Motif ID: TCF4_dimer.p2

Z-value: 2.224


Transcription factors associated with TCF4_dimer.p2:

Gene SymbolEntrez IDGene Name
Tcf4 21413 transcription factor 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf4chr18_+_698435880.295.5e-05Click!


Activity profile for motif TCF4_dimer.p2.

activity profile for motif TCF4_dimer.p2


Sorted Z-values histogram for motif TCF4_dimer.p2

Sorted Z-values for motif TCF4_dimer.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TCF4_dimer.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_107806887 28.736 NM_001163183
NM_001163184
NM_001163185
 Plekhb1


pleckstrin homology domain containing, family B (evectins) member 1


chr7_-_51780003 27.214 NM_146189
 Mybpc2
myosin binding protein C, fast-type
chr15_+_81641832 27.027 NM_017376
 Tef
thyrotroph embryonic factor
chr19_+_7131270 25.989 Macrod1
MACRO domain containing 1
chr15_+_81641869 25.880 Tef
thyrotroph embryonic factor
chr2_-_52194317 24.690 NM_010889
 Neb
nebulin
chr7_-_30066642 24.230 Spint2
serine protease inhibitor, Kunitz type 2
chr19_+_7131234 23.909 NM_134147
 Macrod1
MACRO domain containing 1
chr7_-_30066867 23.210 Spint2
serine protease inhibitor, Kunitz type 2
chr15_+_54402914 23.129 NM_178920
 Mal2
mal, T-cell differentiation protein 2
chr7_-_30066910 22.104 NM_001082548
NM_011464
 Spint2

serine protease inhibitor, Kunitz type 2

chr15_+_54402988 21.689 Mal2
mal, T-cell differentiation protein 2
chr3_-_126701367 21.618 NM_178655
 Ank2
ankyrin 2, brain
chrX_+_162676903 21.529 Gpm6b
glycoprotein m6b
chrX_+_162676870 21.270 NM_001177961
NM_001177962
NM_023122
 Gpm6b


glycoprotein m6b


chr19_+_20676453 20.860 NM_013467
 Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr4_+_84851330 19.271 NM_019535
 Sh3gl2
SH3-domain GRB2-like 2
chr3_-_97571863 19.028 Pde4dip
phosphodiesterase 4D interacting protein (myomegalin)
chr15_+_99548011 18.977 Gpd1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr2_-_170232008 18.864 Bcas1
breast carcinoma amplified sequence 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 74 entries
Enrichment   P-value GO Accession GO Term
2.64 7.13e-04 GO:0006941 striated muscle contraction
1.92 1.58e-03 GO:0006936 muscle contraction
1.90 1.99e-02 GO:0006836 neurotransmitter transport
1.87 9.60e-04 GO:0003012 muscle system process
1.82 3.04e-04 GO:0006813 potassium ion transport
1.70 8.18e-06 GO:0048812 neuron projection morphogenesis
1.69 6.92e-03 GO:0007517 muscle organ development
1.68 6.51e-03 GO:0051493 regulation of cytoskeleton organization
1.67 3.60e-04 GO:0007409 axonogenesis
1.66 2.74e-06 GO:0048858 cell projection morphogenesis
1.65 2.54e-06 GO:0032990 cell part morphogenesis
1.64 7.77e-05 GO:0007268 synaptic transmission
1.64 2.77e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.62 3.84e-02 GO:0042391 regulation of membrane potential
1.61 9.45e-06 GO:0031175 neuron projection development
1.60 7.66e-04 GO:0061061 muscle structure development
1.60 1.54e-02 GO:0031344 regulation of cell projection organization
1.58 7.25e-07 GO:0048666 neuron development
1.58 4.38e-05 GO:0019226 transmission of nerve impulse
1.58 4.38e-05 GO:0035637 multicellular organismal signaling

Gene overrepresentation in compartment category:

Showing 1 to 20 of 62 entries
Enrichment   P-value GO Accession GO Term
2.57 2.08e-04 GO:0042734 presynaptic membrane
2.52 8.37e-03 GO:0044304 main axon
2.47 5.98e-07 GO:0031674 I band
2.36 1.30e-04 GO:0030018 Z disc
2.19 1.36e-06 GO:0030017 sarcomere
2.08 9.72e-06 GO:0008021 synaptic vesicle
2.03 5.34e-03 GO:0008076 voltage-gated potassium channel complex
2.03 5.34e-03 GO:0034705 potassium channel complex
2.02 4.97e-06 GO:0030016 myofibril
2.00 3.65e-05 GO:0044449 contractile fiber part
1.98 1.24e-03 GO:0005923 tight junction
1.98 1.24e-03 GO:0070160 occluding junction
1.98 4.47e-03 GO:0044309 neuron spine
1.97 2.66e-04 GO:0016327 apicolateral plasma membrane
1.97 6.16e-03 GO:0043197 dendritic spine
1.96 9.02e-06 GO:0043292 contractile fiber
1.93 1.05e-03 GO:0043296 apical junction complex
1.86 1.63e-03 GO:0034703 cation channel complex
1.84 1.44e-04 GO:0033267 axon part
1.81 7.22e-19 GO:0045202 synapse

Gene overrepresentation in function category:

Showing 1 to 20 of 36 entries
Enrichment   P-value GO Accession GO Term
3.03 9.74e-03 GO:0015459 potassium channel regulator activity
2.57 5.99e-03 GO:0035254 glutamate receptor binding
2.25 2.33e-03 GO:0016247 channel regulator activity
2.18 9.96e-09 GO:0005516 calmodulin binding
1.83 9.24e-04 GO:0005267 potassium channel activity
1.83 2.69e-02 GO:0005249 voltage-gated potassium channel activity
1.76 3.07e-03 GO:0022843 voltage-gated cation channel activity
1.74 1.02e-04 GO:0005244 voltage-gated ion channel activity
1.74 1.02e-04 GO:0022832 voltage-gated channel activity
1.66 3.98e-13 GO:0008092 cytoskeletal protein binding
1.62 5.43e-06 GO:0003779 actin binding
1.61 2.54e-05 GO:0022836 gated channel activity
1.61 1.63e-04 GO:0005261 cation channel activity
1.56 5.82e-06 GO:0005216 ion channel activity
1.55 7.78e-06 GO:0022838 substrate-specific channel activity
1.54 7.55e-06 GO:0022803 passive transmembrane transporter activity
1.53 2.18e-07 GO:0008324 cation transmembrane transporter activity
1.53 1.18e-05 GO:0015267 channel activity
1.48 3.57e-06 GO:0005509 calcium ion binding
1.47 3.58e-02 GO:0005083 small GTPase regulator activity