Motif ID: SRF.p3

Z-value: 3.336


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
Srf 20807 serum response factor

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Srfchr17_-_466931100.431.1e-09Click!


Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_156601175 211.935 NM_172118
Myl9
myosin, light polypeptide 9, regulatory
chr2_+_156601150 208.324 Myl9
myosin, light polypeptide 9, regulatory
chr6_-_83486194 190.924 NM_009610
Actg2
actin, gamma 2, smooth muscle, enteric
chr2_-_113878535 172.612 NM_009608
Actc1
actin, alpha, cardiac muscle 1
chr8_-_126418628 114.220 NM_009606
Acta1
actin, alpha 1, skeletal muscle
chr9_-_45744036 102.443 NM_011526
Tagln
transgelin
chr9_-_45743950 87.772 Tagln
transgelin
chr16_+_34995000 81.222 Mylk
myosin, light polypeptide kinase
chr3_+_14863507 69.169 NM_007606
Car3
carbonic anhydrase 3
chr17_+_71368860 68.917 NM_001083934
NM_010867
Myom1

myomesin 1

chr19_-_34329804 67.433 NM_007392
Acta2
actin, alpha 2, smooth muscle, aorta
chr7_+_31338319 67.180 NM_001012401
Hspb6
heat shock protein, alpha-crystallin-related, B6
chr16_+_34921598 67.025 Mylk
myosin, light polypeptide kinase
chr1_-_43220692 62.698 Fhl2
four and a half LIM domains 2
chr3_-_57379831 61.968 NM_001168281
Wwtr1
WW domain containing transcription regulator 1
chr1_-_43220725 61.733 Fhl2
four and a half LIM domains 2
chr1_-_43220804 60.799 NM_010212
Fhl2
four and a half LIM domains 2
chr14_-_46149660 58.983 NM_146054
Fermt2
fermitin family homolog 2 (Drosophila)
chr11_+_82724754 57.730 NM_178680
Unc45b
unc-45 homolog B (C. elegans)
chr12_+_31950252 56.666 Lamb1
laminin B1
chr12_-_104594210 55.442 NM_023049
Asb2
ankyrin repeat and SOCS box-containing 2
chr3_-_57379600 52.661 NM_133784
Wwtr1
WW domain containing transcription regulator 1
chr14_-_35401845 51.490 NM_001039071
NM_001039072
NM_001039073
NM_001039075
NM_001039076
NM_011918
Ldb3





LIM domain binding 3





chr10_-_6080145 49.765 NM_031185
Akap12
A kinase (PRKA) anchor protein (gravin) 12
chr8_+_15057652 49.554 NM_008664
Myom2
myomesin 2
chr12_+_31950097 42.724 NM_008482
Lamb1
laminin B1
chr7_-_106501620 42.671 Serpinh1
serine (or cysteine) peptidase inhibitor, clade H, member 1
chr14_-_35401654 42.329 NM_001039074
Ldb3
LIM domain binding 3
chr16_+_57549340 41.979 NM_001177871
Filip1l
filamin A interacting protein 1-like
chr14_+_21748602 39.465 Vcl
vinculin
chr11_-_120593310 38.628 NM_007621
Cbr2
carbonyl reductase 2
chr16_+_34994935 37.792 Mylk
myosin, light polypeptide kinase
chr3_+_68272097 37.016 Schip1
schwannomin interacting protein 1
chr16_+_24448176 36.293 NM_001145952
Lpp
LIM domain containing preferred translocation partner in lipoma
chr18_-_33623668 35.950 NM_001109988
D0H4S114
DNA segment, human D4S114
chr17_-_56249206 35.220 NM_020568
Plin4
perilipin 4
chr11_-_120593289 34.157 Cbr2
carbonyl reductase 2
chr7_+_19996439 33.060 NM_007710
Ckm
creatine kinase, muscle
chr13_+_51942043 31.869 NM_011817
Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
chr8_-_87297283 31.395 Nfix
nuclear factor I/X
chr4_+_140977613 30.227 Hspb7
heat shock protein family, member 7 (cardiovascular)
chr15_-_99650502 28.415 NM_023063
Lima1
LIM domain and actin binding 1
chr19_-_4877874 28.052 NM_013456
Actn3
actinin alpha 3
chr9_+_110666178 27.337 NM_010859
Myl3
myosin, light polypeptide 3
chr9_+_110666191 26.691 Myl3
myosin, light polypeptide 3
chr11_-_73137838 26.151 Aspa
aspartoacylase
chr11_+_58192533 25.758 NM_001083884
NM_027339
2210415F13Rik

RIKEN cDNA 2210415F13 gene

chr14_+_21748646 25.108 NM_009502
Vcl
vinculin
chr2_-_163223660 23.756 NM_021566
Jph2
junctophilin 2
chr6_-_52154325 23.305 Hoxa5
homeobox A5
chr15_-_63676716 23.113 NM_001168274
NM_177912
Gsdmc2

gasdermin C2

chr10_+_79451332 22.790 NM_007725
Cnn2
calponin 2
chr13_-_34744511 22.219 NM_025831
1300014I06Rik
RIKEN cDNA 1300014I06 gene
chr6_-_4697009 21.760 NM_001130188
NM_001130189
NM_001130190
NM_001130191
NM_011360
Sgce




sarcoglycan, epsilon




chr7_-_144506112 21.741 NM_001113414
NM_001113415
NM_010096
Ebf3


early B-cell factor 3


chr15_+_101097276 21.318 NM_010444
Nr4a1
nuclear receptor subfamily 4, group A, member 1
chr7_+_3293008 21.006 NM_001093766
Myadm
myeloid-associated differentiation marker
chr13_+_23838602 20.844 NM_175664
Hist1h2bb
histone cluster 1, H2bb
chr4_-_141155782 20.508 NM_001163256
Fblim1
filamin binding LIM protein 1
chr7_-_106501584 20.504 Serpinh1
serine (or cysteine) peptidase inhibitor, clade H, member 1
chr7_-_144506091 20.341 Ebf3
early B-cell factor 3
chr4_+_140977621 20.312 Hspb7
heat shock protein family, member 7 (cardiovascular)
chr14_+_3049284 20.155 NM_001177715
NM_001177714
Gm2897

predicted gene 2897

chr14_-_8491067 20.094 Gm2897
predicted gene 2897
chr1_-_174149989 20.024 NM_009813
Casq1
calsequestrin 1
chr10_+_79451369 19.186 Cnn2
calponin 2
chr15_-_63743844 19.032 NM_028992
Gsdmc2
Gsdmc4
gasdermin C2
gasdermin C4
chr2_+_143741050 18.929 NM_019771
Dstn
destrin
chr11_-_5798780 18.929 NM_022879
Myl7
myosin, light polypeptide 7, regulatory
chr1_-_33814537 18.345 Bag2
BCL2-associated athanogene 2
chr11_-_101285982 17.829 1700113I22Rik
RIKEN cDNA 1700113I22 gene
chr2_+_158328317 17.696 NM_145635
Adig
adipogenin
chr1_-_33814590 16.801 NM_145392
Bag2
BCL2-associated athanogene 2
chr19_-_4042215 16.726 NM_181796
Gstp2
glutathione S-transferase, pi 2
chr14_-_7859962 16.170 NM_001164727
Gm10406
predicted gene 10406
chr2_-_60511707 15.670 NM_021359
Itgb6
integrin beta 6
chr8_-_73905790 15.524 NM_010150
Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr11_-_73138102 15.070 NM_023113
Aspa
aspartoacylase
chr2_+_143741243 14.915 Dstn
destrin
chr19_-_4037895 14.592 NM_013541
Gstp1
glutathione S-transferase, pi 1
chr10_+_127472624 14.072 Naca
nascent polypeptide-associated complex alpha polypeptide
chr7_-_149846916 13.201 NM_001122736
Igf2
insulin-like growth factor 2
chr10_+_127472725 13.026 Naca
nascent polypeptide-associated complex alpha polypeptide
chr4_+_129985957 12.943 NM_010174
Fabp3
fatty acid binding protein 3, muscle and heart
chr4_+_150227911 12.210 Errfi1
ERBB receptor feedback inhibitor 1
chr2_-_52194317 12.194 NM_010889
Neb
nebulin
chr11_+_101192080 11.829 Aoc3
amine oxidase, copper containing 3
chr2_-_84316891 11.737 NM_001177319
NM_001177320
Tfpi

tissue factor pathway inhibitor

chr7_+_135390456 11.466 Tgfb1i1
transforming growth factor beta 1 induced transcript 1
chrX_+_130385690 11.291 Tnmd
tenomodulin
chr4_-_148829073 11.260 NM_022020
Rbp7
retinol binding protein 7, cellular
chr16_-_17842060 11.115 Dgcr2
DiGeorge syndrome critical region gene 2
chr10_-_33816255 10.686 NM_178908
Fam26e
family with sequence similarity 26, member E
chr11_+_96164825 10.457 NM_008268
Hoxb5
homeobox B5
chr11_-_118216591 10.374 Timp2
tissue inhibitor of metalloproteinase 2
chrX_+_130385546 10.105 NM_022322
Tnmd
tenomodulin
chr14_-_7937970 10.092 NM_001024712
Gm3696
predicted gene 3696
chr8_-_73905523 9.883 Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr11_-_100007218 9.881 NM_008471
Krt19
keratin 19
chr5_+_17080553 9.804 NM_013657
Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr7_+_73007017 9.546 NM_011048
Pcsk6
proprotein convertase subtilisin/kexin type 6
chr6_+_3954225 9.456 Gng11
guanine nucleotide binding protein (G protein), gamma 11
chr11_-_118163704 9.357 Timp2
tissue inhibitor of metalloproteinase 2
chr2_-_181406313 9.350 NM_009236
Sox18
SRY-box containing gene 18
chr9_-_45763233 9.198 Sidt2
SID1 transmembrane family, member 2
chr16_+_24393435 9.159 NM_178665
Lpp
LIM domain containing preferred translocation partner in lipoma
chr5_+_138696947 9.070 0910001L09Rik
RIKEN cDNA 0910001L09 gene
chr1_+_39044599 9.007 NM_026850
Pdcl3
phosducin-like 3
chr1_+_74455956 8.292 NM_009509
Vil1
villin 1
chr2_-_84680194 8.139 D930003E18Rik
RIKEN cDNA D930003E18 gene
chr15_-_79656745 8.100 Cbx6
chromobox homolog 6
chr18_-_56721860 7.861 Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr1_-_95342228 7.538 Hdlbp
high density lipoprotein (HDL) binding protein
chr17_-_46693110 7.184 NM_020493
Srf
serum response factor
chr6_+_42300005 7.071 Zyx
zyxin
chr5_-_143668369 6.730 Actb
actin, beta
chr8_-_47296201 6.702 NM_007450
Slc25a4
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
chr11_+_96164905 6.702 Hoxb5
homeobox B5
chr5_-_143668403 6.521 Actb
actin, beta
chr3_-_122737855 6.386 NM_021503
Myoz2
myozenin 2
chr5_+_138696988 6.234 0910001L09Rik
RIKEN cDNA 0910001L09 gene
chr18_-_33623400 6.058 NM_001109989
D0H4S114
DNA segment, human D4S114
chr6_+_15135505 6.024 NM_212435
Foxp2
forkhead box P2
chr2_-_13192850 5.968 NM_009105
Rsu1
Ras suppressor protein 1
chr1_-_95342168 5.870 Hdlbp
high density lipoprotein (HDL) binding protein
chr1_+_137732910 5.855 Tnnt2
troponin T2, cardiac
chr13_-_46060325 5.832 NM_009124
Atxn1
ataxin 1
chr16_+_55966458 5.714 Rpl24
ribosomal protein L24
chr1_+_120524521 5.540 NM_023755
Tcfcp2l1
transcription factor CP2-like 1
chr11_-_100749131 5.508 Stat3
signal transducer and activator of transcription 3
chr1_+_78813482 5.475 NM_021342
Kcne4
potassium voltage-gated channel, Isk-related subfamily, gene 4
chr4_-_138648762 5.454 NM_008675
Nbl1
neuroblastoma, suppression of tumorigenicity 1
chr11_+_120210028 5.166 0610009L18Rik
RIKEN cDNA 0610009L18 gene
chr16_+_14705932 5.131 NM_011415
Snai2
snail homolog 2 (Drosophila)
chr8_+_55635768 5.001 Asb5
ankyrin repeat and SOCs box-containing 5
chr5_-_143668398 4.992 NM_007393
Actb
actin, beta
chr5_+_30890386 4.934 NM_010608
Kcnk3
potassium channel, subfamily K, member 3
chr2_-_51004604 4.847 NM_028810
Rnd3
Rho family GTPase 3
chr18_+_35020867 4.646 Egr1
early growth response 1
chr9_+_43851466 4.548 NM_009382
Thy1
thymus cell antigen 1, theta
chr3_+_89251875 4.509 Pbxip1
pre-B-cell leukemia transcription factor interacting protein 1
chr7_+_18557472 4.463 NM_023289
Ceacam11
carcinoembryonic antigen-related cell adhesion molecule 11
chr2_+_131776596 4.461 NM_001126338
NM_023043
Prnd

prion protein dublet

chr6_+_3954259 4.431 Gng11
guanine nucleotide binding protein (G protein), gamma 11
chr9_-_43047862 4.406 NM_178644
Oaf
OAF homolog (Drosophila)
chr11_+_29640992 4.358 Rtn4
reticulon 4
chr8_+_96910392 4.321 NM_022331
Herpud1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr3_-_84283349 4.212 Fhdc1
FH2 domain containing 1
chr5_+_138696709 4.153 NM_001081108
0910001L09Rik
RIKEN cDNA 0910001L09 gene
chr10_+_32803288 4.141 NM_029726
Trdn
triadin
chr11_-_99354417 4.141 NM_033373
Krt23
keratin 23
chr2_+_84680479 4.096 NM_024497
Slc43a1
solute carrier family 43, member 1
chr7_-_29164215 3.856 NM_011756
Zfp36
zinc finger protein 36
chr11_-_99354449 3.796 Krt23
keratin 23
chr11_-_101285951 3.777 1700113I22Rik
RIKEN cDNA 1700113I22 gene
chr9_-_42913797 3.737 NM_027144
Arhgef12
Rho guanine nucleotide exchange factor (GEF) 12
chr3_+_102877936 3.583 NM_001033303
Ampd1
adenosine monophosphate deaminase 1
chr11_+_66891799 3.537 NM_001099635
Myh3
myosin, heavy polypeptide 3, skeletal muscle, embryonic
chr1_+_159436875 3.535 NM_033354
Sec16b
SEC16 homolog B (S. cerevisiae)
chr10_+_80657435 3.490 2310050B05Rik
RIKEN cDNA 2310050B05 gene
chr18_+_37833939 3.429 NM_033586
Pcdhga3
protocadherin gamma subfamily A, 3
chr9_+_7764067 3.425 NM_133739
Tmem123
transmembrane protein 123
chr5_-_5514729 3.307 Cldn12
claudin 12
chr3_+_89240625 3.243 NM_146131
Pbxip1
pre-B-cell leukemia transcription factor interacting protein 1
chr17_+_26792701 3.208 Ergic1
endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
chr5_-_5514787 3.163 NM_001193660
NM_001193659
NM_001193661
NM_022890
Cldn12



claudin 12



chr11_+_75469516 3.104 NM_001080775
Myo1c
myosin IC
chr1_-_95375363 2.959 Hdlbp
high density lipoprotein (HDL) binding protein
chr5_-_135422795 2.954 NM_009903
Cldn4
claudin 4
chr2_+_5058794 2.896 NM_028804
Ccdc3
coiled-coil domain containing 3
chr7_-_88711829 2.578 NM_172904
Fsd2
fibronectin type III and SPRY domain containing 2
chr1_-_63223287 2.479 Ndufs1
NADH dehydrogenase (ubiquinone) Fe-S protein 1
chr1_+_182872588 2.450 NM_144794
Tmem63a
transmembrane protein 63a
chr5_-_143667004 2.441 Actb
actin, beta
chr8_-_87417600 2.437 Gcdh
glutaryl-Coenzyme A dehydrogenase
chr17_-_73748552 2.321 NM_001033444
Capn13
calpain 13
chr1_-_95375372 2.294 NM_133808
Hdlbp
high density lipoprotein (HDL) binding protein
chr5_-_38952934 2.172 Wdr1
WD repeat domain 1
chr4_-_40226373 2.155 NM_001033305
Ndufb6
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6
chr5_-_107125783 2.115 NM_026856
Zfp644
zinc finger protein 644
chr5_+_91197542 2.035 NM_023785
Ppbp
pro-platelet basic protein
chr3_+_102538692 2.016 NM_027533
Tspan2
tetraspanin 2
chr1_+_74438182 2.016 NM_153088
Ctdsp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr2_+_91493364 2.006 NM_146124
Arhgap1
Rho GTPase activating protein 1
chr5_-_77544147 1.944 NM_175606
Hopx
HOP homeobox
chr2_-_11475504 1.924 Pfkfb3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr5_+_44260035 1.886 NM_007646
Cd38
CD38 antigen
chr7_-_19857195 1.883 NM_009499
Vasp
vasodilator-stimulated phosphoprotein
chr5_-_38952777 1.859 NM_011715
Wdr1
WD repeat domain 1
chr1_-_63223190 1.784 Ndufs1
NADH dehydrogenase (ubiquinone) Fe-S protein 1
chr7_-_77511607 1.757 NM_183261
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr7_-_19857121 1.752 Vasp
vasodilator-stimulated phosphoprotein
chr10_-_12581443 1.698 NM_011682
Utrn
utrophin
chr1_-_173465366 1.659 Itln1
intelectin 1 (galactofuranose binding)
chr2_-_60719361 1.572 NM_001141931
NM_001141932
Rbms1

RNA binding motif, single stranded interacting protein 1

chr15_-_90509751 1.530 NM_001033851
NM_025815
Cpne8

copine VIII

chr14_-_65035722 1.526 Msra
methionine sulfoxide reductase A
chrX_-_45388010 1.490 NM_013912
Apln
apelin
chr8_-_120195414 1.422 NM_028725
Sdr42e1
short chain dehydrogenase/reductase family 42E, member 1
chr7_-_19856882 1.361 Vasp
vasodilator-stimulated phosphoprotein

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
12.79 1.28e-07 GO:0006936 muscle contraction
11.13 6.57e-07 GO:0003012 muscle system process
2.07 3.45e-05 GO:0032502 developmental process
23.59 1.29e-04 GO:0031032 actomyosin structure organization
2.76 1.70e-04 GO:0009653 anatomical structure morphogenesis
2.05 2.53e-04 GO:0007275 multicellular organismal development
5.89 2.74e-04 GO:0061061 muscle structure development
6.28 3.94e-04 GO:0030036 actin cytoskeleton organization
2.08 5.93e-04 GO:0048856 anatomical structure development
5.90 7.63e-04 GO:0030029 actin filament-based process
3.15 8.63e-04 GO:0009888 tissue development
25.91 8.80e-04 GO:0030239 myofibril assembly
2.29 9.90e-04 GO:0030154 cell differentiation
2.12 1.29e-03 GO:0048731 system development
7.00 1.37e-03 GO:0007517 muscle organ development
2.34 1.92e-03 GO:0048513 organ development
2.22 2.01e-03 GO:0048869 cellular developmental process
6.30 1.07e-02 GO:0060537 muscle tissue development
2.17 1.72e-02 GO:0065008 regulation of biological quality
10.37 1.88e-02 GO:0055002 striated muscle cell development
2.85 1.90e-02 GO:0048468 cell development
42.75 2.79e-02 GO:0070252 actin-mediated cell contraction
3.78 3.42e-02 GO:0060429 epithelium development
19.83 3.44e-02 GO:0045446 endothelial cell differentiation
3.51 3.90e-02 GO:0032989 cellular component morphogenesis
9.12 3.91e-02 GO:0055001 muscle cell development
3.70 4.21e-02 GO:0043086 negative regulation of catalytic activity
9.00 4.22e-02 GO:0008016 regulation of heart contraction
7.19 4.27e-02 GO:0051146 striated muscle cell differentiation
7.13 4.53e-02 GO:0032970 regulation of actin filament-based process
18.24 4.84e-02 GO:0003158 endothelium development
8.77 4.88e-02 GO:0007015 actin filament organization

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
9.74 6.52e-15 GO:0015629 actin cytoskeleton
14.71 2.24e-12 GO:0043292 contractile fiber
16.29 3.27e-12 GO:0044449 contractile fiber part
14.00 2.12e-10 GO:0030016 myofibril
16.11 2.19e-10 GO:0030017 sarcomere
3.11 3.85e-08 GO:0005856 cytoskeleton
14.03 1.55e-05 GO:0031674 I band
18.14 1.63e-05 GO:0032432 actin filament bundle
1.51 1.67e-05 GO:0005737 cytoplasm
2.24 2.10e-05 GO:0043228 non-membrane-bounded organelle
2.24 2.10e-05 GO:0043232 intracellular non-membrane-bounded organelle
17.35 2.24e-05 GO:0042641 actomyosin
1.36 4.11e-05 GO:0005622 intracellular
1.37 4.99e-05 GO:0044424 intracellular part
11.55 7.21e-05 GO:0005925 focal adhesion
6.19 9.44e-05 GO:0016323 basolateral plasma membrane
10.99 1.06e-04 GO:0005924 cell-substrate adherens junction
3.08 1.51e-04 GO:0044430 cytoskeletal part
10.25 1.81e-04 GO:0030055 cell-substrate junction
16.69 2.31e-04 GO:0001725 stress fiber
30.40 1.16e-03 GO:0005865 striated muscle thin filament
30.40 1.16e-03 GO:0031672 A band
12.44 1.35e-03 GO:0016459 myosin complex
7.07 2.91e-03 GO:0005912 adherens junction
1.55 3.63e-03 GO:0044444 cytoplasmic part
1.36 3.87e-03 GO:0043229 intracellular organelle
1.35 4.47e-03 GO:0043226 organelle
6.47 5.53e-03 GO:0070161 anchoring junction
11.40 1.20e-02 GO:0005884 actin filament
10.56 1.74e-02 GO:0030018 Z disc
1.56 4.96e-02 GO:0044422 organelle part

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
5.70 1.03e-05 GO:0003779 actin binding
4.05 8.24e-05 GO:0008092 cytoskeletal protein binding
3.55 2.47e-02 GO:0005198 structural molecule activity