Motif ID: SRF.p3

Z-value: 3.336


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
Srf 20807 serum response factor

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Srfchr17_-_466931100.431.1e-09Click!


Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_156601175 211.935 NM_172118
 Myl9
myosin, light polypeptide 9, regulatory
chr2_+_156601150 208.324 Myl9
myosin, light polypeptide 9, regulatory
chr6_-_83486194 190.924 NM_009610
 Actg2
actin, gamma 2, smooth muscle, enteric
chr2_-_113878535 172.612 NM_009608
 Actc1
actin, alpha, cardiac muscle 1
chr8_-_126418628 114.220 NM_009606
 Acta1
actin, alpha 1, skeletal muscle
chr9_-_45744036 102.443 NM_011526
 Tagln
transgelin
chr9_-_45743950 87.772 Tagln
transgelin
chr16_+_34995000 81.222 Mylk
myosin, light polypeptide kinase
chr3_+_14863507 69.169 NM_007606
 Car3
carbonic anhydrase 3
chr17_+_71368860 68.917 NM_001083934
NM_010867
 Myom1

myomesin 1

chr19_-_34329804 67.433 NM_007392
 Acta2
actin, alpha 2, smooth muscle, aorta
chr7_+_31338319 67.180 NM_001012401
 Hspb6
heat shock protein, alpha-crystallin-related, B6
chr16_+_34921598 67.025 Mylk
myosin, light polypeptide kinase
chr1_-_43220692 62.698 Fhl2
four and a half LIM domains 2
chr3_-_57379831 61.968 NM_001168281
 Wwtr1
WW domain containing transcription regulator 1
chr1_-_43220725 61.733 Fhl2
four and a half LIM domains 2
chr1_-_43220804 60.799 NM_010212
 Fhl2
four and a half LIM domains 2
chr14_-_46149660 58.983 NM_146054
 Fermt2
fermitin family homolog 2 (Drosophila)
chr11_+_82724754 57.730 NM_178680
 Unc45b
unc-45 homolog B (C. elegans)
chr12_+_31950252 56.666 Lamb1
laminin B1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 32 entries
Enrichment   P-value GO Accession GO Term
42.75 2.79e-02 GO:0070252 actin-mediated cell contraction
25.91 8.80e-04 GO:0030239 myofibril assembly
23.59 1.29e-04 GO:0031032 actomyosin structure organization
19.83 3.44e-02 GO:0045446 endothelial cell differentiation
18.24 4.84e-02 GO:0003158 endothelium development
12.79 1.28e-07 GO:0006936 muscle contraction
11.13 6.57e-07 GO:0003012 muscle system process
10.37 1.88e-02 GO:0055002 striated muscle cell development
9.12 3.91e-02 GO:0055001 muscle cell development
9.00 4.22e-02 GO:0008016 regulation of heart contraction
8.77 4.88e-02 GO:0007015 actin filament organization
7.19 4.27e-02 GO:0051146 striated muscle cell differentiation
7.13 4.53e-02 GO:0032970 regulation of actin filament-based process
7.00 1.37e-03 GO:0007517 muscle organ development
6.30 1.07e-02 GO:0060537 muscle tissue development
6.28 3.94e-04 GO:0030036 actin cytoskeleton organization
5.90 7.63e-04 GO:0030029 actin filament-based process
5.89 2.74e-04 GO:0061061 muscle structure development
3.78 3.42e-02 GO:0060429 epithelium development
3.70 4.21e-02 GO:0043086 negative regulation of catalytic activity

Gene overrepresentation in compartment category:

Showing 1 to 20 of 31 entries
Enrichment   P-value GO Accession GO Term
30.40 1.16e-03 GO:0005865 striated muscle thin filament
30.40 1.16e-03 GO:0031672 A band
18.14 1.63e-05 GO:0032432 actin filament bundle
17.35 2.24e-05 GO:0042641 actomyosin
16.69 2.31e-04 GO:0001725 stress fiber
16.29 3.27e-12 GO:0044449 contractile fiber part
16.11 2.19e-10 GO:0030017 sarcomere
14.71 2.24e-12 GO:0043292 contractile fiber
14.03 1.55e-05 GO:0031674 I band
14.00 2.12e-10 GO:0030016 myofibril
12.44 1.35e-03 GO:0016459 myosin complex
11.55 7.21e-05 GO:0005925 focal adhesion
11.40 1.20e-02 GO:0005884 actin filament
10.99 1.06e-04 GO:0005924 cell-substrate adherens junction
10.56 1.74e-02 GO:0030018 Z disc
10.25 1.81e-04 GO:0030055 cell-substrate junction
9.74 6.52e-15 GO:0015629 actin cytoskeleton
7.07 2.91e-03 GO:0005912 adherens junction
6.47 5.53e-03 GO:0070161 anchoring junction
6.19 9.44e-05 GO:0016323 basolateral plasma membrane

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
Enrichment   P-value GO Accession GO Term
5.70 1.03e-05 GO:0003779 actin binding
4.05 8.24e-05 GO:0008092 cytoskeletal protein binding
3.55 2.47e-02 GO:0005198 structural molecule activity