Motif ID: STAT2,4,6.p2

Z-value: 1.403


Transcription factors associated with STAT2,4,6.p2:

Gene SymbolEntrez IDGene Name
Stat2 20847 signal transducer and activator of transcription 2
Stat4 20849 signal transducer and activator of transcription 4
Stat6 20852 signal transducer and activator of transcription 6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat6chr10_+_1270800130.351.5e-06Click!
Stat2chr10_+_1277075550.312.0e-05Click!
Stat4chr1_+_52065469-0.036.6e-01Click!


Activity profile for motif STAT2,4,6.p2.

activity profile for motif STAT2,4,6.p2


Sorted Z-values histogram for motif STAT2,4,6.p2

Sorted Z-values for motif STAT2,4,6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT2,4,6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_84615535 26.343 NM_009776
Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr11_-_117830455 26.219 Socs3
suppressor of cytokine signaling 3
chr9_+_107199169 25.734 Cish
cytokine inducible SH2-containing protein
chr9_+_107199019 25.552 NM_009895
Cish
cytokine inducible SH2-containing protein
chr11_-_117830554 21.835 NM_007707
Socs3
suppressor of cytokine signaling 3
chr2_-_84614976 19.778 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr10_-_94879435 19.387 NM_007706
Socs2
suppressor of cytokine signaling 2
chr2_-_84614960 18.983 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr10_-_94879369 17.781 Socs2
suppressor of cytokine signaling 2
chr1_-_71642303 15.930 Fn1
fibronectin 1
chr2_+_35159780 13.754 Gsn
gelsolin
chr18_-_53577625 11.624 NM_008908
Ppic
peptidylprolyl isomerase C
chr15_+_101933364 10.571 NM_153533
Tenc1
tensin like C1 domain-containing phosphatase
chr9_+_20820403 9.895 NM_010493
Icam1
intercellular adhesion molecule 1
chr8_+_11443165 9.495 Col4a2
collagen, type IV, alpha 2
chr11_-_55233354 9.132 Sparc
secreted acidic cysteine rich glycoprotein
chr9_+_5345475 8.525 NM_009808
Casp12
caspase 12
chr6_+_4483741 8.470 Col1a2
collagen, type I, alpha 2
chr17_-_56261311 8.172 NM_029796
Lrg1
leucine-rich alpha-2-glycoprotein 1
chr7_+_134944168 8.156 Hsd3b7
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
chr3_+_19857053 7.732 NM_001042611
NM_007752
Cp

ceruloplasmin

chr7_-_133768983 7.695 NM_019738
Nupr1
nuclear protein 1
chr18_-_33623069 7.415 NM_001109990
D0H4S114
DNA segment, human D4S114
chr5_+_7960430 7.399 NM_054098
Steap4
STEAP family member 4
chr1_-_157642492 7.321 Qsox1
quiescin Q6 sulfhydryl oxidase 1
chr10_-_27336648 7.304 NM_008481
Lama2
laminin, alpha 2
chr17_+_35610430 7.206 H2-Q10
histocompatibility 2, Q region locus 10
chr12_-_71087988 6.917 NM_022028
Sav1
salvador homolog 1 (Drosophila)
chr12_+_105644917 6.885 NM_009252
Serpina3n
serine (or cysteine) peptidase inhibitor, clade A, member 3N
chr5_-_116858596 6.744


chr18_-_52689504 6.727 Lox
lysyl oxidase
chr17_-_80114299 6.643 NM_009994
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
chr16_+_45094214 6.563 Ccdc80
coiled-coil domain containing 80
chr13_+_49704471 6.416 Ogn
osteoglycin
chr15_-_103395483 6.378 NM_008134
Glycam1
glycosylation dependent cell adhesion molecule 1
chr17_+_43804373 6.347 NM_018887
Cyp39a1
cytochrome P450, family 39, subfamily a, polypeptide 1
chr7_+_147960463 6.294 Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr16_+_45094196 6.288 Ccdc80
coiled-coil domain containing 80
chr17_-_34999458 6.141 NM_001142706
NM_008198
Cfb

complement factor B

chr11_-_117829514 6.124 Socs3
suppressor of cytokine signaling 3
chr10_-_120335907 6.061 NM_177092
Msrb3
methionine sulfoxide reductase B3
chr12_+_105474449 6.012 Serpina3g
serine (or cysteine) peptidase inhibitor, clade A, member 3G
chr16_+_45094163 5.881 NM_026439
Ccdc80
coiled-coil domain containing 80
chr18_-_52689185 5.810 Lox
lysyl oxidase
chr6_+_34548512 5.685 Cald1
caldesmon 1
chr12_+_105452740 5.670 NM_009251
NM_001168294
NM_001168295
NM_001033335
Serpina3g
Serpina3f


Serpina3h
serine (or cysteine) peptidase inhibitor, clade A, member 3G
serine (or cysteine) peptidase inhibitor, clade A, member 3F


serine (or cysteine) peptidase inhibitor, clade A, member 3H
chr14_+_31699648 5.634 NM_001159299
NM_018746
Itih4

inter alpha-trypsin inhibitor, heavy chain 4

chr1_+_40522396 5.577 NM_001161842
NM_001161843
Il18r1

interleukin 18 receptor 1

chr9_-_58160063 5.555 Loxl1
lysyl oxidase-like 1
chr12_-_104869612 5.551 NM_144834
Serpina10
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr1_-_82232392 5.503 Irs1
insulin receptor substrate 1
chr11_-_55233366 5.470 Sparc
secreted acidic cysteine rich glycoprotein
chr7_+_134944106 5.451 NM_001040684
NM_133943
Hsd3b7

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

chr1_+_132723277 5.444 Pigr
polymeric immunoglobulin receptor
chr2_+_13501725 5.280 Vim
vimentin
chr16_+_45093784 5.278 Ccdc80
coiled-coil domain containing 80
chr6_-_124492297 5.276 NM_144938
NM_001097617
C1s

complement component 1, s subcomponent

chr1_+_132723258 5.214 NM_011082
Pigr
polymeric immunoglobulin receptor
chr5_-_66542161 5.193 NM_178446
Rbm47
RNA binding motif protein 47
chr11_+_100721765 5.156 NM_001164062
Stat5a
signal transducer and activator of transcription 5A
chr5_-_66542128 5.067 Rbm47
RNA binding motif protein 47
chr15_+_79178063 4.974 NM_010755
Maff
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
chr5_+_20878459 4.959 NM_008013
Fgl2
fibrinogen-like protein 2
chr17_-_34999068 4.944 Cfb
complement factor B
chr16_+_45094383 4.942 Ccdc80
coiled-coil domain containing 80
chr9_-_119248925 4.941 NM_010851
Myd88
myeloid differentiation primary response gene 88
chrX_+_136219520 4.933 NM_001081499
Tbc1d8b
TBC1 domain family, member 8B
chr16_+_24721940 4.902 NM_001145954
Lpp
LIM domain containing preferred translocation partner in lipoma
chr8_-_74061134 4.898 NM_198095
Bst2
bone marrow stromal cell antigen 2
chr15_+_79177959 4.889 Maff
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
chr18_-_35881144 4.887 NM_001033141
Ecscr
endothelial cell-specific chemotaxis regulator
chr7_+_148662315 4.815 Tspan4
tetraspanin 4
chr17_+_44413168 4.799 Clic5
chloride intracellular channel 5
chr7_-_18940223 4.775 NM_001163685
NM_011963
Psg18

pregnancy specific glycoprotein 18

chr7_+_148662278 4.760 Tspan4
tetraspanin 4
chr18_-_33623287 4.742 NM_053078
D0H4S114
DNA segment, human D4S114
chr11_-_55233339 4.696 Sparc
secreted acidic cysteine rich glycoprotein
chr4_+_132796732 4.673 NM_016693
Map3k6
mitogen-activated protein kinase kinase kinase 6
chr15_-_6824238 4.653 NM_011019
Osmr
oncostatin M receptor
chr11_-_69509298 4.640 BC096441
cDNA sequence BC096441
chr3_+_79690082 4.520 Fam198b
family with sequence similarity 198, member B
chr3_+_82830071 4.512 NM_001111048
NM_010196
Fga

fibrinogen alpha chain

chr17_+_35576081 4.484 NM_001198560
NM_001198561
NM_010394
H2-Q9
H2-Q7


histocompatibility 2, Q region locus 9
histocompatibility 2, Q region locus 7


chr8_-_112103065 4.457 NM_017370
Hp
haptoglobin
chr17_-_59152686 4.360 NM_026497
Nudt12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
chr11_+_48900507 4.329 NM_008330
Ifi47
Olfr56
interferon gamma inducible protein 47
olfactory receptor 56
chr18_+_61204953 4.326 Pdgfrb
platelet derived growth factor receptor, beta polypeptide
chr16_+_35939047 4.316 Parp9
poly (ADP-ribose) polymerase family, member 9
chr8_-_112102961 4.307 Hp
haptoglobin
chr17_-_35018943 4.272 C2
complement component 2 (within H-2S)
chr10_-_126507271 4.234 NM_025982
Tspan31
tetraspanin 31
chr16_+_57353389 4.205 NM_001040397
Filip1l
filamin A interacting protein 1-like
chr18_-_33623668 4.158 NM_001109988
D0H4S114
DNA segment, human D4S114
chr1_+_161974815 4.155 4930523C07Rik
RIKEN cDNA 4930523C07 gene
chr3_+_79689897 4.152 Fam198b
family with sequence similarity 198, member B
chr17_-_34134101 4.145 H2-K1
histocompatibility 2, K1, K region
chr9_-_115997747 4.122 Tgfbr2
transforming growth factor, beta receptor II
chr14_-_56880985 4.062 NM_013542
Gzmb
granzyme B
chr16_-_14291427 4.026 NM_001161775
NM_013607
Myh11

myosin, heavy polypeptide 11, smooth muscle

chr7_+_138122822 4.004 Htra1
HtrA serine peptidase 1
chr16_+_91373153 3.998 Ifnar2
interferon (alpha and beta) receptor 2
chr16_+_77013880 3.985 NM_013918
Usp25
ubiquitin specific peptidase 25
chr13_-_34744188 3.970 1300014I06Rik
RIKEN cDNA 1300014I06 gene
chr7_+_148021164 3.958 1190003J15Rik
RIKEN cDNA 1190003J15 gene
chr2_-_30758745 3.958 Ptges
prostaglandin E synthase
chr8_-_112102946 3.947 Hp
haptoglobin
chr9_+_62705890 3.943 NM_001102468
NM_138304
Calml4

calmodulin-like 4

chr17_-_35019039 3.928 NM_013484
C2
complement component 2 (within H-2S)
chr2_-_44968728 3.926 NM_015753
Zeb2
zinc finger E-box binding homeobox 2
chr10_+_87321789 3.891 NM_001111275
NM_010512
Igf1

insulin-like growth factor 1

chr17_+_35561811 3.888 NM_207648
H2-Q6
histocompatibility 2, Q region locus 6
chr11_-_48877704 3.853 NM_001145164
Tgtp2
T-cell specific GTPase 2
chr7_+_109358966 3.837 Pgap2
post-GPI attachment to proteins 2
chr11_-_120587426 3.815


chr17_-_57387033 3.803 NM_030084
Gpr108
G protein-coupled receptor 108
chr17_-_34880784 3.797 NM_009780
C4b
complement component 4B (Childo blood group)
chrX_-_49967112 3.788 NM_016697
Gpc3
glypican 3
chr10_-_14264800 3.783 NM_001002268
Gpr126
G protein-coupled receptor 126
chr11_+_81849074 3.782 NM_011333
Ccl2
chemokine (C-C motif) ligand 2
chr16_+_45093816 3.746 Ccdc80
coiled-coil domain containing 80
chr9_+_102620096 3.743 NM_019764
Amotl2
angiomotin-like 2
chr1_+_173367685 3.741 NM_172647
F11r
F11 receptor
chr17_+_35403130 3.734 H2-D1
histocompatibility 2, D region locus 1
chr7_-_31861665 3.698 NM_008557
Fxyd3
FXYD domain-containing ion transport regulator 3
chr17_-_34133397 3.682 H2-K1
histocompatibility 2, K1, K region
chr17_-_34137221 3.672 NM_001001892
H2-K1
histocompatibility 2, K1, K region
chr18_-_33623400 3.668 NM_001109989
D0H4S114
DNA segment, human D4S114
chr7_+_148021207 3.641 1190003J15Rik
RIKEN cDNA 1190003J15 gene
chr17_-_34134309 3.619 H2-K1
histocompatibility 2, K1, K region
chrX_-_49967090 3.609 Gpc3
glypican 3
chr7_-_116760069 3.608 St5
suppression of tumorigenicity 5
chr12_+_34642516 3.575 NM_011658
Twist1
twist homolog 1 (Drosophila)
chr15_-_102008126 3.557


chr4_-_55545337 3.549 NM_010637
Klf4
Kruppel-like factor 4 (gut)
chr11_+_94812919 3.545 Col1a1
collagen, type I, alpha 1
chr8_+_74676404 3.493 Tpm4
tropomyosin 4
chr11_-_48877544 3.477 Tgtp2
Tgtp1
T-cell specific GTPase 2
T-cell specific GTPase 1
chr18_-_52689279 3.463 NM_010728
Lox
lysyl oxidase
chr15_+_101974792 3.458 Igfbp6
insulin-like growth factor binding protein 6
chr16_+_91373008 3.457 NM_001110498
NM_010509
Ifnar2

interferon (alpha and beta) receptor 2

chr15_+_101974978 3.453 Igfbp6
insulin-like growth factor binding protein 6
chr3_+_142193286 3.440 NM_001083312
NM_145545
Gbp6

guanylate binding protein 6

chr11_-_48805585 3.431 NM_001145164
NM_011579
Tgtp2
Tgtp1
Gm12185
T-cell specific GTPase 2
T-cell specific GTPase 1
predicted gene 12185
chr6_+_15670660 3.417 NM_175088
Mdfic
MyoD family inhibitor domain containing
chr7_-_87080143 3.409 NM_027420
2610034B18Rik
RIKEN cDNA 2610034B18 gene
chr17_+_35607032 3.392 NM_010391
H2-Q10
histocompatibility 2, Q region locus 10
chr7_-_31729018 3.381 NM_032541
Hamp
hepcidin antimicrobial peptide
chr6_+_4471231 3.379 Col1a2
collagen, type I, alpha 2
chr3_+_82811777 3.373 Fgg
fibrinogen gamma chain
chr3_+_82811802 3.366 NM_133862
Fgg
fibrinogen gamma chain
chr6_-_21802087 3.366 Tspan12
tetraspanin 12
chr12_+_34642676 3.364 Twist1
twist homolog 1 (Drosophila)
chr8_-_11199802 3.361 Col4a1
collagen, type IV, alpha 1
chr5_+_88203590 3.355 NM_007785
Csn1s2a
casein alpha s2-like A
chr11_+_69778280 3.352 NM_001193619
Cldn7
claudin 7
chr6_+_133985988 3.304 Etv6
ets variant gene 6 (TEL oncogene)
chr9_+_102620058 3.297 Amotl2
angiomotin-like 2
chr6_+_133985717 3.281 NM_007961
Etv6
ets variant gene 6 (TEL oncogene)
chr4_-_63681749 3.273 NM_011607
Tnc
tenascin C
chr13_-_13097596 3.247 NM_031191
Prl2c2
prolactin family 2, subfamily c, member 2
chr3_+_89032973 3.231 NM_013605
Muc1
mucin 1, transmembrane
chr17_+_34324700 3.230 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr15_+_101242832 3.226 NM_033073
Krt7
keratin 7
chr10_-_53795556 3.225 NM_008548
Man1a
mannosidase 1, alpha
chr3_-_144423699 3.202 NM_009899
Clca1
chloride channel calcium activated 1
chr5_+_114615526 3.182 NM_133904
Acacb
acetyl-Coenzyme A carboxylase beta
chr10_-_79538107 3.169 Sbno2
strawberry notch homolog 2 (Drosophila)
chr2_-_163575826 3.155 NM_007398
Ada
adenosine deaminase
chr12_-_81213930 3.146 NM_007564
Zfp36l1
zinc finger protein 36, C3H type-like 1
chr6_+_108610606 3.144 NM_011498
Bhlhe40
basic helix-loop-helix family, member e40
chr6_-_48791052 3.139 NM_001164209
Tmem176b
transmembrane protein 176B
chr18_+_61204798 3.137 NM_001146268
NM_008809
Pdgfrb

platelet derived growth factor receptor, beta polypeptide

chr17_+_35399970 3.135 H2-D1
histocompatibility 2, D region locus 1
chr8_+_36439713 3.133 Ppp1r3b
protein phosphatase 1, regulatory (inhibitor) subunit 3B
chr17_+_43526389 3.131 NM_001081178
Gpr116
G protein-coupled receptor 116
chr18_-_75099989 3.118 Lipg
lipase, endothelial
chr6_+_124462696 3.111 C1ra
complement component 1, r subcomponent A
chr1_-_151808361 3.104 NM_008869
Pla2g4a
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr18_+_35278553 3.101 NM_009818
Ctnna1
catenin (cadherin associated protein), alpha 1
chr5_+_88095232 3.092 NM_007784
Csn1s1
casein alpha s1
chr5_-_147888037 3.085 NM_080795
Lnx2
ligand of numb-protein X 2
chr16_-_35871459 3.082 NM_001039530
Parp14
poly (ADP-ribose) polymerase family, member 14
chr4_-_126991216 3.073 NM_008120
Gja4
gap junction protein, alpha 4
chr7_-_88851823 3.063 Homer2
homer homolog 2 (Drosophila)
chr11_+_58028478 3.042 NM_019440
Irgm2
immunity-related GTPase family M member 2
chr2_-_51816123 3.032 Nmi
N-myc (and STAT) interactor
chr17_+_34324636 3.029 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr7_+_89484203 3.019 NM_001190374
Adamtsl3
ADAMTS-like 3
chr14_-_56332217 3.015 NM_001161714
NM_001161715
Tgm1

transglutaminase 1, K polypeptide

chr15_+_79178408 3.012 Maff
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
chr19_+_12535268 3.004 NM_010821
Mpeg1
macrophage expressed gene 1
chr11_-_78349594 3.001 NM_001159392
NM_009395
Tnfaip1

tumor necrosis factor, alpha-induced protein 1 (endothelial)

chr19_+_12535536 2.991 Mpeg1
macrophage expressed gene 1
chr1_+_180117547 2.983 NM_024282
Pppde1
PPPDE peptidase domain containing 1
chr15_+_54964990 2.980 NM_001037937
Deptor
DEP domain containing MTOR-interacting protein
chr17_+_35400038 2.977 NM_010380
H2-D1
histocompatibility 2, D region locus 1
chr17_-_34324234 2.955 NM_013585
Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr11_+_83517517 2.954 NM_001081957
Gm11428
predicted gene 11428
chr8_-_64381465 2.945 NM_001081390
Palld
palladin, cytoskeletal associated protein
chr9_+_102620051 2.944 Amotl2
angiomotin-like 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.57 6.64e-20 GO:0048518 positive regulation of biological process
1.57 2.29e-17 GO:0048522 positive regulation of cellular process
1.45 1.19e-15 GO:0060255 regulation of macromolecule metabolic process
1.95 2.62e-15 GO:0031328 positive regulation of cellular biosynthetic process
1.93 4.14e-15 GO:0009891 positive regulation of biosynthetic process
1.39 7.10e-15 GO:0019222 regulation of metabolic process
1.51 8.46e-15 GO:0010468 regulation of gene expression
1.42 1.78e-14 GO:0080090 regulation of primary metabolic process
1.25 2.77e-14 GO:0008152 metabolic process
1.72 7.66e-14 GO:0009893 positive regulation of metabolic process
1.94 7.73e-14 GO:0010557 positive regulation of macromolecule biosynthetic process
1.96 2.61e-13 GO:0010628 positive regulation of gene expression
1.40 3.11e-13 GO:0031323 regulation of cellular metabolic process
2.24 4.56e-13 GO:0072358 cardiovascular system development
2.24 4.56e-13 GO:0072359 circulatory system development
1.73 7.31e-13 GO:0010604 positive regulation of macromolecule metabolic process
1.47 8.31e-13 GO:0031326 regulation of cellular biosynthetic process
1.72 1.50e-12 GO:0031325 positive regulation of cellular metabolic process
1.46 2.28e-12 GO:0009889 regulation of biosynthetic process
1.48 2.47e-12 GO:0010556 regulation of macromolecule biosynthetic process
1.50 3.21e-12 GO:0051252 regulation of RNA metabolic process
2.13 3.44e-12 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.87 5.38e-12 GO:0051173 positive regulation of nitrogen compound metabolic process
1.30 6.08e-12 GO:0043170 macromolecule metabolic process
1.48 6.30e-12 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.25 1.14e-11 GO:0044238 primary metabolic process
1.94 1.35e-11 GO:0045893 positive regulation of transcription, DNA-dependent
1.58 1.87e-11 GO:0048513 organ development
1.82 1.90e-11 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.84 2.05e-11 GO:0002376 immune system process
1.49 2.28e-11 GO:0006355 regulation of transcription, DNA-dependent
1.42 2.57e-11 GO:0007275 multicellular organismal development
1.86 2.72e-11 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.48 3.69e-11 GO:0048731 system development
1.91 4.79e-11 GO:0051254 positive regulation of RNA metabolic process
1.48 5.30e-11 GO:0048519 negative regulation of biological process
1.63 5.43e-11 GO:0051239 regulation of multicellular organismal process
1.98 2.04e-10 GO:0070887 cellular response to chemical stimulus
1.73 6.06e-10 GO:0010033 response to organic substance
1.55 6.39e-10 GO:0042221 response to chemical stimulus
1.79 8.90e-10 GO:0042127 regulation of cell proliferation
1.41 9.59e-10 GO:0051171 regulation of nitrogen compound metabolic process
1.37 1.51e-09 GO:0032502 developmental process
2.44 1.54e-09 GO:0001568 blood vessel development
1.41 2.25e-09 GO:0048856 anatomical structure development
1.41 2.25e-09 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.23 2.37e-09 GO:0044237 cellular metabolic process
2.34 5.64e-09 GO:0001944 vasculature development
1.28 5.87e-09 GO:0044260 cellular macromolecule metabolic process
1.60 6.45e-09 GO:0009653 anatomical structure morphogenesis
1.52 9.32e-09 GO:0006351 transcription, DNA-dependent
1.76 9.73e-09 GO:0009888 tissue development
1.51 1.14e-08 GO:0032774 RNA biosynthetic process
1.45 2.77e-08 GO:0048523 negative regulation of cellular process
1.70 2.86e-08 GO:0043067 regulation of programmed cell death
1.68 3.45e-08 GO:0010941 regulation of cell death
1.53 4.03e-08 GO:0048583 regulation of response to stimulus
1.70 4.11e-08 GO:0042981 regulation of apoptosis
1.98 4.56e-08 GO:0008284 positive regulation of cell proliferation
2.03 9.50e-08 GO:0043069 negative regulation of programmed cell death
2.03 1.06e-07 GO:0043066 negative regulation of apoptosis
2.73 1.22e-07 GO:0001525 angiogenesis
2.01 1.78e-07 GO:0071310 cellular response to organic substance
1.99 1.83e-07 GO:0060548 negative regulation of cell death
2.44 2.19e-07 GO:0048514 blood vessel morphogenesis
1.71 3.10e-07 GO:2000026 regulation of multicellular organismal development
2.55 3.28e-07 GO:0034097 response to cytokine stimulus
1.64 3.31e-07 GO:0050793 regulation of developmental process
1.93 3.38e-07 GO:0051094 positive regulation of developmental process
1.39 3.65e-07 GO:0009059 macromolecule biosynthetic process
1.50 3.78e-07 GO:0006950 response to stress
1.39 5.13e-07 GO:0034645 cellular macromolecule biosynthetic process
1.33 6.70e-07 GO:0009058 biosynthetic process
2.63 7.96e-07 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
1.43 8.69e-07 GO:0030154 cell differentiation
1.71 9.65e-07 GO:0009790 embryo development
2.07 1.12e-06 GO:0006955 immune response
1.84 1.24e-06 GO:0002682 regulation of immune system process
1.89 1.87e-06 GO:0048646 anatomical structure formation involved in morphogenesis
1.36 2.00e-06 GO:0010467 gene expression
1.38 2.17e-06 GO:0016070 RNA metabolic process
1.32 2.23e-06 GO:0044249 cellular biosynthetic process
2.40 3.67e-06 GO:0048732 gland development
2.04 4.90e-06 GO:0048729 tissue morphogenesis
1.70 5.26e-06 GO:0048584 positive regulation of response to stimulus
2.22 6.42e-06 GO:0007507 heart development
1.40 7.26e-06 GO:0048869 cellular developmental process
2.19 1.01e-05 GO:0002009 morphogenesis of an epithelium
2.33 1.21e-05 GO:0043193 positive regulation of gene-specific transcription
1.97 1.55e-05 GO:0002684 positive regulation of immune system process
2.03 3.63e-05 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
4.44 5.25e-05 GO:0030850 prostate gland development
1.99 6.10e-05 GO:0002520 immune system development
1.81 6.95e-05 GO:0009792 embryo development ending in birth or egg hatching
1.82 7.14e-05 GO:0043009 chordate embryonic development
2.41 7.89e-05 GO:0051272 positive regulation of cellular component movement
2.63 1.38e-04 GO:0061138 morphogenesis of a branching epithelium
2.52 1.46e-04 GO:0001655 urogenital system development
1.89 1.55e-04 GO:0032583 regulation of gene-specific transcription
2.41 1.69e-04 GO:0030335 positive regulation of cell migration
2.41 1.69e-04 GO:2000147 positive regulation of cell motility
1.89 1.73e-04 GO:0060429 epithelium development
2.50 1.76e-04 GO:0002252 immune effector process
1.78 1.85e-04 GO:0006952 defense response
1.62 1.97e-04 GO:0045595 regulation of cell differentiation
1.49 2.07e-04 GO:0009966 regulation of signal transduction
1.52 2.11e-04 GO:0010646 regulation of cell communication
2.00 2.16e-04 GO:0051270 regulation of cellular component movement
1.66 2.19e-04 GO:0010629 negative regulation of gene expression
1.98 2.22e-04 GO:0048534 hemopoietic or lymphoid organ development
1.70 2.23e-04 GO:0009887 organ morphogenesis
5.12 2.27e-04 GO:0060512 prostate gland morphogenesis
1.30 2.33e-04 GO:0019538 protein metabolic process
1.53 2.43e-04 GO:0032879 regulation of localization
1.39 2.45e-04 GO:0065008 regulation of biological quality
2.58 2.54e-04 GO:0071345 cellular response to cytokine stimulus
2.45 3.08e-04 GO:0001763 morphogenesis of a branching structure
2.94 3.51e-04 GO:0022612 gland morphogenesis
1.77 3.64e-04 GO:0051704 multi-organism process
1.30 4.44e-04 GO:0090304 nucleic acid metabolic process
2.02 4.70e-04 GO:0030334 regulation of cell migration
3.29 4.97e-04 GO:0016202 regulation of striated muscle tissue development
1.29 5.45e-04 GO:0016043 cellular component organization
1.50 5.90e-04 GO:0009892 negative regulation of metabolic process
1.77 5.92e-04 GO:0009967 positive regulation of signal transduction
2.30 6.59e-04 GO:0040017 positive regulation of locomotion
1.94 7.16e-04 GO:0035295 tube development
1.52 7.49e-04 GO:0010605 negative regulation of macromolecule metabolic process
2.00 7.76e-04 GO:2000145 regulation of cell motility
3.20 8.97e-04 GO:0048634 regulation of muscle organ development
1.27 9.35e-04 GO:0071840 cellular component organization or biogenesis
1.80 1.09e-03 GO:0048598 embryonic morphogenesis
1.71 1.11e-03 GO:0010647 positive regulation of cell communication
4.94 1.18e-03 GO:0060740 prostate gland epithelium morphogenesis
2.00 1.37e-03 GO:0001501 skeletal system development
5.72 1.39e-03 GO:0060441 epithelial tube branching involved in lung morphogenesis
1.70 1.44e-03 GO:0023056 positive regulation of signaling
1.09 1.45e-03 GO:0009987 cellular process
1.80 1.56e-03 GO:0040008 regulation of growth
2.11 1.63e-03 GO:0035239 tube morphogenesis
3.07 2.07e-03 GO:0048704 embryonic skeletal system morphogenesis
2.78 2.12e-03 GO:0048706 embryonic skeletal system development
2.32 2.16e-03 GO:0002521 leukocyte differentiation
1.85 2.34e-03 GO:0008285 negative regulation of cell proliferation
1.72 2.34e-03 GO:0048585 negative regulation of response to stimulus
2.51 2.54e-03 GO:0048754 branching morphogenesis of a tube
5.43 2.80e-03 GO:0048645 organ formation
2.93 3.15e-03 GO:0002250 adaptive immune response
1.80 3.27e-03 GO:0051240 positive regulation of multicellular organismal process
4.32 3.27e-03 GO:0060425 lung morphogenesis
1.47 3.37e-03 GO:0051246 regulation of protein metabolic process
1.79 3.50e-03 GO:0045597 positive regulation of cell differentiation
1.88 3.94e-03 GO:0040012 regulation of locomotion
2.95 4.52e-03 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
1.92 4.54e-03 GO:0030097 hemopoiesis
1.39 4.69e-03 GO:0023051 regulation of signaling
1.12 5.77e-03 GO:0065007 biological regulation
3.29 6.00e-03 GO:0042476 odontogenesis
1.80 6.63e-03 GO:0009725 response to hormone stimulus
1.61 6.96e-03 GO:0045892 negative regulation of transcription, DNA-dependent
2.24 7.01e-03 GO:0006916 anti-apoptosis
2.08 7.01e-03 GO:0052547 regulation of peptidase activity
1.60 7.63e-03 GO:0051253 negative regulation of RNA metabolic process
3.14 7.68e-03 GO:0007160 cell-matrix adhesion
2.61 7.78e-03 GO:0019221 cytokine-mediated signaling pathway
2.79 8.18e-03 GO:0060485 mesenchyme development
2.38 9.07e-03 GO:0001503 ossification
1.22 9.09e-03 GO:0006807 nitrogen compound metabolic process
1.50 9.12e-03 GO:0048468 cell development
1.22 9.73e-03 GO:0034641 cellular nitrogen compound metabolic process
1.94 1.02e-02 GO:0001817 regulation of cytokine production
1.92 1.29e-02 GO:0045321 leukocyte activation
6.58 1.32e-02 GO:0060525 prostate glandular acinus development
2.16 1.38e-02 GO:0060562 epithelial tube morphogenesis
1.72 1.42e-02 GO:0009719 response to endogenous stimulus
4.14 1.43e-02 GO:0048701 embryonic cranial skeleton morphogenesis
2.23 1.49e-02 GO:0048705 skeletal system morphogenesis
1.58 1.57e-02 GO:0022610 biological adhesion
2.99 1.72e-02 GO:0014031 mesenchymal cell development
1.88 1.77e-02 GO:0048568 embryonic organ development
1.45 1.84e-02 GO:0031324 negative regulation of cellular metabolic process
1.84 1.87e-02 GO:0001775 cell activation
1.58 1.92e-02 GO:0007155 cell adhesion
2.35 2.31e-02 GO:0030324 lung development
1.22 2.39e-02 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.55 2.44e-02 GO:0019220 regulation of phosphate metabolic process
1.55 2.44e-02 GO:0051174 regulation of phosphorus metabolic process
2.84 2.50e-02 GO:0010810 regulation of cell-substrate adhesion
1.74 2.51e-02 GO:0009968 negative regulation of signal transduction
4.23 2.58e-02 GO:0043535 regulation of blood vessel endothelial cell migration
1.72 2.64e-02 GO:0009611 response to wounding
3.23 2.82e-02 GO:0019882 antigen processing and presentation
2.61 3.00e-02 GO:0035270 endocrine system development
1.73 3.01e-02 GO:0051093 negative regulation of developmental process
2.49 3.06e-02 GO:0045765 regulation of angiogenesis
1.12 3.06e-02 GO:0050789 regulation of biological process
6.08 3.12e-02 GO:0060742 epithelial cell differentiation involved in prostate gland development
1.78 3.13e-02 GO:0050776 regulation of immune response
2.32 3.23e-02 GO:0030323 respiratory tube development
1.22 3.39e-02 GO:0051179 localization
1.98 3.60e-02 GO:0046649 lymphocyte activation
1.51 3.66e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
1.68 3.88e-02 GO:0010648 negative regulation of cell communication
2.77 3.98e-02 GO:0048762 mesenchymal cell differentiation
1.88 3.98e-02 GO:0003002 regionalization
1.75 4.02e-02 GO:0022603 regulation of anatomical structure morphogenesis
2.93 4.11e-02 GO:0045580 regulation of T cell differentiation
2.13 4.18e-02 GO:0030855 epithelial cell differentiation
2.15 4.55e-02 GO:0050678 regulation of epithelial cell proliferation
2.12 4.82e-02 GO:0060537 muscle tissue development
1.48 4.84e-02 GO:0044093 positive regulation of molecular function
1.34 4.91e-02 GO:0065009 regulation of molecular function

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.20 4.68e-19 GO:0044424 intracellular part
1.25 1.77e-18 GO:0043227 membrane-bounded organelle
1.19 1.99e-18 GO:0005622 intracellular
1.25 4.93e-18 GO:0043231 intracellular membrane-bounded organelle
1.21 5.06e-16 GO:0043226 organelle
1.21 3.07e-15 GO:0043229 intracellular organelle
1.23 2.09e-14 GO:0005737 cytoplasm
1.86 1.00e-13 GO:0044421 extracellular region part
1.28 1.81e-12 GO:0044444 cytoplasmic part
1.56 6.13e-12 GO:0005576 extracellular region
1.92 1.42e-11 GO:0005615 extracellular space
1.24 9.10e-08 GO:0005634 nucleus
1.44 2.80e-07 GO:0044459 plasma membrane part
1.59 4.91e-07 GO:0005783 endoplasmic reticulum
2.00 3.44e-05 GO:0005792 microsome
1.98 3.95e-05 GO:0042598 vesicular fraction
1.77 6.81e-05 GO:0009986 cell surface
1.07 8.08e-05 GO:0005623 cell
1.07 8.08e-05 GO:0044464 cell part
1.93 1.14e-04 GO:0031012 extracellular matrix
2.15 1.18e-04 GO:0016323 basolateral plasma membrane
1.23 1.63e-04 GO:0071944 cell periphery
1.24 1.67e-04 GO:0005886 plasma membrane
1.52 1.72e-04 GO:0005626 insoluble fraction
2.89 1.92e-04 GO:0030055 cell-substrate junction
1.95 3.62e-04 GO:0005578 proteinaceous extracellular matrix
1.60 6.46e-04 GO:0030054 cell junction
1.41 1.21e-03 GO:0000267 cell fraction
2.31 1.54e-03 GO:0070161 anchoring junction
2.37 1.68e-03 GO:0005912 adherens junction
1.47 2.18e-03 GO:0005624 membrane fraction
2.74 2.37e-03 GO:0005924 cell-substrate adherens junction
2.75 3.45e-03 GO:0005925 focal adhesion
1.83 5.89e-03 GO:0015629 actin cytoskeleton
1.90 1.03e-02 GO:0005911 cell-cell junction
1.41 1.21e-02 GO:0005794 Golgi apparatus
2.25 1.42e-02 GO:0043235 receptor complex
1.99 2.59e-02 GO:0031252 cell leading edge
2.20 4.11e-02 GO:0044420 extracellular matrix part
1.85 4.46e-02 GO:0009897 external side of plasma membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.24 2.21e-29 GO:0005488 binding
1.37 3.15e-22 GO:0005515 protein binding
1.79 9.24e-09 GO:0001071 nucleic acid binding transcription factor activity
1.79 9.24e-09 GO:0003700 sequence-specific DNA binding transcription factor activity
1.69 5.21e-08 GO:0030528 transcription regulator activity
1.72 7.64e-06 GO:0043565 sequence-specific DNA binding
1.93 2.20e-05 GO:0030246 carbohydrate binding
2.53 2.64e-05 GO:0001871 pattern binding
2.53 2.64e-05 GO:0030247 polysaccharide binding
1.25 1.31e-04 GO:0043167 ion binding
1.61 1.48e-04 GO:0046983 protein dimerization activity
1.30 1.58e-04 GO:0003676 nucleic acid binding
1.24 3.02e-04 GO:0043169 cation binding
1.54 3.67e-04 GO:0019899 enzyme binding
1.89 4.33e-04 GO:0016563 transcription activator activity
1.24 5.24e-04 GO:0046872 metal ion binding
1.48 5.89e-04 GO:0005102 receptor binding
1.89 6.94e-04 GO:0016564 transcription repressor activity
1.35 7.47e-04 GO:0003677 DNA binding
1.54 8.64e-04 GO:0042802 identical protein binding
2.63 9.48e-04 GO:0019838 growth factor binding
2.40 1.14e-03 GO:0005539 glycosaminoglycan binding
2.61 1.71e-03 GO:0008201 heparin binding
1.88 1.72e-03 GO:0019900 kinase binding
1.97 1.76e-03 GO:0019901 protein kinase binding
1.35 2.07e-03 GO:0046914 transition metal ion binding
1.55 1.62e-02 GO:0070011 peptidase activity, acting on L-amino acid peptides
1.54 1.88e-02 GO:0008233 peptidase activity
1.66 2.20e-02 GO:0005198 structural molecule activity
5.76 4.21e-02 GO:0048407 platelet-derived growth factor binding