleic acid binding
2.02 3.48e-06 GO:0043565 sequence-specific DNA binding
1.56 8.62e-06 GO:0003677 DNA binding
1.27 9.55e-06 GO:0005515 protein binding
1.81 1.20e-05 GO:0030528 transcription regulator activity
8.63 2.88e-03 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism
2.47 5.07e-03 GO:0022890 inorganic cation transmembrane transporter activity
1.20 1.98e-02 GO:0003824 catalytic activity
2.03 2.41e-02 GO:0022804 active transmembrane transporter activity
3.62 2.52e-02 GO:0042625 ATPase activity, coupled to transmembrane movement of ions