Motif ID: TBX4,5.p2

Z-value: 1.595


Transcription factors associated with TBX4,5.p2:

Gene SymbolEntrez IDGene Name
Tbx4 21387 T-box 4
Tbx5 21388 T-box 5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbx5chr5_+_1202846710.153.9e-02Click!
Tbx4chr11_+_85710266-0.082.9e-01Click!


Activity profile for motif TBX4,5.p2.

activity profile for motif TBX4,5.p2


Sorted Z-values histogram for motif TBX4,5.p2

Sorted Z-values for motif TBX4,5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBX4,5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_8622882 25.177 NM_198620
Rundc3b
RUN domain containing 3B
chr11_+_23978110 12.450 Bcl11a
B-cell CLL/lymphoma 11A (zinc finger protein)
chr7_+_29767872 10.909 NM_008279
Map4k1
mitogen-activated protein kinase kinase kinase kinase 1
chr11_+_23978029 10.644 NM_001159289
NM_016707
Bcl11a

B-cell CLL/lymphoma 11A (zinc finger protein)

chr8_-_108457731 9.856 NM_023182
Ctrl
chymotrypsin-like
chr3_+_133903056 9.836 NM_001004367
Cxxc4
CXXC finger 4
chr7_-_52494097 9.536 NM_007645
Cd37
CD37 antigen
chr2_-_91023004 9.490 Madd
MAP-kinase activating death domain
chr11_+_6289339 9.470 NM_028601
Zmiz2
zinc finger, MIZ-type containing 2
chr12_+_4082739 9.123 Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr11_+_54117703 8.803 NM_001033597
NM_144823
Acsl6

acyl-CoA synthetase long-chain family member 6

chr7_-_52494453 8.673 Cd37
CD37 antigen
chr7_+_86955612 8.603 NM_008589
Mesp2
mesoderm posterior 2
chr6_-_136610399 8.335 NM_025806
Plbd1
phospholipase B domain containing 1
chr7_-_30066910 8.282 NM_001082548
NM_011464
Spint2

serine protease inhibitor, Kunitz type 2

chr8_-_126957835 8.278 NM_171824
Pgbd5
piggyBac transposable element derived 5
chrX_-_71156567 8.165 NM_001162423
NM_001162424
NM_138630
Arhgap4


Rho GTPase activating protein 4


chr7_-_30066867 8.054 Spint2
serine protease inhibitor, Kunitz type 2
chr16_+_17276434 7.905 Tmem191c
transmembrane protein 191C
chr16_+_17276384 7.817 NM_177473
Tmem191c
transmembrane protein 191C
chr10_+_97155692 7.813 NM_025724
4921510H08Rik
RIKEN cDNA 4921510H08 gene
chr5_-_147396407 7.774 Gpr12
G-protein coupled receptor 12
chr2_-_25325196 7.703 Ptgds
prostaglandin D2 synthase (brain)
chr14_+_41918624 7.545 NM_133653
Mat1a
methionine adenosyltransferase I, alpha
chr2_-_5635547 7.488 NM_177343
Camk1d
calcium/calmodulin-dependent protein kinase ID
chr17_+_31433159 7.454 Slc37a1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr16_+_17276720 7.388 Tmem191c
transmembrane protein 191C
chr5_+_129242120 7.348 NM_021311
Piwil1
piwi-like homolog 1 (Drosophila)
chr8_+_68142423 7.265 NM_175188
March1
membrane-associated ring finger (C3HC4) 1
chr2_+_70400179 7.232 NM_008077
Gad1
glutamic acid decarboxylase 1
chr10_+_118891074 7.197 Grip1
glutamate receptor interacting protein 1
chr7_-_25101619 7.108 NM_009568
Zfp94
zinc finger protein 94
chr6_+_115189004 6.932 Syn2
synapsin II
chr5_+_98609872 6.788 NM_029947
Prdm8
PR domain containing 8
chr9_-_107134182 6.662 NM_153413
Dock3
dedicator of cyto-kinesis 3
chr17_+_31432427 6.578 NM_153062
Slc37a1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr6_+_7505070 6.514 NM_009311
Tac1
tachykinin 1
chr15_+_103333554 6.464 NM_008800
Pde1b
phosphodiesterase 1B, Ca2+-calmodulin dependent
chr6_+_107479719 6.449 NM_008516
Lrrn1
leucine rich repeat protein 1, neuronal
chr18_+_74893369 6.441 Myo5b
myosin VB
chr6_+_48668619 6.367 NM_146167
Gimap7
GTPase, IMAP family member 7
chr4_-_41464365 6.349 NM_001048005
1110017D15Rik
RIKEN cDNA 1110017D15 gene
chr2_-_5635517 6.344 Camk1d
calcium/calmodulin-dependent protein kinase ID
chr7_+_50692442 6.334 NM_024253
Nkg7
natural killer cell group 7 sequence
chr19_-_11340591 6.330 NM_007641
Ms4a1
membrane-spanning 4-domains, subfamily A, member 1
chr7_-_107806887 6.199 NM_001163183
NM_001163184
NM_001163185
Plekhb1


pleckstrin homology domain containing, family B (evectins) member 1


chr6_+_103460955 6.192 Chl1
cell adhesion molecule with homology to L1CAM
chr9_+_72892614 6.181 NM_023635
Rab27a
RAB27A, member RAS oncogene family
chr7_+_51751957 6.177 NM_028169
Fam71e1
family with sequence similarity 71, member E1
chr2_-_25325248 6.168 NM_008963
Ptgds
prostaglandin D2 synthase (brain)
chr2_-_33226946 6.058 Ralgps1
Ral GEF with PH domain and SH3 binding motif 1
chr5_-_101148612 5.914 NM_152803
Hpse
heparanase
chr16_-_14159346 5.910 NM_001081154
4921513D23Rik
RIKEN cDNA 4921513D23 gene
chr18_-_46372017 5.903 NM_178872
Trim36
tripartite motif-containing 36
chr5_-_114280434 5.858 NM_009151
Selplg
selectin, platelet (p-selectin) ligand
chr3_+_75361454 5.846 NM_009250
Serpini1
serine (or cysteine) peptidase inhibitor, clade I, member 1
chr19_-_45890238 5.795 NM_030716
NM_145703
NM_145704
Kcnip2


Kv channel-interacting protein 2


chr2_-_91023154 5.789 NM_001177719
NM_145527
Madd

MAP-kinase activating death domain

chr6_+_41634429 5.749 NM_029671
1700034O15Rik
RIKEN cDNA 1700034O15 gene
chr17_+_48403658 5.743 NM_001033922
NM_001163795
NM_001163796
NM_172623
Treml4



triggering receptor expressed on myeloid cells-like 4



chr15_-_95358306 5.730 Nell2
NEL-like 2 (chicken)
chr15_-_78226314 5.602 NM_001163612
NM_028522
1700061J05Rik

RIKEN cDNA 1700061J05 gene

chr4_-_24778203 5.600 NM_001033531
NM_001163020
Klhl32

kelch-like 32 (Drosophila)

chr7_-_27943743 5.579


chr17_-_36408313 5.569 NM_178281
Trim39
tripartite motif-containing 39
chr6_+_50060895 5.564 Mpp6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr11_-_3763899 5.508 NM_152818
Osbp2
oxysterol binding protein 2
chr7_+_28964486 5.505 NM_001037957
NM_010092
Dyrk1b

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b

chr11_-_69373707 5.462 NM_007911
Efnb3
ephrin B3
chr9_-_62384483 5.460 Coro2b
coronin, actin binding protein, 2B
chr2_-_44782719 5.399 Gtdc1
glycosyltransferase-like domain containing 1
chr7_-_134041745 5.396 NM_026827
NM_028389
Tmem219

transmembrane protein 219

chr8_+_123263681 5.366 Irf8
interferon regulatory factor 8
chr7_-_53080056 5.303 NM_145963
Kcnj14
potassium inwardly-rectifying channel, subfamily J, member 14
chr9_-_102256709 5.236 Ephb1
Eph receptor B1
chr9_+_95459990 5.181 NM_198414
Paqr9
progestin and adipoQ receptor family member IX
chr17_+_24625709 5.156 NM_027937
Caskin1
CASK interacting protein 1
chr1_-_177422520 5.114 Rgs7
regulator of G protein signaling 7
chr1_-_177422630 5.086 NM_001199003
NM_011880
Rgs7

regulator of G protein signaling 7

chr2_-_52532100 5.079 NM_001037099
Cacnb4
calcium channel, voltage-dependent, beta 4 subunit
chr5_-_123183537 5.065 Camkk2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr2_-_33226980 5.054 NM_175211
Ralgps1
Ral GEF with PH domain and SH3 binding motif 1
chr17_+_8436671 5.040 NM_001190334
NM_001190335
NM_001190336
NM_001190337
Ccr6



chemokine (C-C motif) receptor 6



chr1_-_133096633 5.033 Rassf5
Ras association (RalGDS/AF-6) domain family member 5
chr1_-_133141708 5.028 NM_018750
Rassf5
Ras association (RalGDS/AF-6) domain family member 5
chr6_-_28781687 5.017 NM_138682
Lrrc4
leucine rich repeat containing 4
chr2_-_9970235 5.011 NM_027748
Taf3
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr15_-_95358989 4.999 Nell2
NEL-like 2 (chicken)
chr7_-_26004848 4.998 Dedd2
death effector domain-containing DNA binding protein 2
chr19_+_7457020 4.993 1700105P06Rik
RIKEN cDNA 1700105P06 gene
chr8_-_106816961 4.914 NM_027022
Cmtm2a
CKLF-like MARVEL transmembrane domain containing 2A
chr5_-_147395979 4.909 NM_008151
Gpr12
G-protein coupled receptor 12
chr19_+_56796861 4.906 NM_007419
Adrb1
adrenergic receptor, beta 1
chr6_-_129225348 4.890 NM_001033122
Cd69
CD69 antigen
chr5_-_51848420 4.885 Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr11_+_100437204 4.851 NM_001146318
Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
chrX_-_34529689 4.824 NM_001177324
NM_019942
Sept6

septin 6

chr6_-_91757386 4.762 NM_001159507
Grip2
glutamate receptor interacting protein 2
chr3_+_40754552 4.751 NM_001040399
Larp1b
La ribonucleoprotein domain family, member 1B
chr7_+_86956134 4.727 Mesp2
mesoderm posterior 2
chr7_-_133558344 4.696 NM_009844
Cd19
CD19 antigen
chr12_+_75385267 4.677 1700086L19Rik
RIKEN cDNA 1700086L19 gene
chr10_+_126760748 4.654 NM_146011
Arhgap9
Rho GTPase activating protein 9
chr11_-_69373555 4.652 Efnb3
ephrin B3
chr14_+_28435613 4.612 NM_177814
Erc2
ELKS/RAB6-interacting/CAST family member 2
chr5_-_9725158 4.609 Grm3
glutamate receptor, metabotropic 3
chr7_-_19608879 4.539 NM_008260
Foxa3
forkhead box A3
chr15_-_95358674 4.510 Nell2
NEL-like 2 (chicken)
chr6_+_128349783 4.490 NM_001162858
NM_021717
Nrip2

nuclear receptor interacting protein 2

chr12_+_71008808 4.455 Atl1
atlastin GTPase 1
chr3_+_31048841 4.452 NM_008770
Cldn11
claudin 11
chr7_-_109248450 4.427 Art5
ADP-ribosyltransferase 5
chr11_-_120486525 4.421 Sirt7
sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae)
chr8_+_13037307 4.415 NM_007972
F10
coagulation factor X
chr9_-_102256962 4.413 NM_001168296
NM_173447
Ephb1

Eph receptor B1

chr1_-_138157449 4.400 NM_001101516
Gpr25
G protein-coupled receptor 25
chr8_-_74533511 4.399 NM_024444
Cyp4f18
cytochrome P450, family 4, subfamily f, polypeptide 18
chr8_+_91220921 4.398 NM_001128170
NM_001128171
NM_173369
NM_001128169
Cyld



cylindromatosis (turban tumor syndrome)



chr15_-_95358578 4.391 Nell2
NEL-like 2 (chicken)
chrX_+_144749072 4.306 NM_001122734
NM_011022
Gm15085
Ott
Gm15107
predicted gene 15085
ovary testis transcribed
predicted gene 15107
chrX_+_145532494 4.306 NM_001122734
NM_011022
Gm15085
Ott
Gm15107
predicted gene 15085
ovary testis transcribed
predicted gene 15107
chr12_+_89961317 4.284 NM_001198587
Nrxn3
neurexin III
chr9_-_35365985 4.278 NM_013932
Ddx25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr12_-_81537261 4.258 Dcaf5
DDB1 and CUL4 associated factor 5
chr1_-_75215798 4.255 NM_009447
Tuba4a
tubulin, alpha 4A
chr5_-_23857421 4.255 NM_013569
Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr7_-_109248742 4.235 NM_007491
Art5
ADP-ribosyltransferase 5
chr7_-_25857275 4.227 NM_008168
Grik5
glutamate receptor, ionotropic, kainate 5 (gamma 2)
chrX_+_104284572 4.215 NM_172435
P2ry10
purinergic receptor P2Y, G-protein coupled 10
chr7_-_86938475 4.197 NM_008588
Mesp1
mesoderm posterior 1
chr3_-_89206571 4.188 NM_020517
Lenep
lens epithelial protein
chr5_-_143084677 4.185 NM_175217
Mmd2
monocyte to macrophage differentiation-associated 2
chr6_+_139990045 4.177 NM_007605
Capza3
capping protein (actin filament) muscle Z-line, alpha 3
chr4_-_126427788 4.123 Ncdn
neurochondrin
chr8_+_48760744 4.121 AA386476
expressed sequence AA386476
chr12_+_4082573 4.120 NM_153082
Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr5_+_121098830 4.094 NM_013832
Rasal1
RAS protein activator like 1 (GAP1 like)
chr6_+_53989925 4.061 NM_001163640
Chn2
chimerin (chimaerin) 2
chr17_+_24625530 4.040 Caskin1
CASK interacting protein 1
chr11_-_51670897 4.038 NM_199299
Phf15
PHD finger protein 15
chrX_+_145098146 4.034 NM_001114400
Gm10439
Gm15127
predicted gene 10439
predicted gene 15127
chr7_-_26460180 4.034 NM_177102
Tmem91
transmembrane protein 91
chr11_-_98407281 4.022 NM_011771
Ikzf3
IKAROS family zinc finger 3
chr5_+_22940283 4.021 Mll5
myeloid/lymphoid or mixed-lineage leukemia 5
chr9_-_123587923 4.002 NM_139142
Slc6a20a
solute carrier family 6 (neurotransmitter transporter), member 20A
chr11_+_72774709 4.000 Atp2a3
ATPase, Ca++ transporting, ubiquitous
chr5_+_22940294 3.959 Mll5
myeloid/lymphoid or mixed-lineage leukemia 5
chr10_+_7552260 3.932 NM_172785
Zc3h12d
zinc finger CCCH type containing 12D
chr1_-_197002841 3.926 NM_007758
Cr2
complement receptor 2
chr19_+_6341137 3.920 NM_009006
Map4k2
mitogen-activated protein kinase kinase kinase kinase 2
chr6_+_3944011 3.916 NM_010314
Gngt1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr1_+_9788206 3.895 NM_133220
NM_177547
Sgk3

serum/glucocorticoid regulated kinase 3

chr15_-_76648532 3.890 NM_001168288
NM_198420
Arhgap39

Rho GTPase activating protein 39

chr9_+_81757308 3.859 NM_175213
Mei4
meiosis-specific, MEI4 homolog (S. cerevisiae)
chr6_-_139989932 3.859 NM_054066
Plcz1
phospholipase C, zeta 1
chr9_+_21330620 3.855 NM_001198794
NM_206536
AB124611

cDNA sequence AB124611

chr11_+_97258202 3.832 Socs7
suppressor of cytokine signaling 7
chr11_-_70846926 3.812 6330403K07Rik
RIKEN cDNA 6330403K07 gene
chr18_-_5334425 3.801 NM_178722
Zfp438
zinc finger protein 438
chr7_+_28964518 3.792 Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr7_+_34880449 3.785 NM_001099330
Gm12776
predicted gene 12776
chr7_+_52962402 3.784 Dbp
D site albumin promoter binding protein
chr3_-_88259621 3.783 Sema4a
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr17_+_71901400 3.774 NM_001142631
NM_029254
Spdya

speedy homolog A (Xenopus laevis)

chr3_+_92211912 3.754 NM_011475
Sprr2i
small proline-rich protein 2I
chr4_+_141102699 3.753 B330016D10Rik
RIKEN cDNA B330016D10 gene
chrX_+_68303282 3.748 NM_001081354
Mamld1
mastermind-like domain containing 1
chr12_-_115526405 3.746 Igh-VJ558
Igh-2
LOC432699
immunoglobulin heavy chain (J558 family)
immunoglobulin heavy chain 2 (serum IgA)
VH gene product
chr4_+_49072327 3.744 NM_178756
E130309F12Rik
RIKEN cDNA E130309F12 gene
chr4_-_123427465 3.715 NM_023423
Akirin1
akirin 1
chr5_-_23835349 3.703 Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr6_+_53989992 3.702 Chn2
chimerin (chimaerin) 2
chr15_-_96471920 3.701 Slc38a1
solute carrier family 38, member 1
chr5_+_113919352 3.696 NM_177292
Wscd2
WSC domain containing 2
chrX_+_130829929 3.687 Tmem35
transmembrane protein 35
chr9_+_72892697 3.686 Rab27a
RAB27A, member RAS oncogene family
chr17_-_23908488 3.669 NM_153791
Flywch1
FLYWCH-type zinc finger 1
chr3_+_94758056 3.641 Rfx5
regulatory factor X, 5 (influences HLA class II expression)
chr6_+_115084919 3.640 NM_001111015
NM_013681
Syn2

synapsin II

chr5_+_22940281 3.640 Mll5
myeloid/lymphoid or mixed-lineage leukemia 5
chr7_-_79451480 3.639 NM_001024703
Mctp2
multiple C2 domains, transmembrane 2
chr13_-_62989520 3.622 Fbp1
fructose bisphosphatase 1
chr1_-_87500465 3.620 NM_175397
Sp110
Sp110 nuclear body protein
chr6_+_114081227 3.617 NM_172890
Slc6a11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr16_+_20590162 3.615 Vwa5b2
von Willebrand factor A domain containing 5B2
chr7_+_97278722 3.610 NM_146194
Picalm
phosphatidylinositol binding clathrin assembly protein
chr4_+_83171448 3.602 NM_001081012
4930473A06Rik
RIKEN cDNA 4930473A06 gene
chrX_+_7215705 3.588 NM_009305
Syp
synaptophysin
chr5_+_22940275 3.588 Mll5
myeloid/lymphoid or mixed-lineage leukemia 5
chr1_+_74648028 3.587 NM_175031
Stk36
serine/threonine kinase 36 (fused homolog, Drosophila)
chr3_-_100293092 3.579 NM_001142952
Fam46c
family with sequence similarity 46, member C
chr1_-_173582969 3.564 NM_144539
Slamf7
SLAM family member 7
chr8_+_91220965 3.556 Cyld
cylindromatosis (turban tumor syndrome)
chr13_-_113971103 3.554 NM_008196
Gzmk
granzyme K
chr14_+_80400057 3.530 NM_001030294
Olfm4
olfactomedin 4
chrX_+_144756676 3.524 NM_001099920
Gm15093
predicted gene 15093
chrX_+_145706919 3.524 NM_001099920
Gm15093
predicted gene 15093
chrX_+_145540098 3.524 NM_001099920
Gm15093
predicted gene 15093
chrX_+_145889719 3.524 NM_001099920
Gm15093
predicted gene 15093
chrX_+_144923491 3.524 NM_001082966
Gm15114
predicted gene 15114

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.57 2.54e-03 GO:0043005 neuron projection
1.84 4.84e-03 GO:0030424 axon
1.74 1.54e-02 GO:0030425 dendrite
1.18 1.65e-02 GO:0071944 cell periphery
1.53 3.20e-02 GO:0045202 synapse
1.17 3.22e-02 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.09 1.36e-03 GO:0005488 binding