Motif ID: STAT2,4,6.p2

Z-value: 1.403


Transcription factors associated with STAT2,4,6.p2:

Gene SymbolEntrez IDGene Name
Stat2 20847 signal transducer and activator of transcription 2
Stat4 20849 signal transducer and activator of transcription 4
Stat6 20852 signal transducer and activator of transcription 6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat6chr10_+_1270800130.351.5e-06Click!
Stat2chr10_+_1277075550.312.0e-05Click!
Stat4chr1_+_52065469-0.036.6e-01Click!


Activity profile for motif STAT2,4,6.p2.

activity profile for motif STAT2,4,6.p2


Sorted Z-values histogram for motif STAT2,4,6.p2

Sorted Z-values for motif STAT2,4,6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT2,4,6.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_84615535 26.343 NM_009776
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr11_-_117830455 26.219 Socs3
suppressor of cytokine signaling 3
chr9_+_107199169 25.734 Cish
cytokine inducible SH2-containing protein
chr9_+_107199019 25.552 NM_009895
 Cish
cytokine inducible SH2-containing protein
chr11_-_117830554 21.835 NM_007707
 Socs3
suppressor of cytokine signaling 3
chr2_-_84614976 19.778 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr10_-_94879435 19.387 NM_007706
 Socs2
suppressor of cytokine signaling 2
chr2_-_84614960 18.983 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr10_-_94879369 17.781 Socs2
suppressor of cytokine signaling 2
chr1_-_71642303 15.930 Fn1
fibronectin 1
chr2_+_35159780 13.754 Gsn
gelsolin
chr18_-_53577625 11.624 NM_008908
 Ppic
peptidylprolyl isomerase C
chr15_+_101933364 10.571 NM_153533
 Tenc1
tensin like C1 domain-containing phosphatase
chr9_+_20820403 9.895 NM_010493
 Icam1
intercellular adhesion molecule 1
chr8_+_11443165 9.495 Col4a2
collagen, type IV, alpha 2
chr11_-_55233354 9.132 Sparc
secreted acidic cysteine rich glycoprotein
chr9_+_5345475 8.525 NM_009808
 Casp12
caspase 12
chr6_+_4483741 8.470 Col1a2
collagen, type I, alpha 2
chr17_-_56261311 8.172 NM_029796
 Lrg1
leucine-rich alpha-2-glycoprotein 1
chr7_+_134944168 8.156 Hsd3b7
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 212 entries
Enrichment   P-value GO Accession GO Term
6.58 1.32e-02 GO:0060525 prostate glandular acinus development
6.08 3.12e-02 GO:0060742 epithelial cell differentiation involved in prostate gland development
5.72 1.39e-03 GO:0060441 epithelial tube branching involved in lung morphogenesis
5.43 2.80e-03 GO:0048645 organ formation
5.12 2.27e-04 GO:0060512 prostate gland morphogenesis
4.94 1.18e-03 GO:0060740 prostate gland epithelium morphogenesis
4.44 5.25e-05 GO:0030850 prostate gland development
4.32 3.27e-03 GO:0060425 lung morphogenesis
4.23 2.58e-02 GO:0043535 regulation of blood vessel endothelial cell migration
4.14 1.43e-02 GO:0048701 embryonic cranial skeleton morphogenesis
3.29 4.97e-04 GO:0016202 regulation of striated muscle tissue development
3.29 6.00e-03 GO:0042476 odontogenesis
3.23 2.82e-02 GO:0019882 antigen processing and presentation
3.20 8.97e-04 GO:0048634 regulation of muscle organ development
3.14 7.68e-03 GO:0007160 cell-matrix adhesion
3.07 2.07e-03 GO:0048704 embryonic skeletal system morphogenesis
2.99 1.72e-02 GO:0014031 mesenchymal cell development
2.95 4.52e-03 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
2.94 3.51e-04 GO:0022612 gland morphogenesis
2.93 3.15e-03 GO:0002250 adaptive immune response

Gene overrepresentation in compartment category:

Showing 1 to 20 of 40 entries
Enrichment   P-value GO Accession GO Term
2.89 1.92e-04 GO:0030055 cell-substrate junction
2.75 3.45e-03 GO:0005925 focal adhesion
2.74 2.37e-03 GO:0005924 cell-substrate adherens junction
2.37 1.68e-03 GO:0005912 adherens junction
2.31 1.54e-03 GO:0070161 anchoring junction
2.25 1.42e-02 GO:0043235 receptor complex
2.20 4.11e-02 GO:0044420 extracellular matrix part
2.15 1.18e-04 GO:0016323 basolateral plasma membrane
2.00 3.44e-05 GO:0005792 microsome
1.99 2.59e-02 GO:0031252 cell leading edge
1.98 3.95e-05 GO:0042598 vesicular fraction
1.95 3.62e-04 GO:0005578 proteinaceous extracellular matrix
1.93 1.14e-04 GO:0031012 extracellular matrix
1.92 1.42e-11 GO:0005615 extracellular space
1.90 1.03e-02 GO:0005911 cell-cell junction
1.86 1.00e-13 GO:0044421 extracellular region part
1.85 4.46e-02 GO:0009897 external side of plasma membrane
1.83 5.89e-03 GO:0015629 actin cytoskeleton
1.77 6.81e-05 GO:0009986 cell surface
1.60 6.46e-04 GO:0030054 cell junction

Gene overrepresentation in function category:

Showing 1 to 20 of 30 entries
Enrichment   P-value GO Accession GO Term
5.76 4.21e-02 GO:0048407 platelet-derived growth factor binding
2.63 9.48e-04 GO:0019838 growth factor binding
2.61 1.71e-03 GO:0008201 heparin binding
2.53 2.64e-05 GO:0001871 pattern binding
2.53 2.64e-05 GO:0030247 polysaccharide binding
2.40 1.14e-03 GO:0005539 glycosaminoglycan binding
1.97 1.76e-03 GO:0019901 protein kinase binding
1.93 2.20e-05 GO:0030246 carbohydrate binding
1.89 4.33e-04 GO:0016563 transcription activator activity
1.89 6.94e-04 GO:0016564 transcription repressor activity
1.88 1.72e-03 GO:0019900 kinase binding
1.79 9.24e-09 GO:0001071 nucleic acid binding transcription factor activity
1.79 9.24e-09 GO:0003700 sequence-specific DNA binding transcription factor activity
1.72 7.64e-06 GO:0043565 sequence-specific DNA binding
1.69 5.21e-08 GO:0030528 transcription regulator activity
1.66 2.20e-02 GO:0005198 structural molecule activity
1.61 1.48e-04 GO:0046983 protein dimerization activity
1.55 1.62e-02 GO:0070011 peptidase activity, acting on L-amino acid peptides
1.54 3.67e-04 GO:0019899 enzyme binding
1.54 8.64e-04 GO:0042802 identical protein binding